• Journal of Preventive Medicine and Public Health
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• 제28권1호
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• pp.13-26
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• 1995

An outbreak of dermatosis occurred in a livestock fodder factory at Kyongju in May 1994. Authors conducted a questionnaire survey on 60 workers in the factory and a dermatologist examined their skin lesion. Authors also collected mites and identified them. The obtained results were summarized as follows; 1. Twenty-eight cases of dermatosis were identified with attack rate of 46.7%. Attack rate was not different by department, age, sex, educational level and employment duration. Attack rate was 67.5% in productive worker and 5.0% in clerical workers (p<0.01) but was not significantly different between departments among productive workers (p>0.05). 2. Three cases among 28 dermatosis cases and one subject among 32 non-cases had a history of same dermatosis last year. Only one of dermatosis cases had a history of dermatosis among family members. History of other skin lesion and allergy was very rare in both cases and non-cases. 3. Skin lesions of the cases were rice-sized erythematous rapules or vesicles with a central biting point. Onset date of dermatosis was between May 1 and June 10. Duration was from one day to more than 30 days. Skin lesion was most frequent at the back(75.0%), and also observed at the arms(64.3%), abdomen(60.7%), legs(57.1%), chest(32.1%) and neck (25.0%). Skin lesion was aggravated while workers are sweeping the floor(35.7%), working at the workplace(21.4%) and in bed at night(28.6%). 4. Total 1,637 mites were collected and identified into 3 suborder, 7 families and 17 species. Dermatophagoides farinae was most frequent md most of the species identified were blood sucking mites. Authors concluded that the. outbreak of dermatosis was brought about by mite-bites and grain beetle parasitizing Acarophenax tribolii was the most suspected species. Further studies to identify the specific species causing dermatosis and route of import are needed.

• 식물병연구
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• 제22권3호
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• pp.158-167
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• 2016

육묘장과 재배포장의 애호박에서 새롭게 발생한 병원균의 특성을 분석하여 동정하였다. 병징은 잎에 수침상의 병반과 강한 노란색의 둘레무리를 가진 점무늬, 꽃에서 갈색 병반, 열매에 노란색의 점무늬였다. 잎의 점무늬로부터 분리된 세균은 박과작물 8개의 식물체, 흑종호박, 애호박, 쥬키니호박, 풋호박, 참박, 참외, 멜론, 오이에 병원성이 있었지만 수박과 밤호박에서는 병을 일으키지 못했다. 분리세균은 다발모를 가진 막대형으로 그람음성이며 King's B 배지에서 형광성이었으며, LOPAT 1a 그룹에 속했다. 그들의 Biolog 기질이용성은 Biolog database의 P. syringae pv. syringae 이용성과 유사하였다. 16S rRNA 유전자 염기서열을 이용한 계통수와 4개의 항존유전자(gapA, gltA, gyrB, rpoD)의 염기서열과 PAMDB에 있는 P. syringae균주들의 염기서열을 이용한 MLST는 애호박 분리균주들이 P. syringae pv. syringae 균주들과 동일한 그룹(clade)으로 그룹화되었고, MLST 계통수에서 애호박 분리균주들의 그룹(clade)은 genomospecies 1에 속하였다. 표현형적, 유전적 특성은 애호박 분리균이 P. syringae pv. syringae임을 제시하였다.

• Toxicological Research
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• 제31권2호
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• pp.157-163
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• 2015

