• International Journal of Human Ecology
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• v.14 no.1
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• pp.103-113
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• 2013

Using data from the 2010 National Survey of Korean Families (NSKF), we investigated factors associated with marital conflict for baby boomers in South Korea. Korean baby boomers are those born during the post-Korean War period from 1955 to 1963. OLS regression examined the marital conflict of these couples. Baby boomer couples reported that they experienced occasional marital conflict; subsequently individual and family level variables explained 15% of baby boomers' marital conflict. The key findings were that satisfaction in spousal communication was negatively associated with conflict for baby boomer couples. However, the existence of unmarried adult children was positively associated with baby boomers' marital conflict. Work and family balance was also negatively associated with marital conflict. We found that the more satisfied with communication with the spouse, the fewer unmarried adult children, and the more work and family balance the couple maintained, the less marital conflict these baby boomers experienced.

• Journal of Chest Surgery
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• v.18 no.3
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• pp.428-435
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• 1985

Tetralogy of Fallot associated with a single pulmonary artery is a rare cardiac anomaly. In previously reported cases, left pulmonary arteries were absent except 2 cases. Congenital absence of the pulmonary valve is a rare anomaly too. In the majority of cases, this lesion is associated with TOF. TOF associated with a single pulmonary artery and absent pulmonary valve is a very rare anomaly and only less than 20 cases were reported in the literatures. We have operated on one patient with TOF associated with absent right pulmonary artery and rudimentary pulmonary valve, a variant of absent pulmonary valve, and report this case with review of the literatures.

• International Journal of Industrial Entomology and Biomaterials
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• v.10 no.2
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• pp.125-129
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• 2005

Ribosome-associated membrane protein 4 (RAMP4) is a membrane protein that exposes its N-terminal hydrophilic portion on the cytoplasmic side and spans the membrane close to the C-terminal end. RAMP4 has previously been reported to belong to the set of proteins that remains associated with membrane-bound ribosomes, and controls the glycosylation of major histocompatbility complex class II-associated invariant chain. RAMP4 also may be relative to the stabilization of membrane proteins in response to stress, with other components of translocon, and molecular chaperons in ER. Application of 5'-RACE technique with specially designed primer, we cloned a 715 bp cDNA fragment which contains a 195 bp ORF, termed RAMP4. The deduced protein has 64 amino acid residues and contains a putative transmembrane-spanning domain at the COOH terminus.

• Journal of Korean Public Health Nursing
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• v.27 no.1
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• pp.76-88
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• 2013

Purpose: The purpose of this study was to identify the degree of sleep quality and its associated factors in adults. Methods: The data was collected from 986 adults aged 19 to 64 by convenience sampling. Subjects completed a questionnaire composed of Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory, and other questions that self-rated health and sociodemographic variables. Statistical methods used included descriptive statistics, simple logistic regression, and multiple logistic regression analyses. Results: The global PSQI score was 5.7. About 45% of the subjects were poor sleepers (global PSQI score >5). Multiple logistic regression analyses showed that factors significantly associated with sleep quality were depression and poor self-rated health in young and middle-aged adults. Depression was the most significant associated factor. The presence of a spouse was also associated with sleep quality in young adults. Conclusion: These findings suggest that people with poor sleep quality should have their health carefully screened for depression. In addition, we recommend the development of a nursing program for improving sleep quality.

• Parasites, Hosts and Diseases
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• v.52 no.6
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• pp.695-699
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• 2014

Chronic Opisthorchis viverrini-induced hepatobiliary disease is associated with significant leukocyte infiltration, including activated macrophages; however, the polarization of infiltrating macrophages remains to be fully characterized. In this study, we characterized macrophage polarization and phenotype in chronic O. viverrini-induced hepatobiliary disease in humans and hamsters using gene expression and histochemical analysis. Chronic O. viverrini infection and associated hepatobiliary diseases were associated with iron loaded M2-like macrophages in both humans and hamsters. This study provides suggestive evidence that iron loaded M2-like macrophages promote hepatobiliary disease in chronic O. viverrini infection.

