• Natural Product Sciences
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• 제4권3호
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• pp.161-169
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• 1998

The analogues of lichen components showing anti-tyrosinase activities were synthesized. 4-Alkylresorcinol derivatives showed both the inhibitory activity and cytotoxicity in B-16 melanoma cells at the doses of 10 mM to 1.2 mM. Resorcinol and 4-methylresorcinol showed the inhibitory effect with a low cytotoxicity at the doses of 2.5 mM and $600\;{\mu}M$ among 4-alkylresorcinols, respectively. Some diphenylmethane derivatives (Type A, B, and C) had strong activities with a low cytotoxicity. While xanthine derivatives had no effect. Glucosides of 4,5-alkylresorcinol and the diphenylmethane derivative (Type B) were prepared to decrease the cytotoxicity. As a result, no effect were observed. Liposome of the diphenylmethane derivative (Type B) was prepared for the same purpose, and the latter showed a remarkable effect at the dose of $15\;{\mu}M$ with a low cytotoxicity.

• 대한전자공학회논문지SD
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• 제44권8호
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• pp.16-21
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• 2007

본 논문은 구조물 모니터링을 위한 광섬유 센서 시스템의 수신단 응용을 위한 CMOS 기반의 가변 이득 증폭기 집적회로 설계에 초점을 두고 있다. 차동증폭기와 선형 linear-in-dB 제어기를 사용한 3단 가변 이득 증폭기를 제시하였다. 제안된 가변이득 증폭기는 전류의 비에 의해 증폭기의 이득이 linear-in-dB 하게 조절되는 일반적인 가변 이득 증폭기의 변형된 형태이다. 본 논문에서 제안된 가변 이득 증폭기는 1.5 dB의 간격으로 77 dB의 다이내믹 영역을 가졌다. 이득오차는 77 dB 다이내믹 영역에서 1.5 dB 이하를 얻었다. 동작범위는 10 MHz를 얻었으며, 단일 1.8 V 전압에서 13.8 mW의 전력소모 특성을 보였다. 이 가변 이득 증폭기는 Magnachip 사의 $0.18{\mu}m$ CMOS 공정을 사용하여 구현되었으며, 유효면적은 $430{\mu}m{\times}350{\mu}m$ 이었다. 제안된 가변 이득 증폭기는 구조물 모니터링을 위한 광섬유 센서 시스템의 수신단에 적용이 가능하였다 측정 결과에 따라 제안된 방법은 다이내믹 영역의 증대와 좋은 linear-in-dB 특성 관점에서 유효하였다.

• KSBB Journal
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• 제17권2호
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• pp.189-194
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• 2002

Trametes sp.에서 생산되는 laccase는 CNBr-activated Sepharose-4B(CAS4B)에 고정화 되었고, 염료의 연속적인 분해를 위하여 테스트되었다. Laccase는 CAS4B에 효율적으로 고정화되었고, CAS4B에 고정화 된 laccase는 pH, 열, 단백질 구조적인 안정성 면에서 상당히 증가하였다. CAS4B에 고정화 된 accase의 최적 pH는 5, 온도는 4$0^{\circ}C$로서 free laccase와 비교하여 변화가 없었다 기질로서 Reactive Blue 19를 사용하였을 때 free laccase와 고정화 laccase의 $K_{m}$ ($\mu$mol/mL) 값은 각각 0.34와 2.0이었고,V$_{max}$($\mu$mol/mL.min) 값은 각각 0.12, 0.1이었다. Repeated-batch 반응에서 효소의 안정성과 높은 분해 효율 만족하는 조건은 pH 5, 3$0^{\circ}C$이였다. 또한 HBT에 의한 효소의 불활성은 크게 나타나지 않았다. Packed-bed reactor에서 최적으로 운전되었을 때 100 $\mu$M Reactive Blue 19과 0.1 mM HBT가 존재하는 50 $\mu$M Acid Red 57의 연속적인 분해에서 30시간 후에도 분해 효율이 70%로 유지되었다. 고정화 laccase는 Packed-bed reactor에서 azo 염료의 연속적인 분해를 매우 안정적으로 수행하였다.다.

• Kyungpook Mathematical Journal
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• 제58권4호
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• pp.747-759
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• 2018

A graph G = (V (G), E(G) of order n = |V (G)| and size m = |E(G)| is said to be odd harmonious if there exists an injection $f:V(G){\rightarrow}\{0,\;1,\;2,\;{\ldots},\;2m-1\}$ such that the induced function $f^*:E(G){\rightarrow}\{1,\;3,\;5,\;{\ldots},\;2m-1\}$ defined by $f^*(uv)=f(u)+f(v)$ is bijection. While a bipartite graph G with partite sets A and B is said to be bigraceful if there exist a pair of injective functions $f_A:A{\rightarrow}\{0,\;1,\;{\ldots},\;m-1\}$ and $f_B:B{\rightarrow}\{0,\;1,\;{\ldots},\;m-1\}$ such that the induced labeling on the edges $f_{E(G)}:E(G){\rightarrow}\{0,\;1,\;{\ldots},\;m-1\}$ defined by $f_{E(G)}(uv)=f_A(u)-f_B(v)$ (with respect to the ordered partition (A, B)), is also injective. In this paper we prove that odd harmonious graphs and bigraceful graphs are equivalent. We also prove that the number of distinct odd harmonious labeled graphs on m edges is m! and the number of distinct strongly odd harmonious labeled graphs on m edges is [m/2]![m/2]!. We prove that the Cartesian product of strongly odd harmonious trees is strongly odd harmonious. We find some new disconnected odd harmonious graphs.

