• Air Cleaning Technology
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• v.2 no.4 s.8
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• pp.27-45
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• 1990

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.12
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• pp.2820-2827
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• 2015

HSMS communication system using low-cost micro controller units(MCUs) is an essential technique for online semiconductor equipment system developments. It is intended as an alternative to SEMI E4 (SECS-I) for applications where higher speed communication is needed and the facilitated hardware setup is convenient. In this paper, an HSMS communication system using low-cost MCUS is designed and implemented. Using a MCU with a low price but high-performance as a main board, a module which processes HSMS communication is designed, and a circuit is designed to process BCR independently with a microminiature MCU. To convert tag data which is recognized from BCR into data based on HSMS communication protocol, SECS-II message is designed. Lastly, an HSMS communication system is implemented based on these designs. A low-cost HSMS communication module developed in this study can be applied in realtime monitoring and controlling system for semiconductor processes.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.1
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• pp.19-24
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• 2006

The intermediate conductance $Ca^{2+}-activated$ $K^+$ channels (SK4, IKCa1) are present in lymphocytes, and their membrane expression is upregulated by various immunological stimuli. In this study, the activity of SK4 was compared between Bal-17 and WEHI-231 cell lines which represent mature and immature stages of murine B lymphocytes, respectively. The whole-cell patch clamp with high-$Ca^{2+}$ ($0.8{\mu}M$) KCl pipette solution revealed a voltage-independent $K^+$ current that was blocked by clotrimazole (1 mM), an SK4 blocker. The expression of mRNAs for SK4 was confirmed in both Bal-17 and WEHI-231 cells. The density of clotrimazole-sensitive SK4 current was significantly larger in Bal-17 than WEHI-231 cells ($-11.4{\pm}3.1$ Vs. $-5.7{\pm}1.15$ pA/pF). Also, the chronic stimulation of B cell receptors (BCR) by BCR-ligation (anti-IgM Ab, $3{\mu}g$/ml, 8∼12 h) significantly upregulated the amplitude of clotrimazolesensitive current from $-11.4{\pm}3.1$ to $-53.1{\pm}8.6$ pA/pF in Bal-17 cells. In WEHI-231 cells, the effect of BCR-ligation was significantly small ($-5.7{\pm}1.15$ to $-9.0{\pm}1.00$ pA/pF). The differential expression and regulation by BCR-ligation might reflect functional changes in the maturation of B lymphocytes.

• Korean Journal of Community Nutrition
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• v.23 no.5
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• pp.385-396
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• 2018

Objectives: This study aims to evaluate the economic efficiency of a nutrition management program for children under 5 years of age in Kenge, Kwango District, Democratic Republic of the Congo (DR Congo) from 2014 to 2016. Methods: The economic efficiency of a nutrition management program for children under 5 years of age who have recovered from malnutrition status was evaluated using a cost-benefit analysis. The costs were analyzed according to the executed budget incurred during the project period. The benefits were estimated as the monetary value of the saved lives of children under 5 years of age. The economic efficiency of the program was determined by the Benefit-Cost Ratio (BCR). The BCR was calculated by dividing the total discounted benefit by the total discounted costs. The project is economically efficient when the BCR is greater than 1. Results: The costs of the nutrition management program were calculated as 1,677,609,648 Korean Won (KRW). A total of 2,466 children survived with improved malnutrition status through this program. The benefit for the reduction of mortality for children under 5 years of age was estimated to be 6,814,354,467 KRW, the estimated value of life for 2,466 children. The BCR was 4.06. Conclusions: The nutrition management program for children under 5 years of age in DR Congo was found to be a cost-effective project. Successful and efficient Official Development Assistance (ODA) for a health project requires integrated and comprehensive strategies and specialized international development consulting to improve efficiency. Future nutrition management programs should take into account the national health program to maintain the sustainability of the project.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.25 no.1
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• pp.7-13
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• 2013

Bio Clean Room(BCR) and pharmaceutical product manufacturing facilities require careful assessment of many factors, including HVAC, controls, room finishes, process equipment, room operations, and utilities. Flow of equipment, personnel, and product must also be considered along with system flexibility, redundancy, and maintenance shutdown strategies. It is important to involve designers, operators, commissioning staff, quality control, maintenance, constructors, validation personnel, and the production representative during the conceptual stage of design. Critical variables for room environment and types of controls vary greatly with the clean space's intended purpose. It is particularly important to determine critical parameters with quality assurance to set limits and safety factors for temperature, humidity, room pressure, and other control requirements. In this paper, oxygen cluster ion equipment was utilized in order to enhance the indoor air quality and to prevent the airborne infection of ward in hospital. Moreover, the performance test of the equipment was also performed in order to develop the optimal sterilization system of BCR using the equipment.

