• Journal of agricultural medicine and community health
• /
• v.31 no.3
• /
• pp.245-253
• /
• 2006

Objectives: Since 1983, vaccination for Hepatitis B virus has been recommended for all neonates in Korea. The objectives of this study was to assess the changing trend of the positive rate of HBsAg and anti-HBs in university students in one province. Methods: The study population consisted of one university students who taken physical exam in 2004, which included 8,527 students (3,391 males and 5,136 females). Serum HBsAg and anti-HBs were detected by immunochromatography method. Results: The positivities of HBsAg and anti-HBs were 2.7% and 61.1%. The positivity of HBsAg was significantly higher in males(p< .05), while that of anti-HBs was significantly higher in females(p< .05). There was some differences of HBsAg positivities among age groups. But there was no correlation between age and the positivities. There was some differences of anti-HBs positivities among age groups. But there was no correlation between age and the positivities. Conclusion: The positivity of HBsAg has significantly decreased and that of anti-HBs has increased with years. It was suggested that the changes of positivity were caused by nationwide hepatitis B vaccination program.

• Pediatric Infection and Vaccine
• /
• v.18 no.2
• /
• pp.124-134
• /
• 2011

Purpose : We have tried to search all concerning data on the policies of hepatitis B vaccination or surveillance of medical equipments that can transmit blood mediated diseases, including disposable syringe, in Republic of Korea, to propose references to other medical professionals. Methods : Data from domestic journals, government websites, computerized newspapers, etc. were reviewed. The data were arranged into four categories (governmental policies on hepatitis B control, hepatitis B mass immunization program in school, using process of hepatitis B vaccine, and policies on medical equipments surveillance, including disposable syringes, which is considered as source of blood mediated infection), and the periodic changes on each subjects in policies were reviewed. Results : Due to growing social concerns on hepatitis B in early 1980s, swift introduction and production of hepatitis B vaccine was made. After establishment of "5 year project for eradication of hepatitis B" in late 1983, number of vaccinated population jumped up to 6 million within 2 years (1984-85). However, since the immunization targets were mainly adult, not infant, this project was annulled in late 1985. Following this project, hepatitis B mass immunization program in school was carried out. In year 1995, hepatitis B vaccine was included in national immunization program. The use of disposable syringe was recommended from year 1980 but legislated in year 1985, finally. Conclusion : The mainstay in controlling hepatitis B in Republic of Korea was coordination of prompt introduction of vaccine, mass immunization, high vaccination coverage rate, or use of disposable syringes. However, since there is lack of official data available, it is urgent to arrange and computerize all government data related to infectious diseases.

• The Safety technology
• /
• no.75
• /
• pp.30-31
• /
• 2004

B형 간염에 감염된 근로자가 과중한 업무에 종사하다가 원발성 간종양 진단을 받고 사망한 경우, B형 간염에 감염된 것은 업무와 관련이 없다 하더라도 계속되는 근무로 인하여 육체적 과로와 정신적 스트레스가 지속되어 자연적인 속도 이상으로 악화되어 사망하였다면 업무상 재해에 해당한다

• The Journal of the Korea Contents Association
• /
• v.16 no.4
• /
• pp.729-740
• /
• 2016

This study was conducted to assess the needs of smartphone application development for self care performance of 374 patients with chronic hepatitis B. The mean age of the subjects was 46.2 years. The patients obtained information about chronic hepatitis B from the internet (41.3%), nurses or doctors (23.8%), television (15.6%), and smartphones (6.2%). The reason that the information about hepatitis B didn't come from a smartphone were 'Lack of useful applications' (75.9%), 'Could not believe the information' (15.0). If the application is developed, subjects replied 'Frequently use' (59.9%), 'When needed' (33.2%). The desired contents were 'Knowledge of disease' (27.1%), 'Drug calender' (16.8%), 'Reference of information' (15.5%), 'Record of lab data' (14.6%). Ability to use the smartphone, depended on age and level of education, however the needs for the development of the smartphone application, there were not differences. Also, there were different desired contents of application, depended on age and level of education. Therefore, when developing smartphone applications for self care performance of chronic hepatitis B patients considering educational level and age, it could be widely utilized as a tool which can help to the self care performance of chronic hepatitis B patients.

