• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3403-3410
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• 2014

Context: Interest exits in whether TNF-alpha antagonists increase the risk of breast cancer and total malignancies in patients with rheumatoid arthritis (RA). Objectives: To analyze the risk of malignancies, especially breast cancer, in patients with RA enrolled in randomized control trials (RCTs). Methods: A systematic literature search for RCTs from 1 January 1998 to 1 July 2013 from online databases, such as PubMed, WILEY, EMBASE, ISI web of knowledge and Cochrane Library was conducted. Studies included RCTs that compared the safety of at least one dose of the five TNF-${\alpha}$ antagonists with placebo or methotrexate (MTX) (or TNF-${\alpha}$ antagonists plus MTX vs placebo plus MTX) in RA patients for more than 24 weeks and imported all the references into document management software EndNote${\times}6$. Two independent reviewers selected studies and extracted the data about study design, patients' characteristics and the type, number of all malignancies. Results: 28 RCTs from 34 records with 11,741 patients were analyzed. Of the total, 97 developed at least one malignancy during the double-blind trials, and breast cancer was observed in 17 patients (17.5% of total malignancies). However, there was no statistically significant increased risk observed in either the per protocol (PP) model (OR 0.65, 95%CI [0.22, 1.93]) or the modified intention to treat (mITT) model (OR 0.75, 95%CI [0.25, 2.21]). There were also no significant trend for increased risk of total malignancies on anti-TNF-${\alpha}$ therapy administered at approved doses in either model (OR, 1.06, 95%CI [0.64, 1.75], and OR, 1.30, 95%CI [0.80, 2.14], respectively). As to the two models, modified intention to treat model analysis led to higher estimation than per protocol model analysis. Conclusions: This study did not find a significantly increased risk of breast cancer and total malignancies in adults RA patients treated with TNF-${\alpha}$ antagonists at approved doses. However, it cannot be ignored that more patients developed malignancies with TNF-${\alpha}$ antagonists therapy compared with patients with placebo or MTX, in spite of the lack of statistical significance, so that more strict clinical trials and long-term follow-up are needed, and both mITT and PP analyses should be used in such safety analyses.

• 한국수산과학회지
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• 제34권3호
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• pp.199-206
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• 2001

1999년 3월, 7월, 9월 및 11월에 섬진강 하구역에서 염분경사에 따른 영양염의 거동을 조사하였다. 조사 정점은 지리적 위치보다는 각 조사시마다 표층 염분을 현장에서 측정하여 결정하였다. 질산 질소와 규산 규소의 주요 공급원은 섬진강이었으며 아질산 질소와 인산 인은 섬진강 하구입구와 인접한 광양만에서 배출되는 도시하수와 공장폐수에 영향을 받고 있는 것으로 나타났다. 암모니아 질소는 난초도로부터 약 $6\~8km$ 지점에서 공급양상을 보였다. 암모니아 질소, 인산 인,규산 규소의 강한 제거 거동은 엽록소 $\alpha$ 농도가 $>8{\mu}g/L$ 이상으로 매우 높았던 11월 $5\~15psu$ 염분역에서 나타났다. 엽록소 a 최고치 지점에서 N : P 비가 높고 인산 인이 거의 제거된 것은 인산 인이 식물플랑크톤 성장의 제한 요인으로 작용하고 있다는 것을 시사해 주고 있다. 11월에 $5\~15psu$ 염분 역에서의 상대적으로 높은 Rb/Ra (Rb: Fluorescence before acidifcation, Ra: Fluorescence after acidification) 비는 식물플랑크톤이 이 지역에서 생리적으로 성장하기에 좋은 환경이었음을 의미한다.

