• Development and Reproduction
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• v.18 no.1
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• pp.65-71
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• 2014

Cell cycle process is regulated by a number of protein kinases and among them, serine/threonine kinases carry phosphate group from ATP to substrates. The most important three kinase families are Cyclin-dependent kinase (Cdk), Polo-like kinase (Plk), and Aurora kinase. Polo-like kinase family consists of 5 members (Plk1-Plk5) and they are involved in multiple functions in eukaryotic cell division. It regulates a variety of aspects such as, centrosome maturation, checkpoint recovery, spindle assembly, cytokinesis, apoptosis and many other features. Recently, it has been reported that Plks are related to tumor development and over-expressed in many kinds of tumor cells. When injected the anti-Plk antibody into human cells, the cells show aneuploidy, and if inhibit Plks, most of the mitotic cell division does not proceed properly. For that reasons, many inhibitors of Plk have been recently emerged as new target for remedy of the cancer therapeutic research. In this paper, we reviewed briefly the characteristics of Plk families and how Plks work in regulating cell cycles and cancer formation, and the possibilities of Plks as target for cancer therapy.

• Journal of muscle and joint health
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• v.21 no.3
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• pp.255-264
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• 2014

Purpose: The purpose of the study were to analyze the research trends of compassion fatigue in Korea nurses and to suggest future research directions. Methods: For this study, RISS, KISTI, KISS, National Assembly Library databases were searched using the key words 'compassion fatigue', 'secondary traumatic stress', 'professional quality of life' that contains compassion fatigue as a sub-element, and 'nurses' for this study. A total of 124 articles published in June 2014 were searched and analyzed 19 articles for the final analysis. Results: The most frequently used study design was descriptive (N=17, 89.5%). High compassion fatigue was reported in this study. Factors affecting compassion fatigue were personal factors (e.g., age, health state, and sleep hours), work-related factors (e.g., experience with traumatized patients), and psychological factors (e.g., job stress, anxiety, excessive empathy, social support, and coping strategy). Finally, Consequence factors of compassion fatigue was reported burnout, silencing response and turnover intention. Conclusion: There was a few studies on compassion fatigue. Further research on compassion fatigue needs to use a variety of study designs instruments suitable for Korean nurses, and to develop management programs on compassion fatigue in nurses.

• The Journal of Korean Physical Therapy
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• v.32 no.4
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• pp.258-265
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• 2020

Purpose: This study examined the legal basis related to a physical therapist's home-based rehabilitation. Methods: The policy data were referenced to the comprehensive plan for national health promotion and the guidebook Community Health Promotion Project issued by the Korea Health Promotion Institute and other institutes. The legal data were referenced to the Bill information system on the National Assembly website. Results: The physical therapist's home-based rehabilitation did not have a legal basis in the community-based rehabilitation project (CBR) of the HP 2020 project. On the other hand, according to the Home health care part of the community health promotion project that began in 2013, physical therapists were allowed to play a role from 2020 under Article 16-2 (Public Officials in Exclusive Charge of Visiting Health Management) of the REGIONAL PUBLIC HEALTH ACT. Conclusion: Policies and laws are being developed in the field of healthcare, but the necessary policies and laws in the field of rehabilitation are still insufficient. A bill to rehabilitate in a variety of fields and spaces by modifying the scope of work of physical therapists will be needed.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.360-360
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• 2011

In this work, SUS310S used for valve plate assembly was electron beam (EB) welded to determine the influence of the parametric conditions on the characteristics of the weld and to minimize porosity and micro-fissures among others. The evolution in the weld geometry and microstructure was examined as a function of the process conditions such as beam current and focusing current under a constant welding speed and accelerating voltage. The integrity of the EB welds in SUS310S was examined for defects (e.g. cracking, porosity, etc.), adequate penetration depth, and tolerable weld width deviation for the various welding conditions. Optical microscopy (OM), x-ray photoelectron spectroscopy analysis (XPS), scanning electron microscopy (SEM) and 3D micro-computed tomography (Micro-CT) for the cross section analysis of the electron beam welded SUS310S were utilized. The tensile strength and hardness were analyzed for the mechanical properties of the EB weld. At the 6 kV accelerating voltage, it was determined that a satisfactory penetration depth and desirable weld width deviation requires a beam current of 30 mA and a focusing current of 0.687 A at the welding speed of 25 mm/sec.

• Design & Manufacturing
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• v.2 no.4
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• pp.54-61
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• 2008

Warpage, which is one of the molding trouble, acts as possible factor which results in defect in assembly. In this study, a mold was designed to produce specimens with rib parallel to flow direction, specimens with rib perpendicular to flow direction and specimens without rib. This work researched change of warpage according to injection molding condition such as injection pressure, packing pressure, packing time, resin temperature, mold temperature in non-crystalline resins(PC, ABS), crystalline resins(PP, PA66), and 30% glass fiber reinforced-resins(PC, ABS, PP, PA66).Specimens with rib and Crystalline resins show more warpage than specimens without rib and non-crystalline resins, respectively. Glass fiber reinforced-resins and specimens with rib parallel to flow direction show smaller warpage than conventional resins and specimens with rib perpendicular to flow, respectively. Specimens with rib and specimens without rib show reduced warpage as packing time increases. In addition, warpage increase as resin temperature increases. It is found that CAE shows similar tendency with experiment as packing time, resin temperature. when the rib is caused, warpage will reduce and prevent the transformation. product of a irregular form occurs warpage. In the study It'll be basic data that product occurs warpage, preferablity.

