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A Study for Dose-Reduction of Antipsychotics in Chronic Schizophrenics (만성 정신분열병 환자에서 항정신병약물 감량에 관한 연구)

  • Hwang, Tae-Yeon;Lee, Min Soo;Kim, Hyeong-Seob
    • Korean Journal of Biological Psychiatry
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    • v.5 no.2
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    • pp.263-277
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    • 1998
  • Conventional high-dose antipsychotics tend to result in more side effects, negative symptoms and dysphoria, and at the same time lower the cognitive function which is already impaired in most schizophrenics. Florid psychotic symptoms, negative symptoms and cognitive impairment greatly impede psychosocial performance and eventual reintegration into society. The reduction of symptom and the improvement of cognitive funtions and social skills are therefore central to the psychiatric rehabilitation process. The purpose of this study was to evaluate the dose-reduction effects of antipsychotics on chronic schizophrenics prescribed conventional high-dose antipsychotics more than 1,500mg equivalent of chlorpromazine. Fifty-one chronic schizophrenics who maintained high-dose antipsychotics for more than three months were randomly assigned to two groups : 20 patients comprised the dose-maintaining group and 31 patients made the dose-reduction group. Over a sixteen weekperiod Positive and Negative Syndrome Scale(PANSS), Extrapyramidal Symptom(EPS), Nurses' Observation Scale for Inpatient Evaluation(NOSIE-30), Continuous Performance Test(CPT), Quality of Life(QOL), and haloperidol/reduced haloperidol blood levels were determined at the base line and after 2, 4, 6, 8, 12, 16 weeks to evaluate the dose reduction effects of high-dose antipsychotics. The results were as follows : 1) Dose-reduction is highly effective in reducing positive and negative symptoms, and general psychopathology. Effects were most prominent at 8, 12, 16 weeks. Among the dose reduction group, positive symptoms in positive symptom group and negative symptoms in negative symptom group were more reduced. 2 Extrapyramidal symptoms showed no significant difference between two groups. But the EPS was reduced time after time within two groups. 3) Hit rates of Continuous Performance Test, which indicate attentional capacity, increased significantly after dose reduction. 4) Haloperidol and reduced haloperidol blood levels decreased until the 4th week, after which they were constant. 5) Total scores of Nurses' Observation Scale for Inpatient Evaluation were unchanged between the two groups. But among the indices, social interest and personal neatness were improved in the dose-reduction group and retardation was aggrevated in the dose-maintaining group. 6) Total quality of life scores were unchanged between two groups. But in the dose maintaining group, satisfaction scores of attention, autonomy, and interpersonal relationship decreased progressively. These findings suggest that the dose reduction of antipsychotics for chronic schizophrenics on programs of high-dose antipsychotics were effective. Dose reduction should therefore be implemanted to spread the rehabilitation and improve quality of life for chronic schizophrenics.

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A Study on the Regulatory Focus, Entrepreneurial Orientation, and Entrepreneurial Intentions of College Students in Korea (대학생의 조절초점성향이 기업가정신 및 창업의도에 미치는 영향에 관한 연구)

  • Bae, Byung Yun;Lee, Joo-Heon
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.10 no.6
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    • pp.215-223
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    • 2015
  • Recently, in OECD countries, youth unemployment has become one of the most serious problems in society. Entrepreneurship creates innovative new companies that create more jobs than big traditional companies. In addition, entrepreneurship develops creative human resources leading to fertile ground for new technology and business innovation. Recently, regulatory theory has drawn a lot of attention and interest in the literature of psychology and marketing management. However, the theory has not been applied to the study of entrepreneurship. In this article, we try to examine the relationship among regulatory focus, entrepreneurial orientation, and entrepreneurial intentions of korean college students who show their interests in entrepreneurship. From our empirical study, we find the followings. First, promotion focus thriving on optimism, taking risks, and trying new actively affect positively on entrepreneurial orientation and entrepreneurial intention. Second, prevention focus concentrating on security, fulfilling responsibilities and maintaining efficiency does not always affect negatively on entrepreneurial orientation and entrepreneurial intention. In other words, prevention-focused students do not always have bad impression on entrepreneurship and may consider entrepreneurship as viable career path similar to average college students. Third, our empirical findings are consistent with previous studies that entrepreneurial intention is positively affected by entrepreneurial orientation.

