• Transactions of Materials Processing
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• v.30 no.3
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• pp.125-133
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• 2021

In this study, response surface method (RSM), back propagation neural network (BPNN), and genetic algorithm (GA) were used for modeling and multi-objective optimization of the parameters of AA5052-H32 in incremental sheet forming (ISF). The goal of optimization is to determine the maximum forming angle and minimum surface roughness, while varying the production process parameters, such as tool diameter, tool spindle speed, step depth, and tool feed rate. A Box-Behnken experimental design (BBD) was used to develop an RSM model and BPNN model to model the variations in the forming angle and surface roughness based on variations in process parameters. Subsequently, the RSM model was used as the fitness function for multi-objective optimization of the ISF process the GA. The results showed that RSM and BPNN can be effectively used to control the forming angle and surface roughness. The optimized Pareto front produced by the GA can be utilized as a rational design guide for practical applications of AA5052 in the ISF process

• Steel and Composite Structures
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• v.46 no.4
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• pp.525-538
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• 2023

This paper focuses on the energy absorption of lattice core sandwich structures of different configurations. The diamond lattice unit cell, which has been extensively investigated for energy absorption applications, is the starting point for this research. The energy absorption behaviour of sandwich structures with an expanded metal sheet as the core is investigated at low-velocity impact loading. Numerical simulations were carried out using ABAQUS/EXPLICIT and the results were thoroughly compared with the experimental results, which indicated desirable accuracy. A parametric analysis, using a Box-Behnken design (BBD), as a method for the design of experiments (DOE), was performed. The samples fabricated in three levels of parameters include 0.081, 0.145, and 0.562 mm² Cell sizes, and 0, 45, and 90-degree cell orientation, which were investigated. It was observed from experimental data that the angle of cells orientation had the highest degree of influence on the specific energy absorption. The results showed that the angle of cells orientation has been the most influential parameter to increase the peak forces. The results from using the design expert software showed the optimal specific energy absorption and peak force to be 1786 J/kg and 26314.4 N, respectively. The obtained R2 values and normal probability plots indicated a good agreement between the experimental results and those predicted by the model.

• Journal of Mushroom
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• v.21 no.3
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• pp.110-117
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• 2023

Cordycepin (3'-deoxyadenosine) is a nucleoside analog known for its diverse range of biological activities. This study investigated the effect of different types of sawdust on the production of the bioactive compound cordycepin. The results of the study showed that different types of wood sawdust affected the biosynthesis of cordycepin and a significant increase was observed when the conventional SDB medium was replaced with 1% NaOH treated pine sawdust. To optimize cordycepin production from Paecilomyces tenuipes in a medium containing 1% NaOH-pretreated pine sawdust, we employed Response Surface Methodology (RSM) in its Box-Behnken design (BBD) canonical form. The optimal conditions were determined as follows: a particle size of 109.5111-mesh (140 ㎛) for 1% NaOH-pretreated pine sawdust, an input weight of 21.1679 g/L, and an incubation time of 73.8423 hours. According to our model, this combination is expected to yield a maximum cordycepin content of 896.1428 ㎍/mL. Experimental validation of this prediction was performed using the suggested optimal conditions, resulting in an average cordycepin content of 922.6771 ㎍/mL across three replicates, thus confirming the model's accuracy.

• Advances in nano research
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• v.14 no.2
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• pp.117-126
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• 2023