• Nuclear Engineering and Technology
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• v.48 no.5
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• pp.1126-1139
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• 2016

In this research, for the first time, a new optimization method, i.e., strength Pareto evolutionary algorithm II (SPEA-II), is developed for the burnable poison placement (BPP) optimization of a nuclear reactor core. In the BPP problem, an optimized placement map of fuel assemblies with burnable poison is searched for a given core loading pattern according to defined objectives. In this work, SPEA-II coupled with a nodal expansion code is used for solving the BPP problem of Kraftwerk Union AG (KWU) pressurized water reactor. Our optimization goal for the BPP is to achieve a greater multiplication factor ($K_{eff}$) for gaining possible longer operation cycles along with more flattening of fuel assembly relative power distribution, considering a safety constraint on the radial power peaking factor. For appraising the proposed methodology, the basic approach, i.e., SPEA, is also developed in order to compare obtained results. In general, results reveal the acceptance performance and high strength of SPEA, particularly its new version, i.e., SPEA-II, in achieving a semioptimized loading pattern for the BPP optimization of KWU pressurized water reactor.

• Proceedings of the SAREK Conference
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• 2008.06a
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• pp.637-642
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• 2008

The concept of district heating involves centralised heat production where heat is distributed to consumer via a piping network. The objective of this work is to identify the Flexible Pipe from an economy, execution, maintenance point of view. Flexible Pipe has in some countries, especially in Europe, been used for many years in district heating. In spite of years of experience, there still exist doubts about the possibilities of using flexible pipes in district heating applications, mostly because of no experiences in domestic market. The advantage of flexible pipe systems is their flexibility. This holds not only for the inner pipe but also for the total pipe system including insulation and jacket. Even for the largest diameter the minimum radius of curvature is given to 1.5m. The most important difference between flexible pipe systems and preinsulated steel pipes is their simple and quick assembly. Such information could provide a basis for making reasonable hypotheses about consumer preferences, to foam a basis for making future marketing more effective.

• Nuclear Engineering and Technology
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• v.33 no.4
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• pp.441-456
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• 2001

ABB-CE＇s regionalization methodology for the core inlet flow distribution map is reviewed. This methodology merges the test data of fuel assembly locations which are either in symmetry or strongly correlated with others. It increases the number of available test data for each regional flow factor It makes up effectively for the deficiency due to limited number of test data. It also contributes to making the core inlet flow distribution smoother not only locally but also over the entire core, and to relieving the impacts of test errors that may happen due to some do- calibrated local pressure measurement taps. As a result, the core inlet How distribution data becomes more statistically useful and thus the conservatism involved in handling the core inlet flow factors for the thermal margin analysis is expected to be reduced. Meanwhile, the regionalized map may lose the unique local characteristics in core inlet flow distribution too much. By an alternative approach introduced in the present work, it is shown that such a disadvantage can be mitigated somewhat if the engineering judgement is made more

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2008.06a
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• pp.143-143
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• 2008

Nanowires are promising options for building nanoscale electronic structures coming from high conductivity of nanowires. In particular, Deoxyribonucleic acid (DNA), which is structurally nanowire, can obtain highly ordered electronic components for nanocircuitry and/or nanodevices because of its very flexible length controllability, nanometer-size diameter, about 2 nm, and self-assembling properties. In this work, we used the method to form DNA-Nanowires (NWs) by using chemical treatment on Silicon (Si) surface, and Aminopropyl-triethoxysilane (APTES) was used as inducer of DNA sequence to modify the characteristics of Si surface. Moreover, we performed tilting technique to align DNA by the direction of flow of DNA solution. We investigated the assembly process between DNA molecules and APTES - coated Si surface according to the APTES concentration, from $1.2{\mu}\ell$ to $120{\mu}\ell$. Atomic Force Microscopy (AFM) images showed the combination rate of DNA molecules by the change of APTES concentration. As APTES concentration becomes thicker, aggregation of DNA molecules occurs, and this makes a kind of DNA networks. In this respect, we confirmed that there's a positive relationship between the concentration of APTES and the formation rate of DNA nanowires. Since there have been lots of research preceded to utilize DNA nanowires as template, so by using this positive relationship with proper alignment technique, realization of nano electronic devices with DNA nanowires might be feasible.

• Journal of the Ergonomics Society of Korea
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• v.22 no.1
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• pp.43-56
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• 2003

Observational methods such as OWAS, RULA, and REBA have been widely used to identify posture-related risks of musculoskeletal disorders in industry, since they are useful and efficient in evaluating postural stresses. However. there are few studies comparing the methods and providing guidelines for selecting and using the methods. They have been developed based on different backgrounds and with different application areas. Each method has its own characteristics. which must be considered in selecting and using them. In this study. 17 male subjects evaluated 42 different working postures that frequently assumed in the automobile assembly line using a psychophysical method. The postures were then evaluated by different observational methods. The results of the observational methods were compared with psychophysically evaluated stresses. The observational methods resulted in different values of stresses for certain postures. For some postures showing high values of perceived discomfort. the observational methods showed different values of stresses. These results showed that the observational methods should be used differently according to application area and they have some weak points to be improved.