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Eleutherococcus sessiliflorus induces differentiation of prechondrogenic ATDC5 Cells (오가피(Eleutherococcus sessiliflorus)의 전연골성 ATDC5 세포의 분화 유도)

  • Shrestha, Saroj Kumar;Song, Jungbin;Lee, Sung Hyun;Lee, Donghun;Kim, Hocheol;Soh, Yunjo
    • The Korea Journal of Herbology
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    • v.37 no.1
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    • pp.51-59
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    • 2022
  • Objectives : The process through which mesenchymal cells condense and differentiate into chondrocytes to form new bone is known as endochondral bone formation. Chondrogenic differentiation and hypertrophy are essential steps in bone formation and are influenced by various factors. The stem bark and root bark of Eleutherococcus sessiliflorus (ES) have been widely used to treat growth retardation and arthritis in traditional Korean Medicine. In this study, we aimed to investigate the possible role of the stem bark of ES in the stimulation of chondrogenic differentiation in clonal murine chondrogenic ATDC5 cells. Methods : In ATDC5 cells treated with ES extract, cell viability and extracellular matrix production were determined using CCK-8 assay and Alcian blue staining, respectively, and alkaline phosphatase activity was measured. We also examined mRNA and protein expression levels of genes related to chondrogenic expression in ATDC5 cells using reverse transcription-polymerase chain reaction and western blot analyses. Results : ES extract increased the accumulation of Alcian blue-stained cartilage nodules and alkaline phosphatase activity in ATDC5 cells. It increased the mRNA expressions of chondrogenic markers including bone sialoprotein (BSP), cartilage collagens, Runt-related transcription factor-2 (RUNX-2), osteocalcin (OCN), β-catenin, and bone morphogenetic protein-2 (BMP-2), as well as the protein expressions of β-catenin, RUNX-2, BMP-2, and alkaline phosphatase (ALP). Conclusion : Taken together, these results suggest that ES extract exhibits a chondromodulating activity and therefore may be a possible agent for the treatment of bone growth disorders.

Evaluation of Lead Exposure Characteristics Using Domestic Occupational Exposure Literature Data (납에 대한 국내 직업적 노출 문헌 자료 고찰을 통한 노출 특성 평가)

  • Choi, Sangjun;Seo, Sung Chul;Park, Ju-Hyun;Koh, Dong-Hee;Kim, Hwan-Cheol;Park, Donguk;Choi, Hee Eun;Sung, Yeji;Oh, Se-Eun;Ko, Kyoung Yoon
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.32 no.1
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    • pp.1-9
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    • 2022
  • Objectives: The purpose of this study is to evaluate exposure characteristics of lead using data from the domestic occupational exposure literature. Methods: Occupational airborne exposure data on lead reported in the domestic literature from 1981 to 2018 were collected and re-analyzed. The exposure levels in the data were expressed as an estimated arithmetic mean and a weighted arithmetic mean (WAM) of the number of samples. Lead exposure characteristics were analyzed by industry, process, and year. Results: From a total of 14 documents, 8,305 airborne lead measurements for 17 industries were identified, and the WAM concentration in eight industries exceeded the occupational exposure limit of 50 ㎍/m3. Three industries (battery manufacturing, lead smelting, and litharge manufacturing) accounted for 95% of the total data, and exposure trends could be confirmed over 10 years. Exposure levels continue to decrease in all three industries. Conclusions: Considering the distribution outlook of lead and lead compounds, the main management targets are lead storage battery manufacturing and secondary smelting for lead regeneration.

On the Initial Plans (1959) of UNESCO House in Seoul, Korea by Kuzosa Architects & Engineers (구조사건축기술연구소의 유네스코회관 초기 계획안(1959)에 관한 고찰)

  • Woo, Don-Son;Kim, Tae-Hyung;Lee, Sumin
    • Journal of architectural history
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    • v.31 no.2
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    • pp.35-50
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    • 2022
  • This study examines the design intent and the construction background of the UNESCO House in Korea planned in the 1950s, with a focus on the initial plans of the House by Kuzosa Architects & Engineers in 1959. To this day, the House has been evaluated as a representative example of an office building in the 1960s, and an early case of introducing curtain walls in Korea. However, only its technical characteristics have been explored with less emphasis on further research data. This study attempts to demonstrate the social and cultural expectations and the demands of the construction of the House by examining the documents produced at the time and the initial plan. This study also highlights the fact that the House was the first project of the architect Pai Ki Hyung to realize high-rise reinforced concrete construction in Seoul's dense center. In the 1950s, the House was planned as a modern building with a complex of various cultural facilities and offices due to the character of activities of the Commission, and the lack of public cultural facilities in Korea. The plan of the Kuzosa Architects & Engineers was selected through a design competition held in 1959. The House was completed in 1967, which took about eight years from planning to completion with design modification in the 1960s. The initial plan submitted before the design modification shows that Pai used the vocabulary and logic of modern architecture and planned the House not as a simple office building but as a complex cultural facility.

