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Exposure Assessment for Toxic Hepatitis Caused by HCFC-123

  • Kim, Ki-Woong;Park, Hae Dong;Jang, Konghwa;Ro, Jiwon
    • Safety and Health at Work
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    • v.9 no.3
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    • pp.356-359
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    • 2018
  • This case report attempts to present a case of acute toxic hepatitis in fire extinguisher manufacturing workers exposed to 2,2-dichloro-1,1,1-trifluoro-ethane (HCFC-123) in August 2017 in Korea. Twenty-two-year-old male workers were exposed to HCFC-123 for 1.5 hours one day and for 2.5 hours the other day, after which one worker died, and the other recovered after treatment. The workers were diagnosed with acute toxicity of hepatitis. However, exposure levels of HCFC-123 were not known with no work environment measurement done. Therefore, this study was conducted to estimate the exposure concentration of HCFC-123 via a job simulation experiment. In the simulation, the HCFC-123 exposure concentration was measured with the same working practice and working time as with the workers aforementioned. As a result, the workers who infused HCFC-123 into storage tanks were estimated to be exposed to HCFC-123 at a concentration of $20.65{\pm}10.81ppm$, and a mean concentration of area samples within a working radius were estimated as $70.30{\pm}18.10ppm$. Valve assembly workers working on valves of a fire extinguisher filled with HCFC-123 were exposed to HCFC-123 at concentrations of $91.65{\pm}4.03ppm$ and $115.55{\pm}7.28ppm$, respectively, in the simulation, and area samples simulated within the working radius were also found to be high with concentrations of $122.75{\pm}91.15ppm$ and $126.80{\pm}60.25ppm$, respectively. Nitrogen gas packing workers, who did not handle HCFC-123 directly, were exposed to the agent at a concentration of $71.80{\pm}8.49ppm$. These results suggest that exposure to HCFC-123 at high concentrations for 1.5-2.5 hours caused acute toxic hepatitis in two workers.

Selective Growth of Nanosphere Assisted Vertical Zinc Oxide Nanowires with Hydrothermal Method

  • Lee, Jin-Su;Nam, Sang-Hun;Yu, Jung-Hun;Yun, Sang-Ho;Boo, Jin-Hyo
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.252.2-252.2
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    • 2013
  • ZnO nanostructures have a lot of interest for decades due to its varied applications such as light-emitting devices, power generators, solar cells, and sensing devices etc. To get the high performance of these devices, the factors of nanostructure geometry, spacing, and alignment are important. So, Patterning of vertically- aligned ZnO nanowires are currently attractive. However, many of ZnO nanowire or nanorod fabrication methods are needs high temperature, such vapor phase transport process, metal-organic chemical vapor deposition (MOCVD), metal-organic vapor phase epitaxy, thermal evaporation, pulse laser deposition and thermal chemical vapor deposition. While hydrothermal process has great advantages-low temperature (less than $100^{\circ}C$), simple steps, short time consuming, without catalyst, and relatively ease to control than as mentioned various methods. In this work, we investigate the dependence of ZnO nanowire alignment and morphology on si substrate using of nanosphere template with various precursor concentration and components via hydrothermal process. The brief experimental scheme is as follow. First synthesized ZnO seed solution was spun coated on to cleaned Si substrate, and then annealed $350^{\circ}C$ for 1h in the furnace. Second, 200nm sized close-packed nanospheres were formed on the seed layer-coated substrate by using of gas-liquid-solid interfacial self-assembly method and drying in vaccum desicator for about a day to enhance the adhesion between seed layer and nanospheres. After that, zinc oxide nanowires were synthesized using a low temperature hydrothermal method based on alkali solution. The specimens were immersed upside down in the autoclave bath to prevent some precipitates which formed and covered on the surface. The hydrothermal conditions such as growth temperature, growth time, solution concentration, and additives are variously performed to optimize the morphologies of nanowire. To characterize the crystal structure of seed layer and nanowires, morphology, and optical properties, X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), Raman spectroscopy, and photoluminescence (PL) studies were investigated.

