• 동의생리병리학회지
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• 제20권2호
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• pp.482-487
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• 2006

The identification of the exterior-interior pattern and the cold-heat pattern is one of the most frequently used diagnostic methods in Oriental medicine. No systematic studies, however, have yet been conducted to determine the emotional and autonomic factors involved in the exterior-interior and cold-heat. In this study, the relationships between depression, anxiety, and the exterior-interior and cold-heat patterns in 100 healthy female volunteers with a mean age of 42.77 were also investigated. The autonomic nervous system's control of human temperature is a well known fact. Thus, this paper also aimed to investigate the correlationof the autonomic nervous system and patterns of the exterior-interior and cold-heat. The analysis of heart rate variability (HRV), which has become a popular non-invasive tool for assessing the activities of the autonomic nervous system, was conducted in this study. No relationship was found between the exterior-interior and cold-heat pattern scores and the degree-of-depression scores. But there was a significant difference between the exterior-interior and cold-heat pattern scores of the different anxiety types, and between those of the different anxiety levels. The depression and anxiety levels also had an effect on the HRV indices.

• Journal of Dental Anesthesia and Pain Medicine
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• 제24권4호
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• pp.273-283
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• 2024

Background: This study evaluated the effect of remimazolam and propofol on changes in autonomic nerve activity caused by surgical stimulation during orthognathic surgery, using power spectrum analysis of blood pressure variability (BPV) and heart rate variability (HRV), and their respective associations with cardiovascular fluctuations. Methods: A total of 34 patients undergoing Le Fort I osteotomy were randomized to the remimazolam (Group R, 17 cases) or propofol (Group P, 17 cases) groups. Observables included the low-frequency component of BPV (BPV LF; index of vasomotor sympathetic nerve activity), high-frequency component of HRV (HRV HF; index of parasympathetic nerve activity), balance index of the low- and high-frequency components of HRV (HRV LF/HF; index of sympathetic nerve activity), heart rate (HR), and systolic blood pressure (SBP). Four observations were made: (1) baseline, (2) immediately before down-fracture, (3) down-fracture, and (4) 5 min after down-fracture. Data from each observation period were compared using a two-way analysis of variance with a mixed model. A Bonferroni multiple comparison test was performed in the absence of any interaction. One-way analysis of variance followed by Tukey's multiple comparisons test was performed when a significant interaction was observed between time and group, with P < 0.05 indicating statistical significance. Results: Evaluation of autonomic nerve activity in comparison with baseline during down-fracture showed a significant increase in BPV LF (P < 0.001), an increasing trend in HRV LF/HF in Group P, and an increasing trend in HRV HF in Group R. There were no significant differences in HR or SBP between the two groups. Conclusion: During down-fracture of Le Fort I osteotomy, sympathetic nerve activity was predominant with propofol anesthesia, and parasympathetic nerve activity was predominant with remimazolam anesthesia.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2006년도 춘계공동학술대회 논문집
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• pp.153-158
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• 2006

The emergence of ubiquitous autonomic computing and network environment will change the service architecture information system which will be a new application area in SCM/logistics systems. In this study we surveyed the technical trend map of ubiquitous and its application in SCM/logistics support system design. We described the evolutional model of ubiquitous computing community for SCM/logistics system. It is consisted of three view points; self-growing, autonomic, and context-aware, which will allow the decision makers to be benefited from web and mobile technology and are useful for proactive SCM/logistics support system. Finally, we suggested a cooperative research planning for the development ubiquitous system between the government research center, university, and industry research activities.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권9호
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• pp.4280-4300
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• 2017

The fact that cloud computing services have been proposed in recent years, organizations and individuals face with various challenges and problems such as how to migrate applications and software platforms into cloud or how to ensure security of migrated applications. This study reviews the current challenges and open issues in cloud computing, with the focus on autonomic resource management especially in federated clouds. In addition, this study provides recommendations and research roadmaps for scientific activities, as well as potential improvements in federated cloud computing. This survey study covers results achieved through 190 literatures including books, journal and conference papers, industrial reports, forums, and project reports. A solution is proposed for autonomic resource management in the federated clouds, using machine learning and statistical analysis in order to provide better and efficient resource management.