• Journal of the Korean Geotechnical Society
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• v.22 no.8
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• pp.5-11
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• 2006

A series of large scale plate loading tests are performed to assess bearing capacity characteristic of dredged and reclaimed ground that is reinforced by bamboo net and geotextile as a surface strengthen method. Bearing capacity ratio is distributed from 3.46 to 6.03 for bamboo net and from 2.19 to 3.59 for Geotextile In case of bamboo net, BCR was obtained from 1.6 to 1.7 times than Geotextile. As the comparison of each bearing capacity from test and theory shows, bearing capacity theory for geotextile was not suited for bamboo net. The bearing capacity analysis reinforced by bamboo net shows a good relationship between sand mat thickness (H) / bamboo net space (S), and bearing capacity ratio (BCR).

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7415-7423
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• 2015

Chronic myeloid leukemia (CML) is a stem cell disorder characterized by unrestricted proliferation of the myeloid series that occurs due to the BCR-ABL fusion oncogene as a result of reciprocal translocation t(9;22) (q34;q11). This discovery has made this particular domain a target for future efforts to cure CML. Imatinib revolutionized the treatment options for CML and gave encouraging results both in case of safety as well as tolerability profile as compared to agents such as hydroxyurea or busulfan given before Imatinib. However, about 2-4% of patients show resistance and mutations have been found to be one of the reasons for its development. European Leukemianet gives recommendations for BCR-ABL mutational analysis along with other tyrosine kinase inhibitors (TKIs) that should be administered according to the mutations harbored in a patient. The following overview gives recommendations for monitoring patients on the basis of their mutational status.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.17 no.6
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• pp.29-37
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• 2014

The objective of this study is to estimate the cost and benefits of street trees for their planting types, specifically, single row, single row+bottom, double row, double row+bottom. Different planting types are compared and analyzed by using Net Present Value (NPV) and benefit-cost ratio (BCR). Existing data are collected from the literature reviews for the use of meta-analysis method for estimating cost and benefit. The elements for analyzing costs are management and planting costs, and benefits are air purification, energy saving and landscape view. The discount rate is applied at a minimum of 3% and a maximum of 5.5%. The unit used in this calculation is km/year. The result shows that the net benefit is highest in double row, followed by single row, double row+bottom, and single row+bottom. The BCR is the highest in double row, followed by single row, double row+bottom, and single row+bottom. The BCR reaches the break-even point from 9 to 17 years depending on the planting types.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3025-3033
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• 2016

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative hematopoietic stem cell disorder. Deregulated BCR-ABL fusion tyrosine kinase activity is the main cause of CML disease pathogenesis, making BCR-ABL an ideal target for inhibition. Current tyrosine kinase inhibitors (TKIs) designed to inhibit BCR-ABL oncoprotein activity, have completely transformed the prognosis of CML. Interruption of TKI treatment leads to minimal residual disease reside (MRD), thought to reside in TKI-insensitive leukaemia stem cells which remain a potential reservoir for disease relapse. This highlights the need to develop new therapeutic strategies for CML either as small molecule master TKIs or phytopharmaceuticals derived from nature to achieve chronic molecular remission. This review outlines the past, present and future therapeutic approaches for CML including coverage of relevant mechanisms, whether ABL dependent or independent, and epigenetic factors responsible for developing resistance against TKIs. Appearance of mutant clones along the course of therapy either pre-existing or induced due to therapy is still a challenge for the clinician. A proposed in-vitro model of generating colony forming units from CML stem cells derived from diagnostic samples seems to be achievable in the era of high throughput technology which can take care of single cell genomic profiling.

• Ocean and Polar Research
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• v.36 no.2
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• pp.157-163
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• 2014

This study analysed the economic feasibility per hectare of grow out phase production of Oyster farming by rising water temperature in Ocean. Elevated Water temperature by climate change had a bad influence for oyster production and economic feasibility. In the case of production units, the total output of oyster decreases from 213,840 to 205,594 units. Using cost-benefit analysis with discounting rates (5.5%), we estimated the net present value (NPV) and benefit cost ratio (BCR) until 2100 years. The model results showed that the NPV without water temperature rise was 1,565,619,893 won and the NPV with water temperature rise was 1,540,493,059 won. Also, BCR estimated that the former was 2.095 better than the latter was 2.077. To summarise, the economic effect per hectare of water temperature rise in ocean did the damage to the economic loss about 25,126,834 won.