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A Study on the Improvement Case of Cosmetic Packaging Process Using ARENA Simulation (아레나 시뮬레이션을 활용한 화장품 포장공정의 개선사례 연구)

  • Lee, Nam-Su;Lee, Jae-Yong;Jo, Eun-Hyeon;Lee, Dong-Hyung
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.43 no.2
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    • pp.72-78
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    • 2020
  • Demand for cosmetics with functionality and eco-friendliness has increased dramatically due to recent aging, well-being trends, and increased interest in beauty. Cosmetics production in 2014 was 8,970.4 billion won, an increase of about 50% compared to 6,014.6 billion won in 2010. In the midst of this, similar companies in intense competition are pursuing differentiated strategies and innovation activities to solve quality, price and delivery problems. In particular, cosmetics packaging work is getting more difficult due to the increasing bill of materials (BOM) and difficult assembly methods. Therefore, in this study, the following problems were identified and suggestions for the improvement of the packaging Many research laboratories such as biotechnology, chemistry, and pharmaceuticals, which are undergoing various studies, are equipped with ready-made laboratory safety equipments such as bio-safety workbenches, aseptic bases, and exhaust workbenches. However, most researchers are disadvantaged in using existing safety equipment. This is because existing safety equipment can not take into account all of the unique characteristics of the research. For this reason, researchers are demanding the development of customized safety equipment that is well suited to their research needs. process of Company C, which is facing difficult situation to respond to the customer 's delivery due to the 52 - hour work week. First, we used the stopwatch to find the difficulty process in the packaging process and show ways to improve it. Second, to improve the efficiency of line balancing in the packaging process, we integrate processes, improve work methods, and perform simple automation. As a result, the prepare loss for replacement was reduced by 1 minute from 5 minutes, resulting in a 23% increase in productivity from 112 ea./hour to 137ea./ hour per person. At this time, the LOB of the packaging process was improved from 70% to 82% by operating one more production line through one person per line, total 9 people saving.

Experimental Study on Improvement of Pipe-rack Joint (Pipe-rack접합부 개선방법에 관한 실험적 연구)

  • Lee, Jong-Kun
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.22 no.4
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    • pp.1-9
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    • 2018
  • The development of new technology and process in industrial Plant which builds integrated structures, facilities and systems. Has become a key element for strengthening its competitiveness. Although domestic industrial Plant has demonstrated excellence in technology with a persistent increase in order quantity and orders received, the technology gap between countries has narrowed due to global construction trend. Therefore, it is necessary to develop new technology that could help overcome constraints and limitations of the current one to follow the trend in the age of unlimited competition. This study has focused on assembly technology of Pipe-rack joint connection in an effort to strengthen technological competitiveness in industrial Plant. Through an analysis of earlier studies on Pipe-rack and a coMParative analysis of strengths and weaknesses of current assembly technology of it, a new design plan has been made to improve it efficiently. In doing this, standards for design factors of both structural and performance features have been drawn, and value of stress, strain, moment and rotation has been calculated using finite element analysis. As a result, installation technology of modular type Pipe-rack, which has not been developed in Korea and is differentiated from the current one, has been developed. It is considered that the technology reduces work time and saves cost due to simplified joint connection of steel structure, unlike the current one. Moreover, since it is installed without a welding process in the field, industrial accidents would be reduced, which is likely to have economic competitiveness and satisfy.