• Clinical and Experimental Pediatrics
• /
• v.45 no.12
• /
• pp.1519-1527
• /
• 2002

Purpose : Although influenza virus is one of the most important causes of acute respiratory tract infections(ARTIs) in children, virus isolation is not popular and there are only a few clinical studies on influenza in Korea. We evaluated the epidemiologic and clinical features of ARTIs by influenza virus in children. Methods : From February 1995 to August 2001, nasopharyngeal aspirations were obtained and cultured for the isolation of influenza virus in children admitted with ARTIs. The medical records of patients with influenza virus infection were reviewed retrospectively. Results : Respiratory viruses were isolated in 997(22.0%) out of 4,533 patients examined, and influenza virus was isolated in 164 cases(3.6%). Influenza virus was isolated year after year mainly from December to April of next year. The ratio of male and female was 1.9 : 1 with a median age of 15 months. The most common clinical diagnosis of influenza virus infection was pneumonia, and fever and cough developed in most patients. There was no difference between influenza A and B infection in clinical diagnoses and symptoms. All patients recovered without receiving antiviral treatment except for one patient diagnosed with pneumonia who had underlying disease of Down syndrome with ventricular septal defect. Conclusion : ARTIs caused by influenza virus developed every winter and spring during the period of study. Because fatal complication can develop in the high risk group, prevention, early diagnosis and proper management of influenza should be emphasized.

• Journal of Life Science
• /
• v.2 no.3
• /
• pp.163-173
• /
• 1992

간염바이러스들은 이들의 virology 및 임상적 특징들에 따라 A형, B형, C형, D형 및 E형으로 분류되며, A형 및 E형은 미개발국가들의 약년층에서 흔히 발생하는 급성간염의 원인으로 알려져 왔으나 만성간염 또는 간세포 암의 원인은 되지 않음으로 B형 및 C형에 비해 임상적인 의의는 적다. B형 바이러스는 급성간염 및 간세포 암의 가장 중요한 원인이며 전세계 인구 중에서 3억가량이 HBV에 감염되어 있고 이들의 75%가 아시아인인 것으로 밝혀져 있다. C형 바이러스는 최근에 비A형, 비B형 간염바이러스에 의한 간염의 중요한 원인으로 밝혀졌으며 구미 및 일본에서는 만성간염 및 간세포암의 가장 중요한 원인으로도 간주되고 있다. D형 간염바이러스는 지중해 연안국가, 북아프리카 및 중동국가들에서 HBV에 의해 이미 감염되어 있는 환자들을 침범함으로써 HBV에 의한 급성 및 만성간염을 악화시키나 HDV 단독으로는 간염의 원인이 될 수는 없다고 알려져 있다. 본지에서는 한국인에게서 임상적인 의의를 갖는 HBV에 대해 구체적으로 기술한다.

• The Korean Journal of Zoology
• /
• v.36 no.2
• /
• pp.293-303
• /
• 1993

쇠오징어(Sepiella maindroni)흠반의 외측 상피조직에서 3종류의 감각세포(A, B 및 D형 감각세포)와, 1종류의 감각상피세포(C형 감각 상피세포) 그리고 2종류의 점액세포(a 및 b형 점액세포)가 각각 관찰되었다. A 및 B형 감각세포는 분포상태가 다를 뿐 형태는 거의 유사한 세포이고 많은 분비액포를 지닌 해면질 형태의 세포로서 전자 밀도가 낮은 물질을 분비하는 분비성 감각세포로 확인되었다. 0형 세포는 매우 작은 감각세포로서 세포의 자유면에 긴 융모가 밀생되어있었고, 측면원형질막은 불규칙한 수지상 연접을 이루고 있었다. 이 세포는 전자밀도가 매우 높아서 검게 보였다. C형 감각 상피세포도 세포의 자유면에 긴 미세융모가 밀생되어있는 단층 원주상 세포로서. 이 세포 역시 측면원형질막이 불규칙한 수지상 연접을 이루고 있고. 엽접내에는 많은 소포와 약간의 사립제가 관찰되었다. 3형 점액세포는 세포질속에 내강이 팽창된 활면소포체를 소지하고 있으며 전자밀도가 높은 구형의 점액과립을 형성하였고, b형 점액세포도 전자밀도가 중등도인 점액질 과립을 소지하고 있었다.