• 한국정밀공학회지
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• 제3권2호
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• pp.62-75
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• 1986

An experimental investigation of the machining characteristics such as cutt- ing resistance, surface roughness and tool wear in turning the test pieces of SM45C steel with both coated and uncoated carbide tool tips under various cutting conditions was conducted. Also a specially designed simple vibration damping device was experimentally evaluated for its effectiveness on machined surface roughness and a vibration test was conducted to confirm its ability to reduce the amplitude. Based on these tests finding, the following conclusions are made; 1. The cutting resistance($\textrm{p}_{1}$) increases as the depth of cut(d) increases at fixed feed rate(f) over the cutting speed(v) range of 43-226 m/min and p decreses about 18% average when V is increased for fixed d and f. At V= 226m/min, $\textrm{p}_{1}$/for A, C tips are about the same level but $\textrm{p}_{1}$ for B tip is 15% less than A, C tips. 2. The specific cutting resistance(Ks) at V=226 m/min was derived for A, B, C tips respectively and the value of Ks for B rip is about 20% less than A, C tips. 3. The surface roughness(Ra) improves significantly as the cutting speed(V) is increased and this effect was greater when V>100 m/min. On the other hand, Ra deteriorates as the feed rate(f) is increased and this trend was accelerated when f>0.3 mm/rev. With regard to the difference of Ra values among A, B, C tips, at V=226m/min, d=0.4mm, and f=0.31-0.61mm/rev, Ra values for B.C tips are about 17% less than tip A. 4. The experimental tool wear equations were derived for A, B, C tips and from these equations, the tool life($\textrm{T}_{\textrm{L}}$) baced on the I.S.O. criteria was calculated to be $\textrm{T}_{\textrm{L}}$<$\textrm{T}_{\textrm{LB}}$<$\textrm{T}_{\textrm{LC}}$ for both flank wear($\textrm{V}_{\textrm{B}}$) and boundary wear($\textrm{V}_{\textrm{N}}$). Hence, the coated tips are superior to the uncoated tip and tip C is considered to be the best. 5. The cutting resistance may be slightly reduced and the surface rounghness improved when the damper is used especially when V>100 m/min. Therefore this damping device is considered to be effective and practical. The experimental surface roughness equations were also derived. Based on the vibration test, it is established that the surface roughness improvement was the result of amplitude reduction made possible by the damper.

• Childhood Kidney Diseases
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• 제9권2호
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• pp.175-182
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• 2005

목 적 : IL-1ra는 항염증반응을 가지고 있는 인자로서 IL-1 수용체와 결합하여, IL-l$\alpha$와 IL-1$\beta$의 결합을 경쟁적으로 억제시킴으로써, IL-1에 의해 매개되는 다양한 질환에서 중요한 내인성 조절인자로 작용한다. 이 유전자의 intron 2 부위에 86 bp 크기를 가지는 tandem repeat 에 의한 유전자 다형성이 존재하는데, 다양한 자가면역질환에서는 allele 2형의 빈도가 정상 인구군에 비해 유의하게 높다는 사실이 밝혀져 있다. 이에 저자들은 Henoch-$Sch{\ddot{o}}nlein$ Purpura 환자들을 대상으로 IL-1ra 유전자의 variable number tandem repeats(VNTR) 다형성을 검사하여 정상 대조군과 비교하였으며, 신장 침범 여부 및 중증의 경과에 $IL1RN^{*}2$가 어떤 영향을 미치는 지를 조사하였다. 방 법.: 1998년 1월부터 2002년 12월까지 부산 백병원 .소아과를 방문하여 Henoch-$IL1RN^{*}2$ purpura로 진단된 74명의 환자와 정상 대조군 43명을 대상으로 하였다. EDTA 처리된 전혈에서 상품화된 DNA 추출키트($QIAamp^{\circledR}$ DNA Blood Mini kit, Quiagen, USA)를 사용하여 DNA를 추출하였다. IL-1ra 유전자 다형성(polymorphysm)은 86 bp의 2, 3, 4, 5번의 반복횟수에 따라 각각 240 bp, 325 bp, 410 bp 또는 500 bp 크기의 밴드를 확인하여 결정하였다. 결 과 : HSP 환자군과 정상 대조군 모두에서 $IL1RN^{*}1$의 allele 빈도가 각각 $93.9\%,\;93.2\%$로 가장 높았으며, carriage rate도 각각 $98.6\%,\;97.9\%$로 가장 높았다. $IL1RN^{*}2$의 allele 빈도는 HSP 군에서 4.7$\%$로 대조군의 2.5$\%$에 비해 높았으나, 통계적으로 유의하지 않았다(P=0.794). Carriage rate도 HSP군에서 8.1$\%$로 대조군의 6.8$\%$에 비해 높았으나, 통계적으로 유의하지 않았다(P=0.915). $IL1RN^{*}2$의 allele 빈도는 신장 침범군에서 6.3$\%$로 비침범군의 2.9$\%$에 비해 높게 나타났으나 통계적으로 유의하지 않았다(P=0.356). Carriage rate는 신장 침범군에서 10.0$\%$, 비침범군에서 5.9$\%$였으며, 양군 사이에는 유의한 차이가 관찰되지 않았다(P=0.523). 24시간 채집뇨에서 측정한 총단백량이 1,000 mg 이상이었던 경우가 13명이었는데, 이들의 allele형은 $IL1RN^{*}1$이 11명이었으며, $IL1RN^{*}2와\;IL1RN^{*}4$형이 각각 1명씩 있었다. 마지막 추적관찰 시점까지 단백뇨가 지속되었던 환자는 4명이었으며 이들은 모두 $IL1RN^{*}1$형 이었다. 결 론 : HSP 환자군과 정상 대조군 모두에서 $IL1RN^{*}1$의 allele 빈도와 carriage rate가 가장 높았다. $IL1RN^{*}2$ allele 빈도와 carriage rate는 HSP 환자군에서 대조군과 비교하여 유의한 차이가 관찰되지 않았다. 또한 HSP 환자군에서도 $IL1RN^{*}2$ allele 빈도와 carriage rate는 신장 침범의 정도와도 유의한 관련성이 발견되지 않았다.

