• 보건의료산업학회지
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• 제13권3호
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• pp.127-136
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• 2019

Objectives: This study examined the determinants of quality of life, depending on the presence or absence of asthma in adults, based on secondary wave data. Methods: Among the 21,724 people participating in the 6th Korea National Health and Nutrition Examination Survey as it was conducted from the first to third period, 495 participants who were aged 19 or older and responded to the question of the presence or absence of asthma were included in the final analysis. Demographic characteristics were examined using the SPSS/WIN 23.0 software tool for analysis of complex sample survey data. Health-related characteristics were presented using descriptive and multivariate analysis of data. Rao_Scott ${\chi}^2$ was used for the analysis of differences in quality of life, and multiple regression analysis of complex sample survey data was used to analyze factors affecting quality of life. Results: The variable factors negatively influencing quality of life were aging, cognition of their ill health, and limited activities. Conclusions: Based on the analysis, the study suggests that practical and ongoing nursing intervention proposals to improve the quality of life of asthmatic patients should be implemented not only for physical limitations and aging but also for psychological factors that reflect subjective health statuses.

• Clinical and Experimental Pediatrics
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• 제55권8호
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• pp.259-264
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• 2012

Wheezing is one of the most frequent complaints that lead to the use of medical resources in younger children. Generally, wheezing is caused by bronchiolitis and resolves spontaneously without recurrence, but sometimes, wheezing can progress into asthma. Early data on the natural history of childhood wheezing was mostly obtained from retrospective reviews of medical records or from questionnaires, which made it difficult to exclude biases. Now that many cohort studies are available, reviewing the results of birth cohort studies makes it possible to understand the natural course of early childhood wheezing and the risk factors for asthma. In this study, we have reviewed the various phenotypes of early childhood wheezing and their natural courses to help select the most appropriate management modalities for the different types of early childhood wheezing.

• 대한임상검사과학회지
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• 제53권3호
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• pp.249-256
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• 2021

천식은 만성 염증성 기도 폐쇄 질환이다. 질병 발생 요인은 다양하며 특히, 유전적 요인과 환경적 요인이 천식 발병에 영향을 미치는 것으로 추정된다. MAPK (mitogen-activated protein kinase)경로는 Th1/Th2의 균형을 조절하며, 천식 발생에 중요한 역할을 하는 것으로 알려져 있다. 본 연구에서는 MAPK 경로를 조절하는 NDFIP2 유전자와 천식 발병과의 상관관계를 분석하였다. 193건의 천식 환자와 3,228건의 정상 대조군의 유전형 데이터를 사용하였다. 그 결과 NDFIP2 안에 있는 4개의 SNP이 천식과 유의한 상관관계와 높은 상대적 위험도를 보였다. 특히 NDFIP2의 rs2783122는 천식과 통계적으로 가장 유의한 연관성을 나타냈다(P-value=9.76×10^-6, OR=1.67, 95% CI=1.33~2.10). NDFIP2 유전자에 대한 SNP imputation 결과 16개의 SNP가 추가 발견되었으며, 모두 유의한 상관 관계와 높은 상대적 위험도를 나타냈다. 유전자형 기반 mRNA 발현 분석을 통해 rs1408049가 minor allele을 가질 경우 유전자 발현이 증가됨을 알 수 있었다. 증가된 NDFIP2 발현은 MAPK 경로를 활성화시켜 천식 발병에 영향을 미칠 수 있다. 결론적으로 NDFIP2의 다형성은 천식 발병과 관련이 있으며, 이는 한국 인구의 천식 관리에 대한 새로운 지침을 제공할 수 있다.

• 보건의료산업학회지
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• 제9권3호
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• pp.175-185
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• 2015

Objectives : This study was did a meta-analysis of emergency room visits decreased effectiveness of self management education interventions in asthma among adult patients with asthma. Methods : A search of the database PubMed resulted in identifying 8,619 studies done between January 1990 and November 2012. STATA version 10.0 was used to analyze the effect size, explore possible causes of heterogeneity, and determine publication bias with a funnel plot. Results : We included 7 cases on emergency room visits decreased effectiveness of self management and education. Asthmatic patients experienced fewer attacks (summary effect size, 0.75; 95% confidence interval [CI], 0.65-0.95). We found that emergency room visits decreased effectiveness of self management and education were associated with statistically significant effects. Conclusions : Based on these finding, self management and education on interventions are necessary to prevent asthmatic attacks in patients and to reduce the severity of the attacks, and self management and education programs are needed in Korea.