• Journal of Genetic Medicine
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• v.7 no.1
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• pp.1-8
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• 2010

Hemophilia A is a sex-linked recessive coagulation disorder associated with diverse mutations of the factor VIII gene and a variety of phenotypes. The type of mutation involved dictates the activity of factor VIII, and in turn the severity of bleeding episodes and development of alloantibodies against factor VIII (inhibitors). Missense mutations are the most common genetic risk factors for hemophilia A, especially mild to moderate cases, but carry the lowest risk for inhibitor development. On the other hand, intron 22 inversion is the most common mutation associated with severe hemophilia A and is associated with high risk of inhibitor formation. Large deletions and nonsense mutations are also associated with high risk of inhibitor development. Additional mutations associated with hemophilia A include frameshift and splice site mutations. It is therefore valuable to assess the mutational backgrounds of hemophilia A patients in order to to interpret their symptoms and manage their health problems.

• Genomics & Informatics
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• v.19 no.1
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• pp.3.1-3.12
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• 2021

Functional interpretation of noncoding genetic variants associated with complex human diseases and traits remains a challenge. In an effort to enhance our understanding of common germline variants associated with lung cancer, we categorize regulatory elements based on eight major cell types of human lung tissue. Our results show that 21.68% of lung cancer-associated risk variants are linked to noncoding regulatory elements, nearly half of which are cell type-specific. Integrative analysis of high-resolution long-range chromatin interactome maps and single-cell RNA-sequencing data of lung tumors uncovers number of putative target genes of these variants and functionally relevant cell types, which display a potential biological link to cancer susceptibility. The present study greatly expands the scope of functional annotation of lung cancer-associated genetic risk factors and dictates probable cell types involved in lung carcinogenesis.

• Journal of the Korean Mathematical Society
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• v.58 no.1
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• pp.237-264
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• 2021

In this work the stationary bootstrap of Politis and Romano [27] is applied to the empirical distribution function of stationary and associated random variables. A weak convergence theorem for the stationary bootstrap empirical processes of associated sequences is established with its limiting to a Gaussian process almost surely, conditionally on the stationary observations. The weak convergence result is proved by means of a random central limit theorem on geometrically distributed random block size of the stationary bootstrap procedure. As its statistical applications, stationary bootstrap quantiles and stationary bootstrap mean residual life process are discussed. Our results extend the existing ones of Peligrad [25] who dealt with the weak convergence of non-random blockwise empirical processes of associated sequences as well as of Shao and Yu [35] who obtained the weak convergence of the mean residual life process in reliability theory as an application of the association.

• Korean Journal of Childcare and Education
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• v.18 no.1
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• pp.71-90
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• 2022

Objective: This study examined the experiences of pre-service Early Childhood teachers who participated in major-associated autonomous club activities. Methods: Participants were 31 students of the Department of Child Care at A University located in Gyeonggi-do, who participated in a major-associated autonomous music club activity. A content analysis was conducted to examine the meaning of the participation experience of pre-service Early Childhood teachers. Qualitative content analysis was the best method to analyze the meaning of their experience while participating in the activities. Results: The meaning of the experience of music club activities was organized into three categories: "enjoying abundant college life," "growing as a competent childcare teacher," and "being a responsible member of a community." Conclusion/Implications: The results show that pre-service Early Childhood teacher's participation in the activities of major-associated autonomous clubs has a positive impact on desirable changes in college life and adaptation to the department and on the growth of future professional Early Childhood teachers.

• Journal of Medicine and Life Science
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• v.21 no.1
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• pp.15-19
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• 2024

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing vasculitis that predominantly affects small vessels of the body. The two most common ANCAs are myeloperoxidase ANCA and proteinase 3 ANCA. Neurological manifestations are frequent in patients with AAV, including peripheral neuropathy, meningitis, and stroke. AAV-associated ischemic stroke usually affects small vessels supplying the white matter or brainstem. This case report details the presentation and treatment course of a 70-year-old man with rapidly progressive multiple intracranial large artery involvement attributed to myeloperoxidase ANCA-associated vasculitis. Despite treatment with high-dose steroids and a rituximab infusion, the patient developed new speech difficulties and respiratory distress, and brain imaging confirmed new stroke lesions with progressive multiple intracranial large cerebral artery involvement. The patient died from SARS-CoV-2 infection 4 months after the diagnosis. This case emphasized the rare presentation of rapidly progressive large vessel involvement in a patient with myeloperoxidase ANCA-associated vasculitis despite active immunotherapy.