• 융합정보논문지
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• 제9권3호
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• pp.56-67
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• 2019

본 연구는 농도별 로즈마리 오일 흡입에 따른 기억력, 집중력, 및 자율신경계 반응을 확인하기 위한 비동등성 대조군 전후 실험설계로 65세 이상 노인에게 아몬드 캐리어 오일 흡입군(대조군), 10% 로즈마리 오일 흡입군(실험군 A)과 100% 로즈마리 오일 흡입군(실험군 B)으로 각 오일을 시향지에 묻혀 5분간 흡입하도록 하였고 기억력, 집중력 및 자율신경계 반응을 측정하였다. 수집된 총 89명의 자료는 SPSS win 24.0를 이용하여 반복측정 ANOVA로 분석하였다. 결과는 기억력 평가인 즉각 회상(F=.42, p=.656), 지연 회상(F=.45, p=.639) 재인 검사(F=1.45, p=.242)와 집중력 평가인 숫자 바로 외우기(F=1.53, p=.223)와 숫자 거꾸로 외우기(F=.46, p=.636)에서 세 군 간의 유의한 차이가 없었다. 또한 자율신경계 반응 결과, 교감신경 활성도(LF)(F=.19, p=.828), 부교감신경 활성도(HF)(F=.37, p=.694), 자율신경계 활성도비(LH/HF)(F=1.39, p=.256), 수축기 혈압(F =.37, p=.694) 및 이완기 혈압(F=1.25, p=.291)에서 세 군 간의 유의한 차이가 없었다. 따라서 아몬드 캐리어 오일, 10%와 100% 로즈마리 에센셜 오일 5분간 흡입은 65세 이상 노인의 기억력, 집중력, 자율신경계 반응에 통계적으로 유의한 영향을 주지 않는 것으로 나타났다.

• 인간식물환경학회지
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• 제22권3호
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• pp.255-268
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• 2019

Horticultural therapy, as a kind of complementary alternative therapies using nature as a medium, is an intervention method that can be applied to various subjects by utilizing horticultural activities that anyone can enjoy as a leisure activity. This research defined the resilience of individuals as a personal characteristic, and examined differences in the intervention effect of horticultural activities depending on the level of resilience. The results obtained in this study can be utilized in planning a horticultural activity program and setting the purpose and goals of horticultural activity programs. The subjects of this study were divided into the high resilience experimental group (Group A), the low resilience experimental Group (Group C), the high resilience control group (Group B), and the low resilience control group (Group D). The experiment was conducted in the campus of G University from September to November 2017, and the experimental group participated in the program once per week, a total of 10 sessions. The Korean version of the Connor-Davidson Resilience Scale, autonomic nervous assessment, and the interpersonal relationship change scale were carried out as pre- and post-assessment. Statistical analysis was performed using a non-parametric test. Group A showed statistically significant positive changes in relaxation of physical tension and stability. In conclusion, those with high resilience showed the higher intervention effects of horticultural activities on physical relaxation and stability than those with low resilience. However, there were some possible limitations in this study. Since the number of subjects was small and subjects were limited to college students, it is impossible to generalize the results of this study. Therefore, it is necessary to conduct follow-up studies to address and overcome these limitations.

• 대한의생명과학회지
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• 제13권2호
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• pp.119-125
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• 2007

It is widely known that protein tyrosine kinases (PTKs) are involved in controlling many biological processes such as cell growth, differentiation, proliferation, survival and apoptosis. An $\alpha3\beta4$ subunit combination acts as a major functional acetylcholine receptor (nAChRs) in male rat major pelvic ganglion (MPG) neurons, and their activation induces fast inward currents and intracellular calcium increases. Recently it has been reported that the activity of acetylcholine receptors (AChRs) in some neurons can be negatively regulated by PTKs. However, the exact mechanism of regulation of nAChRs by PTKs is poorly understood. Therefore, we examined the potential role particular in nAChR by PTK using electrophysiology and calcium imaging in male rat MPG neurons. ACh induced inward currents and $(Ca^{2+})_i$ increases in MPG neurons, concomitantly. These responses were inhibited by more than 90% in $Na^+$- or $Ca^{2+}$- free solution. $\alpha$-conotoxin AuIB, a selective $\alpha3\beta4$ nAChR blocket, inhibited ACh-induced inward currents. Genistein (10 $\mu$M), a broad-spectrum tyrosine kinase inhibitor, markedly decreased ACh-induced currents and $Ca^{2+}$ transients, whereas 10 $\mu$M genistin, an inactive analogue, had little effect. Overall these data suggest that the activities of $\alpha3\beta4$ AChRs in MPG neurons are positively regulated by PTK. In conclusion, trosine kinase may be one of the key factors in the regulation of $\alpha3\beta4$ nAChRs in rat MPG neurons, which may play an important roles in the autonomic neuronal function such as synaptic transmission, autonomic reflex, and neuronal plasticity.