Nanotechnology has advanced at an extremely rapid pace over the past several years in numerous fields of research. However, the uptake of nanoparticles (NPs) into the body after administration through various routes may pose a risk to human health. In this study, we investigated the potential ocular toxicity of 20-nm, negatively- charged zinc oxide (ZnO) NPs in rats using micro-computed tomography (micro-CT) and histopathological assessment. Animals were divided into four groups as control group, ZnO NPs treatment group (500 mg/kg/day), control recovery group, and ZnO NPs treatment and recovery group. Ocular samples were prepared from animals treated for 90 days (10 males and 10 females, respectively) and from recovery animals (5 males and 5 females, respectively) sacrificed at 14 days after final treatment and were compared to age-matched control animals. Micro-CT analyses represented the deposition and distribution of foreign materials in the eyes of rats treated with ZnO NPs, whereas control animals showed no such findings. X-ray fluorescence spectrometry and energy dispersive spectrometry showed the intraocular foreign materials as zinc in treated rats, whereas control animals showed no zinc signal. Histopathological examination revealed the retinopathy in the eyes of rats treated with ZnO NPs. Neuronal nuclei expression was decreased in neurons of the ganglion cell layer of animals treated with ZnO NPs compared to the control group. Taken together, treatment with 20-nm, negatively-charged ZnO NPs increased retinopathy, associated with local distribution of them in ocular lesions.

• Clinics in Shoulder and Elbow
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• 제19권3호
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• pp.125-129
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• 2016

Background: Superior migration of humeral head has been conventionally determined by measuring the acromiohumeral distance (AHD), We sought to devise a novel measurement system more reliably and accurately than AHD. We described a structural landmark called 'C-line'. In this study, we investigated the clinical usefulness of 'step-off of the C-line (SOC)' compared to that of AHD. Methods: The C-line formed from the medial margin of the proximal humeral head continuing up to the inferior margin of the articular glenoid and then to the lateral border of the scapula. The superior migration of the humeral head triggered by a rotator cuff tear introduces a discontinuity in this C-line. We measured the distance of this discontinuity. We enrolled 144 patients who underwent a rotator cuff repair. We selected 58 controls who didn't have any cuff lesions apparent on magnetic resonance imaging. Using radiographs derived from standardized true anteroposterior views of the shoulder, we measured the SOC and the AHD. We used t-tests for statistical analyses. Results: A rotator cuff tear was associated with an increase in SOC and a decrease in AHD. In control group, the mean SOC was $1.29{\pm}1.71mm$ and AHD was $9.71{\pm}2.65mm$. In cuff tear group, the mean SOC was $3.15{\pm}3.41mm$ and AHD was $8.28{\pm}1.76mm$. The mean SOCs of the patient group in relation to the mean SOC of the control group according to tear size, the SOCs of medium tear and lager groups showed statistically significant increase (p<0.05). Conclusions: The SOC may be a similarly effective to diagnose cuff tears of medium size and larger compared with AHD.

• 한국균학회지
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• 제35권2호
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• pp.68-75
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• 2007

본 연구는 백합 잎마름병에 관여하는 B. elliptica와 B. cinerea의 형태적, 배양적 특성을 조사하고, 유전자 염기서열에 기초한 분자계통분석을 하며 병원성을 비교하기 위하여 실시하였다. 한국, 일본, 네덜란드의 주요 백합 재배지역에서 잎마름병에 걸린 백합으로부터 79개의 Botrytis속 균주를 분리하였다. 분생자경과 분생포자의 형태적 특징에 의하여 Botrytis 균들은 2개의 그룹으로 분리되었으며 이들은 각각 B. elliptica와 B. cinerea로 동정되었다. 균사생장 속도는 B. cinerea가 B. elliptica에 비해 빨랐으며 이러한 형태적, 배양적 특성에 기초하여 79개의 균주 중 54균주(68%)가 B. elliptica로, 25균주(32%)가 B. cinerea로 동정되었다. RPB2와 HSP60의 염기서열 분석을 통해, 공시균주는 두 그룹으로 구분되었으며 이들은 형태적으로 동정한 그룹과 일치하였다. 포자 현탁액을 이용한 B. elliptica와 B. cinerea의 병원성 검정 결과 B. elliptica 균주들은 백합 잎과 꽃잎 모두에 병원성을 나타내었다. 그러나 B. cinerea 분생포자 현탁액은 꽃잎에만 병원성을 나타내었으며 PDB가 첨가된 포자현탁액을 접종원으로 사용했을 때에만 백합 잎에 병원성을 나타내었다.

