• The Korea Journal of Herbology
• /
• v.24 no.2
• /
• pp.49-56
• /
• 2009

Objectives : Inflammation is important event in the development of vascular diseases including hypertension, atherosclerosis, and restenosis. Bodusan (BDS) was a traditional Korean herbal medicine and widely used in treatment of gastrointestinal complaint and stomach ulcer. The aim of this study was to determine whether BDS and its components inhibit production of nitrite, PGE2 and proinflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Methods : Cytotoxic activity of BDS and its components on RAW 264.7 cells was using 5-(3caroboxymcrophages. eth-oxyphenyj)-2H-tetra-zolium inner salt (MTS) assay. The nitric oxide (NO) production was measured by Griess reagent system. And proinflammatory cytokines were measured by ELISA kit. The levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression were detected by western blot. Results : Our results indicated that BDS and its components significantly inhibited the LPS-induced NO and PGE2 production. Moreover. BDS and its components inhibited iNOS and COX-2 expression accompanied by an attenuation of TNF-${\alpha}$, IL-11${\beta}$, IL-6 and MCP-1 formation in macrophages. Conclusions: These results indicate that BDS and its components have potential as an anti-inflammatory agent.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.26 no.5A
• /
• pp.917-925
• /
• 2006

Experimental tests were performed to estimate velocities of the acoustic signals through prestressed concrete beam and source locations using acoustic emission (AE) techniques. Seven AE sensors are mounted on the surface of 5m length test beam with equal spacing and using Schmidt Hammer AE events are made at 18 locations. The velocities of AE signals are estimated using the time differences of arrival times and the distances between the source locations and the AE sensor locations. In addition, using the Least Square Method, the AE source locations are re-evaluated reversely using both of the arrival times and the velocities of AE signals. Test results show the average velocity of the AE signals is about 4,000 m/sec and the velocity decreased with the increase of the distance from source locations to AE sensors due to the effect of attenuation. Based on the estimation of the source locations, it is observed that the errors of source locations are decreased when the velocities of each AE sensor are used rather than the average velocity.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.18 no.6
• /
• pp.1103-1108
• /
• 2023

In this paper, we propose a new algorithm for attenuating the background noises in acoustic signal. This algorithm improves the noise attenuation performance by using the FNN(: Full-connected Neural Network) deep learning algorithm instead of the existing adaptive filter after wavelet transform. After wavelet transforming the input signal for each short-time period, noise is removed from a single input audio signal containing noise by using a 1024-1024-512-neuron FNN deep learning model. This transforms the time-domain voice signal into the time-frequency domain so that the noise characteristics are well expressed, and effectively predicts voice in a noisy environment through supervised learning using the conversion parameter of the pure voice signal for the conversion parameter. In order to verify the performance of the noise reduction system proposed in this study, a simulation program using Tensorflow and Keras libraries was written and a simulation was performed. As a result of the experiment, the proposed deep learning algorithm improved Mean Square Error (MSE) by 30% compared to the case of using the existing adaptive filter and by 20% compared to the case of using the STFT(: Short-Time Fourier Transform) transform effect was obtained.

• IMMUNE NETWORK
• /
• v.24 no.4
• /
• pp.32.1-32.13
• /
• 2024

Low-dose radiotherapy (LDRT) has been explored as a treatment option for various inflammatory diseases; however, its application in the context of rheumatoid arthritis (RA) is lacking. This study aimed to elucidate the mechanism underlying LDRT-based treatment for RA and standardize it. LDRT reduced the total numbers of immune cells, but increased the apoptotic CD4⁺ T and B220⁺ B cells, in the draining lymph nodes of collagen induced arthritis and K/BxN models. In addition, it significantly reduced the severity of various pathological manifestations, including bone destruction, cartilage erosion, and swelling of hind limb ankle. Post-LDRT, the proportion of apoptotic CD4⁺ T and CD19⁺ B cells increased significantly in the PBMCs derived from human patients with RA. LDRT showed a similar effect in fibroblast-like synoviocytes as well. In conclusion, we report that LDRT induces apoptosis in immune cells and fibro-blast-like synoviocytes, contributing to attenuation of arthritis.

