• Korean Journal of Pharmacognosy
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• v.53 no.4
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• pp.181-191
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• 2022

As the incidence of skin cancer increases every year, non-surgical treatment methods for cancer are being sought. Esculetin, a natural dihydroxy coumarin, is attracting attention as a therapeutic agent for certain diseases, such as cancer, based on its broad pharmacological activity. In this study, the anticancer ability of esculetin was evaluated using the epidermoid carcinoma cell line A431. As a result of evaluating the apoptosis ability of esculetin by MTT assay, apoptosis was observed in a time-concentration-dependent manner regardless of the presence or absence of FBS. As a result of quantitative real-time PCR, esculetin reduced cyclin D1 mRNA in a time-concentration-dependent manner. In addition, as a result of western blotting, esculetin significantly inhibited phosphorylation of ERK, JNK, and p38 in a concentration-dependent manner. The results of this study suggest that esculetin has the potential to be used as an effective natural medicine for the treatment of skin cancer.

• Science of Emotion and Sensibility
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• v.16 no.3
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• pp.409-416
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• 2013

Attention is one of important cognitive functions in human affecting on the selectional concentration of relevant events and ignorance of irrelevant events. The discrimination of attentional and inattentional status is the first step to manage human's attentional capability using computer assisted device. In this paper, we newly combine the non-linear recurrence pattern analysis and spectrum analysis to effectively extract features(total number of 13) from the electroencephalographic signal used in the input to classifiers. The performance of diverse types of attention-inattention classifiers, including supporting vector machine, back-propagation algorithm, linear discrimination, gradient decent, and logistic regression classifiers were evaluated. Among them, the support vector machine classifier shows the best performance with the classification accuracy of 81 %. The use of spectral band feature set alone(accuracy of 76 %) shows better performance than that of non-linear recurrence pattern feature set alone(accuracy of 67 %). The support vector machine classifier with hybrid combination of non-linear and spectral analysis can be used in later designing attention-related devices.

• Journal of The Korean Society of Integrative Medicine
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• v.1 no.3
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• pp.79-95
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• 2013

Purpose : This study aims to investigate the effect of the Snoezelen and Rehacom programs on improvement of attention and memory, and the effect of the Snoezelen program on stress reduction. Method : This study was targeted at 11 subjects in the Snoezelen experimental group, 11 subjects in the Rehacom group and 11 subjects in the non-experimental group. As the initial evaluation, all the subjects took electroencephalography. Then, the Snoezelen group and Rehacom group did Snoezelen training and Rehacom training, respectively total 12 times(for 20 minutes twice per week for six weeks), but no training was applied to the control group. Three weeks after the training, the interim was carried out, and four weeks after the training, the final evaluation was carried out. Results : Subjects' attention increased to $58.15{\pm}4.96$ from $43.75{\pm}4.69$ during the Snoezelen training, and increased to $49.85{\pm}1.91$ from $43.28{\pm}2.71$ during the Rehacom training, which means the Snoezelen training was more effective in improving attention(P<0.05). Subjects' memory increased to $56.14{\pm}1.26$ from $43.19{\pm}3.46$ during the Snoezelen training, and increased to $50.94{\pm}4.0$ from $43.07{\pm}2.58$ during the Rehacom training. This also implies that the Snoezelen training was more effective in improving memory(P<0.05). Conclusion : Though both of the Snoezelen training and Rehacom training improved attention and memory, the Snoezelen program was more effective, and it also influenced stress resistance and physical arousal.

• Therapeutic Science for Rehabilitation
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• v.6 no.1
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• pp.45-54
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• 2017

Objective : The purpose of this study was to investigate the effects of an Interactive Metronome on increasing attention and impulsivity control for children with attention deficit hyperactivity disorder(ADHD). Methods : This study was conducted through the ABA'design among single-case research methods with one child with ADHD. From May to July, 2014, 3 sessions of baseline phase(A), 15 sessions of intervention phase(B), and 3 sessions of post baseline(A') were conducted. The intervention was IM training, and each session carried out short form assessment(SFA) of IM and concentration tasks. In addition, long form assessment(LFA) of IM and Self-Control Rating Scale (SCRS) were conducted at baseline, intervention and post baseline. Results : After IM training as the intervention, the participation showed an increase in attention and controled in impulsivity. After the intervention, it was demonstrated that the effects were maintained or improved in the post baseline. Conclusions : IM training can be useful for increasing attention and impulsivity control of children with ADHD. The results demonstrated the efficacy of IM training as a new approach for children with ADHD.

• Corrosion Science and Technology
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• v.23 no.1
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• pp.41-53
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• 2024

Titanium alloy is gaining attention in the medical industry due to its excellent biocompatibility and osteoconductivity. However, the natural oxide film on the titanium surface is insoluble, resulting in inadequate bone adhesion. Therefore, it is necessary to optimize the contact between biological tissues and implant surfaces, and alter the chemical composition and morphological characteristics of the implant surface. In this study, the anodization method was applied to titanium surface treatment to form a uniform and robust oxide film. Subsequently, a chemical process, pore-widening, was employed to change the morphological characteristics of the oxide film. The concentration of the pore-widening solution was varied at 2, 4, 6, and 8 wt% and the process time was set at 30 and 60 minutes. As the concentration of the pore-widening solution increased the pore diameter of the oxide film increased. Notably, at 6 wt% for 60 minutes, the oxide film exhibited a coexistence of pillars and pores. Based on this, it was determined that surface roughness increased with higher concentration and longer process time. Additionally, the presence of pillars and pores structures maximized hydrophilicity. This study provides insights into enhancing the surface properties of titanium for improved performance in medical implants.