• Clinical and Experimental Pediatrics
• /
• v.49 no.6
• /
• pp.630-634
• /
• 2006

Purpose : This study was conducted to assess the current(2003-2005) prevalence of anti-HBs and immunologic memory for Hepatitis B vaccine in children from the central area of Korea. Methods : Subjects were chosen from children and adolescents who received tests for hepatitis B surface antigen(HBsAg) and anti-HBs at Dankook University Hospital from March 2003 to May 2005. Among these, antibodies to hepatitis B core antigen(IgG anti-HBc) were checked. A single booster vaccination was performed on children whose anti-HBs titers were under 10 mIU/mL. One month after booster vaccination we rechecked the anti-HBs titer. Results : A total of 3,277 subjects were tested for HBsAg/anti-HBs, and 1,913(58.4 percent) of them were positive for anti-HBs. Of these, 29 subjects(0.9 percent) were positive for HBsAg. Positive results for anti-HBs by age were 78.6 percent for 6-12 months of age, 62.7 percent for 1-3 years of age, 51.9 percent for 4-6 years of age, 49.5 percent for 7-12 years of age, 63.4 percent for 13-15 years of age and 72.2 percent for 16-18 years of age. The 80 subjects who were tested negative for HBsAg/anti-HBs received a single booster vaccine, 71 subjects were tested positive for antibodies. IgG anti-HBc titer was checked for 169 of the subjects, 5 subjects were positive. Conclusion : In our study, a significant anamnestic response was observed in 88.8 percent of children. This is believed to be a result of the relatively long immunologic memory effect of the hepatitis B vaccination in children from the central area of Korea.

• 간의등불
• /
• s.27
• /
• pp.4-5
• /
• 2002

• Korean Journal of Clinical Laboratory Science
• /
• v.47 no.2
• /
• pp.78-82
• /
• 2015

The purpose of this study was to survey the anti-HBs positivity and titers of antibody in current students who received nationwide vaccination against Hepatitis B virus which targeted infants in 1995. The subjects were 262 students in Gyeongnam province from April 2014 to October 2014. The positive rate of anti-HBs was 55.3% (145 people) and the negative rate of anti-HBs was 44.7% (117 people). Positivity was shown to be higher in women than men. However, there was no statistically significant difference. Of the HBV-vaccinated subjects, 117 (44.7%) had anti-HBs titer <10, which is judged to be negative, 126 (47.8%) had anti-HBs titer 10-499.9 mIU/mL, which is judged to be positive, and 22 (7.3%) had anti-HBs titer more than 500 mIU/mL. The rate of anti-HBs with lower titer (10-99.9 mIU/mL) was 62% in the positive group. Classifying the antibody titer according to age, the rate of anti-HBs positivity in titer with less than 100 mIU/mL was indicated to be 78.3% in cases of 19-20 year old and 46.7% in 21-22 year old, 52.3% in 23-24 year old. A case of the lower titer with 10-99.9 mIU/mL, showed significant difference according to age. As a result of research, the antibody titers is decreased depending on the passage of time. Hence, the checking of anti-HBs titer is needed after Hepatitis B vaccination and many healthy adults will need periodic boosters of hepatitis B vaccine to maintain production of antibody to hepatitis B surface antigen.