• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5571-5575
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• 2014

Background: The ability to predict the survival time of breast cancer patients is important because of the potential high morbidity and mortality associated with the disease. To develop a predictive inference for determining the survival of breast cancer patients, we applied a novel Bayesian method. In this paper, we propose the development of a databased statistical probability model and application of the Bayesian method to predict future survival times for White Hispanic female breast cancer patients, diagnosed in the US during 1973-2009. Materials and Methods: A stratified random sample of White Hispanic female patient survival data was selected from the Surveillance Epidemiology and End Results (SEER) database to derive statistical probability models. Four were considered to identify the best-fit model. We used three standard model-building criteria, which included Akaike Information Criteria (AIC), Bayesian Information Criteria (BIC), and Deviance Information Criteria (DIC) to measure the goodness of fit. Furthermore, the Bayesian method was used to derive future survival inferences for survival times. Results: The highest number of White Hispanic female breast cancer patients in this sample was from New Mexico and the lowest from Hawaii. The mean (SD) age at diagnosis (years) was 58.2 (14.2). The mean (SD) of survival time (months) for White Hispanic females was 72.7 (32.2). We found that the exponentiated Weibull model best fit the survival times compared to other widely known statistical probability models. The predictive inference for future survival times is presented using the Bayesian method. Conclusions: The findings are significant for treatment planning and health-care cost allocation. They should also contribute to further research on breast cancer survival issues.

• International Journal of Oral Biology
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• 제33권4호
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• pp.217-221
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• 2008

Bicuculline is one of the most commonly used $GABA_A$ receptor antagonists in electrophysiological research. Because of its poor water solubility, bicuculline quaternary ammonium salts such as bicuculline methiodide (BMI) and bicuculline methbromide are preferred. However, a number of studies have shown that BMI has non-$GABA_A$ receptor-mediated effects. The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) is implicated in the processing of nociceptive signaling. In this study, we investigated whether BMI has non-GABA receptor-mediated activity in Vc SG neurons using a whole cell patch clamp technique. SG neurons were depolarized by application of BMI ($20{\mu}M$) using a high $Cl^-$ pipette solution. GABA ($30-100{\mu}M$) also induced membrane depolarization of SG neuron. Although BMI is known to be a $GABA_A$ receptor antagonist, GABA-induced membrane depolarization was enhanced by co-application with BMI. However, free base bicuculline (fBIC) and picrotoxin (PTX), a $GABA_A$ and $GABA_C$ receptor antagonist, blocked the GABA-induced response. Furthermore, BMI-induced membrane depolarization persisted in the presence of PTX or an antagonist cocktail consisting of tetrodotoxin ($Na^+$ channel blocker), AP-5 (NMDA receptor antagonist), CNQX (non-NMDA receptor antagonist), and strychnine (glycine receptor antagonist). Thus BMI induces membrane depolarization by directly acting on postsynaptic Vc SG neurons in a manner which is independent of $GABA_A$ receptors. These results suggest that other unknown mechanisms may be involved in BMI-induced membrane depolarization.

• The Journal of Advanced Prosthodontics
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• 제6권6호
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• pp.505-511
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• 2014

PURPOSE. The purpose of this study was to assess the effect of systemically administered oxytocin (OT) on the implant-bone interface by using histomorphometric analysis and the removal torque test. MATERIALS AND METHODS. A total of 10 adult, New Zealand white, female rabbits were used in this experiment. We placed 2 implants (CSM; CSM Implant, Daegu, South Korea) in each distal femoral metaphysis on both the right and left sides; the implants on both sides were placed 10 mm apart. In each rabbit, 1 implant was prepared for histomorphometric analysis and the other 3 were prepared for the removal torque test (RT). The animals received intramuscular injections of either saline (control group; 0.15 M NaCl) or OT (experimental group; $200{\mu}g/rabbit$). The injections were initiated on Day 3 following the implant surgery and were continued for 4 subsequent weeks; the injections were administered twice per day (at a 12-h interval), for 2 days per week. RESULTS. While no statistically significant difference was observed between the two groups (P=.787), the control group had stronger removal torque values. The serum OT concentration (ELISA value) was higher in the OT-treated group, although no statistically significant difference was found. Further, the histomorphometric parameter (bone-to-implant contact [BIC], inter-thread bone, and peri-implant bone) values were higher in the experimental group, but the differences were not significant. CONCLUSION. We postulate that OT supplementation via intramuscular injection weakly contributes to the bone response at the implant-bone interface in rabbits. Therefore, higher concentrations or more frequent administration of OT may be required for a greater bone response to the implant. Further studies analyzing these aspects are needed.