A Study on the Model of Inter-library Cooperation's Network in the Information of Library Materials (정보의 상호협력을 위한 네트웍모형에 관한 연구)

  • 권기원
    • Journal of Korean Library and Information Science Society
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    • v.4
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    • pp.39-60
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    • 1977
  • The purpose of this study is to build a model of inter-library cooperation's network in the information of library materials. Results of this study are 1. The YTational Assembly Library and the Central National I, ibrar:; should be unified. 2. The unified organization should be organized its cooperative quarter for itself (in the Central National Library). .And every library should he organized his quarter and personnel for the inter-library cooperation. 3. The cooperatior, organization in the re~ion should organized by the Regional Central Public Library. 4. In case of the Central National Library, financial problems required of the performance in the inter-library cooperation should he charged equally among the Central National Library, the library belong to the reader and the reader. In case of the regional Central Public Library, it should be charged equally arnozlg the regional Central Public Library, the library belon-g' to the reader and the reader. 5. The Regional Central Public Library in the seat of provincial government should be managed the cooperation's work of the individual library, and upward the unified Central Xarional Library should generalize. 6. The purchase of materials should be done by the character of the each library 1r:ith the assignment of the each subject should be decided in the meeting of the each library personne!. -2nd the budget for purchasing per the year should be decided on the minimum by the circumstances of the each library regionally. 7. The unified Regional Central Public Library in the seat of provincial government should be charged of the Union Catalog's expense regionally, and the Central National Library should be charged of that National Union Catalog's expense to cumulative the Fegional Union Catalog within a definite period of time. 8. Books without presentation of a specimen copy to the unified Central National Library should be purchased, and r.cr 'oe included to the National Union Catalog. 9. The cooperation of the each library should be decided on the law, and considered the character of the each region.

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Posture Analysis of Workers in an Excavator Factory Using 3D Human Simulation (3D 작업자 시뮬레이션을 이용한 굴삭기 생산공정 작업자 자세분석)

  • Moon, Dug-Hee;Baek, Seung-Geun;Zhang, Bing-Lin;Lee, Jun-Seok
    • Journal of the Korea Society for Simulation
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    • v.15 no.3
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    • pp.93-101
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    • 2006
  • Recently, work-related musculoskeletal disorders (WMSDs) become a hot issue in the industrial fields. To prevent the potential risk of workers, various approaches have been adopted. One of the approaches is to improve the design of product, that of jig (or fixture) and that of workstation in the early stage of the development. 3D simulation technology is known as the powerful method for detecting such problems before constructing the workstation, because it is possible to evaluate the posture of worker using 3D models in a cyber space. It enables to find the unexpected problems and save the time and cost for redesign and rework. This paper introduces a 3D simulation case study of workers in an excavator factory. 3D models of products, jigs were developed with CATIA. The assembly processes were animated in IGRIP and DPM. Finally the various postures of worker were simulated using Human. As a result, some postures were analysed as the risky jobs and the result of simulation was used to improve the system.

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A Study on the Development of Automated Gangform Climbing System for Apartment Housing Construction (공동주택 전용 갱폼 인양 자동화 기술 개발에 관한 연구)

  • Yang, Sang-Hoon;Cho, Jae-Yong;Cho, Ji-Won;Lee, Jeong-Ho;Kim, Young-Suk
    • Korean Journal of Construction Engineering and Management
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    • v.13 no.1
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    • pp.53-66
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    • 2012
  • Gangform compared with conventional wood and steel form is systemized form which has a capability to install and dismantle form at a time without repeating to assembly and disassembly small members. Gangform compared with ACS has some problems such as 1) Tower Crane load increase, 2) increase in safety incidence during climbing Gangform, 3) decrease in detachment operation productivity, 4) stop work due to climate impacts, and 5) decrease in labor cost, productivity, quality. A conceptual design model of automated Gangform climbing system is suggested for apartment housing construction to show its technical/economic feasibility and workers' safety while increasing operation productivity and concrete quality.