• 대한수의학회지
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• 제25권2호
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• pp.103-112
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• 1985

국내에서 분리된 enterovirus의 병원성을 관찰하기 위하여 1~2일령의 자돈 10두와 35일 령의 유돈 6두에 enterovirus 조직배양부유액을 뇌내 또는 근육내 주사한 후 임상 및 병리학적으로 관찰하였던 바 다음과 같은 결과를 얻었다. 임상적으로는 체온의 상승, 보양창랑, 보행실조, 유약성 마비 및 고도의 삭수가 관찰되었다. 병리조직학적으로는 중추신경계 전반에 걸쳐 수막하 세포침윤, 혈관주위 원형세포침윤, 신경세포의 변성, 미만성과 한국성 gliosis, glial nodule의 형성 등이 관찰되었으며 백질부보다 회백질부에서 다소 심한 경향이었고 배측 신경절염이 전 실험예에서 인정되었다. 한편 hog cholera백신과 enterovirus의 공동주사예에서는 중추신경계의 병변이 enterovirus 단독주사예에 비해 급격히 진행되는 경향이었다. 이상의 소견들을 종합해 볼때 국내에서 분리된 enterovirus는 뇌내 또는 근육내에 접종하였을 때 자돈에서 polioencephalomyelitis를 일으킬 수 있는 병원성이 강한 형으로 추측되며 hog cholera백신과 enterovirus를 공동주사한 예에서 병변의 진행이 급격한 점으로 보아 enterovirus의 자연감염에 hog cholera 백신 등의 stress요인이 작용될 것으로 추측된다.

• 치과방사선
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• 제12권1호
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• pp.27-33
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• 1982

The purpose of this study is to obtain some informations for the differential diagnosis of ameloblastoma from dentigerous cyst by analysis of the radiographic findings of these lesions. The author studied age and sex distribution, the site of the lesion, tooth behavior and several radiographic features of ameloblastoma and dentigerous cyst. The material consisted of 65 patients of ameloblastoma and 37 patients of dentigerous cyst. The results were obtained as followings. 1) The incidence was highest in 2nd decade (29.2%) and total 65 cases consists of 35 males (53.8%) and 30 females (46.2%) in ameloblastoma. 62 cases were found in lower jaw (95.4%) and the highest site of occurence of ameloblastoma was mandibular molar. region 27 cases. (41.5%) 2) In 65 cases of amelobl!!stoma, 18 cases were seen in association with tooth and 15 cases (83.2%) out of those were associated with mandibular molar teeth. Mandibular molar were most frequently involved in dentigerous cyst (11/31 cases, 29.7%). 3) (a) 23 cases (35.3%) of tooth resorption were found in ameloblastoma and 11 cases (29.7%) of tooth resorption were found in dentigerous cyst. (b) 15 cases (23.1%) of tooth migration were found in ameloblastoma and 10 cases (27.0%) of tooth migration were found in dentigerous cyst. 4) Several radiographic features. (a) Monolocular type ameloblastoma were seen in 23 cases (35.4) and multilocular type of ameloblastoma were seen in 42 cases (64.6%). Monolocular type of dentigerous cyst were seen in 33 cases (89.2%) and multilocular type was seen in 4 cases. (b) Monolocular type ameloblastoma showed 20 cases (87.0%) of scalloped border but 32 cases (97.0%) of dentigerous cyst showed smooth border. (c) 34 cases (81.0%) of ameloblastoma showed honey-comb appearance, soap-bubble appearance or mixed appearance. but all 4 cases of dentigerous cyst showed multicystic appearance. (d) 12 cases (52.2%) of monolocular type ameloblastoma showed slightly increased radiopacity in surrounding bone, and 22 cases (66.7%) of monolocular type dentigerous cyst showed sharp osteosclerotic border. 27 cases (64.3%) of multilocular type ameloblastoma and 3 cases (75.0%) of multilocular type dentigerous cyst showed no changes in surrounding bone.

