• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2407-2412
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• 2013

Background and Objectives: Data on associations between soy food intake after cancer diagnosis with breast cancer survival are conflicting, so we conducted this meta-analysis for more accurate evaluation. Methods: Comprehensive searches were conducted to find cohort studies of the relationship between soy food intake after cancer diagnosis and breast cancer survival. Data were analyzed with comprehensive meta-analysis software. Results: Five cohort studies (11,206 patients) were included. Pooling all comparisons, soy food intake after diagnosis was associated with reduced mortality (HR 0.85, 95%CI 0.77 0.93) and recurrence (HR 0.79, 95%CI 0.72 0.87). Pooling the comparisons of highest vs. lowest dose, soy food intake after diagnosis was again associated with reduced mortality (HR 0.84, 95%CI 0.71 0.99) and recurrence (HR 0.74, 95%CI 0.64 0.85). Subgroup analysis of ER status showed that soy food intake was associated with reduced mortality in both ER negative (highest vs. lowest: HR 0.75, 95%CI 0.64 0.88) and ER positive patients (highest vs. lowest: HR 0.72, 95%CI 0.61 0.84), and both premenopausal (highest vs. lowest: HR 0.78, 95%CI 0.69 0.88) and postmenopausal patients (highest vs. lowest: HR 0.81, 95%CI 0.73 0.91). In additioin, soy food intake was associated with reduced recurrence in ER negative (highest vs. lowest: HR 0.64, 95%CI 0.44 0.94) and ER+/PR+ (highest vs. lowest: HR 0.65, 95%CI 0.49 0.86), and postmenopausal patients (highest vs. lowest: HR 0.67, 95%CI 0.56 0.80). Conclusion: Our meta-analysis showed that soy food intake might be associated with better survival, especially for ER negative, ER+/PR+, and postmenopausal patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1675-1679
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• 2014

Objectives: MicroRNAs (miRNAs) are important regulators of many physiological and pathological processes, including tumorigenesis and metastasis. In this study, we sought to determine the underlying molecular mechanisms of metastatic cervical carcinoma by performing miRNA profiling. Methods: Tissue samples were collected from ten cervical squamous cancer patients who underwent hysterectomy and pelvic lymph node (PLN) dissection in our hospital, including four PLN-positive (metastatic) cases and six PLN-negative (non-metastatic) cases. A miRNA microarray platform with 1223 probes was used to determine the miRNA expression profiles of these two tissue types and case groups. MiRNAs having at least 4-fold differential expression between PLN-positive and PLN-negative cervical cancer tissues were bioinformatically analyzed for target gene prediction. MiRNAs with tumor-associated target genes were validated by quantitative reverse transcription-polymerase chain reaction (RT-PCR). Results: Thirty-nine miRNAs were differentially expressed (>4-fold) between the PLN-positive and PLN-negative groups, of which, 22 were up-regulated and 17 were down-regulated. Sixty-nine percent of the miRNAs (27/39) had tumor-associated target genes, and the expression levels of six of those (miR-126, miR-96, miR-144, miR-657, miR-490-5p, and miR-323-3p) were confirmed by quantitative (q)RT-PCR. Conclusions: Six MiRNAs with predicted tumor-associated target genes encoding proteins that are known to be involved in cell adhesion, cytoskeletal remodeling, cell proliferation, cell migration, and apoptosis were identified. These findings suggest that a panel of miRNAs may regulate multiple and various steps of the metastasis cascade by targeting metastasis-associated genes. Since these six miRNAs are predicted to target tumor-associated genes, it is likely that they contribute to the metastatic potential of cervical cancer and may aid in prognosis or molecular therapy.

• 충청수학회지
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• 제31권3호
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• pp.343-352
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• 2018

We study the complete convergence for sequences of dependent random variables in Hilbert spaces. Results are obtained for negatively associated random variables and ${\phi}$-mixing random variables in Hilbert spaces.

