• 폴리머
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• 제38권3호
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• pp.386-390
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• 2014

덴드리머의 중심에 삼발이 핵을 갖는 덴드리머의 합성을 위한 효율적인 연결 방법이 개발되었다. 합성전략은 알데히드 덴드론과 아자이드기를 갖는 삼발이 핵 사이의 반응을 톨루엔 용매와 triphenylphosphine 존재하에서 진행하는 새로운 클릭화학(Staudinger/aza-Wittig 반응)을 이용하였다. 덴드리머의 삼발이 핵으로 작용할 수 있는 단위체인 1,3,5-tris-(3-azido-propoxy)-benzene을 합성하였고, 이 화합물의 아자이드기는 덴드리머의 형성에 이용되었다. 1,3,5-Tris-(3-azido-propoxy)-benzene을 이용하여 알데히드 덴드론과 Staudinger/aza-Wittig 반응을 통해 덴드리머를 합성하였으며, 모든 덴드리머는 높은 수득률로 얻어졌다.

• Bulletin of the Korean Chemical Society
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• 제27권10호
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• pp.1667-1670
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• 2006

• Bulletin of the Korean Chemical Society
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• 제30권5호
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• pp.1001-1002
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• 2009

• Bulletin of the Korean Chemical Society
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• 제32권10호
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• pp.3624-3628
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• 2011

Fr$\acute{e}$chet-type dendritic benzaldehydes were efficiently synthesized using 3,5-dihydroxybenzaldehyde as an aldehyde focal point functionalized unit by adding a generation to the existing dendron or direct oxidation of Fr$\acute{e}$chet-type dendritic benzyl alcohols. These dendritic benzaldehydes were applied for the construction of dendrimers containing secondary amines as connectors via Staudinger/aza-Wittig Reactions with ${\alpha}$,${\alpha}'$,-diazidop-xylene core.

• Bulletin of the Korean Chemical Society
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• 제32권8호
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• pp.2700-2704
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• 2011

The 1:1 imine intermediate generated by the addition of primary amine to chloroacetone is trapped by N-isocyaniminotriphenylphosphorane in the presence of (E)-cinnamic acids and the corresponding iminophosphorane intermediate was formed. Disubstituted 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reactions were completed in neutral conditions at room temperature. The disubstituted 1,3,4-oxadiazole derivatives were produced in excellent yields.

• Bulletin of the Korean Chemical Society
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• 제33권2호
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• pp.453-458
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• 2012

Reactions of (N-isocyanimino)triphenylphosphorane with (1R)-(-)-campherchinon in the presence of aromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed.

• Bulletin of the Korean Chemical Society
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• 제35권2호
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• pp.617-621
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• 2014

An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate and aromatic isocyanates, followed by addition of amines/phenols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.