• Tuberculosis and Respiratory Diseases
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• 제42권4호
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• pp.600-604
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• 1995

저지들은 캐나다 방문당시 복부 팽만감을 주소로 그곳 병원을 림프관평활근 종증을 진단받고 귀국 후 본 병원에서 매달 Depo provera를 근주하고 매달 폐기능 검사등을 실시하여 추적관찰하고 있는 폐와 후복강에 발생한 림프관평활근종증의 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한약침학회지
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• 제18권1호
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• pp.72-78
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• 2015

Objectives: The stomach is a sensitive digestive organ that is susceptible to exogenous pathogens from the diet. In response to such pathogens, the stomach induces oxidative stress, which might be related to the development of both gastric organic disorders such as gastritis, gastric ulcers, and gastric cancer, and functional disorders such as functional dyspepsia. This study was accomplished to investigate the effect of Ganoderma lucidum pharmacopuncture (GLP) on chronic gastric ulcers in rats. Methods: The rats were divided into 4 groups of 8 animals each: the normal, the control, the normal saline (NP) and the GLP groups. In this study, the modified ethanol gastritis model was used. The rats were administrated 56% ethanol orally every other day. The dose of ethanol was 8 g/kg body weight. The normal group received the same amount of normal saline instead of ethanol. The NP and the GLP groups were treated with injection of saline and GLP respectively. The control group received no treatment. Two local acupoints CV12 (中脘) and ST36 (足三里) were used. All laboratory rats underwent treatment for 15 days. On last day, the rats were sacrificed and their stomachs were immediately excised. Results: Ulcers of the gastric mucosa appeared as elongated bands of hemorrhagic lesions parallel to the long axis of the stomach. In the NP and GLP groups, the injuries to the gastric mucosal injuries were not as severe as they were in the control group. Wound healings of the chronic gastric ulcers was promoted by using GLP and significant alterations of the indices in the gastric mucosa were observed. Such protection was demonstrated by gross appearance, histology and immunehistochemistry staining for Bcl-2-associated X (BAX), B-cell lymphoma 2 (Bcl-2) and Transforming growth factor-beta 1 (TGF-${\beta}1$). Conclusion: These results suggest that GLP at CV12 and ST36 can provide significant protection to the gastric mucosa against an ethanol induced chronic gastric ulcer.

• Clinics in Shoulder and Elbow
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• 제12권1호
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• pp.102-108
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• 2009

목적: 견관절 전방 불안정성에서 골 결손에 동반되면 관절경 하 재건술에서 실패 요인이 될 수 있다. 외상성으로 발생하는 견관절 불안정성의 치료에서 관절와의 골 결손과 상완골 두의 골 결손에 대한 관절경 술식을 이용한 해결방법에 대하여 알아보고자 하였으며, 골 결손이 동반된 견관절 전방 불안정성에서 관절경 재건술의 수술 술기에 대하여 고찰하는 것이 이 논문의 목적이다. 대상 및 방법: 견관절 전방 불안정성에서 최근 발표된 논문을 분석하여 관절경적 수술방법에 대하여 고찰하였고, 재발의 원인으로 간주되는 전하방 관절와의 골 결손과 후외방 견관절 두의 골 결손에 대한 관절경 수술 방법에 대하여 논문 고찰과 저자의 방법을 비교하였다. 결과: 전방 불안정성에서 발생하는 골 결손에는 관절와의 전하방 골 결손과 Hill-Sachs 병소가 있다. 이러한 골 결손은 현재까지 견관절 불안정성에서 관절경적인 수술의 실패의 원인이다. 결론: 의미 있는 관절와의 골 결손과 상완골 두의 골 결손을 가진 견관절 불안정성에 대하여 가장 좋은 치료방법은 개방적 수술이라고 할 수 있으나, 관절경적인 접근법으로 개방적 수술의 단점을 극복하기 위한 노력이 주목되고 있다.