• Health Policy and Management
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• v.20 no.4
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• pp.1-18
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• 2010

Much policy attention has been directed to the concentration of patients in large hospitals, especially in tertiary care hospitals. In order to address the problem, the government has enforced referral requirement for accessing care in tertiary care hospitals by denying insurance benefits to the patients who do not observe the requirement. This approach somehow has failed to produce expected effects although it still exists in theory. The concentration of patients in a certain type of providers results in the distortion of functional differentiation among various types of providers and vice versa. Thus the approaches for the alleviation of the problem should be directed to both patients and providers. However, policy approaches has so far focused on ways of directly affecting patients' choice of a provider neglecting the effects of providers. Based upon the observation, this paper has reviewed selected issues that should be considered in agenda setting for policies concerned with the concentration of patients in large hospitals or the distortion of functional differentiation among health care providers. A brief discussion of each of the issues suggests three general guidelines for the formulation and implementation of policies intended to address the problem. First, attention should be directed to both patients and providers. Secondly, it is necessary to employ diverse measures including regulation, incentives and administrative supports. Thirdly, some of the approaches should be planned from a long range perspective, for it often takes a long time to change some aspects of health care utilization and provision.

• The Journal of the Korea Contents Association
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• v.19 no.6
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• pp.105-113
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• 2019

This study is to analyze the concentration of visual perception of the subject through the eye-tracking experiments targeting popular characters and to investigate it is effective to highlight which part of the character in inducing consumers' interest and curiosity. As a result of the study, the subjects paid more attention to the face than the character's body, and also noted a little attention to auxiliary elements such as pants, tees, shoes, and whiskers. These results mean there is clearly different factor in which the subject's gaze on the character frequently stays and does for a long time. Therefore, the designers should recognize the differences of the concentration of visual perception by character components as a differentiating factor to feel the emotional satisfaction such as the user's interest, empathy, and immersion in the character and actively reflect it when developing the character design. In addition, there was a difference in the visual perception concentration of each of the auxiliary elements, and if careful research is done on whether the influence factors are also due to individual characteristics or another influential factors, it will be a wider study on character design.

• Journal of the Korean housing association
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• v.13 no.5
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• pp.71-76
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• 2002

Recently, much attention has been paid to the problem such as sick building syndrome, which caused by the air pollutant indoor. In addition, Volatile Organic Compounds(VOCs) has been paid attention to as one of the main reason that causes air pollutant indoor, and the exposure of VOCs indoor is recognizes as an important factor which have an effect on the health of resident. In this study, measuring of VOCs in newly houses, and the results are as follows; 1)TVOC(Total Volatile Organic Compounds) indoor is detected high concentration(11314$\mu\textrm{g}$/㎤). 2)There are detected acetaldehyde, methylenechloride, benzene, trichloroethylene and styrene that have to take precaution against human carcinogenicity

• Korea Science and Art Forum
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• v.23
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• pp.347-358
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• 2016

The design of children's hospitals is highly dependent on color schemes. As a space shared together by both adults and children, the design of children's hospitals require color coordination that takes account of the users' characteristics. However, because the majority of prior research on color perception has focused overly on the emotional aspects, there is a necessity for more rational and scientific analyses to identify the characteristics of the visual perception of colors. Adopting this perspective in analyzing the characteristics of the visual perception of colors, this study aims to move beyond the abstract to focus on more objective methods, such as eye-tracking experiments, to examine the characteristics of hospital visitors' visual attention with respect to colors. Visual perception tracking experiment was conducted on the 2 chosen experimental images with a target group made up of adults and children, the following results were found. Firstly, spaces created with the preference colors of the different groups were found to develop a characteristic of developing higher attention. Secondly, observing the common tendencies for attention for adults and children, the highest region for visual concentration was formed towards the middle, as attention progresses to lower stages visually focused area changes in the order of upper-middle, left and right, and lower regions and edge regions show characteristics of not triggering attention Thirdly, it is understood that children's level of attention drops a lot faster than adults when identifying space therefore it is suspected that children need more elaborate color coordination than adults.

• Journal of Korea Multimedia Society
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• v.20 no.8
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• pp.1208-1215
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• 2017

Recently, people's attention and worries about fine particulate matter have been increasing. Due to the construction and maintenance costs, there are insufficient air quality monitoring stations. As a result, people have limited information about the concentration of fine particulate matter, depending on the location. Studies have been undertaken to estimate the fine particle concentrations in areas without a measurement station. Yet there are limitations in that the estimate cannot take account of other factors that affect the concentration of fine particle. In order to solve these problems, we propose a framework for estimating the concentration of fine particulate matter of a specific area using meteorological data and traffic data. Since there are more grids without a monitor station than grids with a monitor station, we used a domain adversarial neural network based on the domain adaptation method. The features extracted from meteorological data and traffic data are learned in the network, and the air quality index of the corresponding area is then predicted by the generated model. Experimental results demonstrate that the proposed method performs better as the number of source data increases than the method using conditional random fields.