• Journal of Preventive Medicine and Public Health
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• 제50권4호
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• pp.268-273
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• 2017

Objectives: Influenza is a significant worldwide public health issue. Knowledge and perceptions regarding the flu vaccination are associated with whether individuals obtain the vaccination. The purpose of this study was to examine how such perceptions were related to knowledge and self-efficacy regarding influenza and the flu vaccination in Vietnam and the US. Methods: College students (n=932) in Vietnam (n=495) and the US (n=437) completed a self-administered survey regarding knowledge and perceptions of influenza vaccinations in September and October 2016. Results: Vietnamese participants reported significantly lower levels of awareness about flu risk, higher levels of negative attitudes toward flu vaccination, lower levels of knowledge about the flu and vaccination, and lower levels of self-efficacy than US participants. Higher levels of flu and flu vaccination knowledge and self-efficacy regarding general responsible health practices were associated with lower levels of negative perceptions of flu risk and attitudes toward vaccination. At the same time, self-efficacy regarding responsible health practices was associated with higher levels of awareness of flu risk and lower levels of negative attitudes toward vaccination. Self-efficacy regarding exercise was associated with lower levels of perceptions of flu risk and higher levels of negative attitudes toward vaccination. Conclusions: Vietnam could benefit from influenza education based on this comparison with the US. In both countries, knowledge and self-efficacy were found to be important factors influencing perceptions of influenza risk and vaccination.

• Journal of applied mathematics & informatics
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• 제30권3_4호
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• pp.623-633
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• 2012

Let {${\Omega}$, $\mathcal{F}$, P} be a probability space and {$X_n|n{\geq}1$} be a sequence of random variables defined on it. A finite sequence of random variables {$X_n|n{\geq}1$} is said to be conditionally negatively associated given $\mathcal{F}$ if for every pair of disjoint subsets A and B of {1, 2, ${\cdots}$, n}, $Cov^{\mathcal{F}}(f_1(X_i,i{\in}A),\;f_2(X_j,j{\in}B)){\leq}0$ a.s. whenever $f_1$ and $f_2$ are coordinatewise nondecreasing functions. We extend the H$\grave{a}$jek-R$\grave{e}$nyi-type inequality from negative association to conditional negative association of random variables. In addition, some corollaries are given.

• Asian Pacific Journal of Cancer Prevention
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• 제15권5호
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• pp.2231-2238
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• 2014

This study investigated how self-rated health and socioeconomic status are associated with behaviour of cancer survivors regarding desire for information. For this association, we compared survivors who did not seek information about cancer with those who did. We examined how sociodemographic, socioeconomic, cancerrelated, and health information factors are associated with self-rated health (SRH) by health information seeking/avoiding behavior in a survey of 502 post-treatment cancer patients. In the information seeking group, all four factors exhibited significant relationships with SRH. SRH values were significantly high for women (p<0.05), non-Hispanic White (p<0.05), and educated (p<0.01) participants, and for those who had high self-efficacy to use health information by themselves (p<0.01). Furthermore, in the information avoiding group, not only were there no significant relationships between socioeconomic status (SES) and SRH, but there were negative associations between their attitude/capacity and the SRH. In terms of communication equity, the promotion of information seeking behavior can be an effective way to reduce health disparities that are caused by social inequalities. Information avoiding behavior, however, does not exhibit a negative contribution toward the relationship between SRH and SES. Information seeking behavior was positively associated with SRH, but avoiding behavior was not negatively associated. We thus need to eliminate communication inequalities using health intervention to support information seeking behavior, while simultaneously providing support for avoiders.

• 국토계획
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• 제53권7호
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• pp.49-66
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• 2018

The purpose of this study is to analyze neighborhood environmental factors affecting bicycle accidents and accidental severity in Seoul, Korea. The use of bicycles has increased rapidly as daily transportation means in recent years. As a result, bicycle accidents are also steadily increasing. Using Traffic Accident Analysis System (TAAS) data from 2015 to 2017, this study uses negative binomial regression analysis to identify neighborhood environmental factors affecting bicycle accidents and accidential severity. The main results are as follows. First, bicycle accidents are more likely to occur in commercial and mixed land use areas where pedestrians, bicycle and vehicles are moving together. Second, bicycle accidents are positively associated with road structures such as four-way intersection. In contrast, three-way intersection is negatively associated with serious bicycle accidents. The density of speed hump or street tree is negatively associated with bicycle accidents and accidential severity. This finding indicates the effect of speed limit or street trees on bicycle safety. Fourth, bicycle infrastructures are also important factors affecting bicycle accidents and accidential severity. Bicycle-exclusive roads or bicycle-pedestrian mixed roads are positively associated with bicycle accidents and accidential severity. Finally, this study suggests policy implications to improve bicycle safety.

