• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.4
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• pp.614-619
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• 1997

This study was designed to investigate the biochemical pollutant markers for diagnosis of marine pollutions by changes in cholinesterase activity of the flounder (Pleuronichthys cornutus) in the Yellow Sea of Korea. Acetylchotinesterase (AChE) activities in brain and muscle of wild flounders in the Yellow Sea were significantly lower $(20\~30\%\;and\;10\~40\%,\;respectively)$ than those of wild flounder in Pohang (control) of the last Sea. Butyrylcholinesterase (BChE) activities in brain and muscle of wild flounders in the Yellow Sea were significantly lower $(10\~30\%\;and\;35\~45\%,\;respectively)$ than those of wild flounder in Pohang of the East Sea. lactate dehydrogenase (LDH) activities in serum of wild flounders in the yellow Sea were significantly $(about\;30\%)$ lower than those of wild flounder in Pohang of the East Sea. These results suggest that AChE and BChE activities in brain and muscle of wild flounders of the Yellow Sea may be used as the most effective mean in a biochemical marker for diagnosis of pollutant effects by organophosphorus pesticides.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.7
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• pp.1118-1130
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• 1999

In this paper, error performance of DS/FH CDMA system has been analyzed in a radio channel which is characterized by near-far problem and multi-path fading. The DS/FH CDMA system adopts Maximum Ratio Combining(MRC) diversity and BCH(Bose-Chau dhuri-Hocquenghem) coding techniques to enhance system performance. Using the derived error probability equation, the error performance of DS/FH CDMA system has been evaluated and shown in figures to discuss as a function of PN code length(N), hopping rate(q), number of diversity branch(M), coding rate($\gamma$) and bit energy per noise power ratio ${E_b/N_o}$. The results show that DS/FH system is more effective to restrain the affection of near-far problem and multi-path fading than DS system. And there is a substantial enhancement in performance by employing an MRC diversity or BCH coding techniques. Consequently, we expected that proposed system structure is reliable to the voice communication system in near-far problem and multi-path fading channel.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.4
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• pp.539-549
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• 1999

In this paper, the bit error rare (BER) performance of DS/CDMA DQPSK communication system in the presence of multi access interference, impulsive noise and Nakagami fading is investigated. The DS/CDMA DQPSK communication system adopts Maximum Ratio Combining (MRC) diversity reception and error correcting BCH code technique to enhance system performance. Using the derived error probability equation, the error rate performance of DS/CDMA DQPSK communication system has been evaluated and shown in figures to discuss as a function of impulsive index(A), Gaussian noise to impulsive noise power ratio($\Gamma$'), multi access interference(Κ), Nakagami fading parameter(m), the number of diversity branch (Ｌ), the number of error correction symbol (t), PN code sequence length(N) and $E_b/N_0$. The error performance of DS/CDMA-MDPSK signals improve by adopting MRC diversity and BCH(15,7) coding technique in the environment of impulsive noise plus Nagakami fading. From the results, we known that proposed system is affected by multi access interference, impulsive noise and Nakagami fading in radio communication system environment. Also, BER performance of DS/CDMA DQPSK communication system cam be improved increasing either the power of desired signal or the value of Gaussian noise to impulsive noise power ratio. And BCH(15,7) code technique is more effective to restrain the affection of multi access, interference, impulsive noise and Nakagami fading in DS/CDMA DQPSK communication system than MRC diversity reception technique.

• KIPS Transactions on Computer and Communication Systems
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• v.8 no.6
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• pp.127-138
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• 2019

The data response speed is a critical issue of cloud services because it directly related to the user experience. As such, the in-memory database is widely adopted in many cloud-based applications for achieving fast data response. However, the current implementation of the in-memory database is mostly based on the linked list-based hash table which cannot guarantee the constant data response time. Thus, cuckoo hashing was introduced as an alternative solution, however, there is a disadvantage that only half of the allocated memory can be used for storing data. Subsequently, bucketized cuckoo hashing (BCH) improved the performance of cuckoo hashing in terms of memory efficiency but still cannot overcome the limitation that the insert overhead. In this paper, we propose a data management solution called Wall Cuckoo which aims to improve not only the insert performance but also lookup performance of BCH. The key idea of Wall Cuckoo is that separates the data among a bucket according to the different hash function be used. By doing so, the searching range among the bucket is narrowed down, thereby the amount of slot accesses required for the data lookup can be reduced. At the same time, the insert performance will be improved because the insert is following up the operation of the lookup. According to analysis, the expected value of slot access required for our Wall Cuckoo is less than that of BCH. We conducted experiments to show that Wall Cuckoo outperforms the BCH and Sorting Cuckoo in terms of the amount of slot access in lookup and insert operations and in different load factor (i.e., 10%-95%).

• Natural Product Sciences
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• v.22 no.4
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• pp.225-230
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• 2016

Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin (1), (+)-sesartemin (2), (+)-excelsin (3), (+)-sesamin (4), and (+)-syringaresinol (5), together with lupeol (6), lupenone (7), ${\beta}-sitosterol$ (8), and ${\beta}-sitostenone$ (9). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans (1 - 5) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with $IC_{50}$ values ranging from $168.8-504.2{\mu}M$ and $21.0-59.4{\mu}M$, respectively.

• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2247-2250
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• 2012

Two new bibenzyl glucosides, 3,3',4',5-tetramethoxybibenzyl-4-O-${\beta}$-D-glucopyranoside (1) and 3,4,4',5-tetramethoxybibenzyl-3'-O-${\beta}$-D-glucopyranoside (2), together with five known ones, chrysotobibenzyl (3), erianin (4), chrysotoxine (5), gigantol (6) and tristin (7) were isolated from the stems of Dendrobium chrysotoxum. The structures of those compounds were elucidated by extensive spectroscopic analysis. Moreover, compounds 1-7 were assessed for inhibitory activity of two enzymes-AChE (acetylcholine esterase) and BChE (butyrylcholine esterase).

• Natural Product Sciences
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• v.24 no.4
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• pp.259-265
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• 2018

The three flavone glycosides, 4'-O-methylisoscutellarein 7-O-(6'''-O-acetyl)-${\beta}$-D-allopyranosyl(1${\rightarrow}$2)-${\beta}$-D-glucopyranoside (1), isoscutellarein 7-O-(6'''-O-acetyl)-${\beta}$-D-allopyranosyl(1${\rightarrow}$2)-${\beta}$-D-glucopyranoside (3), and isoscutellarein 7-O-${\beta}$-D-allopyranosyl(1${\rightarrow}$2)-${\beta}$-D-glucopyranoside (4) in addition to a flavonol glycoside, kaempferol 3-O-${\beta}$-D-glucopyranoside (astragalin, 2), were isolated from Stachys japonica (Lamiaceae). In cholinesterase inhibition assay, compound 1 significantly inhibited aceylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities ($IC_{50}s$, $39.94{\mu}g/ml$ for AChE and $86.98{\mu}g/ml$ for BChE). The content of isolated compounds were evaluated in this plant extract by HPLC analysis. Our experimental results suggest that the flavonoid glycosides of S. japonica could prevent the memory impairment of Alzheimer's disease.

• Natural Product Sciences
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• v.25 no.2
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• pp.115-121
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• 2019

Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the cholinesterase inhibitory activity of Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR: kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glucopyranosyl($1{\rightarrow}6$)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5), 14,15-dihydroxypregn-4-ene-3,20-dione (6), 14,15-dihydroxy-pregn-4-ene-3,20-dione-$15{\beta}$-D-glucopyranoside (7) and solargin I (8). Two of them (compounds 2 and 3) could inhibit over 50 % of butyrylcholinesterase activity at $100{\mu}M$. Compound (2) displayed the highest inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a slight selectivity towards the latter. Molecular docking studies supported the in vitro results and revealed that (2) had made several hydrogen and ${\pi}-{\pi}$ stacking interactions which could explain the compound potency to inhibit AChE and BChE.

• Natural Product Sciences
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• v.26 no.2
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• pp.165-170
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• 2020

Carica papaya is a medicinal and fruit plant owing biological activities including antioxidant, antiviral, antibacterial and anticancer. The present study aims to investigate the acetyl (AChE) and butyryl (BChE) cholinesterase inhibitory potentials of C. papaya extracts as well as their chemical compositions. The chemical composition of the active extract was identified using a gas chromatography-mass spectrometry (GC-MS). Ellman enzyme inhibition assay showed that the alkaloid-enriched leaf extract of C. papaya possessed significant anti-BChE activity with an enzyme inhibition of 75.9%. GC-MS analysis showed that the alkaloid extract composed mainly the carpaine (64.9%) - a major papaya alkaloid, and some minor constituents such as aliphatic hydrocarbons, terpenes and phenolics. Molecular docking of carpaine revealed that this molecule formed hydrogen bond and hydrophobic interactions with choline binding site and acyl pocket. This study provides some preliminary findings on the potential use of C. papaya leaf as an herbal supplement for the prevention and treatment of Alzheimer's disease.

• Journal of Information Processing Systems
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• v.13 no.5
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• pp.1229-1242
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• 2017

In this paper, an interference aware distributed multi-channel MAC (IDMMAC) protocol is proposed for wireless sensor and actor networks (WSANs). The WSAN consists of a huge number of sensors and ample amount of actors. Hence, in the IDMMAC protocol a lightweight channel selection mechanism is proposed to enhance the sensor's lifetime. The IDMMAC protocol divides the beacon interval into two phases (i.e., the ad-hoc traffic indication message (ATIM) window phase and data transmission phase). When a sensor wants to transmit event information to the actor, it negotiates the maximum packet reception ratio (PRR) and the capacity channel in the ATIM window with its 1-hop sensors. The channel negotiation takes place via a control channel. To improve the packet delivery ratio of the IDMMAC protocol, each actor selects a backup cluster head (BCH) from its cluster members. The BCH is elected based on its residual energy and node degree. The BCH selection phase takes place whenever an actor wants to perform actions in the event area or it leaves the cluster to help a neighbor actor. Furthermore, an interference and throughput aware multi-channel MAC protocol is also proposed for actor-actor coordination. An actor selects a minimum interference and maximum throughput channel among the available channels to communicate with the destination actor. The performance of the proposed IDMMAC protocol is analyzed using standard network parameters, such as packet delivery ratio, end-to-end delay, and energy dissipation, in the network. The obtained simulation results indicate that the IDMMAC protocol performs well compared to the existing MAC protocols.