• Journal of Korea Port Economic Association
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• v.35 no.1
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• pp.97-116
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• 2019

National industrial complexes, airports, and seaports are major logistics nodes and the availability of their logistics services is a key factor for the successful operation of entire supply chains. For this reason, the central government has established a plan for their development and is investing in development projects. However, some difficulties exist in project prioritization and investment plan creation owing to the absence of a clear appraising method. For a smooth flow of national logistics and efficient investment on facilities, it is necessary to diagnose the logistics facilities' present conditions and practice sustainable management. In this study, a diagnostic method for logistics services, which consists of service factors and facility factors, is proposed. Adopting the method, facility factors can be prioritized to improve facilities' services; further, a standard procedure is proposed to support decision making for effective investments in logistics facilities. The method is applied to actual logistics facilities (three national industrial complexes, three seaports, and two airports) and the results indicate that it can be effectively applied to actual logistics facilities.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.234-241
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• 2021

By recognizing the importance of demand forecasting, the military is conducting many studies to improve the prediction accuracy for repair parts. Demand forecasting for repair parts is becoming a very important factor in budgeting and equipment availability. On the other hand, the demand for intermittent repair parts that have not constant sizes and intervals with the time series model currently used in the military is difficult to predict. This paper proposes a method to improve the prediction accuracy for intermittent repair parts of the Patriot. The authors collected intermittent repair parts data by classifying the demand types of 701 repair parts from 2013 to 2019. The temperature and operating time identified as external factors that can affect the failure were selected as input variables. The prediction accuracy was measured using both time series models and data mining models. As a result, the prediction accuracy of the data mining models was higher than that of the time series models, and the multilayer perceptron model showed the best performance.

• Journal of the Korea Society of Computer and Information
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• v.27 no.1
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• pp.51-59
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• 2022

As the weapon system's dependence on software functions increased, software became a key factor in controlling the weapon system. In addition, as software development becomes more important domestically and internationally, software verification becomes an issue. The recent defense market has recognized this point and is demanding a plan for weapon system software maintenance. In this paper, we propose a weapon system software maintenance plan using Automatic Test Equipment. The specific method is to use a simulator to check the software function and identify failure cases. This is an effective way for developers to reduce the Total Corrective Maintenance Time(TCM) of the weapon system by reducing the time it takes to identify failure cases. It has been proven that the proposed Automatic Test Equipment can achieve software maintenance and excellent Maintainability and Operational Availability compared to the existing ones.

• Conservation Science in Museum
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• v.26
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• pp.1-12
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• 2021

The bisphenol A epoxy resin currently used for the conservation of stone cultural heritage items is known to suffer from yellowing discoloration. In order to mitigate this yellowing and explore the availability of more diverse materials for the conservation of stone cultural heritage items, a hydrogenated Bisphenol A-based epoxy resin was prepared and compared with the epoxy resin currently used in the conservation treatment of stone cultural heritage items. The newly prepared epoxy resin showed improved physical properties relative to the existing materials, especially in terms of tensile strength, adhesion, and machinability, while the yellowing discoloration was reduced by a factor of roughly five to eight. The results suggest that epoxy resin could be used as a stable material for the conservation treatment of stone cultural heritage items, most of which are located outdoors.

• Journal of Aerospace System Engineering
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• v.15 no.3
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• pp.30-44
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• 2021

Experimental investigation of counter-rotating propellers is subject to multiple time and cost constraint because of additional design parameters unlike single propeller. Also, a lot of computing time and resources are required for numerical analysis due to consideration of the interference between the upper and lower propellers. In the present study, numerical simulations were conducted to investigate the hover performance of counter-rotating propellers by using actuator method which is considered to be time-efficient. The accuracy of the present numerical methods was validated by comparing the ANSYS Fluent which is commercial CFD code. The axial spacing and rotational speed were selected as the analysis variables, and the aerodynamic performance was obtained under various conditions. Based on the obtained results, the Figure of Merit (FM) of single propeller and counter-rotating propellers and a prediction factor which enables prediction of counter-rotating propeller performance using a single propeller were derived to evaluate availability of the actuator method.

• Architectural research
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• v.24 no.3
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• pp.85-91
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• 2022

The public rental housing policy aims to provide the housing to the vulnerable class who do not have enough credit to own houses. The Korean government introduced new policies for housing supply to improve the availability of new houses. However, it is difficult to expand the supply because of the accumulated deficit of public rental housing. In this study, the economic feasibility of long-term public rental housing reconstruction projects was examined to ensure the economic and sustainable growth of public rental housing. The research found that the compensation for the accumulated deficit is needed. Also the research analyzed and identified the factors affecting the economic feasibility of reconstruction projects. The significant factors identified in this research are: the supply price of pre-sale/rental housing in the reconstruction project, total cost of the reconstruction project, and total floor area of the reconstruction project. According to the analysis results, it is necessary to increase the rent of existing long-term public rental housing, expand the government subsidy, increase the supply price of pre-sale/rental housing, and reduce the total project cost. However, there are limitations. For example, the fluctuations of construction market, residents' burden of housing costs, and the limit of the budget of the public housing authority. The increasing total Floor Area Ratio(FAR) limitation of the reconstruction project would be the realistic solution to the problem because it gives incentives to the reconstruction project.