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Design Thinking Methodology for Social Innovation using Big Data and Qualitative Research (사회혁신분야에서 근거이론 기반 질적연구와 빅데이터 분석을 활용한 디자인 씽킹 방법론)

  • Park, Sang Hyeok;Oh, Seung Hee;Park, Soon Hwa
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.13 no.4
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    • pp.169-181
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    • 2018
  • Under the constantly intensifying global competition environment, many companies are exploring new business opportunities in the field of social innovation using creating shared value. In seeking social innovation, it is a key starting point of social innovation to clarify the problem to be solved and to grasp the cause of the problem. Among the many problem solving methodologies, design thinking is getting the most attention recently in various fields. Design Thinking is a creative problem solving method which is used as a business innovation tool to empathize with human needs and find out the potential desires that the public does not know, and is actively used as a tool for social innovation to solve social problems. However, one of the difficulties experienced by many of the design thinking project participants is that it is difficult to analyze the observed data efficiently. When analyzing data only offline, it takes a long time to analyze a large amount of data, and it has a limit in processing unstructured data. This makes it difficult to find fundamental problems from the data collected through observation while performing design thinking. The purpose of this study is to integrate qualitative data analysis and quantitative data analysis methods in order to make the data analysis collected at the observation stage of the design thinking project for social innovation more scientific to complement the limit of the design thinking process. The integrated methodology presented in this study is expected to contribute to innovation performance through design thinking by providing practical guidelines and implications for design thinking implementers as a valuable tool for social innovation.

A Comparative Study of Entrepreneurial Motivation, Entrepreneurship and Entrepreneurial Intention between the Students of Experiential Entrepreneurship Class and Theory Centered Class (체험형 창업강좌와 이론형 창업강좌 학습자간의 창업동기, 기업가정신 및 창업의지 비교 연구)

  • Kim, Yong Tae
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.13 no.4
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    • pp.49-58
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    • 2018
  • In recent years, various studies have been carried out on various types of entrepreneurship and comparative activities according to policy efforts and support such as the activation of a bachelor's degree in the establishment of a university, and attention has been paid to the fact that the participation and the educational effect of the students may be different depending on the type. The purpose of this study is to investigate entrepreneurial motivation, entrepreneurship, and entrepreneurial intention in the case of experiential entrepreneurship class focusing on the theoretical-oriented general entrepreneurship class, And the effect of entrepreneurship on entrepreneurial intention. The data were collected and empirical analysis was conducted to compare the difference between the two groups. The results of this study are as follows: First, out of the motivation factors of entrepreneurs, entrepreneurship education, achievement desire, human network, self - esteem, etc. We can confirm that the motivation of entrepreneurs is recognized more greatly. Second, the entrepreneurship factor was not significantly different from the perception between experiential entrepreneurship lecture and theoretical entrepreneurship learner. Third, experiential entrepreneurship learner perceived more willingness to start business than theoretical entrepreneurship learner. Finally, among the entrepreneurship motivation factors, among the entrepreneurship education, achievement desire and entrepreneurship factor, the risk sensitivity affects the entrepreneurial will. This study suggests that the direction of entrepreneurial education focused on quantitative expansion and the creation of qualitative effects of entrepreneurship education are needed. In the future, it will provide policy implications for revitalizing experiential entrepreneurship education In addition, it can contribute to the diffusion of research on the effect of entrepreneurship education.

The Influence of Dual-Income Married Men' Job Autonomy on Job Satisfaction: Focusing on Mediating Effect of Parenting Involvement (맞벌이 기혼남성의 직무자율성이 직무만족에 미치는 영향: 자녀양육참여의 매개효과)

  • Seo, Jong-Soo;Cho, Hee-Keum;Lee, Jae-Byub
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.13 no.5
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    • pp.119-129
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    • 2018
  • Today, many organizations, including venture companies, are focusing on attention on securing and attracting talented people, and on the job satisfaction of their members. However, many organizations, including venture companies, lack understanding of work-family interaction. This study was conducted to investigate the interactions between work and family. Specifically, this study aims to verify the mediating effects of paternal involvement in child care, specifically effects on influences of autonomy at work over satisfaction at work for Dual-income married man living in Gyungbuk province, whose spouse is also working. In order to achieve the aim, I conducted survey from August 29 to September 22 in 2014, targeting married man living in Gyungbuk province, and collected data were analysed using SPSS 20.0. Characteristics of each factors were analysed through frequency and descriptive statistic analysis, and correlation, causal relation, and mediating effects of factors were analysed through correlation analysis and hierarchial analysis. The summary of this study is as follows. First, satisfaction at work for married man showed positive relations with all the sub factors of autonomy at work and paternal involvement, which are housekeeping activities, cognitive fulfillment counselling, life style counselling, and leisure activity participation. Second, satisfaction at work for married man appears to be affected by autonomy at work, life style counselling, leisure activity participation, monthly income, and occupation. Also, in relationship between autonomy at work and satisfaction at work, life style counselling and leisure activity participation, that are sub factors of paternal involvement, appeared to be partially mediating. Therefore, in order to improve the job satisfaction of men, it is necessary not only to increase job autonomy, but also to improve the job satisfaction by preparing ways to parenting involvement.

