• The Korean Journal of Malacology
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• v.32 no.2
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• pp.133-139
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• 2016

The incubation time required for hatching of O. ocellatus were investigated through the processes of egg and embryonic developments by the dissecting microscopic and visual observations. And differences in ecological characteristics of the plankton mode of life or the benthic mode of life according to total numbers of the suckers on each short arm of the hatched juvenile larvae of O. ocellatus were studied by comparisons with other octopodidae species. Compared with the recent a few results reported by other researchers associated with the incubation time required for hatching by female adult mother of O. minor (73-90 days after spawning at $20.9-21.5^{\circ}C$ ranges), in this study, the incubation time required for hatching by female adult mother of O. ocellatus was 56-57 days after spawning at $11.0-20.4^{\circ}C$. Therefore, the incubation time required for hatching by female adult mother varied with Octopodidae species. In this studies, each ovarian egg laid by a female was connected to an egg string attaching to the surface of the wall or bottom of vacunt shell of Rapana venosa. Egg and embryonic developments of this species were studied in the indoor aquaria, in the specific gravity ranging 1.024-1.025. the hatched juvenile of O. ocellatus is 10.3 mm in the mean total length and 4.5 mm in mantle length, and each of its short arms has 18-20 suckers. The just hatched juvenile larvae of O. ocellatus enter the benthic mode of life (benthic larval stage) after hatching. In particular, regarding differences in ecological characteristics of the mode of life according to total numbers of the suckers, O. vulgaris may not need to have many suckers because they enter the planktonic mode of life after hatching, however O. ocellatus may need to have many suckers, because they should adapt to the benthic mode of life. And also the just hatched juvenile larvae of O. minor (bearing many suckers more than O. ocellatus) enter the benthic mode of life (benthic larval stage) after hatching. Therefore, the total number of the suckers on each short arm of the hatched juvenile larvae can be used for determining whether an octopus species has planktonic larval stages or benthic larval stage (benthic mode of life). In particular, The intracohort cannibalism phenomena appeared at the hatched juvenile larval stage because the larval stage of O. ocellatus and O. minor enter into the benthic larval stage in the early stage, unlike entering into the plaktonic larval stage in other Octopus species such as O. vulgaris: at this time, the early hatched larvae fed the late hatched larvae (they are the same species and almost same ages). Therefore, the intracohort cannibalism pheneomena occur in the just hatched juvenile stage of only O. ocellatus and O. minor.

• Journal of Pharmaceutical Investigation
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• v.29 no.2
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• pp.87-92
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• 1999

Drug delivery to the brain may be achieved by producing chimeric peptide, attaching the drug to protein 'vectors' which are transported into the brain from the blood by a receptor-mediated transcytosis through the blood-brain barrier (BBB). Since the BBB expresses high concentrations of transferrin receptor, and it was reported that anti-transferrin receptor mouse monoclonal antibody (OX26) undergoes transcytosis through the BBB, it is logical to assume that a drug delivery system via transferrin receptor-mediated transcytosis is a promising strategy. In the present study, therefore, we tested feasibility of several OX26 based vectors for the brain delivery of a model drug. Avidin-based delivery vectors such as OX26-streptavidin (OX26-SA), OX26-neutralite avidin (OX26-NLA) were chemically synthesized vectors and OX26 immunoglobulin G 3 type $C_{H}3$ fusion avidin $(OX26\;IgG3C_H3-AV)$ was genetically engineered. To improve the efficiency of producing chimeric peptide, we used avidin-biotin technology. Pharmacokinetics of $[^3H]biotin$ bound to OX26-SA, OX26-NLA and $OX26\;IgG3C_H3-AV$ was determined by intravenous injection technique, and their stabilities in plasma were analyzed using HPLC. The brain delivery of $[^3H]biotin$ bound to OX26-SA, OX26-NLA and OX26\;$IgG3C_{H}3-AV$ (expressed as %ID/g brain) was $0.22{\pm}0.01$, $0.18{\pm}0.01$ and $0.25{\pm}0.09$, respectively. The areas under the plasma concentration versus time curve (AUC) for OX26-SA, OX26-NLA, $OX26\;IgG3C_H3-AV$ from time zero to 60 min were $209{\pm}10$, $195{\pm}9$, $134{\pm}29\;%ID\;min/ml$ respectively and their total clearances $(CL_{tot})$ were $1.00{\pm}0.09$, $1.08{\pm}0.07$ and $1.54{\pm}0.29\;ml/min/kg$, espectively. These results showed that these vectors possess preferable pharmaceutical (e.g., resonable stability) and pharmacokinetics (e.g., significant brain uptake and enhanced AUC) for brain delivery. Therefore, these vectors may be broadly useful in the brain delivery of drugs that are not transported into the brain to a significant extent.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.15 no.4
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• pp.381-390
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• 2017

