• Tuberculosis and Respiratory Diseases
• /
• 제75권6호
• /
• pp.256-259
• /
• 2013

Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which is specific to chronic myeloid leukemia (CML), and the c-transmembrane receptor, which is specific to gastrointestinal stromal tumors. Interstitial pneumonitis is a rare adverse event of imatinib therapy. It is clinically difficult to distinguish from infectious pneumonia, which can frequently occur due to the underlying disease. The standard treatment for imatinib-induced pneumonitis is to discontinue the medication and optionally administer corticosteroids. However, there are a few cases of successful retrial with imatinib. We describe a case of successful rechallenge of imatinib in a patient with imatinib-induced interstitial pneumonitis and CML without a recurrence of the underlying disease after 3 months of follow-up.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권9호
• /
• pp.3793-3797
• /
• 2015

Background: Chronic myeloid leukemia (CML) is a myeloproliferative disorder of pluripotent stem cells, caused by reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11), known as the Philadelphia chromosome. Materials and Methods: A total of 51 CML patients were recruited in this study. Complete blood counts of all CML patients were performed to find out their total leukocytes, hemoglobin and platelets. FISH was performed for the detection of BCR-ABL fusion and cryptogenic tests using bone marrow samples were performed for the conformation of Ph (9;22)(q34;q11) and variant translocation mechanisms. Results: In cytogenetic analysis we observed that out of 51 CML patients 40 (88.9%) were Ph positive and 4 (8.88%) had Ph negative chromosomes. Mean values of WBC 134.5 $10^3/{\mu}l$, hemoglobin 10.44 mg/dl, and platelets 288.6 $10^3/{\mu}l$ were observed in this study. Conclusions: In this study, Ph positive translocation between chromosome (9:22)(q34;q11) were observed in 40 (88.9%) CML patients.

• Journal of Forest and Environmental Science
• /
• 제34권4호
• /
• pp.304-312
• /
• 2018

This study investigates to identify the impact factors of timber production cost on the relationship between production cost components and revenues generated by evaluating the entire timber supply chain. In this research, selected 13 logging zones as target areas and classified 14 forest production cost factors, six groups. Additionally, established 13 externalenvironmental factors with related stakeholders and forestry experts. And the BCR (Benefit Cost Ratio) method was then used to analyze the economics of each zone. Filled up a checklist and rated using 5 point scale for each target region, and extracted major cost factors for the production economy of the item. The analysis of major cost factors in the timber production revealed that wood grab equipment usage fee was the first ranked and forest trees purchase cost was ranked in the $2^{nd}$Also, the $3^{rd}$ranking was logging expenses, and transport cost, which accounted for 84% of the total cost, was ranked in the $4^{th}$. In addition, the rock land ratio, slope, timber payment (forest trees purchase cost), special timber, ratio of timber, DBH (Diameter at Breast Height), and mixed forest ratio were the factors that most affected the timber supply chain cost.

• Weed & Turfgrass Science
• /
• 제7권2호
• /
• pp.120-129
• /
• 2018

This experiment was conducted to find the most suitable crop establishment method and weed management practices for transplanted aman rice in Bangladesh. Rice variety Bangladesh Rice Research Institute (BRRI) dhan44 was used as planting materials where three crop establishment methods ($T_1$: direct wet seeding by drum seeder; $T_2$: hand broadcasting; $T_3$: transplanting) and four weeding options ($W_1$: Hand weeding (HW); $W_2$: BRRI weeder+HW; $W_3$: Herbicide+HW; and $W_4$: no weeding) were tested. Among the crop establishment methods, the highest grain yield ($5.12t\;ha^{-1}$) was obtained with the $T_3$, while the highest benefit cost ratio (BCR) of 2.08 was found in $T_2$. In case of the weed management method, $W_1$ showed superior results on the plant $density/m^2$ (139.66) at 60 days after transplanting (DAT), grain yield ($4.97t\;ha^{-1}$), and BCR (2.03). On the other hand, the highest plant dry matter (36.20 g) at 60 DAT and the highest yield ($6.10t\;ha^{-1}$) were obtained in a $T_3W_1$ combination. The results of this study show that the productivity of rice during aman season could be most significantly increased with the use of transplanting ($T_3$) alone, hand weeding ($W_1$) alone, or a combination of the two methods ($T_3W_1$).