• 센서학회지
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• 제13권2호
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• pp.79-84
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• 2004

Asthma is one of the important respiratory diseases requiring home self care usually performed by commercialized peak expiratory flow meter (PEFM). However, this simple device can measure only single parameter, PEF, due to its purely mechanical principle, significantly limiting desease management quality. The present study introduced a new expiratory flow measurement technique by miniatured air expansion chamber easily installed within PEFM. Continuous pressure signal obtained from the chamber demonstrated an accurate quadratic relationship with flow. The volume measurement error was $<{\pm}1%$ well within the American Thoracic Society (ATS) criteria of 3%. Important spirometric parameters of FVC, PEF, and FEF25-75% were all accurately estimated with correlation coefficients > 0.95. The present technique obtains continuous expiratory air flow signal, making possible and convenient to perform spirometric test at home. Electronic interface capability would be also useful for remote asthma management.

• Tuberculosis and Respiratory Diseases
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• 제61권4호
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• pp.339-346
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• 2006

연구배경: 우리나라에서 대체-보완의료가 기관지천식의 환자에서 광범위하게 사용되어지리라고 추측되고 있다. 그러나 우리나라 성인천식환자에서의 대체-보완의료의 실태는 아직 보고된 바가 없다. 이 연구는 우리나라의 성인천식환자에 있어서 대체-보완의료의 사용실태와 경향을 알아보고자 시행하였다. 방 법: 2000년 1월부터 2003년 12월까지 경희대병원에 1회 이상 입원한 병력이 있는 천식 환자를 대상으로 하였으며 설문조사 연구에 동의하는 환자 100명에게 직접면담 하거나 전화를 통해 설문조사를 시행했다. 환자들의 병력은 병록지를 참고로 조사하였다. 결 과: 조사환자 100명 중 53명이 대체-보완 의료를 경험하였다. 환자가 치료받은 병원 수가 많을수록 대체-보완의료를 경험한 횟수가 많았으며, 연령 별로는 50대가 가장 많이 대체-보완의료를 경험하였다. 흔히 사용한 대체-보완의료의 종류는 음식 및 건강식품이 35명으로 가장 많았다. 그 다음으로 약초가 28명, 침 요법이 9명, 쑥뜸요법이 6명, 그리고 호흡운동이 1명이었다. 결 론: 연구에 참여한 천식환자의 절반이상(53%)에서 대체-보완의료를 경험하였다. 향후 천식치료에 있어 한방 및 대체-보완의료에 대한 실태와 임상적 유용성에 대한 추가적인 연구가 필요할 것으로 보인다.

• 디지털융복합연구
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• 제14권6호
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• pp.317-323
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• 2016

본 연구의 목적은 백삼, 오미자, 맥문동, 길경, 감초 등으로 구성된 백삼복합물이 난알부민으로 유도된 천식 마우스에서의 천식개선에 대한 융복합 연구를 통한 효능을 확인하는 것입니다. 난알부민으로 천식을 유발한 마우스에 백삼복합물을 100 mg/kg과 300 mg/kg을 경구 투여한 후 혈청 내 Th2 사이토카인 IL-4, IL-5, IL-13을 루미넥스를 이용하여 측정하였다. 또한, 혈청과 혈액 내 난알부민 특이-IgE 수치와 호산구, BALF 내 총 세포수는 자동혈구계산기 및 현미경을 통해 측정하였다. 그 결과, 혈청 내 IL-4, IL-5, IL-13 및 난알부민 특이-IgE 수치가 대조군에 비해 각각 감소하였다. 또한, 혈액 내 호산구 및 BALF 내 총 세포수 역시 감소를 보였다. 이러한 결과는 백삼복합물이 Th2 사이토카인과 천식 요인에 대해 감소가 나타나 효과적인 항천식 치료 약물로서 사용될 수 있음을 시사하는 바이다.