Development of PEID for Acquiring Maintenance Information during Product Lifecycle of Marine Vessels (선박해양구조물의 제품수명주기 내 유지보수 정보 획득을 위한 PEID에 관한 연구)

  • Jeon, Jeong-Ik;Lee, Jang-Hyun;Son, Gum-Jun
    • Journal of Ocean Engineering and Technology
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    • v.26 no.5
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    • pp.63-72
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    • 2012
  • The product lifecycle of a marine vessel can be classified into the design-production, operation-maintenance, and disposal phases. During the operation and maintenance phase, status data should be gathered from the major machinery and instruments installed on the marine vessel in order to perform efficient maintenance work. Although a PLM (product lifecycle management) system can manage the product information during the design and assembly stage, a PLM based on asset management technology is more appropriate for product information management during the operation stage. Product embedded information devices (PEIDs) are suggested for gathering real-time maintenance information during the operation and maintenance lifecycle. A PEID allows PLM to provide the capability of offering active information exchange between the lifecycle management system and equipment. This study designed a PEID to effectively obtain information and interact with a PLM system. It consists of sensors, wireless communication, and a micro-processor, which allow it to accumulate status data on the PLM system. The embedded information device and PLM enable the seamless information flow, tracking, and updating of MRO (maintenance repair and overhaul) information for a product throughout the middle of the product lifecycle.

Strengthening BCP for the Prevention of Infectious Diseases in Companies (기업의 감염병 예방을 위한 BCP 강화방안 연구)

  • Kim, Young-Kook;Jeong, Kyung-Ok;Yang, Kyung-Ah
    • Journal of the Korea Safety Management & Science
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    • v.23 no.3
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    • pp.11-18
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    • 2021
  • As the number of confirmed cases of Covid-19 is not decreasing, it is time for domestic companies to respond preemptively and in terms of business continuity. The purpose of this study is to present measures to strengthen BCP to prevent infectious diseases in the enterprise. In this work, three methods of data investigation are used. The first was to search for keywords in academic databases such as the National Assembly Library and the Korea Research and Information Service to investigate degree papers and academic papers. Second, we investigated literature such as research reports, manuals, and guidelines on infectious diseases. Finally, the researchers visited official websites such as KDCA, MOHW, and MOIS to collect and analyze recent data. BCP In view of the Board, a new risk analysis should be made and a disaster preparedness system tailored to the characteristics of the entity should be established. We need to analyze corporate weaknesses and focus on safety culture. It is also important to look at how customers choose their services and products. Based on this, differentiated service strategies should be presented. It is hoped that the results of this study can be used as basic data for companies that want to systematically manage and operate BCP to prevent infectious diseases.

Whole-Genome Characterization of Alfalfa Mosaic Virus Obtained from Metagenomic Analysis of Vinca minor and Wisteria sinensis in Iran: with Implications for the Genetic Structure of the Virus

  • Moradi, Zohreh;Mehrvar, Mohsen
    • The Plant Pathology Journal
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    • v.37 no.6
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    • pp.619-631
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    • 2021
  • Alfalfa mosaic virus (AMV), an economically important pathogen, is present worldwide with a very wide host range. This work reports for the first time the infection of Vinca minor and Wisteria sinensis with AMV using RNA sequencing and reverse transcription polymerase chain reaction confirmation. De novo assembly and annotating of contigs revealed that RNA1, RNA2, and RNA3 genomic fragments consist of 3,690, 2,636, and 2,057 nucleotides (nt) for IR-VM and 3,690, 2,594, and 2,057 nt for IR-WS. RNA1 and RNA3 segments of IR-VM and IR-WS closely resembled those of the Chinese isolate HZ, with 99.23-99.26% and 98.04-98.09% nt identity, respectively. Their RNA2 resembled that of Canadian isolate CaM and American isolate OH-2-2017, with 97.96-98.07% nt identity. The P2 gene revealed more nucleotide diversity compared with other genes. Genes in the AMV genome were under dominant negative selection during evolution, and the P1 and coat protein (CP) proteins were subject to the strongest and weakest purifying selection, respectively. In the population genetic analysis based on the CP gene sequences, all 107 AMV isolates fell into two main clades (A, B) and isolates of clade A were further divided into three groups with significant subpopulation differentiation. The results indicated moderate genetic variation within and no clear geographic or genetic structure between the studied populations, implying moderate gene flow can play an important role in differentiation and distribution of genetic diversity among populations. Several factors have shaped the genetic structure and diversity of AMV: selection, recombination/reassortment, gene flow, and random processes such as founder effects.