• Journal of Periodontal and Implant Science
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• 제36권1호
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• pp.253-263
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• 2006

Purpose: Recently, dental implant systems have been widely used for the treatment of the extraction site, but we have been confronted with many limitations in esthetics, phonetics and function. Transitional implants(TI) were developed as a method of providing fixed provisional restorations during conventional implant healing. Until now, little data have been provided on korean transitional implants. The purpose of this study is to evaluate the implant placement site histologically after 4 weeks and 8 weeks. Materials and Methods : Test group( IntermetzzoTM MEGAGEN, KOREA) and control group(Mini Drive Lock, Intra Rock, U.S.A.) were immediately placed in interseptal or interproximal bone of beagle dog after mandibular premolars extraction, and had a healing period with non-submerged state but without loading, Both TI surfaces were composed of rough surfaces. Results: In the test group, the average percentage of BIC were respectively 39.40%(SD7.35) after 4 weeks and 44.05%(16.76) after 8 weeks, and In the control group were 50.75%(1.48) and 59.40%(0.00). Discussion: We evaluated the initial ability of the osseointegration of TI through this study. Because TI is placed with a conventional implant simultaneously and loaded immediately, the ability of osseointegration is a very important factor for the success of TI during the initial healing phase. Conclusion: The results of the histological evaluation of these two groups were similar to those mentioned in other studies for osseointegration of implant.

• 대한치과보철학회지
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• 제45권3호
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• pp.339-344
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• 2007

Statement of problem. Various anodic oxidation techniques can be applied to dental implant surfaces. But the condition for optimal anodized surfaces has not been described yet. Purpose. The purpose of this investigation was to compare an implant that was oxidized by another method with $TiUnite^{TM}$ through resonance frequency analysis and histomorphometry. Material and methods. Turned (control), $TiUnite^{TM}$ and another oxidized fixtures, which used $Ca^{2+}$ solution for anodic oxidation, were placed in the tibiae of 5 New Zealand White rabbits. The bone responses were evaluated and compared by consecutive resonance frequency analysis once a week for 6 weeks and histomorphometry after a healing period of 6 weeks. Results. At the first week, both oxidized implants showed significantly higher implant stability quotient (ISQ) values than the control. No significant differences in resonance frequency analysis were found between the two oxidized groups for 6 weeks. The means and standard deviations of bone-to-implant contact (BIC) ratios were $71.0{\pm}4.2$ for $TiUnite^{TM}$, $67.5{\pm}10.3$ for the $Ca^{2+}$-based oxidation fixture, $22.8{\pm}6.5$ for the control. Both oxidized implants were significantly superior in osseointegration to the turned one. There was, however, no statistically significant difference between the two oxidized implants. Conclusion. $TiUnite^{TM}$ and the $Ca^{2+}$-based oxidation fixture showed superior early bone response than the control with respect to resonance frequency analysis and histomorphometry. No significant differences between the oxidized groups, however, were found in this investigation using the rabbit tibia model.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제27권2호
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• pp.123-130
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• 2005

Many of the molecular and genotypic events taking place at the osteoblast cell level during bone-implant integration are still largely unknown. The objective of this study was to examine expression patterns of TGF-$\beta$ and IGF-I related genes during bone-implant integration. Titanium implants with machined surface were placed into 8 rabbit tibias. At 3rd, 7th, 14th, 28th day after implantation, the expression pattern of TGF-$\beta$ and IGF-I genes in bone with or without implant was examined using reverse transcriptase-polymerase chain reaction (RT-PCR). At the same time, histomorphometric analysis was evaluated, respectively. The bone-to-implant contacts (BIC) of experimental groups were 5.2%, 6.2%, 6.6%, 24.6% at 3rd, 7th, 14th, 28th day. This indicated that newly formed bone increased at the implant surface in bone marrow space after implantation. The expressions of TGF-$\beta$ and IGF-I were higher in implantation groups than untreated control groups during all experimental days. The increased expression of TGF-$\beta$ and IGF-I genes may be associated with the increased bone-to-implant contact. This result provided the evidence for existing biologic differences in tissue response after implantation and helped us to understand molecular biologic processes in tissue-implant integration.

• 한국산학기술학회논문지
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• 제17권5호
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• pp.645-652
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• 2016

입력 랜덤 변수(input random variable)의 통계 모델링은 기계시스템의 신뢰성 해석(reliability analysis), 신뢰성 기반 설계(reliability-based design optimization), 해석모델의 통계적 검정(validation) 및 보정(calibration)을 위해 반드시 필요하다. 대표적인 통계모델링 기법에는 Akaike Information Criterion (AIC), AIC correction (AICc), Bayesian Information Criterion, Maximum Likelihood Estimation (MLE), Bayesian 방법 등이 있다. 이러한 방법들은 기본적으로 주어진 데이터로부터 후보 모델의 우도함수값을 이용하여 후보 모델 중 가장 적합한 모델을 선택하는 방법이며, 방법에 따라 데이터 수 혹은 파라미터의 수를 고려하여 모델을 선정한다. 하지만 실제 현장에서 데이터의 통계모델링을 하는 엔지니어는 각 방법의 장단점에 대한 이해가 부족하여 어떤 방법이 정확한 방법인지 몰라 통계모델링 수행 시 어려움이 있다. 본 논문에서는 다양한 통계모델링 방법들을 비교하고 각 방법의 장단점 분석을 통해 가장 적합한 모델링 기법을 제안하고자 한다. 각 방법의 검증을 위해 다양한 모분포를 가정하고 다양한 사이즈의 샘플을 임의로 생성하여 시뮬레이션을 수행하였으며, 실제 공학 데이터를 사용하여 통계모델링 방법의 유효성을 검증하였다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2017년도 학술발표회
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• pp.4-4
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• 2017