• The Korean Journal of Pain
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• 제35권3호
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• pp.327-335
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• 2022

Background: The pathophysiology of fibromyalgia (FM) involves many mechanisms including central nervous system sensitization theory, autonomic nervous system (ANS) dysfunction, and recently small fiber neuropathy. While the small fiber neuropathy itself can cause ANS dysfunction and neuropathic pain (NP), it is still unknown whether ANS problems have an association with severity of disease and NP in patients with FM. The aim of this study was to evaluate ANS dysfunction in FM patients and to explore possible associations of ANS dysfunction with disease severity and NP. Methods: Twenty-nine FM patients and 20 healthy controls were included in this cross-sectional study. Participants were tested using sympathetic skin responses (SSR) and R-R interval variation analyses for sympathetic and parasympathetic ANS dysfunction, respectively. Disease severity and somatic symptoms of patients with FM were evaluated using the ACR-2010 scales and Fibromyalgia Impact Questionnaire, and NP symptoms were evaluated using the Pain Detect Questionnaire and Douleur Neuropathique questionnaire. Results: FM patients were found to have ANS dysfunction characterized by increased sympathetic response and decreased parasympathetic response. SSR amplitudes were found to be correlated with a more severe disease. Although nonsignificant, NP severity tended to be associated with a decrease in sympathetic and parasympathetic activities. Conclusions: ANS dysfunction may play a role in the pathophysiology of FM. The trend of decreased ANS functions in FM patients exhibiting NP contradicts the notion that FM is a sympathetically maintained NP and may be explained with small fiber involvement.

• 대한의생명과학회지
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• 제12권2호
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• pp.113-118
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• 2006

Major pelvic ganglia (MPG) in rats are an unique autonomic ganglia, containing both sympathetic and parasympathetic neurons related with the function of bladder, penis and bowel. It has been widely known that ionotropic $GABA_A$ receptors are the molecular target of $\gamma$-aminobutric acid (GABA), a major inhibitory neurotransmitter in central nervous system. However, their functions and regulations of $GABA_A$ receptors expressed in autonomic ganglia have been poorly understood. 1 examined the modulatory role of adenylyl cyclase (AC) and protein kinase A(PKA) on $GABA_A$-induced inward currents in the neurons of rat MPG. $GABA_A$ receptors were identified using immunofluorescent labeling in the rat major pelvic ganglion. Electrophysiological experiments were performed to record the activities of $GABA_A$ receptors. $GABA_A$ receptors were expressed only in sympathetic neurons. GABA induced marked inward currents in a concentration-dependent manner. Mucimol ($5{\mu}M$), a $GABA_A$ receptor agonist induced inward currents were significantly reduced in the presence of SQ 225361 $20{\mu}M$, a AC inhibitor and myristoylated PKA inhibitor 100 nM. In addition, forskolin ($1{\mu}M$), AC activator, augmented the GABA induced currents. The activation of AC/PKA-dependent pathway could involve in the regulation $GABA_A$ receptors, expressed only in sympathetic neurons of rat MPG. These findings are helpful for the better understanding the function of various pelvic organs innervated by MPG.

• 대한약리학회지
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• 제5권2호
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• pp.135-140
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• 1969

In order to investigate the effect of autonomic nervous system on salivary gland, the authors have observed the effects of various drugs acting on the autonomic nervous system to the rat submaxillary gland by comparing the changes of gland weight, the amylase activity and various electrolyte contents with control group. The results are as follows; 1. The pilocarpine, physostigmine, norepinephrine, atropine and DMPP increased the rat submaxillary gland weight. 2. The amylase activities of rat submaxillary gland were increased by pilocarpine, physostigmine and norepinephrine, but decreased by atropine and DMPP. 3. Calcium contents of rat submaxillary gland were highly increased by pilocarpine and physostigmine, hut slightly increased by norepinephrine. 4. Magnesium contents of rat submarillary gland were increased by DMPP, but decreased by pilocarpine, physostigmine and norepinephrine. 5. Sodium contents of rat subnaxillary gland were increased by pilocarpine, physostigmine, norepinephrine and DMPP, but decreased by atropine. 6. Potassium contents of rat submaxillary gland were highly increased by atropine, and slightly increased by DMPP and norepinephrine, but decreased by pilocarpine and physostigmine.