• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.1903-1907
• /
• 2016

Background: Studies of effects of IL-1 polymorphisms, CYP2C19 genotype together with antibiotic resistance for H. pylori eradication are rare worldwide. The present study was designed to evaluate efficacy of 10-day sequential therapy (SQT) and 14-day standard triple therapy (STT) with four- times-daily dosing of amoxicillin for H. pylori eradication related to these important host and bacterial factors in Thailand. Materials and Methods: This prospective randomized study was performed during March 2015 to January 2016. H. pylori infected gastritis patients were randomized to receive 10-day sequential therapy and 14-day standard triple therapy. CYP2C19 genotyping, IL1 polymorphism (IL-1B and IL-1RN genotypes) and antibiotic susceptibility tests were performed in all patients. 13C-UBT was conducted to confirm H. pylori eradication at least 4 weeks after treatment. Results: A total of 100 patients (33 males and 67 females, mean age=51.1 years) were enrolled. Eradication rate by PP analysis was 97.9% (47/48) with the 10-day SQT regimen and 87.8% (43/49) with 14-day STT regimen (97.9% vs 87.8%; p-value=0.053). Antibiotic susceptibility testing demonstrated 45% resistance to metronidazole, 14.8% to clarithromycin, and 24.1% to levofloxacin. CYP2C19 genotyping revealed 44.9% RM, 49% IM and 6.1% PM. IL-1B and IL-1RN genotypes were demonstrated as 21.4% for CC, 48.1% for TC, 36.8% for TT, 72.7% for 1/1, and 21.2% for 1/2 genotypes, respectively. The 10-day SQT regimen provided 100% eradication in patients with clarithromycin or dual clarithromycin and levofloxacin H. pylori resistant strains. Moreover, the 10-day SQT regimen resulted in a 100% eradication rate in all patients with CYP2C19 genotype RM and almost type of IL-1B (TC and TT) and IL1-RN genotypes ( 1/2 and other). Conclusions: Treatment with 10-day sequential therapy is highly effective for H. pylori eradication regardless of the effects of clarithromycin resistance, dual clarithromycin and levofloxacin resistance, CYP2C19 genotype, IL-1B and IL1-RN genetic polymorphisms and can be used as effective first line therapy in Thailand.

• The Korean Journal of Ceramics
• /
• v.5 no.1
• /
• pp.19-24
• /
• 1999

The influences of TiB2 additions to the β-sialon on mechanical propeties and electrical discharge machinability were investigated. Samples were prepared by adding 15, 30 and 45 vol.% TiB2 particles as a second phase to a β-sialon matrix. The β-sialon-TiB2 composites were sintered by hot pressing in a nitrogen atmosphere at 1800℃ with pressure of 30 MPa. The fracture toughness of the composites was increased with TiB2 content except 45 vol.% TiB2 composite. The crack propagation and crack deflection were observed with a SEM for etched samples after vicker's indentation. The composites containing more than 30 vol.% TiB3 had resistivity lower than 10-3 Ω㎝. The electrical discharge machining (EDM) of composited was conducted with two kind of machines such as die-sinker and wire cutter. The machinability was evaluated with the cutting rate surface roughness after machining.

• Journal of Microbiology and Biotechnology
• /
• v.19 no.6
• /
• pp.556-559
• /
• 2009

Compounds extracted from Platycodon grandiflorum were evaluated for an activation effect on nuclear factor-kappa B (NF-${\kappa}B$). In its active state, NF-${\kappa}B$ turns on the expression of genes related to cell proliferation or death. NF-${\kappa}B$ activators promote growth of neuron cells and can be used to control neurodegenerative diseases. The biological activity of P. grandiflorum extracts toward NF-${\kappa}B$ had not yet been studied. Although the biological activity of several compounds extracted from P. grandiflorum was evaluated, only three exhibited any significant activation effect on NF-${\kappa}B$.

• Journal of the Korean Ceramic Society
• /
• v.11 no.3
• /
• pp.19-26
• /
• 1974

Mechanical properties of the system PbO-B2O3-V2O5 low melting glass during crystallization by heat-treatment were investigated. Wettability of the system PbO-B2O3-V2O5 was excellent and appropriate for commercial sealing as a low melting solder glass. Crystals, during heat-treated at 30$0^{\circ}C$ of the system PbO-B2O3-V2O5 were $\beta$-4PbO.B2O3, 5PbO.4B2O3, and Pb2V2O7 mainly. The percent of crystallinity was 82$\pm$5%. Mechanical properties of the system PbO-B2O3-V2O5 were influenced not only by the differences of density and coefficient of thermal expansion and the stress induced from the difference in the density and coefficient of thermal expansion between glass phase and crystals but also crystallization conditions.

• Archives of Pharmacal Research
• /
• v.22 no.2
• /
• pp.194-201
• /
• 1999

The reaction of thiocyanoacetamide (1) with ${\alpha},{\beta}$-unsaturated ketones 2a,b resulted in the formation of the corresponding newly synthesized 1(H)-pyridinethione derivatives 3a,b. Compounds 3a,b were used as synthons for the preparation of 2-S-alkyl-, 2-S-acetamidopyridine, thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives via a wide range of reactions with different reagents. The antimicrobial activity of some of the newly synthesized compounds was tested. Compounds 3a, 11a, 15a, and 19a,b were found to be the most active ones.