In Korea, commercial nuclear power plants and research reactors have on-site storage systems for the spent nuclear fuel, but it is difficult to expand the facilities used for the storage systems. If decommissioning of nuclear power plants starts, an amount of high level radioactive waste will be generated. In this study, a radiological impact assessment of the railroad transport of high level radioactive waste was carried out considering radiation workers and the public, using the developed transport container as the transport package. The dose rates for workers and the public during the transport period were estimated, considering anticipated transport scenarios, and the results compared with the regulatory limit. A sensitivity analysis was also carried out by considering the different release ratios of the radioactive materials in the high level radioactive waste, and different distances between the transport container and workers during loading and unloading phases and while attaching another freight car. For all the anticipated transport scenarios, the radiological impacts for workers and the public met the regulatory limits.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.9
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• pp.2105-2112
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• 2010

The noise component of electrocardiogram is not distributed in a certain frequency band. It is expressed in various types of signals by rater's physical and environmental conditions. Particularly, since the baseline wander is occurred by the mixture of the original signal and 0 ~ 2 [Hz] range of the frequency components according to muscle constraction of part attaching to an electrode and respiration rythm, it makes the ECG signal analysis difficult. Several methods have been proposed to eliminate the wandering effectually. However, they have some problems. In some methods, the high processing time is required due to the computational complexity, while in other cases ECG signal morphology can be distorted. This paper suggests a simple and effective algorithm that eliminates baseline wander with low computational complexity and without distorting signal morphology. First, the algorithm detects and segments a baseline wandering interval using slope analysis and curve point detection, second, approximates the wandering in the interval as a sinusoid, and then subtracts the sinusoid from signal. Finally, ecg signals without baseline wander are obtained. In order to evaluate the performance of the algorithm, several ECG signals with baseline wandering in MIT/BIH ECG database 101, 111, 113, 234 record were chosen and applied to the algorithm. It is found that the algorithm removes baseline wanders effectively without significant morphological distortion.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.1
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• pp.241-255
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• 2005

Objectives : In order to comprehend and utilize external therapy, we considered that we needed to research Wu Shi-Ji who was a medical specialist of external therapy. We looked at the special study on external therapy in his book, ${\ll}li-yao-pian-wen{\gg}$, especially ; in this part his generai approach to external therapy was well-detaiied. Methods : We translated and analyzed . Results : In , he gives a supplementary explanation about the insufficient attention paid to external therapy, 膏(gao) - (ti) 坐(zuo) (yu) 抹(mo) 纏法(chan fa), through San Jiao(三焦). And he insisted on his conception of external therapy: ointment(膏) and the moth of sneezing, sitting on herbs(坐), steaming or attaching herbs patients's navel, rubbing(抹) and binding(縛), based on ${\ll}nei-jing{\gg}$ and ${\ll}shang-han-lun{\gg}$. He put forward the general rules of external therapy using those methods. And through , he explained that the efficacy of his external therapy was basically the same as internal therapy and medicine, the only difference was in the method. In addition, this external therapy has some merits when compared with internal medicine. First, it's easier to diagnose a disease and treat patients compared to internal medicine. For instance, when a patient has a problem with his abdomen, we just have to diagnose a disease of the abdomen and treat using one method of external therapy on the abdomenal area. Second, external therapy has fewer side effects. And third, we can utilize the meridian theory when we use external therapy. Conclusions : Through , we basically understood his conception of external therapy. Although more research is needed, we suggest that we need to enlarge our usage of external therapy, not just confine ourselves to smaller areas of focus. His point of view suggests that external therapy is not merely an adjunct to internal therapy, but an interdependent course of study and action in its own right.

• Journal of Korean Society of Steel Construction
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• v.29 no.1
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• pp.25-36
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• 2017

In the 1994 Northridge earthquake, connection damage initiated from the beam bottom flange was prevalent. The presence of a concrete slab and resulting composite action was speculated as one of the critical causes of the prevalent bottom flange fracture. In this study, four seismic retrofit schemes are proposed in order to salvage welded steel moment connections with composite floor slabs in existing steel moment frames. Because top flange modification of existing beams is not feasible due to the presence of a concrete floor slab, three schemes of bottom flange modification by using welded triangular or straight haunches or RBS(reduced beam section), and beam web strengthening by attaching heavy shear tab were cyclically tested and analyzed. Test results of this study show that haunch and web-strengthened specimens can eliminate the detrimental effect caused by composite action and ensure excellent connection plastic rotation exceeding 5% rad. Design recommendations for each retrofit scheme together with supplemental numerical studies are also presented.