This experimental study investigated friction stir welding (FSW) of the acrylonitrile-butadiene-styrene (ABS) T-joint in the presence of various nano-silica levels. This study aim to handle the drawbacks of the friction stir welding (FSW) of an ABS T-joint with various quantity of nanoparticles and assess the performance of nanoparticles in the welded joint. Moreover, the relationship between the nanoparticle quantity and FSW was analyzed using response surface methodology (RSM) Box-Behnken design. The input parameters were the tool rotation speed (400, 600, 800 rpm), the transverse speed (20, 30, 40 mm/min), and the nano-silica level (0.8, 1.6, 2.4 g). The tensile strength of the prepared specimens was determined by the universal testing machine. Silica nanoparticles were used to improve the mechanical properties (the tensile strength) of ABS and investigate the effect of various FSW parameters on the ABS T-joint. The results of Box-Behnken RSM revealed that sound joints with desired characteristics and efficiency are fabricated at tool rotation speed 755 rpm, transverse speed 20 mm/min, and nano-silica level 2.4 g. The scanning electron microscope (SEM) images revealed the crucial role of silica nanoparticles in reinforcing the ABS T-joint. The SEM images also indicated a decrease in the nanoparticle size by the tool rotation, leading to the filling and improvement of seams formed during FSW of the ABS T-joint.

• Natural Product Sciences
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• v.29 no.2
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• pp.83-90
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• 2023

To our knowledge, this is the first study aiming to optimize the extraction conditions of total phenolic compounds (TPC) and total flavonoids contents (TFC) from Argania spinosa leaves using Response Surface Methodology (RSM) with a Box-Behnken design (BBD). The optimal conditions obtained were 5% (w/v) solvent-to-solid ratio, 72.33% ethanol concentration, and 10h ours as an extraction time, which resulted in an extract with maximum TPC (131.63 mg GAE/g dw) and TFC (10.66 mg QE/g dw). Under the optimal extraction conditions, the antioxidant activity of the extracts of leaves of argan tree showed a moderate antiradical capacity of DPPH (IC₅₀ = 0,130 mg/mL) and ABTS (IC₅₀ = 0.198 mg/mL). However, the leaves of argan tree showed a very interesting reducing power of Iron (IC₅₀ = 0.448 mg/ml) which is similar to that of the ascorbic acid (IC₅₀ = 0.371 mg/mL).

• Advances in materials Research
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• v.13 no.1
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• pp.1-18
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• 2024

The present experimental investigation focuses on finding optimal parametric data-set of laser micro-drilling operation with minimum taper and Heat-affected zone during laser micro-drilling of Carbon Nanotube/Epoxy-based composite materials. Experiments have been conducted as per Box-Behnken design (BBD) techniques considering cutting speed, lamp current, pulse frequency and air pressure as input process parameters. Then, the relationship between control parameters and output responses is developed using second-order nonlinear regression models. The analysis of variance test has also been performed to check the adequacy of the developed mathematical model. Using the Response Surface Methodology (RSM) and an Accelerated particle swarm optimization (APSO) technique, optimum process parameters are evaluated and compared. Moreover, confirmation tests are conducted with the optimal parameter settings obtained from RSM and APSO and improvement in performance parameter is noticed in each case. The optimal process parameter setting obtained from predictive RSM based APSO techniques are speed=150 (m/s), current=22 (amp), pulse frequency (3 kHz), Air pressure (1 kg/cm²) for Taper and speed=150 (m/s), current=22 (amp), pulse frequency (3 kHz), air pressure (3 kg/cm²) for HAZ. From the confirmatory experimental result, it is observed that the APSO metaheuristic algorithm performs efficiently for optimizing the responses during laser micro-drilling process of nanocomposites both in individual and multi-objective optimization.

• Natural Product Sciences
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• v.22 no.4
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• pp.270-274
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• 2016