• 성인간호학회지
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• 제19권4호
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• pp.614-623
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• 2007

Purpose: The purpose of this study was to examine the relationships among knowledge, attitudes, and the use of negative control maintenance techniques toward older adults among nurses working in geriatric hospitals (n=86). Methods: Data were collected from April 4th to May 30th in 2006 by using questionnaires of Fact on Aging Quiz Part I, Aging Semantic Differential Scaling, and Control Maintenance Techniques. Results: The findings showed that the nurses displayed lack of knowledge concerning older adults and their average rate of correct answer was 45.6%. They also hold some negative bias and attitudes, especially in psychological and social aspects. The level of using negative control maintenance techniques in managing older patients' problematic behaviors was reported as the mean of 5.65 with a possible range of 0-40. Nurse's knowledge of older adults was positively associated with their attitudes toward older adults, but their knowledge and attitudes were not associated with the use of negative control maintenance techniques. Conclusion: It is necessary to provide educational programs for nurses that focus on a comprehensive understanding of aging with lifetime developmental perspectives. Further studies are needed to understand the factors associated with using negative control maintenance techniques and to evaluate the intervention programs in reducing the use of negative control maintenance techniques.

• Tuberculosis and Respiratory Diseases
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• 제70권3호
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• pp.191-198
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• 2011

Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection in the intensive care unit (ICU), with an incidence ranging from 8% to 38%. Patients who acquire VAP have higher mortality rates and longer ICU and hospital stays. Because there are other potential causes of fever, leukocytosis, and pulmonary infiltrates, clinical diagnosis of VAP is overly sensitive. The only alternative approach to the clinical diagnosis of VAP is the Clinical Pulmonary Infection Score (CPIS). Employing quantitative cultures of respiratory secretions in the diagnosis of VAP leads to less antibiotic use and probably to lower mortality. With respect to microbiologic diagnosis, however, it is not clear that the use of invasive sampling using bronchoscopy is associated with better outcomes. Delayed administration of antibiotic therapy is associated with an increased mortality, and inadequate antibiotic therapy is also associated with higher mortality. Therefore, prompt initiation of adequate antibiotic therapy is a cornerstone of the treatment of VAP. The initial antibiotic therapy should be based on the most common organisms in each hospital and the most likely pathogens for that specific patient. When final cultures and susceptibilities are available, de-escalation to less broad spectrum antibiotics should be done. Since clinical improvement usually takes 2 to 3 days, clinical responses to the initial empirical therapy should be evaluated by day 3. A short course of antibiotic therapy appears to be equivalent to a traditional course of more than 14 days, except when treating non-fermenting gram-negative organisms. If patients receive initially adequate antibiotic therapy, efforts should be made to shorten the duration of therapy to as short as 7 days, provided that the etiologic pathogen is not a non-fermenting gram-negative organism.

• 한국보육지원학회지
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• 제13권2호
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• pp.1-19
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• 2017

Objective: The purpose of this study was to examine the relationship among perceived mothers'psychological control, affectionate-rational parenting and children's attributional style. The main and interaction effects of psychological control, affectionate-rational parenting on children's attributional style were also explored. Methods: The participants of this study were 253 children from elementary schools located in Seoul and Incheon. Data were analyzed through Pearson's correlation, and hierarchical regression using SPSS 22.0. Results: The major findings of this study were as follows. First, children's attributional style for negative events was positively associated with psychological control but negatively associated with affectionate-rational parenting. Moreover, attributional style for positive events was positively associated with only affectionate-rational parenting. Second, affectionate-rational parenting significantly influenced children's attributional style for both negative events and positive events. Finally, significant interaction effects of psychological control and affectionate-rational parenting on children's attributional style for negative events were observed. Conclusion/Implications: This study revealed that mothers' psychological control and affectionate-rational parenting are important factors in explaining children's attributional style. Such results could be used as an effective resource in developing parent education programs or intervention programs for attributional style.