• Korean Journal of Social Welfare Studies
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• v.41 no.4
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• pp.345-368
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• 2010

The purpose of this study is to develop the School Multicultural Climate(SMC) scale for students and to evaluate its reliability and validity. This study comprises of both qualitative and quantitative research. Preliminary items were developed based on the theoretical literature and interviews with students. The scale was evaluated with students in grades 4 through 6 in the seven elementary schools. Exploratory factor analysis was determined that the scale was composed of four components: Equal Status, Mutual Cooperation, Friendly Relations, Supportive Norms. The scale demonstrated that Cronbach's alpha=.943 for the internal consistency of total items. And the standard error of the measurement, another way of evaluating reliability, was 3.33. Criteria-related validity was evaluated by showing that the differences of the students' recognition of the school multicultural climate level, which depend on the availability of the multiculture-related policy, was statistically significant. The correlation analysis for the convergent validity was performed with the theoretically related variables such as self esteem and school adjustment. It was found that the SMC scale was a reliable and valid measure for evaluating the multicultural climate level of elementary school.

• BMB Reports
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• v.56 no.11
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• pp.600-605
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• 2023

Intrahepatic cholangiocarcinoma (ICC) is a bile duct cancer and a rare malignant tumor with a poor prognosis owing to the lack of an early diagnosis and resistance to conventional chemotherapy. A combination of gemcitabine and cisplatin is the typically attempted first-line treatment approach. However, the underlying mechanism of resistance to chemotherapy is poorly understood. We addressed this by studying dynamics in the human ICC SCK cell line. Here, we report that the regulation of glucose and glutamine metabolism was a key factor in overcoming cisplatin resistance in SCK cells. RNA sequencing analysis revealed a high enrichment cell cycle-related gene set score in cisplatin-resistant SCK (SCK-R) cells compared to parental SCK (SCK WT) cells. Cell cycle progression correlates with increased nutrient requirement and cancer proliferation or metastasis. Commonly, cancer cells are dependent upon glucose and glutamine availability for survival and proliferation. Indeed, we observed the increased expression of GLUT (glucose transporter), ASCT2 (glutamine transporter), and cancer progression markers in SCK-R cells. Thus, we inhibited enhanced metabolic reprogramming in SCK-R cells through nutrient starvation. SCK-R cells were sensitized to cisplatin, especially under glucose starvation. Glutaminase-1 (GLS1), which is a mitochondrial enzyme involved in tumorigenesis and progression in cancer cells, was upregulated in SCK-R cells. Targeting GLS1 with the GLS1 inhibitor CB-839 (telaglenastat) effectively reduced the expression of cancer progression markers. Taken together, our study results suggest that a combination of GLUT inhibition, which mimics glucose starvation, and GLS1 inhibition could be a therapeutic strategy to increase the chemosensitivity of ICC.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.56 no.6
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• pp.861-869
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• 2023

This study aimed to evaluate the effectivity of full-fat black soldier fly Hermetia illucens (BSF) and defatted mealworm Tenebrio molitor (MW) larvae meal as a fish meal (FM) substitute in a low-fish meal (LFM) diet for juvenile olive flounder Paralichthys olivaceus. The LFM diet comprising 45% FM with tankage meal, poultry byproduct meal, soy protein concentrate and wheat gluten was the control diet. Three experimental diets were 10% FM in Con with BSF, MW and a mixture of both at the same ratio (designated as B10, M10 and B5M5, respectively). Four hundred and forty-fourth juvenile P. olivaceus (34.3±0.1 g) were randomly distributed into 12 tanks (425 L) in three replicate groups per treatment and fed the experimental diets for 15 weeks. At the end of the feeding trial, growth performance, survival, biological indices (condition factor, viscerosomatic index, hepatosomatic index), non-specific immune responses (lysozyme, myeloperoxidase) and intestinal histology (villi length and goblet cells) were not significantly affected by treatments. Feed utilization was significantly decreased in M10 compared to the control group. Alanine aminotransferase level was significantly higher in M10 than in the control group. Glucose level was significantly lower in B10 than in the control group. These results suggest that BSF and MW can be used as FM substitutes. However, considering feed conversion ratio and AST level, MW availability is thought to be lower than that of BSF, and feeding fish with a diet containing MW for an extended period is thought to adversely affect fish growth.

• IMMUNE NETWORK
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• v.24 no.1
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• pp.9.1-9.21
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• 2024

The cytokine IL-7 plays critical and nonredundant roles in T cell immunity so that the abundance and availability of IL-7 act as key regulatory mechanisms in T cell immunity. Importantly, IL-7 is not produced by T cells themselves but primarily by non-lymphoid lineage stromal cells and epithelial cells that are limited in their numbers. Thus, T cells depend on cell extrinsic IL-7, and the amount of in vivo IL-7 is considered a major factor in maximizing and maintaining the number of T cells in peripheral tissues. Moreover, IL-7 provides metabolic cues and promotes the survival of both naïve and memory T cells. Thus, IL-7 is also essential for the functional fitness of T cells. In this regard, there has been an extensive effort trying to increase the protein abundance of IL-7 in vivo, with the aim to augment T cell immunity and harness T cell functions in anti-tumor responses. Such approaches started under experimental animal models, but they recently culminated into clinical studies, with striking effects in re-establishing T cell immunity in immunocompromised patients, as well as boosting anti-tumor effects. Depending on the design, glycosylation, and the structure of recombinantly engineered IL-7 proteins and their mimetics, recombinant IL-7 molecules have shown dramatic differences in their stability, efficacy, cellular effects, and overall immune functions. The current review is aimed to summarize the past and present efforts in the field that led to clinical trials, and to highlight the therapeutical significance of IL-7 biology as a master regulator of T cell immunity.