Green tea, the leaves of Camellia sinsneis (Theaceae), is generally acknowledged as the most consumed beverage with multiple pharmacological functions including antioxidant activity. This study was performed to analyze the effect of extraction conditions of green tea on its antioxidant effects using DPPH assay. Three extraction factors such as extraction solvent (EtOH, 0 - 100%), extraction time (3 - 15 min) and extraction temperature ($10-70^{\circ}C$) were analyzed and optimized extraction condition for antioxidant activity of green tea extract (GTE) was determined using response surface methodology with three-level-three-factor Box-Behnken design (BBD). Regression analysis showed a good fit of data and the optimal conditions of extraction were found to be 57.7% EtOH, 15 min and $70^{\circ}C$. Under this condition, antioxidant activity of experimental data was 88.4% which was almost fit to the ideal value of 88.6%. As epigallocatechin gallate (EGCG) is known for the major ingredient for antioxidant activity of green tea, we investigated the effect of EGCG on antioxidant activity of GTE. EGCG showed antioxidant activity with the $IC_{50}$ value of $4.2{\mu}g/ml$ and a positive correlation was observed between EGCG content and the antioxidant activity of GTE with $R^2=0.7134$. Interestingly, however, GTE with 50 - 70% antioxidant activity contain less than $1.0{\mu}g/ml$ of EGCG, which is much lower than $IC_{50}$ value of EGCG. Therefore, we suppose that EGCG together with other constituents contribute to antioxidant activity of GTE. Taken together, these results suggest that green tea is more beneficial than EGCG alone for antioxidant ability and optimal extraction condition of green tea will be useful for the development of food and pharmaceutical applications

• Natural Product Sciences
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• v.24 no.2
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• pp.103-108
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• 2018

The usage of wild ginseng (Panax ginseng C.A. Meyer) has been limited due to short supply and high price. Therefore, sufficient production as well as efficient extraction of mountain ginseng are required for the development as products. In this study, wild ginseng adventitious root cultures were prepared for efficient production with advantages of fast growth and stable production. Treatment of methyl jasmonate (MJ) to wild ginseng adventitious root cultures increased the extraction yield and antioxidative activity. Further investigation on effect of extraction conditions suggested the importance of ethanol concentration on antioxidative activity and extraction yield of MJ-treated wild ginseng adventitious root cultures. Optimized extraction condition of MJ-treated wild ginseng adventitious root cultures for maximum extraction yield and antioxidative activity was determined using response surface methodology with three-level-three-factor Box-Behnken design (BBD). Extraction of 1 g MJ-treated wild ginseng adventitious root culture with 30 ml of 9% ethanol at $30^{\circ}C$ produced 310.2 mg extract with 71.0% antioxidative activity at $100{\mu}g/ml$. Taken together, MJ-treated wild ginseng adventitious root culture is valuable source for wild ginseng usage and optimized extraction condition can be used for the development of functional products or folk remedies.

• Applied Chemistry for Engineering
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• v.24 no.3
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• pp.299-304
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• 2013

A 17-run Box-Behnken design was used to optimize the synthesis conditions of a monolithic sorbent. The effects of the amount of monomer (mL), crosslink (mL) and porogen (mL) were investigated. The experimental data were fitted to a second-order polynomial equation by the multiple regression analysis and examined using statistical methods. The adjusted coefficient of determination ($R^2$) of the model was 0.9915. The probability value (p < 0.0001) demonstrated a high significance for the regression model. A mean amount of polymer as 2120.15 mg was produced under the following optimum synthesis conditions: the optimized volumes of monomer, crosslink and porogen are 0.30, 1.40, and 1.47 mL, respectively. This was in good agreement with the predicted model value.

• Journal of Soil and Groundwater Environment
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• v.20 no.2
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• pp.47-54
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• 2015

The objective of this study was to optimize the experimental conditions for bioleaching of arsenic (As) using Herbaspirillum sp. GW103 and to understand the interaction between bacteria and As during bioleaching. Five variables, temperature, time, CaCO₃, coconut oil cake, and shaking rate, were optimized using response surface methodology (RSM) based Box-Behnken design (BBD). Maximum (73.2%) bioleaching of As was observed at 30℃, 60 h incubation, 1.75% CaCO₃, 3% coconut oil cake, and 140 rpm. Sequential extraction of bioleached soil revealed that the isolate Herbaspirillum sp. GW103 significantly reduced 28.6% of water soluble fraction and increased 38.8% of the carbonate fraction. The results of the study indicate that the diazotrophic bacteria Herbaspirillum sp. could be used for bioleaching As from mine soil.