• Journal of Pharmaceutical Investigation
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• v.41 no.3
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• pp.179-184
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• 2011

This study aimed to confirm the effect of molecular weight (MW) in solid dispersion of carvedilol with poly-vinylpyrrolidone (PVP) of various MW. Solid dispersion of carvedilol with PVP was prepared by spray-drying method. Scanning electron microscopy (SEM) was used to analyze the surface of solid dispersion samples. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystalline of solid dispersion. Fourier transform infrared spectroscopy (FT-IR) was used to analyze the change of chemical structure characteristic of solid dispersion. DSC and XRD show that drug crystalline was changed. FT-IR revealed that chemical structure of solid dispersion comparing the chemical structure of drug was changed. The dissolution studies of solid dispersion presented at simulated gastric juice (pH 1.2). The dissolution rate of solid dispersion was dramatically enhanced than pure drug and the MW of PVP has an effect on the release property of carvedilol in solid dispersion. In conclusion, the present study has confirmed the effect of MW of PVP on release property of solid dispersion formulation of carvedilol with PVP.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.610-613
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• 2009

New rod-disc liquid crystal (LC) molecule RD12 (12 is the number of carbon atoms between the rod and disc mesogenic liquid crystals) was synthesized via the chemical attachment of six cyanobiphenly calamitic mesogens linked to the triphenyl discotic mesogen with six alkyl chain linkage. Aligning characteristics associated with homogenous alignment is investigated at first and then field-dependent molecular reorientation under a vertical electric field is studied. Interestingly, they show abnormal slow molecular transition from initiate state (no electric field condition) to certain voltage. In this condition, we observe the molecular competition during reorientation. However, once a tilting direction of disk molecules are defined, the frustration is not observed anymore. The origin of this phenomenon is explained with a suggested model for the first time.

• Journal of the Optical Society of Korea
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• v.20 no.6
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• pp.794-798
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• 2016

A polymer-stabilized vertical alignment (PS-VA) mode with fishbone-shaped pixel electrode structure is mainly used in large-sized liquid crystal displays (LCDs) owing to its advantages such as wide viewing angle, good transmittance and fast response time. One drawback of this mode is a main bone electrode, which crosses in the center of a pixel. It causes the transmittance to decrease badly because LCs cannot be reoriented in this region, and thus, it is particularly unfavorable in an ultra-high-definition LCD. Here, we propose an innovative structure with the main bone electrode relocated to the edge area in a pixel, and investigate how this reverse directed fishbone-shaped pixel electrode structure affects electro-optic characteristics. The proposed structure shows enhanced electro-optic performance, such as the higher transmittance and the faster response time than the conventional VA mode with fishbone-shaped pixel electrode structure.

• Journal of Pharmaceutical Investigation
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• v.37 no.6
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• pp.339-347
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• 2007

SMEDDS is mixture of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle agitation and digestive motility that would be encountered in the gastro-intestinal(GI) tract. The main purpose of this work is to prepare self-microemulsifying drug delivery system(SMEDDS) for oral bioavailability enhancement of a poorly water soluble drug, atorvastatin calcium. Solubility of atorvastatin calcium was determined in various vehicles. Pseudo-ternary phase diagrams were constructed to identity the efficient self-emulsification region and particle size distributions of the resultant micro emulsions were determined using a laser diffraction sizer. Optimized formulations for in vitro dissolution and bioavailability assessment were $Capryol^{(R)}$ 90(50%), Tetraglycol(16%), and $Cremophor^{(R)}$ EL(32%). The release rate of atorvastatin from SMEDDS was significantly higher than the conventional tablet ($Lipitor^{(R)}$), 2-fold. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as atorvastatin calcium by the oral route.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.119-126
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• 2008

Solid dispersions of poorly water-soluble drug, sibutramine, were prepared with hydrophilic polymer, poly-N-vinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC) and organic acid, citric acid, to improve the solubility of drug. Physicochemical variation and shape of microsphere were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and Fourier-transform infrared spectroscopy (FT-IR). Microspheres containing additives showed more spherical shape than non additive microspheres. In vitro release behavior of microspheres presented at simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The solid dispersion form transformed the drug into an amorphous state and dramatically improved its dissolution rate. These data suggest that the solid dispersion technique is an effective approach for developing the appetite depressant drug products and various pharmaceutical excipients are able to control the release behaviors.

