• 미생물과산업
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• 제13권3호
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• pp.3-11
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• 1987

Hepatitis B virus (HBV) is a very serious threat to public health in most of the developing countries of the world. It is estimated that around 300 million people worldwide are chronic carriers of this virus and will transmit the disease both vertically and horizontally. Infection by this virus may cause a wide range of clinical manifestations ranging from an asymptomatic infection to liver cirrhosis.

• Journal of Chest Surgery
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• 제33권3호
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• pp.265-267
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• 2000

Castleman's disease is a relatively rate disorder of lymphoid tissue and poorly understood etiology. The disease may occur anywhere along the lymphatic chain, but is most commonly found as a solitary mass in the mediastinum. The hyaline vascular type represents 91% of Castlemen's disease, and these are most often discovered in the asymptomatic patient on routine chest film. Patients with the plasma cell type often exhibit systemic symptoms, including fever, night sweats, anemia, and hypergammaglobulinemia. Surgical excision effects cure, although resection of the hyaline vascular type may be associated with significant hemprrage owing to extreme vascularity. We recently experienced a case of hyaline vascular type Castleman's disease which was treated by surgical resection through the anterior mini-thoracotomy, and report with its review.

• 대한유전성대사질환학회지
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• 제14권2호
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• pp.174-177
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• 2014

단독 메틸말론산혈증은 상염색체 열성으로 유전되는 선천성 유전대사질환으로 methylmalonyl-coenzyme A mutase (MCM)의 결핍에 의해 야기된다. MCM를 코딩하는 MUT 유전자의 돌연변이가 단독 메틸말론산 혈증의 주된 원인이다. 저자들은 생후 15일 여아가 신생아 선별검사를 통하여 C3-acylcarnitine (C3)이 증가되어 있었던 증례를 경험하였다. 환아의 혈장 homocysteine은 정상이었고, 소변 methylmalonic acid는 증가되어 있어서 단독 메틸말론산혈증이 의심되었다. 환아는 단백제한식이와 함께 carnitine 보충요법을 시작하였고, 생후 3개월까지 특별한 증상없이 정상적인 성장을 하고 있다. MUT 유전자 검사를 시행하였으며, 환아는 c.323G>A와 c.1672+2T>C (IVS8 (+2)T>C 변이를 각각 이형접합자로 가지고 있었다. 이중 c.1672+2T>C (IVS8(+2)T>C)은 이전에 보고되지 않은 새로운 돌연변이로 이에 증례 보고하는 바이다.

• 한국어병학회지
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• 제23권1호
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• pp.17-25
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• 2010

We have identified an iridovirus CH-1 from sea perch Lateolabrax sp. healthy externally and imported from China to Korea. In a comparison of the nucleotide sequences of the five different genomic regions, the CH-1 appears to be closely related to the ISKNV, IVS-1 and Ehime-1 strains detected in China, Korea and Japan respectively. In quantitative comparison of the viral DNA, level of CH-1 in tissue of imported fish was 10,000 times lower than that of IVS-1 strain presented in the infected rock bream Oplegnathus fasciatus of moribund stage. It allowed us to speculate the possibility of the asymtomatic iridovirus infection in the culturing sea perch. Such possibility of asymptomatic infection was supported by result of no appearance of dead fish with typical symptoms of iridoviral disease in keeping experiment of the imported sea pearch in laboratory for more than three weeks. Such asymptomatic infections with iridovirus were also found in spleen of the culturing and externally healthy sea perch of Korea by the presence of the iridoviral DNA in nested PCR.