• 식물병연구
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• 제19권4호
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• pp.294-299
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• 2013

새로운 채소류를 뿌리혹선충이 감염된 시설재배지에 윤작작물로 추천하기 위하여 7과 13속, 25종, 총 39품종을 고구마뿌리혹선충과 땅콩뿌리혹선충을 대상으로 저항성을 검정하였다. 2종류의 뿌리혹선충에 모두 감수성인 것은 비름과(Amaranthaceae)의 아마란서스와 근대, 낙규과(Basellaceae)의 바우세, 피나무과(Tiliaceae)의 모로헤이야, 메꽃과(Convolvulaceae)의 공심채, 십자화의 청경채, 홍채태(Brassica campestris var. chinensis), 다채(B. campestris var. narinosa), '다청채'(B. campestris var. chinensis x narinosa), 갓, 곱슬겨자(B. juncea), 교나(B. juncea var. laciniate), 채심(B. rapa subsp. arachinenesis), 가이란(B. oleracea var. alboglabra), 로케트샐러드(Eruca sativa), 국화과(Asteraceae)의 쑥갓(Chrysanthemum coronarium), 엔다이브(Cichorium endivia), 아티쵸크(Cynara cardunculus var. scolymus), 상추(Lactuca sativa)였다. M. incognita에는 저항성이나 M. arenaria에는 감수성인 것은 십자화과의 케일(B. oleracea) cv. 맛짱, 콜라비(B. oleracea var. gongyloides) cv. 적콜라비, 치커리(C. intybus) cv. 적치커리였다. 두 종류의 뿌리혹선충에 모두 저항성인 것은 치커리(C. intybus) cv. 슈가로프, 구루모, 통콘네로네(radichio treviso), 십자화과의 케일(B. oleracea) cv. 만추콜라드, 슈퍼맛짱 브로콜리(B. oleracea italica), 잎브로콜리(B. oleracea var. botrytis italiana), 꿀풀과(Lamiaceae)의 차즈기, 들깨였다. 2종류의 뿌리혹선충에 모두 저항성인 채소류는 뿌리혹선충이 감염된 시설재배지에서 부가가치가 높은 저항성 윤작작물로 사용이 가능할 것이다.

• Journal of Acupuncture Research
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• 제21권6호
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• pp.19-36
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• 2004

Objective : The purpose of this study was to investigate the effect of Bee Venom and Melittin Solution on the lipopolysaccharide(LPS) and sodium nitroprusside(SNP)-induced expression of prostaglandin $E_2(PGE_2)$, cyclooxygenase-2(COX-2), nuclear factor kappa B($NF-{\kappa}B$) and nuclear factor kappa B($NF-{\kappa}B$) dependent luciferase activity in RAW 264.7 cells, a murine macrophage cell line. Methods : The expression of PGE2 was determined by determination of $PEG_2$, COX-2 was by western blotting with corresponding antibodies, $NF-{\kappa}B$ was by gel mobility shift assay method and $NF-{\kappa}B$ dependent luciferase activity was investigated by luciferase assay in RAW 264.7 cells. Results : 1. LPS and SNP-induced expression of $PEG_2$ was significant after 24hour. 2. The 0.5, 1 and $5{\mu}g/mL$ of bee venom and the 5 and $10{\mu}g/mL$ of melittin solution inhibited significantly LPS-induced expression of $PEG_2$ and, the $5{\mu}g/mL$ of bee venom and the 5 and $10{\mu}g/mL$ of melittin solution inhibited significantly SNP-induced expression of $PEG_2$ compared with control, respectively. The 0.5 and $1{\mu}g/mL$ of bee venom could not significantly inhibit SNP-induced expression of $PEG_2$ compared with control. 3. The $5{\mu}g/mL$ of bee venom and the 5 and $10{\mu}g/mL$ of melittin solution inhibited significantly LPS and SNP-induced expression of COX-2 compared with control, respectively. The 0.5 and $1{\mu}g/mL$ of bee venom inclined to decrease LPS and SNP-induced expression of COX-2 compared with control. 4. The 0.5, 1 and $5{\mu}g/mL$ of bee venom and the 5 and $10{\mu}g/mL$ of melittin solution inhibited significantly LPS and SNP-induced expression of $NF-{\kappa}B$ compared with control, respectively. 5. The 0.5, 1 and $5{\mu}g/mL$ of bee venom and the 5 and $10{\mu}g/mL$ of melittin solution inhibited significantly LPS-induced expression of $NF-{\kappa}B$ dependent luciferase activity and the 1 and $5{\mu}g/mL$ of bee venom and the 5 and $10{\mu}g/mL$ of melittin solution inhibited significantly SNP-induced expression of $NF-{\kappa}B$ dependent luciferase activity compared with control, respectively. The $NF-{\kappa}B$ inhibitor also inhibited significantly LPS and SNP-induced expression of $NF-{\kappa}B$ dependent luciferase activity compared with control. 6. The 0.5, 1 and $5{\mu}g/mL$ of bee venom and the 5 and $10{\mu}g/mL$ of melittin solution inhibited significantly LPS + IFN-${\gamma}$, TNF-${\alpha}$ and LPS + TNF-${\alpha}$-induced expression of $NF-{\kappa}B$ dependent luciferase activity compared with control, respectively. The $NF-{\kappa}B$ inhibitor also inhibited significantly LPS and SNP-induced expression of $NF-{\kappa}B$ dependent luciferase activity compared with control. Conclusions : These results suggest the inhibitory action of bee venom and melittin solution on the inflammatory mediators such as $PEG_2$, COX-2 and $NF-{\kappa}B$.

