• Journal of the Korean Institute of Intelligent Systems
• /
• v.14 no.4
• /
• pp.457-467
• /
• 2004

In this paper, a robot is considered as an agent, a structure of robot is presented which consisted by multi-subagents and they have diverse capacity such as perception, intelligence, action etc., required for robot. Also, subagents are consisted by micro-agent($\mu$agent) charged for elementary action required. The structure of robot control have two sub-agents, the one is behavior based reactive controller and action selection sub agent, and action selection sub-agent select a action based on the high label action and high performance, and which have a learning mechanism based on the reinforcement learning. For presented robot structure, it is easy to give intelligence to each element of action and a new approach of multi robot control. Presented robot is simulated for two goals: chaotic exploration and obstacle avoidance, and fabricated by using 8bit microcontroller, and experimented.

• Journal of Pharmaceutical Investigation
• /
• v.13 no.4
• /
• pp.153-172
• /
• 1983

The use of carrier systems for the delivery of drugs to areas in the body in need of pharmacological intervention is now the subject of intense research in many laboratories. Because of its obvious advantages (e.g. protection of drugs from hostile environments, facilitated target penetration and avoidance of side effects), drug delivery is expected to ease the pressure and expense of new drug development by making better use of drugs in existence. Generally, carrier-mediated delivery has been envisaged either as direct transport of drugs to a biological target by a carrier that will associate with it selectively, or as release of drugs from a carrier circulating in the blood or immobilized in tissues, at rates compatible with optimal action. One system that has attracted considerable attention is the use of liposomes as carriers of pharmacologically active agents. 154 references were reviewed with special emphasis on the targeting of drugs by use of liposomes in this respect. Recent advances in the other carrier systems and in methods for the preparation of liposomes were also reviewed briefly.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• v.19 no.3
• /
• pp.311-318
• /
• 1997

Ludwig's angina has been defined as a potentially lethal, rapidly spreading cellulitis, involving the sublingual and submandibular spaces, and is manifesed by a brawny, suprahyoid induration, tender swelling in the floor of mouth, elevation and posterior displacement of tongue. This paper is of interest not only because of severity of infection but also because of associated diabetic mellitus. Diabetes mellitus is a complex syndrome of disordered metabolism and elevated blood glucose, it results from deficiency of insulin secretion of combination of insulin resistance and inadequate insulin secretion. The effects of diabetic mellitus include neuropathy, vascular insufficiency, decreased leukocytic function, hematologic change etc. Clinically this may be refelected by the increased severity of infections seen in diabetics. The treatment of infections in diabetics are reduction of number of microbes through the use of appropriated antimicrobial agents and proper surgical drainage and improvement of the host factors by tight control of insulin replacement and immediate intervention to correct abnormalities of the local factors by drainage, debriment, and removal of avoidance of foreign bodies. The authors present the report of the Ludwig's angina in patient with diabetic mellitus, with literature review and good clinical result.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.36 no.3
• /
• pp.133-141
• /
• 2013

The revitalization of e-business via Internet brings big changes to the postal business, and leads to a tremendous increase of heavy and large sized postal mails with continuing growth of home delivery business. Thus, even though the number of intermediate storages for mail delivery that mailmen use for picking up mails in the middle of mail delivery has been being increased, it has still many problems such as insufficient number and size of the storages as well as avoidance of mail keeping of trust agents. It is necessary that safety of mail keeping, seamless mail delivery, and individual parcel pick-up process reestablishment should be made through an improved counter plan for the problems described previously. This study presents the efficient and right operational plan for the intermediate storage for mail delivery with providing the number and size of intermediate storages per mail delivery sequence according to four different types of post offices.

• Journal of Radiation Industry
• /
• v.8 no.2
• /
• pp.97-104
• /
• 2014

Postharvest diseases cause considerable losses to harvested fruits and vegetables worldwide. Fresh produce suspected of harboring postharvest disease must be treated to control any pathogens present. Although there are various treatments to control postharvest losses by pathogens, the current community is eager to take safer and more eco-friendly alternatives to help with human health and reduce environmental risks. Ionizing irradiation is a promising phytosanitary treatment that has a significant potential to control postharvest diseases in use worldwide. Although almost 19000 metric tons of sweet potatoes and various fruits are irradiated each year in six countries to control postharvest disease, irradiation continues to be a debate, with slow acceptance by industries. Irradiation alone is not effective as a fungicide, and an over dose affects the physical properties of irradiated products. A combination of irradiation with other treatments such as heating, biocontrol agents, chlorination, and nano Ag particles is to enhance their effectiveness. Challenges to the use of phytosanitary irradiation are an avoidance of irradiated postharvest and cost of the irradiation facilities, and thus consumers still need to be educated on the principles and benefits of irradiation and prepare an optimum economy of scale for commercial use. In this review, we evaluated the current phytosanitary irradiation, and combination with various other treatments to minimize the postharvest losses.