수문자료의 빈도해석은 자료의 독립성(independence)와 정상성(stationarity)를 가정하여 이뤄진다. 그러나 관측 수문자료에서 비정상성 현상이 발생하고 있다는 사실이 관측되면서 수문자료에 대한 비정상성 빈도해석에 대한 필요성도 커지고 있다. 본 연구의 목적은 수문자료의 빈도해석에서 가장 널리 사용되고 있는 Gumbel 및 GEV 분포에 대한 비정상성 빈도해석 모형을 개발하는 것으로, 이를 위해 비정상성 Gumbel과 GEV 모형의 매개변수를 시간에 따라 변하는 형태로 정의하였다. 비정상성 Gumbel 및 GEV 모형의 정확도를 알아보기 위해 비정상성 모형과정상성 모형을 이용하여 Monte Carlo 모의실험을 수행하였다. 모의실험은 다양한 조건의 재현기간, 표본크기, 매개변수 조건을 고려하여 수행되었다. 그 결과 비정상성 모형의 오차는 비교적 표본크기가 클 때 가장 작은 것으로 나타났다. 또한 복잡한 매개변수의 조합을 가지는 비정상성 모형은 모두 동일한 경향성을 가질 때 가장 작은 오차를 보이는 것으로 나타났다. 비정상성 GEV 모형의 경우는 확률수문량 산정에 음(-)의 형상 매개변수가 큰 영향을 끼치는 것으로 나타났다. 또한 본 연구에서는 비정상성 조건에서 다양하게 존재하는 비정상성 모형 중 어떠한 모형이 주어진 자료에 대해 가장 적절한 모형인지 결정하기 위해 모의실험을 수행하였다. 널리 적용되고 있는 AIC, BIC, likelihood ratio test에 대해 정상성 및 비정상성 Gumbel 모형을 이용하여 모의실험을 수행한 결과, AIC가 비정상성 모형 중 적정 모형 선택에 가장 효과적인 것으로 나타났다. 개발된 비정상성 Gumbel 및 GEV 모형의 적용성을 알아보기 위해 우리나라 연최대강우 자료에 적용한 결과, 위치 매개변수에 시간항을 고려하는 Gumbel 모형이 최적모형으로 가장 많이 선택되는 것으로 나타났다. 따라서 현재 우리나라의 연최대강우자료 중 경향성이 나타나는 자료에 대해서는 위치 매개변수가 시간에 따라 변하는 특성이 가장 많이 나타나고 있는 것으로 판단된다.

• 응용통계연구
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• 제31권6호
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• pp.721-732
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• 2018

잠재집단 모형은 다변량 범주형 자료 안에 숨겨진 집단을 찾는 매우 중요한 도구종의 하나이다. 하지만 실제 자료분석에서 너무 많은 관찰변수들을 포함시킨 모형은 모형을 복잡하게 만들고 또한 모수추정의 정확도에 영향을 주기 때문에 정보가 손실되지 않는 내에서 유용한 변수를 찾는 것은 중요한 문제이다. Dean과 Raftery (2010)은 잠재집단 모형에서의 변수선택을 위해 BIC를 이용한 Headlong search 알고리즘을 제시하였는데 본 논문에서는 이 방법을 대체할 수 있는 방법으로 적합한 모형으로부터 계산된 잠재집단에 속할 사후확률을 이용하여 변수 선택을 하는 방법을 제안하고자 한다. 이를 위하여 잠재집단 모형의 적합성을 측정할 수 있는 새로운 통계량과 이를 이용한 변수선택 알고리즘을 제시할 것이다. 또한 제안된 방법의 효율성을 모의실험과 실증자료 분석을 통해 살펴보고자 한다.

• 한국정보기술학회논문지
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• 제16권11호
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• pp.77-84
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• 2018

본 논문에서는 T-junction 전력 분배기를 이용한 원형 편파 마이크로스트립 패치 안테나를 제안하였다. 제안된 안테나의 동작 주파수는 2.4GHz의 ISM 대역이며, 패치 안테나의 두 가장자리에 $90^{\circ}$의 위상차를 급전하여 원형 편파를 유도하였다. 안테나의 구조는 일반적인 패치 안테나와 T-junction 전력 분배기로 구성된다. 안테나의 최적화를 위해 반사계수, 축비, 방사패턴 등이 분석된다. 안테나의 임피던스 대역폭은 2.39~2.43GHz 대역에서 40MHz의 대역폭이 관찰되었으며, 축비 대역폭은 2.398~2.410GHz 대역에서 약 12MHz의 대역폭이 관찰되었다. 안테나의 방사패턴은 우회전 원형 편파로 동작하였다. 또한 안테나의 이득은 XZ 및 YZ-평면에서 각각 2.04, 3.4㏈ic가 관찰되었다.