• Parasites, Hosts and Diseases
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• 제48권1호
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• pp.67-69
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• 2010

Trypomastogotes of Trypanosoma brucei were detected from 4 asymptomatic kudus (Tragelaphus strepsiceros) on a game ranch located approximately 45 km north east of Lusaka, Zambia. Blood smears examined from 14 wildlife species comprising of the impala (Aepyceros melampus), Kafue lechwe (kobus leche kafuensis), sable antelope (Hippotragus niger), tsessebe (Damaliscus lunatus), warthog (Phacochoerus aethiopicus), puku (Kobus vardoni), zebra (Equus burchelli), waterbuck (Kobus ellipsiprymnus), bushbuck (Tragelaphus scriptus), reedbuck (Redunca arundinum), wilderbeest (Connochaetes taurinus), hartebeest (Alcephelus lichtensteini), African buffalo (Syncerus caffer), and kudu (Tragelaphus strepsiceros) showed that only the kudu had T. brucei. Although game ranching has emerged to be a successful ex-situ conservation strategy aimed at saving the declining wildlife population in the National Parks, our findings suggest that it has the potential of aiding the re-distribution of animal diseases. Hence, there is a need for augmenting wildlife conservation with disease control strategies aimed at reducing the risk of disease transmission between wildlife and domestic animals.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제12권2호
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• pp.221-225
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• 2009

저자들은 구토와 심와부 통증을 주소로 내원한 12세 여아에서 복부 전산화 단층촬영을 시행하여 급성 췌장염과 함께 동반된 비정맥 혈전증을 진단하였고, 정맥류출혈이나 비장 비대 등의 증상을 보이지 않아 보존적치료 후 추적 관찰한 증례를 경험하였기에 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제42권6호
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• pp.487-489
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• 2007

Forestier's disease is a systemic rheumatological abnormality in which exuberant ossification occurs along ligaments throughout the body, but most notably the anterior longitudinal ligament of the spine. This disease is usually asymptomatic; however dysphagia, dyspnea, and peripheral nerve entrapment have all been documented in association with the disorder. We report a rare case of catastrophic neurologic damage caused by Forestier's disease accompanying ossification of the posterior longitudinal ligament.

• Journal of Korean Neurosurgical Society
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• 제43권3호
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• pp.169-171
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• 2008

Giant lymph node hyperplasia (Castleman's disease) is a nonneoplastic lymphoproliferative disorder of unknown etiology that usually occurs in the chest. Its morphological recognition is based on a composition of various histological features. The mass is often asymptomatic, but it can cause nonspecific thoracic symptoms, such as regional pain. This disease can be found wherever lymph nodes are present, but two-thirds of these tumors are found in the chest, along the tracheobronchial tree in the mediastinum or lung hilus. However, we experienced an unusual case of Castleman's disease as a cause of back pain that was localized in the posterior mediastinum bordering the chest wall.

• Childhood Kidney Diseases
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• 제21권2호
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• pp.152-155
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• 2017

Orthostatic or postural proteinuria is the most common cause of asymptomatic proteinuria in children. As orthostatic proteinuria (OP) is a benign disease with relatively good prognosis, it has no specific management, and patients only need to be observed. However, if OP shows a persistently high level of proteinuria, in theory, glomerular changes can occur. An 11-year-old girl was referred to the hospital due to asymptomatic proteinuria and was diagnosed as having OP based on the results of clinical and laboratory examinations, urinalysis, and protein/creatinine (TP/Cr) ratio at both supine and erect positions. During follow-up observation, the 24-hour TP/Cr ratio was persistently higher than 1.5 mg/mg for 2 years. We performed renal biopsy, which showed mesangial proliferative glomerular lesions with focal effacement of the podocyte foot processes, but without immune depositions. OP can be accompanied by glomerular lesions if moderate to severe proteinuria persists.

• 대한두경부종양학회지
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• 제29권1호
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• pp.26-28
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• 2013

Thyroid hemiagenesis is rare congenital anomaly that one lobe of thyroid fails to develop. It is often asymptomatic and discovered incidentally with other thyroid disease such as hypothyroidism, hyperthyroidism, multinodular goiter, benign adenoma and cancer. Most cases reported are left thyroid lobe agenesis and occurred in female. Compensatory hypertrophy occurs in most cases. Many cases are asymptomatic and detected incidentally, so awareness of its existence can help its detection and proper treatment. Here, we report a case of thyroid hemiagenesis accompanying hypothyroidism with a review of literature.