A Conceptual Study on the Types of Entrepreneurial Opportunity and Laboratory Start-ups (창업 기회의 유형과 실험실 창업에 대한 개념적 연구)

  • Zho, Young Pil;Lee, Jong-Keon
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.15 no.3
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    • pp.47-57
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    • 2020
  • This study focuses on the proposition that the qualities and environmental conditions required for exploring entrepreneurial opportunities and realizing entrepreneurial opportunities depend on the types of entrepreneurial opportunities. In particular, this study aims to identify the type of entrepreneurial opportunities for laboratory start-ups, which have recently been gaining policy level attention. If the type of entrepreneurial opportunities for laboratory start-ups is identified as discriminative, appropriate start-up support policies and training programs can be established. For this study, eight major papers were identified among the papers of last 30 years related to the types of entrepreneurial opportunities. After, the classification attributes for each opportunity type were derived. Then, the existing theories of recognition, discovery and creative opportunities were organized, critically reviewed and reorganized. In addition, the substance of laboratory start-ups was verified according to the standardized classification attributes of the revised and reorganized opportunity types and newly classified as 'creative opportunity'. This study also presents networking capabilities and market orientation as examples of the capabilities needed for entrepreneurs of creative opportunity type. The implication of this study is that it makes it easy to discriminate ontological typology of entrepreneurial opportunity, derives important classification attributes, and that it organizes them conceptually. In addition, it critically reconstructs the problems of confusion in the existing typology, and based on this, the type of entrepreneurial opportunities for laboratory start-ups is determined as creative opportunity. These achievements can contribute to the improvement of start-up policies and start-up training programs according to the types of entrepreneurial opportunity and laboratory start-ups in the future, resulting in realization of actual results at the start-up sites.

Analysis of Trends in Dose through Evaluation of Spatial Dose Rate and Surface Contamination in Radiation-Controlled Area and Personal Exposed Dose of Radiation Worker at the Korea Institute of Radiological and Medical Sciences (KIRAMS)

  • Lee, Bu Hyung;Kim, Sung Ho;Kwon, Soo Il;Kim, Jae Seok;Kim, Gi-sub;Park, Min Seok;Park, Seungwoo;Jung, Haijo
    • Progress in Medical Physics
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    • v.27 no.3
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    • pp.146-155
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    • 2016
  • As the probability of exposure to radiation increases due to an increase in the use of radioisotopes and radiation generators, the importance of a radiation safety management field is being highlighted. We intend to help radiation workers with exposure management by identifying the degree of radiation exposure and contamination to determine an efficient method of radiation safety management. The personal exposure doses of the radiation workers at the Korea Institute of Radiological & Medical Sciences measured every quarter during a five-year period from Jan. 1, 2011 till Dec. 31, 2015 were analyzed using a TLD (thermoluminescence dosimeter). The spatial dose rates of radiation-controlled areas were measured using a portable radioscope, and the level of surface contamination was measured at weekly intervals using a piece of smear paper and a low background alpha/beta counter. Though the averages of the depth doses and the surface doses in 2012 increased from those in 2011 by about 14%, the averages were shown to have decreased every year after that. The exposure dose of 27 mSv in 2012 increased from that in 2011 in radiopharmaceutical laboratories and, in the case of the spatial dose rate, the rate of decrease in 2012 was shown to be similar to the annual trend of the whole institute. In the case of the surface contamination level, as the remaining radiation-controlled area with the exception of the I-131 treatment ward showed a low value less than $1.0kBq/m^2$, the annual trend of the I-131 treatment ward was shown to be similar to that of the entire institute. In conclusion, continuous attention should be paid to dose monitoring of the radiation-controlled areas where unsealed sources are handled and the workers therein.

Dynamic Modeling of Cooling System Thermal Management for Automotive PEMFC Application (자동차용 연료전지 냉각계통 열관리 동적 모사)

  • Han, Jae Young;Lee, Kang Hun;Yu, Sang Seok
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.36 no.12
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    • pp.1185-1192
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    • 2012
  • The typical operating temperature of an automotive fuel cell is lower than that of an internal combustion engine, which necessitates a refined strategy for thermal management. In particular, the performance of the cooling module has to be higher for a fuel cell system because the temperature difference between the fuel cell and the surrounding is lower than in the case of the internal combustion engine. Even though the cooling system of an automotive fuel cell determines the operating temperature and temperature distribution of the fuel cell, it has attracted little research attention. This study presents the mathematical model of a cooling system for an automotive fuel cell system using Matlab/$Simulink^{(R)}$. In particular, a radiator model is developed for design optimization from the development stage to the operating stage for an automotive fuel cell. The cooling system model comprises a fan, pump, and radiator. The pump and fan model have an empirical relation, and the dynamics of the pump and fan are only explained by motor dynamics. The basic design study was conducted, and the geometric setup of the radiator was investigated. When the control logic was applied, the pump senses the coolant inlet temperature and the fan senses the coolant out temperature. Additionally, the cooling module is integrated with the fuel cell system model so that the performance of the cooling module can be investigated under realistic operating conditions.

