• BMB Reports
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• v.43 no.1
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• pp.23-28
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• 2010

Binary toxin consisting of BinA and BinB from Bacillus sphaericus is toxic to mosquito larvae. BinB is responsible for specific binding to the larval gut cell membrane while BinA is crucial for toxicity. To investigate functional role of cysteine in BinB, three cysteine residues at positions 67, 161, and 241 were replaced by alanine or serine. Mutations at these positions did not affect protein production and overall structure of BinB. These cysteine residues are not involved in disulfide bond formation between BinB molecules. Mosquito-larvicidal assays revealed that C67 and C161 are essential for toxicity, whereas C241 is not. Mutations at C67 and C161 resulted in weaker BinA-BinB interaction. The loss of toxicity may be due to the reduction of interactions between BinA and BinB or BinB and its receptor. C67 and C161 could also play a part during conformational changes or internalization of the binary toxin into the target cell.

• IE interfaces
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• v.17 no.1
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• pp.1-12
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• 2004

In a modern semiconductor device manufacturing industry, statistical bin limits on wafer level test bin data are used for minimizing value added to defective product as well as protecting end customers from potential quality and reliability excursion. Most wafer level test bin data show skewed distributions. By Monte Carlo simulation, this paper evaluates methods and sample size effect regarding determination of statistical bin limits. In the simulation, it is assumed that wafer level test bin data follow the Poisson distribution. Hence, typical shapes of the data distribution can be specified in terms of the distribution's parameter. This study examines three different methods; 1) percentile based methodology; 2) data transformation; and 3) Poisson model fitting. The mean square error is adopted as a performance measure for each simulation scenario. Then, a case study is presented. Results show that the percentile and transformation based methods give more stable statistical bin limits associated with the real dataset. However, with highly skewed distributions, the transformation based method should be used with caution in determining statistical bin limits. When the data are well fitted to a certain probability distribution, the model fitting approach can be used in the determination. As for the sample size effect, the mean square error seems to reduce exponentially according to the sample size.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.6
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• pp.75-80
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• 2023

We show the design of fast invertible block transforms that can replace the DCT in future wireless and portable computing application. This is called binDCT. In binDCT, both the forward and the inverse transforms can be implemented using only binary shift and addition operation. And the binDCT inherits all desirable DCT characteristics such as high coding gain, no DC leakage, symmetric basis functions, and recursive construction. The binDCT also inherits all lifting properties such as fast implementations, invertible integer-to-integer mapping, in-place computation. Thus, this method has advantage of fast implementation for complex DCT calculations. In this paper, we present computation costs and performance analysis between DCT and binDCT using Shapiro's EZW.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.522-522
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• 2012

최근 각종 하천 개발 사업이 활발히 진행되면서 안정하도 평가가 활발히 이루어지고 있다. 안정하도 평가를 위해서는 흐름과 하천의 수리기하특성간의 관계를 연결시켜주는 기준유량이 필요한데 이러한 유량이 곧 유효유량이라 할 수 있다. 유효유량은 수년에 결쳐 연 유사량의 대부분을 이동시키는 유량의 평균값으로 정의되며, 적어도 일년에 한 번이나 두 번 또는 대부분의 경우 매년 여러번 발생하는 적당한 빈도의 유량규모에 의해 연 유사량의 대부분을 이동시키는 유량이다. 대표적인 유효유량 산정 프로그램인 Geo-tool은 유황곡선과 유사량 관계 곡선을 활용하여 유효유량을 계산한다. 프로그램에 입력하는 유량은 Bin 수와 지정하는 규칙에 따라 유량구간이 나뉜 후 각 구간별 평균유량에 대한 유사량을 산정한다. 이 때 산정된 구간별 유사량값과 이 구간의 유량이 발생한 일수를 산정함으로써 이 구간의 유량을 통해 발생한 연간 총유사량을 산정한다. 각 구간별 연간 총유사량으로부터 가장 많은 유사량을 이송시키는 구간에 해당되는 평균유량을 유효유량으로 선정하게 된다. 즉 유효유량은 유량범위 간격에 민감하게 반응하므로 Bin의 선정이 중요하다고 할 수 있다. 그러나 국내외에서 Bin 산정에 대한 명백한 기준이 없는 상황이므로 본 연구에서는 Arithmeic Bin과 Logarithmic Bin를 모두 사용하여 낙동강 중류 유효유량 산정에 가장 적합한 Bin의 수와 Bin 간격 산정 규칙을 제시하였다.

• Journal of Biosystems Engineering
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• v.32 no.1 s.120
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• pp.13-19
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• 2007

Storage rough rice in low temperature using the winter cold air avoids rough rice temperature increase which happens from early May, and this is possible by installing a cooling system in the top of a bin, the room between top rice level and bin ceiling. The research objective is to establish low temperature rough rice storage technique, furnishing winter cold air to rough rice, by investigating the cooling system potential of maintaining low rough rice temperature and by analyzing rough rice storage characteristics over a storage period. The rough rice storage characteristics were evaluated from January to August 2003, using a storage and dry bin of 400-ton capacity. Results of this research are as follows: Cooling bin using the cooling system in the top of the bin maintained the rice temperature less than 15$^{\circ}C$ in entire portions in August. Moisture contents and germination rates of rough rice were decreased over the storage period, on the other hand, the rough rice stored in the ambient temperature bin had relatively lower moisture contents and germination rates to compare with the bin using winter cold air. Crack ratio and acid value of brown rice in the ambient temperature bin storage had increased more than the cooling bin storage. The result indicates that the storage bin using winter cold air and the cooling system maintains moisture content and germination of rice, minimizes cracked kernel and acid value, and preserves rice quality as well.