• 디지털융복합연구
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• 제13권1호
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• pp.341-351
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• 2015

본 연구는 천식 생쥐 모델을 이용하여 사이프러스 오일(CS)이 알러지성 천식에 미치는 영향을 평가하기 위하여 수행되었다. Ovalbumin으로 천식을 유발시킨 천식 생쥐 모델을 사용하여 실험군에 0.3% CS를 3 주간, 1주 3회, 1회 30분간 분무기를 이용하여 흡입시켰다. 기도과민성, 백혈구 중 호산구 수, 폐 세포 내 면역세포와 Th2 싸이토카인의 변화를 관찰한 결과 CS를 처리한 실험군에서 기도과민성, 호산구 수 및 폐 세포 내 IL-5,IL-13 수치, 혈청내 IgE 분비량, 폐 세포 내 CCR3, CD3, CD4 세포의 수 등 모든 항목에서 현저한 감소효과를 보였다. 이러한 결과는 CS가 천식 반응의 주요인자인 Th2 싸이토카인과 호산구에 긍정적인 영향력이 있음을 시사한다. 따라서 CS는 천식 치료제로서 가능성이 있을 것으로 사료된다.

• Journal of Preventive Medicine and Public Health
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• 제39권1호
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• pp.81-86
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• 2006

Background: A number of studies have reported associations between the ambient air pollution concentrations and various health outcomes. Especially, ozone is well known for primary risk factor of asthma attacks. The results of a recent study indicate that the size of the effect on health outcomes due to air pollution varied according to several conditions, including age, gender, race and the socioeconomic status. Therefore, this study was conducted to examine the associations of ozone with the childhood asthma hospitalizations as stratified by the socioeconomic status (SES) at the community level in Seoul, Korea, 2002. Methods: SES at aggregated levels was measured on the basis of average regional health-insurance rate per citizen in the area. We applied the generalized additive model to analyze the effect of ozone on asthma after controlling for the potential confounding variables that were capable of influencing the results. Results: Our analysis showed that the number of children who were hospitalized for asthma increased as the SES of the residence area decreased. The estimated relative risks of hospitalization for asthma, as stratified by the SES of the community level, were 1.12 (95% confidence interval 1.00-1.25) in districts with the highest SES levels, 1.24 (95% CI=1.08-1.43) within the moderate SES levels, and 1.32 (95% CI=1.11-1.58) in the districts with the lowest SES levels. Conclusions: Our analysis showed that exposure to air pollution did not equally affect the health status of individuals. This suggests that not only the biological-sensitivity markers, but also the SES of the subjects should be considered as potentially confounding factors.

• 대한간호학회지
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• 제47권5호
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• pp.613-623
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• 2017

Purpose: This study was conducted to identify the effects of education regarding action plans according to a self-monitoring program on self-management adherence, knowledge, symptom control, and health-related quality of life (HRQoL) among adults with asthma. Methods: Thirty-four patients were randomly assigned to the intervention group and thirty-two to the control group in this study. A tailored 50-minute intervention based on the contents of self-monitoring and action plans developed by the National Heart Lung and Blood Institute was provided to the intervention group. Structured and well developed questionnaires were used to measure the dependent variables. Results: There were no differences in all general and clinical characteristics, and the dependent variables between two groups in the pre-test. In the post-test, there were differences in the level of self-management adherence (t=4.41, p<.001), knowledge (t=2.26, p=.027), symptom control (t=-2.56, p=.013), and total HRQoL (t=2.14, p=.036) between the two groups, although there was a difference only in the sub-domain of emotion (t=2.03, p=.047) in HRQoL. Conclusion: This study found that action plans according to self-monitoring that enhance a participatory interaction in the treatment and care could help patients with moderate to severe asthma to engagead equately in self-care, to control their symptoms, and to improve their HRQoL. Further studies are still needed to identify longitudinal effects of this program.