• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2011년도 한국우주과학회보 제20권1호
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• pp.30.2-30.2
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• 2011

In this report, we present in-orbit radiometric performance prediction for the Amon-Ra (Albedo Monitor and Radiometer) energy channel instrument. The Integrated Ray Tracing (IRT) computational technique uses the ray sets arriving at the Amon-Ra instrument aperture orbiting around the L1 halo orbit. Using this, the variation of flux arriving at the energy channel detector was obtained when the Amon-Ra instrument including the energy channel design observes the Sun and Earth alternately. The flux detectability was verified at the energy channel detector (LME-500-A, InfraTecTM). The detector time response and RMS signal voltage were then derived from the simulated flux variation results. The computation results demonstrate that the designed energy channel optical system satisfies the in-orbit detectability requirement. The technical details of energy channel instrument design, IRT model construction, radiative transfer simulation and output signal computation results are presented together with future development plan.

• 태양에너지
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• 제17권1호
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• pp.93-102
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• 1997

The numerical study on the natural convection inside the L-shaped enclosure having a protrusion of which left wall is maintained at $T_c$. Right wall and part of the bottom and 2nd floor are at $T_h$ has been performed numerically for aspect ratio A=1, geometrically different cases and for $Ra=5{\times}10^5{\sim}2{\times}10^6$. As the L-shaped of the enclosure goes thicker horizontally and the smaller 2nd floor's length, the mean Nusselt number at the left cold wall becomes smaller for same Ra, and there is little influence of the increase of Ra on mean Nusselt number.

• Journal of Chest Surgery
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• 제17권2호
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• pp.184-188
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• 1984

As OHS is prevalent on whole world, LV-RA shunts once thought as quite rare congenital heart disease are reported frequently. Two cases of LV-RA shunts were operated at N.M.C. in 1983: One of them combined VSD, the other membranous ventricular septal aneurysm protruding into right atrial chamber. In case 1, which was diagnosed correctly, right atriotomy was enough to close the defect under ECC, but in case 2, which was misdiagnosed as ASD preoperatively, atriotomy was added to ventriculotomy. The LV-RA defects were closed by U-shaped direct suture with Teflon felt pledget. Postoperative course was uneventful in both of them.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.149-157
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• 2017

The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing the blood-brain barrier. Thus, this study tested whether intranasal IL-1RA can provide neuroprotection and brain penetration in transient cerebral ischemia. In male Sprague-Dawley rats, focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) for 1 h. The rats simultaneously received 50 mg/kg human IL-1RA through the intranasal (IN group) or intraperitoneal route (IP group). The other rats were given 0.5 mL/kg normal saline (EC group). Neurobehavioral function, infarct size, and the concentration of the administered human IL-1RA in the brain tissue were assessed. In addition, the cellular distribution of intranasal IL-1RA in the brain and its effect on proinflammatory cytokines expression were evaluated. Intranasal IL-1RA improved neurological deficit and reduced infarct size until 7 days after MCAO (p<0.05). The concentrations of the human IL-1RA in the brain tissue 24 h after MCAO were significantly greater in the IN group than in the IP group (p<0.05). The human IL-1RA was confirmed to be co-localized with neuron and microglia. Furthermore, the IN group had lower expression of $interleukin-1{\beta}$ and tumor necrosis $factor-{\alpha}$ at 6 h after MCAO than the EC group (p<0.05). These results suggest that intranasal IL-1RA can reach the brain parenchyma more efficiently and provide superior neuroprotection in the transient focal cerebral ischemia.