• International Journal of Computer Science & Network Security
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• v.23 no.6
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• pp.77-83
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• 2023

This research is conducted to minimize the potential security risks of conducting online exams to an acceptable level as vulnerabilities and threats to this type of exam are presented. This paper provides a general structure for the risk management process and some recommendations for increasing the level of security.

• Progress in Medical Physics
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• v.22 no.3
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• pp.140-147
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• 2011

The purpose of this study was to estimate internal motion using molecular sieve for quantitative improvement of lung tumor and to localize lung tumor in the small animal PET image by evaluated data. Internal motion has been demonstrated in small animal lung region by molecular sieve contained radioactive substance. Molecular sieve for internal lung motion target was contained approximately 37 kBq Cu-64. The small animal PET images were obtained from Siemens Inveon scanner using external trigger system (BioVet). SD-Rat PET images were obtained at 60 min post injection of FDG 37 MBq/0.2 mL via tail vein for 20 min. Each line of response in the list-mode data was converted to sinogram gated frames (2~16 bin) by trigger signal obtained from BioVet. The sinogram data was reconstructed using OSEM 2D with 4 iterations. PET images were evaluated with count, SNR, FWHM from ROI drawn in the target region for quantitative tumor analysis. The size of molecular sieve motion target was $1.59{\times}2.50mm$. The reference motion target FWHM of vertical and horizontal was 2.91 mm and 1.43 mm, respectively. The vertical FWHM of static, 4 bin and 8 bin was 3.90 mm, 3.74 mm, and 3.16 mm, respectively. The horizontal FWHM of static, 4 bin and 8 bin was 2.21 mm, 2.06 mm, and 1.60 mm, respectively. Count of static, 4 bin, 8 bin, 12 bin and 16 bin was 4.10, 4.83, 5.59, 5.38, and 5.31, respectively. The SNR of static, 4 bin, 8 bin, 12 bin and 16 bin was 4.18, 4.05, 4.22, 3.89, and 3.58, respectively. The FWHM were improved in accordance with gate number increase. The count and SNR were not proportionately improve with gate number, but shown the highest value in specific bin number. We measured the optimal gate number what minimize the SNR loss and gain improved count when imaging lung tumor in small animal. The internal motion estimation provide localized tumor image and will be a useful method for organ motion prediction modeling without external motion monitoring system.

• Polymer(Korea)
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• v.38 no.4
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• pp.434-440
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• 2014

We prepared nanoparticles containing insoluble celecoxib by the method of solid dispersions using a spray dryer to improve solubility of celecoxib. We used PVP K30 and Eudragit EPO as water-soluble carriers for the solid dispersion, and poloxamer 407 as a surfactant. Characterization of celecoxib solid dispersion was performed by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The results of SEM, DSC and XRD demonstrated that celecoxib is amorphous in solid dispersion. The dissolution rate measured in intestinal juice showed that the method of solid dispersion improved celecoxib solubility as compared with a conventional drug (Celebres$^{(R)}$). In conclusion, solid dispersion formulation prepared by a spray dryer would improve the solubility of celecoxib in oral administration.

• BMB Reports
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• v.44 no.10
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• pp.674-679
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• 2011

Bacillus sphaericus produces mosquito-larvicidal binary toxin composed of BinA and BinB. While BinB is expected to bind to a specific receptor on the cell membrane, BinA interacts to BinB or BinB receptor complex and translocates into the cytosol to exert its activity via unknown mechanism. To investigate functional roles of aromatic cluster in BinA, amino acids at positions Y213, Y214, Y215, W222 and W226 were substituted by leucine. All mutant proteins were highly produced and their secondary structures were not affected by these substitutions. All mutants are able to insert into lipid monolayers as observed by Langmuir-Blodgett trough and could permeabilize the liposomes in a similar manner as the wild type. However, mosquito-larvicidal activity was abolished for W222L and W226L mutants suggesting that tryptophan residues at both positions play an important role in the toxicity of BinA, possibly involved in the cytopathological process after toxin entry into the cells.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.616-619
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• 2009

Color tracking behavior of in the fringe-field switching (FFS) mode using a liquid crystal with positive dielectric anisotropy has been studied. In the in-plane switching and vertical alignment devices, color chromaticity at normal direction changes from bluish to yellowish white linearly with increasing grey levels from dark to white state. Interestingly, abnormal behavior in color tracking is observed in FFS devices using a liquid crystal with positive dielectric anisotropy, that is, it changes from bluish to yellowish up to a certain middle grey level but turns over to bluish white with further increasing from a grey level to a fully white state. In this paper, we analyze this abnormal effect from the calculated and experimental results.