Characteristics of organic design in Alexander McQueen's collections (알렉산더 맥퀸 컬렉션에 나타난 유기적 디자인 특성)

  • Kim, Dana;Lee, Younhee
    • The Research Journal of the Costume Culture
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    • v.30 no.2
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    • pp.262-280
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    • 2022
  • The purpose of this study is to analyze the organic forms, expressions, and characteristics of Alexander McQueen's fashion design and to present various materials for understanding and utilizing this organic design style. The criteria for organic design expressions and characteristics were classified through a literature review, and the organic design characteristics of Alexander McQueen's fashion were then analyzed. The results are as follows: First, the morphological characteristics of nature's forms are used as objects in Alexander McQueen's fashions to represent organic characteristics. Second, abstraction through the application of organic forms means creating an abstract representation of the object being represented. Abstracting organic forms occurs by partially modifying the structural features of the human body to show characteristics or by visualizing these characteristics within the surface of the natural object. Third, continuity through the expression of the formation process of organisms is characteristic of the expression of the gradual growth of organisms; this reinterpretation is based on the concept that the internal elements of natural objects affect their external forms. Fourth, the structure of using natural materials, as well as regional and cultural characteristics, is shown in the designs through use of the physical characteristics of expressions and materials that use natural elements. Fifth, symbolism through subjective thinking implies that the element of nature that an object expresses is the element that appears in nature; this includes created organisms along with environmental factors. These characteristics are best demonstrated in fashion designs that express themselves through creativity.

Understanding the Association Between Cryptocurrency Price Predictive Performance and Input Features (암호화폐 종가 예측 성능과 입력 변수 간의 연관성 분석)

  • Park, Jaehyun;Seo, Yeong-Seok
    • KIPS Transactions on Software and Data Engineering
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    • v.11 no.1
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    • pp.19-28
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    • 2022
  • Recently, cryptocurrency has attracted much attention, and price prediction studies of cryptocurrency have been actively conducted. Especially, efforts to improve the prediction performance by applying the deep learning model are continuing. LSTM (Long Short-Term Memory) model, which shows high performance in time series data among deep learning models, is applied in various views. However, it shows low performance in cryptocurrency price data with high volatility. Although, to solve this problem, new input features were found and study was conducted using them, there is a lack of study on input features that drop predictive performance. Thus, in this paper, we collect the recent trends of six cryptocurrencies including Bitcoin and Ethereum and analyze effects of input features on the cryptocurrency price predictive performance through statistics and deep learning. The results of the experiment showed that cryptocurrency price predictive performance the best when open price, high price, low price, volume and price were combined except for rate of closing price fluctuation.

Property change of geopolymers after immersion (지오폴리머의 침지 후 물성변화)

  • Kim, Hakmin;Kim, Yootaek
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.31 no.6
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    • pp.247-257
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    • 2021
  • This study was started to investigate why autoclave curing (AC) specimen showed an improvement in compressive strength after immersion in water for a long time, although AC specimen did not showed a high initial compressive strength unlike our expectations. Distilled water and alkaline solutions were used for immersion and three different curing methods were engaged. It was expected that the compressive strength would be improved after immersion in alkaline solutions; however, there was little difference in compressive strength after 21 day immersion because both new crystallites produced by additional geopolymerization and expansion caused by the alkaline aggregate reaction may prevent the additional improvement in compressive strength. It was concluded that in order to secure the long-term commonality and underwater stability of the geopolymers, it is desirable aging geopolymers while immersing it underwater for more than 21 days after curing using an autoclave.

Growth and thermal annealing of polycrystalline Ga2O3/diamond thin films on Si substrates (다결정 산화갈륨/다이아몬드 이종 박막 성장 및 열처리 효과 연구)

  • Seo, Ji-Yeon;Kim, Tae-Gyu;Shin, Yun-Ji;Jeong, Seong-Min;Bae, Si-Young
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.31 no.6
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    • pp.233-239
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    • 2021
  • In this study, Ga2O3/diamond layers were grown on Si substrates to improve the thermal characteristics of Ga2O3 materials. Firstly, diamond thin film was grown on Si substrates by hot-filament chemical vapor deposition. Afterward, Ga2O3 layer was grown in the growth temperature range of from 450~600℃ by mist chemical vapor deposition. We found that layer separation happens at the Ga2O3/diamond interface at the growth temperature of 500℃. This is attributed to the different thermal expansion coefficient of the mixture of amorphous and crystalline structures during cooling process. Therefore, this study might contribute to the heat-sink-layer bonded power semiconductor applications by stabilizing the thermal properties at Ga2O3/diamond interface.