• The Journal of the Acoustical Society of Korea
• /
• v.35 no.3
• /
• pp.223-233
• /
• 2016

Design of a vegetation type sound barrier was presented as a noise barrier on the boundary of neighborhood facilities including schools, and apartments. The suggested noise barrier is made of unit blocks that are to be formed by stacking over the wall structure containing the plant and soils in the blocks. The advantage of the vegetation noise barrier is to acquire not only sound absorptive effects of plants and soils, but also sound diffusive effect caused by the irregular surface of the barrier which could eventually mitigate the noise. First, the optimum size of the units to obtain the highest noise reduction was investigated using 1/10 scaled model experiment, and sound attenuation experiments were carried out using a 1/2 mock-up model which is 2 m high and 5 m long. Total 1,137 unit blocks were made of synthetic woods with the size of $10{\times}10{\times}9cm$. These unit blocks were installed on the both side of the 1/2 mock-up steel framed noise barrier. As a result, it was revealed that the block typed vegetation noise barrier has 7 dB higher insertion loss in comparison with the general plane noise barrier. Also, it was found that the appropriate size of unit blocks is $20{\times}20cm$ which has large effect of sound insertion loss.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2012.05a
• /
• pp.564-567
• /
• 2012

Optical fibers are going to be used for telecommunication, image fibers, sensors under irradiation in nuclear power plants and various irradiation facilities. Especially, Temperature detection sensors using Raman light scattering, temperature or strain sensors using fiber gratings, magnet-optical sensors using photo-magnetic effect, are already commercialized. However, When fibers are exposed to ionizing radiation, color centers are formed in fibers which reduces their light transmission, and it is limited in applying under radiation environments. In this study, $Co^{60}$ gamma-ray induced optical attenuation on Ge-doped single mode(SM) fiber has been measured. Gamma-ray is irradiated for 4hours at the dose rate of 0.5kGy/hr, 2kGy/hr, 8kGy/hr. Consequently, gamma-ray induced loss based on radiation effects in Ge-doped SM fiber occur precisely. Furthermore, dose rate effect that the higher dose rate in the same total dose, the more increase loss of optical fiber and annealing effect that the higher the loss after irradiation, the more increase the recovery rate of the loss are observed in the fiber. This results plan to make use of bases in the study of the radiation-hardened optical fiber.

• Journal of Applied Biological Chemistry
• /
• v.54 no.2
• /
• pp.71-78
• /
• 2011

Biological activities of sarcocarp and calyx of persimmon (Cheongdo Bansi) were investigated. The electron donating ability of the calyx extract was 91% at a 500 ${\mu}g/mL$ level, which was higher than that of the sarcocarp extract (40%). The superoxide dismutase (SOD)-like activity of calyx extracts was about 22% at a 1,000 ${\mu}g/mL$ level. During the entire experimental period, there was no cytotoxicity found from sarcocarp and calyx up to 50 ${\mu}g/mL$. Our results indicated that sarcocarp and calyx significantly inhibited NO production and iNOS and COX-2 expression accompanied by an attenuation of interleukin (IL)-$1{\beta}$, IL-6, and tumer necrosis factor (TNF)-${\alpha}$ formation in human keratinocyte. These results suggest that sarcocarp and calyx of persimmon may have significant effect on inflammatory factors and can be used as potential anti-inflammatory agents.