• 한국농공학회지
• /
• 제30권1호
• /
• pp.38-49
• /
• 1988

This paper presented as follows results of laboratory model tests with various shaped footings on soil bed reinforced with the strips on the base of behaviour of soil structure according to the loads and triaxial test results reinforced with geotextiles. Their parameters studied were the effects on the bearing capacity of a footing of the first layer of reinforcement, horizontal and vertical spacing of layers, number of layers, tensile strength of reinforcement and iclination load to the vertical 1.Depending on the strip arrangement, ultimate bearing capacity values could be more improved than urreinforced soil and the failure of soil was that the soil structure was transfered from the macrospace to microspase and its arrangement, from edge to edge to face to face. 2.The reinforcement was produced the reinforcing effects due to controlling the value of factor of one and permeable reinforcement was never a barrier of drainage condition. 3.Strength ratio was decreased as a linear shape according to increment of saturation degree of soil used even though at the lower strength ratio, the value of M-factor was rot influenced on the strength ratio but impermeable reinforcement decreased the strength of bearing capacity. 4.Ultimate bearing capacity under the plane-strain condition was appeared a little larger than triaxial or the other theoretical formulars and the circular footing more effective. 5.The maximum reinforcing effects were obtained at U I B=o.5, B / B=3 and N=3, when over that limit only acting as a anchor, and same strength of fabric appeared larger reinforcing effects compared to the thinner one. 6.As the LDR increased, more and more BCR occurred and there was appeared a block action below Z / B=O.5, but over the value, decrement of BCR was shown linear relation, and no effects above one. 7.The coefficient of the inclination was shown of minimum at the three layers of fabrics, but the value of H / B related to the ultimate load was decreased as increment of inclination degree, even though over the value of 4.5 there wasn't expected to the reinforcing effects As a consequence of the effects on load inclination, the degree of inclination of 15 per cent was decreased the bearing capacity of 70 per cent but irnproved the effects of 45 per cent through the insertion of geotextile.

• 한국지반환경공학회 논문집
• /
• 제13권6호
• /
• pp.5-17
• /
• 2012

초연약 지반의 개량을 위한 중장비의 안전한 주행성 확보를 위해 제일 우선적으로 검토되어야 하는 표층처리공법에 대한 연구는 아직 미진하며 표층처리공법 설계 시 건설기계의 반복적인 주행으로 인한 소성침하를 고려하지 못하고 있다. 따라서 본 연구에서는 표층처리공법에서 가장 많이 사용하고 있는 보강재인 지오텍스타일, 인장강도가 200kN/m와 100kN/m인 지오그리드와 대나무망으로 보강한 후 1.0m의 모래로 복토한 지반에서 현장 평판재하시험과 반복 평판재하시험을 실시하여 각 보강재별 지지력과 거동양상을 비교 평가하고자 한다. 평판재하시험 결과 대나무망을 사용하였을 경우 다른 보강재를 사용하였을 때보다 BCR값이 최대 1.5배 증가하였다.

• Journal of Korean Neurosurgical Society
• /
• 제61권6호
• /
• pp.761-766
• /
• 2018

Objective : Chronic subdural hematoma (CSDH) is a rare complication of unruptured intracranial aneurysm (UIA) clipping surgery. To prevent postoperative CSDH by reducing subdural fluid collection, we applied the modified arachnoid plasty (MAP) during the UIA clipping surgery to seal the dissected arachnoid plane. Methods : This retrospective study included 286 patients enrolled from July 2012 to May 2015. We performed arachnoid plasty in all patients, with MAP used after June 17, 2014. Patients were divided into two groups (non-MAP vs. MAP), and by using uni- and multivariate analyses, baseline characteristics, and relationships with postoperative CSDH between the two groups were analyzed. The degree of preoperative brain atrophy was estimated using the bicaudate ratio (BCR) index. Results : Ten patients (3.5%) among 286 patients had postoperative CSDH after clipping. Nine (3.1%) were in the non-MAP group, and one (0.9%) was in the MAP group. The higher BCR index showed statistical significance with occurrence of postoperative CSDH in both uni- (p=0.018) and multivariate (p=0.012; odds ratio [OR], 8.547; 95% confidence interval [CI], 1.616-45.455) analyses. MAP was associated with a lower risk of postoperative CSDH (p=0.022; OR, 0.068; 95% CI, 0.007-0.683). Conclusion : This study shows that the degree of preoperative brain atrophy is associated with an increased occurrence of CSDH after clipping and that MAP could help reduce the risk of postoperative CSDH after unruptured aneurysm clipping via a lateral supraorbital approach.