The Effect of CSR Activities of the Citizens Professional Football Club on Regional Attachment and Expansion of Fans: Focused on Seongnam Football Club, Korea

  • JUNG, Sam Kwon;KWON, Ki Hyun;LEE, Hyuk Jin
    • Journal of Sport and Applied Science
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    • v.5 no.4
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    • pp.9-14
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    • 2021
  • Purpose: This study aims to empirically analyze fans' responses to the types of Corporate Social Responsibility (CSR) activities implemented by the citizens professional football club and seek strategic measures for the continuous growth of the club and the formation of long-term relationships with fans. The purpose of this study is to investigate the relationship between regional attachment and expansion of fans according to the type of CSR activities of the club, and to examine influencing relationships among the types of CSR activities, regional attachment, and expansion of fans. Research design, data, and methodology: To achieve the purpose of the study, the survey was conducted on 150 home spectators of Seongnam Football Club, and the analysis of the data was conducted using SPSS Window Version 21.0. Correlation analysis, simple regression analysis, and multiple regression analysis were conducted to analyze the relationship between regional attachment and expansion of fans according to the types of CSR activities performed by the Seongnam Citizens Football Club. Results: As a result of the analysis, it was found that CSR activities had a statistically significant effect on regional attachment. In addition, CSR activities were found to have a statistically significant effect on expansion of fans. Finally, it was found that regional attachment had a statistically significant effect on the expansion of fans. Conclusions: Based on these results, CSR activities of the professional football club are considered an opportunity to build regional attachment. In addition, it is thought that the expansion of fans can be achieved through CSR activities.

A Comparative Study on the Legal System for Risk Assessment in the Workplace (사업장 위험성평가에 관한 법제의 비교법적 고찰)

  • Jung, Jin-Woo
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.31 no.4
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    • pp.304-316
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    • 2021
  • Objectives: By comparing and analyzing the legal system for risk assessment in South Korea with other advanced countries, the study is designed to identify the key elements of risk assessment and seek improvement measures while focusing on solutions to the execution of risk assessment violations. Methods: The study started with an awareness of the need to improve the legislation on the risk assessment of businesses in Korea. In order to reflect this problem consciousness in Korea's industrial safety and health legislation, risk assessment legislation in Japan, Britain, Germany, and Korea was analyzed in comparative terms through the literature. Results: Unlike the other advanced countries, the concept of risk assessment is defined in Korea in a broad sense that includes measures to reduce risk, and risk assessment in the manufacturing and design stages is not institutionalized. In the case of worker participation, there is a problem regarding effectiveness. It is problematic that compared to the other foreign countries there is a possibility that general risk assessment will be neutralized because it is recognized as a uniform general risk assessment for a particular risk assessment, as well as inadequate risk assessment. Conclusions: The areas diagnosed with problems compared to the legislation in other advanced countries should be improved by revising laws and administrative rules and supplementing the explanatory guidelines, etc. by referring to the legislation of these countries. In particular, the issue of enforcement for violations of risk assessment must be improved in order to ensure the effectiveness of risk assessment.

Effects of the Air-Pressure Asymmetry of Wheelchair Tires on Pelvic Height, Gluteal Pressure, and Muscular Recruitment Pattern in Asymptomatic Participants (타이어 공기압 비대칭이 무증상 대상자의 골반높이, 둔부압력, 근동원패턴에 미치는 영향)

  • Park, Sang-Yeong;Park, Se-Yeon
    • PNF and Movement
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    • v.19 no.3
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    • pp.375-382
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    • 2021
  • Purpose: The objectives of the present study were to investigate the disadvantages of tire pressure asymmetry of a wheelchair tire and recommend the criterion for appropriate tire pressure without generating negative changes in the musculoskeletal system in asymptomatic participants. Methods: Fourteen asymptomatic participants were asked to sit in pressure-controlled wheelchairs and perform desk work for 20 minutes in each tire condition. The asymmetry of the tire conditions was set as 0% difference, 25% difference, and 50% difference from the recommended pressure. The pelvic alignment and muscular recruitment represented as a flexion-relaxation ratio (FRR) were measured at pre-test, and after each condition of desk work. The displacement of the center of pressure (COP) was measured during the desk work. Results: The tire air pressure condition significantly affected the FRR and COP (P < 0.05). Both sides of the FRR values were significantly higher under the symmetrical tire conditions (0% difference) and pre-test, compared with the asymmetrical tire condition of 50% difference (P < 0.05). The mediolateral COP displacement of the asymmetrical tire conditions (25% and 50% difference) was significantly higher than that of the symmetrical tire conditions (0%) (P < 0.05). Conclusion: Asymmetrical tire conditions could cause changes in the muscle recruitment pattern of the erector spine and mediolateral COP displacement. Tire pressure asymmetry higher than 50% could be a risk factor for prevalence of back pain, so this level of asymmetry in tire pressures should be cautioned against for wheelchair users.