• 한국재난정보학회 논문집
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• 제15권1호
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• pp.39-48
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• 2019

연구목적:본 연구에서는 재난현장 또는 산업현장에 투입되는 고위험 직업군의 안전을 위하여 IoT/ICT 융합기반의 스마트 안전관리 시스템을 연구하고 이의 성능을 분석 제시하였다. 연구방법: 연구에서 제시된 고위험 직업군의 안전을 위해 부동상태 감지센서, 각 대원간에 통신을 위한 LoRa기반의 리피팅 기술, 전체를 모니터링할 수 있는 LoRa Gateway를 개발하여 기능을 테스트하여 현장적용을 위한 기반을 제시하였다. 연구결과 :고위험 직업군에 작업현장에서 작업자의 위험 상태를 감지하고 전파할 수 있는 다양한 요소를 파악하고 이에 대한 연구가 진행되었다. 작업자의 부동과 같은 위험상태를 감지하는 센서기술, LoRa 통신 기반의 리티핑 기술, 위험 상황을 실시간으로 모니터링 할 수 있는 LoRa Gateway를 분석하여 그 연구결과를 제시하였다. 특히 통신 음영지역의 최소화를 위한 단말간 리피팅기술을 연구하여 통신 불통 문제를 감소시켰다. 연구결론:본 연구를 통해 다양한 고위험 직업군의 작업자 안전을 위한 스마트 안전관리 시스템의 중요한 기능적 요소를 고찰하고 그 효용성을 검증하였다.

• 한국전문물리치료학회지
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• 제21권1호
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• pp.63-69
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• 2014

Cross knee curl-up is an ideal variation of abdominal curl up exercise to strengthen abdominal musculature without excessive lumbar flexion which can increase the loads on the disc and ligaments. In addition, slowly forced expiration can facilitate the activation of the abdominal musculature. The purpose of this study was to determine the effects of slowly forced expiration on activity of abdominal muscles, such as rectus abdominis (RA), external oblique (EO), and transverse abdominis/internal oblique (TrA/IO), while cross knee curl-up. Eleven young and healthy subjects (6 males and 5 females) participated. All subjects performed the cross knee curl-up slowly forced expiration and natural breathing. Paired t-test was performed in normalized electromyogram (EMG) muscle activity of the bilateral RA, EO, and TrA/IO to compare the differences between the cross curl-up with slowly forced expiration and natural breathing. Statistical significance was set at .05. There were no significant differences in normalized EMG muscle activity of the bilateral RA, EO, and TrA/IO between the cross curl-up with slowly forced expiration and natural breathing. The finding of this study designates that slowly forced expiration does not induce increasing activity of abdominal muscle in cross knee curl-up; hence, learning step of breathing control might not be necessary to strengthen abdominal muscle in cross knee curl-up.