• Journal of Digital Convergence
• /
• v.15 no.10
• /
• pp.19-29
• /
• 2017

The purpose of this study was to identify the multidimensional factors that affect the satisfaction of life by type of baby boomer generation. The subjects of this study were 1,895 households who were born from 1955 to 1963 among the respondents in the Korea welfare panel (the 10th year). The baby boomer generation was classified into four types such as gender, income status, male and female as socioeconomic status. The male type IV (B=.074, t=1.992, p<.05), health status (B=.233, t=7.268, p<.001), household income (B=.174, t=4.476, p<.001), depression (B=-.182, t=-5.242, p<.001), self-esteem (B=.255, t=7.027, p<.001), trust (B=.064, t=2.036, p<.05), etc. were found to have a significant effect on the life satisfaction of the male baby boomer generation. The female type IV (B=.100, t=2.598, p<.05), health status (B=.239, t=6.790, p<.001) (P<.001), depression (B=-.181, t=-5.142, p<.001), and self-esteem (B=.320, t=8.600, p<.001), etc. were found to have a significant effect on the life satisfaction of the female baby boomer generation.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.12 no.5
• /
• pp.815-820
• /
• 2008

Recently the frequency assignment and the technical specifications of UWB systems for communications are completed. Therefore many UWB systems have been developed. In our country $3.1{\sim}4.8GHz$ and $7.2{\sim}10.2GHz$ are assigned for UWB systems for communications. When we consider RF technologies and the easy implementation of UWB systems, UWB systems used in the low band are more developed than high band systems. In this paper we design and implement a BPF for low band UWB systems by means of considering the easy implementation of UWB systems. The designed and implemented BPFs are low band filter and low band channel filters. The measured results of the low band filter show that the filter has 21.85dB and 17.91dB attenuation at 3.1GHz and 4.8GHz, 1.53GHz of -10dB bandwidth and 2dB of insertion loss. Low band can be divided into 3 channels with 500MHz of the channel bandwidth. The channel filter for channel number 1 has the characteristics of 24.85dB attenuation at 3.1GHz, 0.61GHz of -10dB bandwidth and 1.87dB of insertion loss. The filter for channel 3 in low band has 19.2dB of attenuation at 4.8GHz, 0.49GHz of -10dB bandwidth and 2.49dB of insertion loss.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.25 no.1
• /
• pp.19-24
• /
• 2014

In this paper, a multiband LTE antenna satisfying LTE octa-band is proposed. The proposed antenna consists of a modified PIFA structure and a folded monopole which has the height of 4 mm. Each parts operates at lower and upper LTE band. Measured bandwidth(6 dB return loss) was 118 MHz(870~988 MHz) at the lower band and 1,107 MHz(1,650~2,757 MHz) at the upper band. The proposed antenna has a omni-directional radiation pattern and measured peak gains were 3.21 dBi at the lower band and 4.19 dBi at the upper band, respectively. The proposed antenna is expected to be utilized for future LTE-advanced system.

• The Transactions of the Korean Institute of Electrical Engineers B
• /
• v.53 no.7
• /
• pp.452-461
• /
• 2004

A novel multilevel PWM inverter is presented for the use of stand-alone photovoltaic power generation system. In appearance, it consists of three full-bridge modules and three cascaded transformers; therefore, the configuration of the proposed multilevel PW inverter is equal to that of a prior 11-level PWM inverter. Only the turn-ratio of a transformer and its corresponding switching function are different from each other. Owing to these differences, the proposed 19-level PWM inverter has two promising advantages. First, output voltage levels increase almost twofold. Consequently, it can generate more sinusoidal output voltage waveform. Second, due to a revised switching pattern, it lightens power imposed on the transformer, which is used for compensating output voltages with chopped pulses between steps. The validity of the proposed inverter system is verified by computer-aided simulations and experimental results based on a 1 ［kW］ prototype. The performance of the proposed 19-level PWM inverter is compared with the Prior 11-level PWM inverter and other counterparts.

• Korean Journal of Crystallography
• /
• v.6 no.2
• /
• pp.63-68
• /
• 1995

The crystal structure of fenothiocarb(S-4-phenoxybutyl dimethylthiocarbamate), C13H19NO2S is monoclinic, space group P21/c, a=9.045(1)Å, b=14.577(2)Å, c=10.727(2)Å, β=103.56(1)°, Z=4, V=1375.20(6)Å3, Dc=1.23g/cm3, λ(Mo-Kα)=0.71069Å, μ=2.3cm-1, F(000)=544, temperature : 293±3K, R=0.049 for 1543 unique observed reflections. The structure was determined by direct method and refined by full-matrix least squares method. The molecules are contacted to the c axis with two fold screw and van der Waales force.