• The Journal of Engineering Geology
• /
• v.30 no.4
• /
• pp.603-615
• /
• 2020

The design factors of artificial recharge are determined by considering the hydrogeological characteristics of the aquifer. The optimal design factors for artificial recharge were derived after performing the injection tests step by step for each injection type (vertical well, ditch and mixed type), which were built in the test site of the study area. It was analyzed that the difference in the injection effect according to the diameter of the injection well was not large, and the 100 mm well was evaluated as appropriate in consideration of the availability and economy of land use. Since the injection effect was well maintained even in the upper rock, the depth of the injection well was proposed for the alluvial layer and the upper rock layer. On the other hand, in four cases of filter media in the ditch, it was analyzed that the penetration efficiency and the hydraulic interference effect indicated excellent injection performance when a filter medium of 10 to 30 mm diameter was filled in the ditch. In addition, the proper spacing of the injection wells was analyzed as 9~12 m considering the interference efficiency. The interference efficiency attenuation coefficient per 1 m of hole spacing was calculated to be 1.75% in this area. In the future study, the artificial recharge design factors obtained in this stage are applied and verified on site construction and operation. Also it is expected to contribute to securing water in areas where there is always a lack of water.

• Journal of the Korean Society of Radiology
• /
• v.17 no.1
• /
• pp.131-139
• /
• 2023

In this study, we are purposed to find the educational effect of practical training using a 3D printed structure-based blind box on multidimensional radiographic image interpretation. The subjects were 83 (male: 49, female: 34) 2nd year radiological science students who participated in the digital medical imaging practice that was conducted for 3 years from 2020 to 2022. The learning method used 3D printing technology to print out the inside structure of the blind box designed by itself. After taking X-rays 3 times (x, y, z axis), the structure images in the blind box were analyzed for each small group. We made the 3D structure that was self-made with clay based on our 2D radiographic images. After taking X-rays of the 3D structure, it was compared whether it matches the structural image of the blind box. The educational effect for the practical training surveyed class faithfulness, radiographic image interpretation ability (attenuation concept, contrast concept, windowing concept, 3-dimensional reading ability), class satisfaction (interest, external recommendation, immersion) on a 5-point Likert scale as an anonymous student self-writing method. As a result, all evaluation items had high positive effects without significant differences between males and females. Practical education using blind boxes is a meaningful example of radiology education technology using 3D printing technology, and it is expected to be used as content to improve students' problem-solving skills and increase satisfaction with major subjects.

• The Korea Journal of Herbology
• /
• v.24 no.3
• /
• pp.39-50
• /
• 2009

Objectives : Smilacis glabrae rhizoma (SG) has been traditionally used as a herbal medication of musculoskeletal disorders like arthritis, pain, convulsions, and syphilis in traditional Korean medicine. This study was investigated anti-oxidative and anti-inflammatory effect of fractionated extracts of Smilacis Glabrae Rhizoma in Human Umbilical Vein Endothelial Cell (HUVEC). Methods : SG extract prepared with methanol, and then fractionated with hexane, dichloromethane, ethylacetate, n-butanol and water. Inhibitory effect of SG onto free radical generation was determined by measuring DPPH, superoxide anions and nitric oxide scavenging activities in vitro. Cytotoxic activity of extracts on RAW 264.7 cells was measured using 5-(3-caroboxymethoxyphenyl)-2H-tetra-zolium inner salt (MTS) assay. Intracelluar oxidation was analysed by DCF-DA assay. The nitric oxide (NO) production was measured by Griess reagent system. The levels of ICAM-1 and VCAM-1 expression were confirmed by western blot. And proinflammatory cytokines were measured by ELISA kit. Results : Our results indicated that fractionated extracts, especially ethyl acetate (EA) extract, significantly inhibited free radical generation, the TNF-$\alpha$-induced intracellular oxidation. Furthermore, the EA extract protected TNF-$\alpha$-induced adhesion to THP-1, expression of adhesion molecules accompanied by an attenuation of IL-6 and IL-8 formation in HUVEC. Conclusions : These results indicate that EA extract of SG have potential as an agent of atherosclerosis and other chronic inflammatory diseases including diabetes, hypertension, and arthritis.