• The Journal of Korean Physical Therapy
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• 제27권1호
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• pp.1-6
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• 2015

Purpose: The purpose of this study was to examine the effects of a supplementary shouting technique on abdominal muscle activation to the rectus abdominis (RA) and external oblique (EO) muscles during performance of crunch exercise in healthy subjects. Methods: Sixty-four subjects were randomly allocated to two groups, crunch exercise with shouting group (SG) and crunch exercise with non-shouting group (NSG), with 32 subjects in each group, respectively. The interventions were conducted over three trials in each group, and measurements were performed on each subject by one examiner in three trials. Muscle activation of RA and EO was evaluated using electromyography (EMG) during performance of crunch exercise with or without shouting. Results: Our results showed a significantly greater increase in the EMG patterns of the RA and EO muscles during performance of crunch exercise in the SG compared to the NSG (p<0.01). Conclusion: These findings suggest that addition of the shouting technique during performance of crunch exercise, at the same time, would suggest positive evidence for improving activation of abdominal muscles.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2005년도 총회 및 춘계학술발표회
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• pp.308-311
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• 2005

[ $^{222}Rn\;and\;^{226}Ra$ ] in groundwater were determined simultaneously using a gamma-spectroscopy. A nitrogen flushing equipment has been used for elimination and stabilization of high and unstable background activity due to the radon and its progenies in counting shield and room. The aim of present work was to control the background activity for simultaneous measurement of radium$(^{226}Ra)$ and radon$(^{222}Rn)$ in groundwater using a gamma-spectrometry. Background activity was about 1.0dps and the standard deviation was about 50%, The background activity could be minimized using nitrogen flushing equipment in the range of 0.1 to 0.5 and the RSD was about 5% at the experimental condition. The detection limit of $^{222}Rn\;and\;^{226}Ra$ in groundwater was 0.5dps/L in the background control method. In most groundwater used in the work, radon activity was more than the detection limit. However, radium activity in some groundwater was less than the detection limit. If the low level radium in groundwater must be measured, preconcentration process such as concentration should be performed before measuring the groundwater.

• Nuclear Engineering and Technology
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• 제51권8호
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• pp.2013-2017
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• 2019

The radon concentrations in soil air were measured before and after a rainfall. ²²⁶Ra concentration, porosity, moisture content and temperature in soil were measured at Kyungpook National University in Daegu. As the results of measurement and analysis, the arithmetic mean of measured ²²²Rn concentration increased from 12100 ± 500 Bq/㎥ to 16200 ± 600 Bq/㎥ after the rainfall. And the measured ²²⁶Ra concentration was 61.4 ± 5.7 Bq/kg and the measured porosity was 0.5 in soil. The estimated values of ²²⁶Ra concentration and porosity using diffusion model of ²²²Rn in soil were 60.3 Bq/kg and 0.509, respectively. The estimated values were similar to the measured values. ²²²Rn concentration in soil increased with depth and moisture content. The estimations were obtained through fitting based on the diffusion model of ²²²Rn using the measurement values. The measured depth profiles of ²²²Rn were similar to the calculated depth profiles of ²²²Rn in soil. We hope that the results of this study will be useful for environmental radiation analysis.

• ETRI Journal
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• 제38권6호
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• pp.1153-1162
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• 2016

This paper addresses the resource allocation (RA) problem in multi-cell cognitive radio networks. Besides the interference power threshold to limit the interference on primary users PUs caused by cognitive users CUs, a proportional fairness constraint is used to guarantee fairness among multiple cognitive cells and the impact of imperfect spectrum sensing is taken into account. Additional constraints in typical real communication scenarios are also considered-such as a transmission power constraint of the cognitive base stations, unique subcarrier allocation to at most one CU, and others. The resulting RA problem belongs to the class of NP-hard problems. A computationally efficient optimal algorithm cannot therefore be found. Consequently, we propose a suboptimal RA algorithm composed of two modules: a subcarrier allocation module implemented by the immune algorithm, and a power control module using an improved sub-gradient method. To further enhance algorithm performance, these two modules are executed successively, and the sequence is repeated twice. We conduct extensive simulation experiments, which demonstrate that our proposed algorithm outperforms existing algorithms.