• Journal of the Microelectronics and Packaging Society
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• v.27 no.3
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• pp.49-54
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• 2020

To attach a stretchable/flexible electrode to something or something to on electrode, conductive adhesives must be stretchable/flexible to suit the properties of the electrode. In particular, conductive adhesive require durability and heat resistance, and unlike conventional adhesives, they should also have conductivity. To this end, Epoxy, which has good strength and adhesion, was selected as an adhesive, and a plasticizer and a reinforcement were mixed instead of a two-liquid material consisting of a conventional theme and a hardener, and a four-liquid material was used to give stretchability/flexibility to high molecules. The conductive filler was selected as silver, a material with low resistance, and for high conductivity, three shapes of Ag particles were used to increase packing density. Conductivity was compared with these developed conductive adhesives and two epoxy-based conductive adhesives being sold in practice, and about 10 times better conductivity results were obtained than products being actually sold. In addition, conductivity, mechanical properties, adhesion and strength were evaluated according to the presence of plasticizers and reinforcement agent. There was also no problem with 60% tensile after 5 minutes of curing at 120℃, and pencil hardness was excellently measured at 6H. As a result of checking the adhesion of electrodes through 3M tape test, all of them showed excellent results regardless of the mixing ratio of binders. After attaching the Cu sheet on top of the electrode through conductive adhesive, the contact resistance was checked and showed excellent performance with 0.3 Ω.

• Journal of the Korean earth science society
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• v.32 no.6
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• pp.674-686
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• 2011

Choosing a seismic source and geophone type including a coupling method can be the most important factor in shallow seismic surveys. We studied the characteristics of seismic signals by analyzing 6 different seismic data sets that collected from several sources and geophone conditions. Geophones attached to weight plate (1.8 kg) can be easily and economically installed on the paved road where geophones with spikes would cause the coupling problem. In addition, experiments in this study revealed that a small handy hammer can be used as a seismic source by striking the paved road to generate the seismic signals within 200 ms two-way travel time. Attaching weight plates to geophones may change the geophone response curve which generally depends on the geophone mass, but the change seems not to give significant differences in the first arrival of refracted wave and in the pattern of reflection events. Consequently, using weight plates on paved roads can be an efficient and cost-saving method in the near-surface high-resolution seismic surveys.

• Journal of the Korea Concrete Institute
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• v.18 no.3 s.93
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• pp.321-330
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• 2006

In order to remodel old aged reinforced concrete buildings, it is often required to extend the residence area of the buildings by increasing the slab area. The slab area is usually extended by attaching a new slab to the existing slab with hinged joint or rigid joint. Transmission of the loads of the attached slabs to the existing slabs depends on the connecting methods, such as hinged or rigid connection. In this research, 8 specimens and 24 RC slabs connected by rigid joints were tested. The new slab was connected to the existing slab by three types of rigid joints using dowel bars and longitudinal tensile bars. Main parameters of the slabs were three types of the rigid joints, anchor length of steel bars(0, 50, 60, 100, and 120mm), development length of steel bars(100, 200, and 300mm), and the spacing of the steel bars(150, 200, 300, and 450mm). The test results indicated that the flexural strength of the RC test slabs having various types of rigid joints was approximately the same to that of the slab without any connections.

• Journal of Dental Rehabilitation and Applied Science
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• v.26 no.3
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• pp.323-337
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• 2010

The objective of this study was to examine the availability of the new impression coping by comparing with conventional coping in implant pick-up impression technique. Five implant fixtures were installed on #14, 21, 23, 25, 27 in acrylic resin model. That model with 5 fixtures was standard model, which was divided 3 groups; using new flag type impression coping, conventional impression coping splinted with self-curing resin, conventional impression coping without splinting. We made metal circular cones for calculation 3-dimensional coordinates by attaching to implant fixtures or analogs. Three-dimensional relationships of each model were calculated. Data was analyzed by multiple ANOVA and Bonferroni. The accuracy of impression between using new flag type impression coping and conventional impression coping did not show differences in 3 - dimensional analysis.Within limitations of this study, the new flag type impression coping is available in implant pick-up impression technique.