• Journal of Astronomy and Space Sciences
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• 제24권1호
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• pp.69-78
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• 2007

Earth-Sun-Heliosphere Interactions Experiments(EARTHSHINE) 미션의 주 탑재체인 Albedo Monitor and Radiometer(Amon-Ra) 광학계는 최초로 제1 라그랑제 지점(Lagrange point 1) 주위의 혜일로(Halo) 궤도에 위치하여 태양 복사 활동 및 지구 반사율 변화를 1% 정확도 이내로 측정함으로서 현존하는 지구 반사율 추이의 모순을 해결할 수 있는 과학적 측정 자료를 제시하는데 그 목적을 가지고 있다. 이에 이미 개발된 광학 성능 검증용 Amon-Ra 광학계의 가시광채널 시험 모델 및 광선 추적 기법을 이용한 통합적 광선 추적 end-to-end 과학 임무 성능 평가 수치 모사 기법을 확립하였으며, 개발된 기법을 이용하여 실제 제작된 Amon-Ra 광학계를 제1라그랑제 지점에 위치시키고 태양과 지구 밝기를 다양하게 변화시킨 후 광학계에 입사되는 에너지 복사량을 수치 모사로 측정하였다. 관측된 지구 및 태양 밝기로부터 지구 반사율 변환을 위하여 각 분포 모델(GLobal Angular Distribution Model, ADM)을 이용하였으며 수치 모사에 의한 지구 반사율 측정 결과를 Amon-Ra 광학계의 측정 오차 범위인 ${\pm}0.28%$와 비교함으로서 개발된 end-to-end 성능 검증 기법의 계산 정밀도를 확인하였다. 이는 기존의 광학계 성능 검증법의 한계를 뛰어넘어 광학계 성능 평가를 실시간으로 검증할 수 있다는 점에서 큰 의의를 지닌다.

• 한국의학물리학회지:의학물리
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• 제21권2호
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• pp.183-191
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• 2010

본 논문에서는 세기조절방사선치료와 이중회전(double arcs)을 통한 래피드아크 치료용 치료계획을 수행하였고, 각각의 선량분포와 DVH의 특성을 비교, 평가하였다. 또한 정도관리를 통해 래피드아크 치료에 대한 신뢰도 및 정확도를 평가하고 이러한 과정들을 통해 환자에 대한 적절한 치료방법을 제시하고자 하였다. 두 치료기술에 대한 치료계획 시 임상표적 용적(Clinical Target Volume, CTV)과 치료표적용적(Planning Target Volume, PTV)과 직장에 동일한 최적화 조건을 적용하였고, 그 외 정상조직에 대하여 최적화 조건 없이 가장 단순화한 조건에서 최적화의 능력과 결과 차이를 비교하였다. 래피드아크는 세기조절방사선치료와 비교하였을 때 동일한 선량제한치 적용 후 결과는 종양에 전달되는 선량은 증가하고 손상위험장기에 대해서는 더 보호하는 능력을 보여주고 있다. 따라서 세기조절방사선치료와 비교하였을 때 치료부피와 주변 장기의 부작용에 대하여 주변장기에 대한 조사선량은 줄이면서 종양에는 더 많은 선량이 조사되었다. 본 연구를 통하여 래피드아크 치료는 기존에 시행하고 있는 세기조절방사선치료 기법보다 더욱 최적의 선량 분포를 구현하고, 치료시간에 있어 보다 효율적이라는 것을 알 수 있었다. 그리고 정밀한 치료 기법인 만큼 정확한 래피드아크 치료를 시행하기 위해서는 치료 계획과 실제로 시행되는 치료가 일치하는지 확인하는 정도관리 과정이 반드시 필요하다는 것을 알 수 있었다.

• Computers and Concrete
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• 제19권6호
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• pp.717-724
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• 2017

In this paper, four formulas are proposed via gene expression programming (GEP)-based models and regression analysis (RA) to predict the flexural strength ($f_s$) values of mortars containing different mineral admixtures that are ground granulated blast-furnace slag (GGBFS), silica fume (SF) and fly ash (FA) at different ages. Three formulas obtained from the GEP-I, GEP-II and GEP-III models are constituted to predict the $f_s$ values from the age of specimen, water-binder ratio and compressive strength. Besides, one formula obtained from the RA is constituted to predict the $f_s$ values from the compressive strength. To achieve these formulas in the GEP and RA models, 972 data of the experimental studies presented with mortar mixtures were gathered from the literatures. 734 data of the experimental studies are divided without pre-planned for these formulas achieved from the training and testing sets of GEP and RA models. Beside, these formulas are validated with 238 data of experimental studies un-employed in training and testing sets. The $f_s$ results obtained from the training, testing and validation sets of these formulas are compared with the results obtained from the experimental studies and the formulas given in the literature for concrete. These comparisons show that the results of the formulas obtained from the GEP and RA models appear to well compatible with the experimental results and find to be very credible according to the results of other formulas.