• Advances in nano research
• /
• v.13 no.6
• /
• pp.587-597
• /
• 2022

In the present study, a novel optimization method in formation control of multi -system vehicles based on the trajectory of the nearest neighbor trajectory is presented. In this regard, the state equations of each vehicle and multisystem is derived and the optimization scheme based on minimizing the differences between actual positions and desired positions of the vehicles are conducted. This formation control is a position-based decentralized model. The trajectory of the nearest neighbor are optimized based on the current position and state of the vehicle. This approach aids the whole multi-agent system to be optimized on their trajectory. Furthermore, to overcome the cumulative errors and maintain stability in the network a semi-centralized scheme is designed for the purpose of checking vehicle position to its predefined trajectory. The model is implemented in Matlab software and the results for different initial state and different trajectory definition are presented. In addition, to avoid collision avoidance and maintain the distances between vehicles agents at a predefined desired distances. In this regard, a neural fuzzy network is defined to be utilized in conjunction with the control system to avoid collision between vehicles. The outcome reveals that the model has acceptable stability and accuracy.

• Journal of Intelligence and Information Systems
• /
• v.14 no.2
• /
• pp.193-206
• /
• 2008

Medical diagnosis can be considered a classification task which classifies disease types from patient's condition data represented by a set of pre-defined attributes. This study proposes a hybrid genetic algorithm based classification method to develop classifiers for multidimensional pattern classification problems related with medical decision making. The classification problem can be solved by identifying separation boundaries which distinguish the various classes in the data pattern. The proposed method fits a finite number of regional agents to the data pattern by combining genetic algorithms and local adaptive operations. The local adaptive operations of an agent include expansion, avoidance and relocation, one of which is performed according to the agent's fitness value. The classifier system has been tested with well-known medical data sets from the UCI machine learning database, showing superior performance to other methods such as the nearest neighbor, decision tree, and neural networks.

• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.2
• /
• pp.79-89
• /
• 2012

We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, i.p.) 30 min before scopolamine injection (2 mg/kg, i.p.). Daily administration of PA and BER improved memory impairment as measured by the passive avoidance test and reduced the escape latency for finding the platform in the Morris water maze test. Administration of PA and BER significantly alleviated memory-associated decreases in cholinergic immunoreactivity and restored brain-derived neurotrophic factor and cAMP-response element-binding protein mRNA expression in the hippocampus. PA and BER also decreased significantly the expression of proinflammatory cytokines such as interleukin-$1{\beta}$, tumor necrosis factor-${\alpha}$ and cyclooxygenase-2 mRNA in the hippocampus. These results demonstrated that PA and BER had significant neuroprotective effects against neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that PA and BER may be useful as therapeutic agents for improving cognitive functioning by stimulating cholinergic enzyme activity and alleviating inflammatory responses.

• Tuberculosis and Respiratory Diseases
• /
• v.59 no.5
• /
• pp.561-565
• /
• 2005

Bronchiolitis obliterans organizing pneumonia (BOOP) is often diagnosed in patients with pneumonia who respond poorly to antibiotics. BOOP is often idiopathic, and the etiology of the remaining cases has been attributed to a wide range of agents or medical conditions. When a patient develops the clinical symptoms characteristic of BOOP, the medical team must endeavor to determine the etiology of this disease because it can be treated with glucocorticoid and avoidance of the causative agent. In particular, if BOOP is diagnosed during or after chemotherapy for a malignancy, the possible culprit agent can be the anti cancer drugs but other drugs used for supportive care must be also be considered. We report a case of BOOP that arose after CHOP chemotherapy and a filgrastim injection in a patient with a diffuse large B-cell lymphoma.

• Korean journal of dermatology
• /
• v.56 no.10
• /
• pp.581-593
• /
• 2018

Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects both children and adults. AD is the cause of considerable morbidity including severe pruritus and impaired quality of life. Treatments for active disease include avoidance of triggering factors, barrier repair, topical medications including topical corticosteroids (TCs) and topical calcineurin inhibitors (TCIs), phototherapy, antibacterial agents, and systemic immunosuppressants including cyclosporine. Until recently, the only Food and Drug Administration (FDA)-approved systemic treatment options for patients with moderate-to-severe AD were steroids and cyclosporine. Systemic steroids are not recommended by current guidelines and are commonly associated with disease rebound. Instead, clinicians choose from several off-label immunosuppressants. In 2018, the Korean FDA approved dupilumab for adults with moderate-to-severe AD whose disease is not adequately controlled with topical therapies. The implementation of treatment guidelines for AD is challenging. Herein, we review the several treatment modalities for AD and recommend a treatment algorithm.