• 분석과학
• /
• 제33권6호
• /
• pp.245-251
• /
• 2020

납은 암석의 연대측정, 지각의 진화 및 오염원의 기원 추적과 같은 지구화학적 연구에 유용하게 사용되어지는 원소로, 이를 위해선 고순도 원소 분리가 선행되어져야한다. 본 연구에서는 납을 분리해 내는데 있어서 용리액의 농도가 6M HCl 과 8M HCl 중 어느 것이 더 효율적인지 비교 검토 하였다. 그 결과, 6M HCl의 경우 8M HCl 보다 용리액을 다량으로 사용했음에도 불구하고 납 분리에 있어서는 효율적이지 않았다. 그리고 납 분리법에 대한 신뢰성 검증을 위하여 납 동위원소 표준물질(NIST NBS981)과 암석표준시료(BCR-2, GSP-2, JG-1a)의 납 동위원소비를 열이온화질량분석기로 측정한 결과, 기존 보고 값과 오차 범위 내에서 잘 일치하였다.

• Radiation Oncology Journal
• /
• 제21권3호
• /
• pp.227-237
• /
• 2003

목적: 만성 골수성 백혈병 세포인 K562 세포주는 방사선 및 다양한 항암제에 대한 apoptosis에 저항성을 가진다. 지난 연구에서 K562 세포는 방사선에 대하여 내성반응을 보이며, 세포내 PTK의 작용을 억제하고자 방사선 조사와 함께 투여한 herbimycin A (HMA)에 의하여 방사선에 대한 apoptosis와 같은 감수성반응이 유도되는 반면, genistein에 의하여 방사선에 대한 apoptosis 반응이 저해됨을 확인하였다. 본 연구에서는 타이로신 인산화효소 억제에 의한 K562 세포의 방사선 반응변화를 조절하는 신호전달경로를 조사하였다. 대상 및 방법: K562 세포를 지수증식기의 세포들만 선택하여 실험에 이용하였다. 방사선조사는 6 MeV 선형가속기(Clinac 1800C, Varian)를 이 용하여 $200\~300$ cGy/min 선량률로 $0.5\~12 $ Gy를 균일하게 조사하였다. HMA와 genistein은 각각 $0.25/muM,\;25\muM$을 방사선 조사 후 즉시 투여하였다. 실험에서 신호전달 경로로 abl kinase, MAPK family, NF-kB, c-fos, c-myc, thymidine kinase1 (TK1) 등에서의 단백질 또는 유전자 발현 및 활성을 조사하였다. 또한 약제 투여에 따른 유전자 발현차이(differential gene expression)를 조사하였다. 결과: Abl kinase의 발현 및 활성 변화를 조사하였으나 PTK 저해제에 의한 방사선 유도 세포사의 변화와의 연관성을 찾을 수 없었다. 세포 생존 및 사멸의 신호전달체계에서 주요 조절과정인 MAPK family의 관여 여부 확인에서 방사선으로 인한 SAPK/JNK의 활성화의 유도가 관찰되었으나, PTK 저해제에 따른 변화는 없었으며, 또한 MAPK/ERK와 p38 MAPK 활성은 모든 조건에서 변함 없이 일정하였다. 전사인자 활성화에 대한 조사에서 방사선 조사와 함께 genistein을 투여한 경우에 NF-kB활성이 증가하였다. 유전자 발현 차이의 조사에서 genistein 투여에 의한 TK 1 유전자 발현 및 단백질 활성이 증가하였다. 결론: PTK 억제에 의한 K562 세포의 방사선에 대한 반응 변화는 bcrabl kinase 활성과는 무관하게 진행되며, MAPK family 경로 외의 다른 경로를 통한 전사인자 활성화 과정이 연관되어 있음을 확인하였다.

• 한국지반공학회논문집
• /
• 제16권3호
• /
• pp.57-65
• /
• 2000

다층의 지오그리드로 보강된 사질토 지반에 축조된 줄기초의 극한 지지력을 결정하기 위하여 실내모형실험을 실시하였다. 한가지 종류의 사진토와 지오그리드를 사용하였으며, 시험은 기초의 근입깊이(Df)가 없을 때와 근입깊이(Df)가 있을 때로 분류하여 시행되었다. 기초의 근입깊이(Df)는 기초의 폭(B)보다 작도록 제한되었다. 시험결과, 주어진 보강깊이의 두께에 대하여 지지력비(BCR)는 기초의 근입깊이(Df)가 0보다 클 때 증가하였다.