• Journal of Animal Science and Technology
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• 제53권3호
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• pp.223-226
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• 2011

The current study was undertaken to determine the effect of retinoic acid (RA) on proliferation and differentiation of preadipocytes from male and female pigs. The preadipocytes were isolated from new-born male and female pigs by collagenase digestion and washed three times one day after seeding (designated as day 0 of culture). RA was included in the media at various concentratives from day 0 to 2. The cell number was measured on day 2 with hematocytometer after trypsin digestion. Cell differentiation was determined on day 6 by measuring glycerol-3-phosphate dehydrogenase activity. RA (0.1, 1 and 10 uM) showed no effect on proliferation of preadipocytes from both male and female pigs. However, RA significantly decreased differentiation of pig preadipocytes. Degree of differentiation with 0.1 uM, 1 uM and 10 uM of RA treatment was 80%, 41% and 29% respectively, compared with control. Similar inhibitory effect was found in the female pigs; 77%, 28% and 16% respectively. It is interesting that RA treated on cell proliferation stage had no effect on proliferation but had a strong inhibitory effect on differentiation which is happening in the late stage of cell culture.

• Journal of Korean Neurosurgical Society
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• 제57권3호
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• pp.147-151
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• 2015

Objective : Neuroblastoma is one of common childhood tumors. Although its mortality is very high, there is no effective treatment yet. The aim of this project is to evaluate cytotoxic effects of melatonin (MLT) an endogen hormone and 13-cis retinoic acid (13-cis-RA) also named as isotretinoin an analogue of vitamin A on neuroblastoma SH-SY5Y cell line. Methods : In this study, SH-SY5Y cell line was used. After cell culture, the cells were exposed to different doses of MLT and 13-cis-RA. 24 and 48 hours later. While the viabilities was estimated with MTT cell viability assay test, apoptotic indexes were calculated after staining with TUNEL based apoptosis kit. Results : It was observed that MLT has very effective cytotoxic potential than 13-cis-RA on neuroblastoma cell line. At the same time, when MLT and 13-cis-RA were combined, this effect was potentiated. On the other hand, it was found that the effect of 13-cis-RA individually on neuroblastoma cells was very slight. Conclusion : We suggest that in the treatment of patient with neuroblastoma, MLT is very effective and also this effect can be augmented by combination with 13-cis-RA.

• 사상체질의학회지
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• 제1권1호
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• pp.125-138
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• 1989

In order to investigate the effect of Row ginseng (Ra. G.; from $K{\acute{u}}msan$ province, Korea), White ginseng (W.G.; from $K{\acute{u}}msan$ province, Korea), and Red ginseng (Re. G.; form $K{\acute{u}}msan$ province, Korea) on immune response, the author used ICR mice having a body weight of about 20g as experimental animals dividing them into four groups-Saline, Ra. G, W.G., Re. G group. Delayed type hypersensitivity(DTH) and rosette forming cells(RFC) for cell-mediated immune response, hemagglutinin(HA) titers, hemolysin (HL) titers for humoral immune response were measured at 24 hours after challenge, The results were summarized as follows: 1) DTH was increased in all of the treated group as compared with the Saline group, with statistical significance(W.G.> Re. G. > Ra. G.). 2) RFC was increased in all of the treated group as compared with the Saline group, with statistical significance(W.G. > Re. G. > Ra. G.). 3) HA titer was increased in all of the treated group as compared with the Saline group, with statistical significance (Re. G.> W. G.> Ra. G.). 4) HL titer was increased in all of the treated group as compared with the Saline group, with statistical significance (Re. G. > W. G.> Ra. G.). Through the experimental study in ICR mice, these findings suggest that Raw ginseng, White ginseng and Red ginseng enhance both cell-mediated and humoral immune response with statistical significance.