• Earthquakes and Structures
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• v.23 no.6
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• pp.493-502
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• 2022

In recent decades, infrastructural development has exploded, particularly in the coastal region of Saudi Arabia. The rising demand of most consumed aggregate in construction can be effectively compensated by the alternative material like scoria which lavishly exists in the western region. Scoria is characterized as lightweight aggregate beneficially used to develop lightweight concrete (LWC) - a potential alternative of normal weight concrete (NWC) ensuring reduction in the structural element's size, increase in building height, comparatively lighter foundation, etc. Hence, the goal of this study is to incorporate scoria-based structural lightweight concrete and evaluate its impact on superstructure and foundation design beside contributing to the economy of construction. Fresh, mechanical, and rheological properties of the novel LWC have been investigated. The structural analyses employ the NWC as well as LWC based structures under seismic and wind loadings. The commercial finite element package - ETABS was employed to find out the change in structural responses and foundations. The cost estimation and SWOT analysis for superstructure and foundation have also been carried out. It was revealed that the developed LWC enabled a more flexible structural design. Notable reduction in the steel and concrete prices of LWC might be possible in the low-rise building. It is postulated that the cost-effective and eco-friendly LWC will promote the usage of scoria as an effective alternative in Saudi Arabia and GCC countries for structurally viable LWC construction.

• International Journal of Computer Science & Network Security
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• v.23 no.4
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• pp.95-102
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• 2023

The emergence of Internet of Things (IoT) into our daily lives has grown rapidly. It's been integrated to our homes, cars, and cities, increasing the intelligence of devices involved in communications. Enormous amount of data is exchanged over smart devices through the internet, which raises security concerns in regards of privacy evasion. This paper is focused on the forensics and intrusion detection on one of the most common protocols in IoT environments, especially smart home environments, which is the Message Queuing Telemetry Transport (MQTT) protocol. The paper covers general IoT infrastructure, MQTT protocol and attacks conducted on it, and multiple network forensics frameworks in smart homes. Furthermore, a machine learning model is developed and tested to detect several types of attacks in an IoT network. A forensics tool (MQTTracker) is proposed to contribute to the investigation of MQTT protocol in order to provide a safer technological future in the warmth of people's homes. The MQTT-IOT-IDS2020 dataset is used to train the machine learning model. In addition, different attack detection algorithms are compared to ensure the suitable algorithm is chosen to perform accurate classification of attacks within MQTT traffic.

• International Journal of Computer Science & Network Security
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• v.24 no.2
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• pp.15-24
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• 2024

One of the most significant issues in combinatorial optimization is the classical NP-complete conundrum known as the 0/1 Knapsack Problem. This study delves deeply into the investigation of practical solutions, emphasizing two classic algorithmic paradigms, brute force, and dynamic programming, along with the metaheuristic and nature-inspired family algorithm known as the Genetic Algorithm (GA). The research begins with a thorough analysis of the dynamic programming technique, utilizing its ability to handle overlapping subproblems and an ideal substructure. We evaluate the benefits of dynamic programming in the context of the 0/1 Knapsack Problem by carefully dissecting its nuances in contrast to GA. Simultaneously, the study examines the brute force algorithm, a simple yet comprehensive method compared to Branch & Bound. This strategy entails investigating every potential combination, offering a starting point for comparison with more advanced techniques. The paper explores the computational complexity of the brute force approach, highlighting its limitations and usefulness in resolving the 0/1 Knapsack Problem in contrast to the set above of algorithms.

• 한국태양에너지학회:학술대회논문집
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• 2008.04a
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• pp.154-159
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• 2008

Daylight is an important component for human and energy saving. Also, available daylight in inside provides positive influence on psychological and physiological aspects as well as good visual environment. It is important to lighting design for office building not only designing for artificial lighting but also using daylight for energy savings. Therefore, lighting designers and architectures must consider the effects of the daylight for human environment and energy savings. The BIN Method is one of the methods to predict energy savings using computer simulation but it spends more time than expectation. So, this study performs to simulate a simple space using the RADIANCE for examination and simplification of the BIN Method.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.692-698
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• 1993

This paper presents a Bin-Picking method in which robot recognizes the positions and orientations of jumbled objects placed in a bin, then picks up distinctive objects from the top of the jumble. The jumbled objects are recognized comparing the characteristics extracted from stereo images with those in the CAD data. The 3-D information is obtained using the bipartite-matching method which compares image of one camera with the image of the other camera Then the robot picks up the object which will cause the least amount of disturbance to the jumble, and places it at a predetermined place. This paper contributes to the basic study of Bin-Picking, and can be used in an automatic assembly system without using part sorting or orienting devices.