• International Journal of Industrial Entomology and Biomaterials
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• 제10권2호
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• pp.87-94
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• 2005

Mating is an essential behavioural social event in the life cycle of silkworm, Bombyx mori (L.) for the perpetuation of population. A number of intrinsic and extrinsic factors and events of significant importance are involved in successful mating and egg deposition by an adult silk moth which besides biochemical, physiological and environmental factors also includes attraction of reproductively competent male and female moth for mating, duration and frequency of mating, age of moth at the time of mating, reuse of male moth in the production of eggs etc. An attempt has been made in this review article to elucidate briefly the behaviour of male towards female moth after eclosion, impact of duration and frequency of mating on egg deposition and oviposition, reuse of mated male moth in the production of quality and quantity eggs etc. in the silk-worm, B. mori and its significance in silkworm seed production.

• 대한수학회지
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• 제40권2호
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• pp.241-250
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• 2003

Let (B, m$_{B}$, k) be a maximal commutative $textsc{k}$-subalgebra of M$_{m}$(k). Then, for some element z $\in$ Soc(B), a k-algebra R = B［X,Y］/I, where I ＝ (m$_{B}$X, m$_{B}$Y, X$^2$- z,Y$^2$- z, XY) will create an interesting maximal commutative $textsc{k}$-subalgebra of a matrix algebra which is neither a $C_1$-construction nor a $C_2$-construction. This construction will also be useful to embed a maximal commutative $textsc{k}$-subalgebra of matrix algebra to a maximal commutative $textsc{k}$-subalgebra of a larger size matrix algebra.gebra.a.

• 대한산업공학회지
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• 제28권4호
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• pp.379-389
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• 2002

In this paper, we study the competition between two kinds of suppliers, a bricks and mortars(B&M) and a clicks and mortars(C&M). Using the circular spatial market model, we derive and analyze the Nash and Stackelberg equilibria as a function of offline market share and efficiency of online channel of the C&M supplier. The result can be summarized as follows: (1) Stackelberg equilibrium is always superior to the Nash equilibrium, (2) Under certain conditions, the price of online channel can be higher than that of offline channel, (3) It is impossible for the C&M supplier to encroach on all of the B&M supplier's market, (4) In some cases, the C&M supplier has incentive to lower the efficiency of its online channel for more profit.

• 한국산학기술학회논문지
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• 제11권10호
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• pp.3917-3922
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• 2010

본 논문은 U-band(40~60 GHz)대역에 최적화된 epitaxial로 pHEMT(Pseudomorphic High Electron Mobility Transistor)을 제작, 대신호 모델링하여 특성분석 및 60 GHz 대역의 3단 증폭기를 MMIC(Monolithic Microwave Integrated Circuit)로 설계 제작하였다. 본 논문에 사용된 pHEMT는 $0.12\;{\mu}m$의 게이트 길이와 총 게이트 면적 $100\;{\mu}m$, $200\;{\mu}m$를 사용하여 대신호 모델링하였으며 설계시 안정도의 향상을 위하여 부궤환회로와 함께 MIM(Metal-Insulator-Metal) 커패시터 대신 MCLF(Microstriop Coupled Line Filter)를 사용하여 안정도를 향상시켰다. 제작결과 크기가 $2.5{\times}1.5mm^2$이고 소모된 전류는 약 40 mA, 동작주파수 59.5 ~ 60.5 GHz에서 이득 19.9 dB ~ 18.6 dB, 입력정합특성 -14.6 dB ~-14.7 dB, 출력정합 특성 -11.9 dB ~-16.3 dB와 출력 -5 dBm의 특성을 얻었다.