• Bulletin of the Korean Chemical Society
• /
• v.32 no.5
• /
• pp.1769-1772
• /
• 2011

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1994.04a
• /
• pp.223-223
• /
• 1994

FDA가 공인한 항 HIV제로서 사용중인 AZT나 DDI와 같은 화합물은 장기 투여로 심각한 부작용들이 나타나고 있다. 그래서 기존의 activity를 가진 nucleoside류의 sugar 부분에 새로운 base 즉, 5-ethoxymethyl uracil을 축합, 3'-azido-2',3'-dideoxy-5-ethoxy-methyl uridine, 2',3'-aideoxy-3'-fluoro-5-ethoxymethyl uridine과 2',3'-dideoxy-5-ethoxymethyl uridine들을 합성, 구조활성 상관관계를 검토하였다. 이들의 합성은 먼저 적절한 group으로 sugar의 -OH group을 보호한후 uracil류와 반응, uridine 유도체를 먼저 합성하였다. 각각의 uridine 유도체들의 5-위치에 ethoxymethyl group을 도입하기 위해 formalin과 반응시킨후 5-hydroxy-methyl group을 도입하고 산촉매 하에 ethanol과 반응, ethyl ether류를 합성하였다.

• Archives of Pharmacal Research
• /
• v.12 no.4
• /
• pp.300-305
• /
• 1989

The synthetic study of 3' azido and 3'-fluoro secouridines toward development of new antiviral agents is described. These acyclic nucleosides were synthesized from uridine by the method of ring opening reaction of sugar moiety.

• Proceedings of the PSK Conference
• /
• 2003.04a
• /
• pp.238.3-239
• /
• 2003

Among 4'-substituted nucleosides. Nucleocidin. 4'-azido thymidine (ADRT), 4'-fluorinated carbocyclic nucleoside. and 3'-fluoro oxetanosin analogue have demonstrated a variety of biological activities. Since the cyclopentane ring of carbocyclic nucleosides can emulate the furanose moiety. a number of these compounds exhibit interesting biological activity, particularly in the areas of antiviral and anticancer chemotherapy. (omitted)

• Bulletin of the Korean Chemical Society
• /
• v.32 no.2
• /
• pp.547-552
• /
• 2011

Azido contained polymers were treated with various substituted N-propargyl tetrazoles in $CH_2Cl_2/H_2O$ at room temperature by Cu-catalyzed [2+3] cycloaddition to afford high yields of the corresponding polymers, possessing both triazole and tetrazole moiety.

• Macromolecular Research
• /
• v.14 no.6
• /
• pp.668-672
• /
• 2006

• Archives of Pharmacal Research
• /
• v.18 no.5
• /
• pp.364-365
• /
• 1995

• Bulletin of the Korean Chemical Society
• /
• v.32 no.10
• /
• pp.3767-3769
• /
• 2011

• Bulletin of the Korean Chemical Society
• /
• v.28 no.6
• /
• pp.915-916
• /
• 2007

• Bulletin of the Korean Chemical Society
• /
• v.24 no.11
• /
• pp.1641-1648
• /
• 2003

New and facile synthetic routes for preparation of optically active norephedrine, norpseudoephedrine and cathinone with high optical purities via double asymmetric induction by employing asymmetric reduction of 2-N-protected amino (or azido)-1-phenylpropanone and 2-methanesulfonyloxy-1-phenylpropanone with CBS-catalyzed-borane and $^dIpc_2BCl$ as chiral reducing agents are described.