How to Increase the Supply of Rental Housing through Urban Regeneration Program in Korea

  • Huh, Pil-Won;Kim, Duk-Ki;Hong, Yo-Sep;Shim, Gyo-Eon
    • Land and Housing Review
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    • v.5 no.3
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    • pp.137-149
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    • 2014
  • The authors derived rental housing policy measures that are appropriate for the current conditions of Korean housing supply and demand based on the confirmation of the issues of Korean rental housing system and reviewing implications from review of cases of foreign countries and these measures can be categorized into linkage with the urban regeneration and multi-functional development, acquisition of financial resources, operational management, policy and institutional aspects. For the expansion of supply of rental housing, it is essential to link the rental housing policy with urban regeneration. To pursue regeneration of underdeveloped areas and expansion of supply of rental housing in line with urban regeneration, more development sites should be added. Further, the rental home policy must be integrated into a new paradigm that includes securing commercial viability and providing various residential conveniences through multi-functional development. In addition, diversification of developers of real estates turning away from the existing framework of policy that has been focused only on the state-led housing supply so that local governments and private sector players can take part in. Next, new options for funding the supply of rental housing must be sought. First, raising financial resources sequentially through cyclical development approach could be considered. Or, various funding schemes including utilizing Tax-increment financing (TIF) based on the local tax revenues that will be accrued after the development projects and supply of rental housing. Or there should be various schemes to raise funds including utilization of TIFs that are based on the revenues that will be realized after the development projects and supply of rental housing, or utilizing REITs where funds can be provided through private sector investments. Also, getting out from the planning practice that focused only on physical expansion of supply of rental housing, continual operational management must be performed even after the development. These activities must be supported through establishment of control tower at the national level and continuous attention must be paid even after the development by developing specialized operational management companies that are led by private sector players. Finally, in addition to the hardware support that is focused on the public rental housing only, software support such as conditional provision of housing voucher or tax exemption for low-income classes should be provided, too. In other words, a shift from policies that are supplier-centric to ones that are customer-centric must take place.

Microstructural Characteristics of III-Nitride Layers Grown on Si(110) Substrate by Molecular Beam Epitaxy

  • Kim, Young Heon;Ahn, Sang Jung;Noh, Young-Kyun;Oh, Jae-Eung
    • Proceedings of the Korean Vacuum Society Conference
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    • 2014.02a
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    • pp.327.1-327.1
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    • 2014
  • Nitrides-on-silicon structures are considered to be an excellent candidate for unique design architectures and creating devices for high-power applications. Therefore, a lot of effort has been concentrating on growing high-quality III-nitrides on Si substrates, mostly Si(111) and Si(001) substrates. However, there are several fundamental problems in the growth of nitride compound semiconductors on silicon. First, the large difference in lattice constants and thermal expansion coefficients will lead to misfit dislocation and stress in the epitaxial films. Second, the growth of polar compounds on a non-polar substrate can lead to antiphase domains or other defective structures. Even though the lattice mismatches are reached to 16.9 % to GaN and 19 % to AlN and a number of dislocations are originated, Si(111) has been selected as the substrate for the epitaxial growth of nitrides because it is always favored due to its three-fold symmetry at the surface, which gives a good rotational matching for the six-fold symmetry of the wurtzite structure of nitrides. Also, Si(001) has been used for the growth of nitrides due to a possible integration of nitride devices with silicon technology despite a four-fold symmetry and a surface reconstruction. Moreover, Si(110), one of surface orientations used in the silicon technology, begins to attract attention as a substrate for the epitaxial growth of nitrides due to an interesting interface structure. In this system, the close lattice match along the [-1100]AlN/[001]Si direction promotes the faster growth along a particular crystal orientation. However, there are insufficient until now on the studies for the growth of nitride compound semiconductors on Si(110) substrate from a microstructural point of view. In this work, the microstructural properties of nitride thin layers grown on Si(110) have been characterized using various TEM techniques. The main purpose of this study was to understand the atomic structure and the strain behavior of III-nitrides grown on Si(110) substrate by molecular beam epitaxy (MBE). Insight gained at the microscopic level regarding how thin layer grows at the interface is essential for the growth of high quality thin films for various applications.

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