• BMB Reports
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• v.49 no.9
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• pp.459-473
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• 2016

Neurodegenerative diseases (NDs) often involve the formation of abnormal and toxic protein aggregates, which are thought to be the primary factor in ND occurrence and progression. Aged neurons exhibit marked increases in aggregated protein levels, which can lead to increased cell death in specific brain regions. As no specific drugs/therapies for treating the symptoms or/and progression of NDs are available, obtaining a complete understanding of the mechanism underlying the formation of protein aggregates is needed for designing a novel and efficient removal strategy. Intracellular proteolysis generally involves either the lysosomal or ubiquitin-proteasome system. In this review, we focus on the structure and assembly of the proteasome, proteasome-mediated protein degradation, and the multiple dynamic regulatory mechanisms governing proteasome activity. We also discuss the plausibility of the correlation between changes in proteasome activity and the occurrence of NDs.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.11a
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• pp.276-276
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• 2003

This paper dealt with an experimental study on the free vibration of circular-tube-beam submerged in water. A circular-tube-beam is commonly founded on the nuclear fuel assembly system in nuclear reactor. The nuclear fuel assembly susceptible to flow-induced vibration in nuclear reactor. So, the nuclear fuel assembly be designed to avoid any resonance due to the vibration during the reactor operation. In the experiment, applied boundary condition is clamped-free and the effect of water height to natural frequency and damping is studied. The experiment in air and in water has been performed. Used experimental method is impact exciting method. The natural frequencies and damping ratio according to water height is presented.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.08a
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• pp.204-204
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• 2011

During past decades, several types of peptide-based scaffolds, ranging from simple aromatic dipeptide to small protein fragments, have been studied to understand the underlying mechanism and mimic to create artificial nano/microstructures. However, a limited number of design principles have still been reported in peptidic scaffolds allowing well-defined self-assembled structure formation, presumably due to the intrinsic large conformational flexibility of natural peptides. In this presentation, we report the first example of highly homogeneous, well-defined and finite architectures by the ${\beta}$-peptide self-assembly.

• Bulletin of the Korean Chemical Society
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• v.35 no.1
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• pp.45-50
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• 2014

A fully packed capillary electrochromatographic (CEC) microchip with an on-column micro-solid phase extraction (SPE) bed for the preconcentration and separation of organic analytes was prepared. A linear microchannel with monodisperse colloidal silica packing was formed on a cyclic olefinic copolymer microchip with two reservoirs on both ends. Silver-cemented silica packing frit structure was formed at the entrance of the microchannel by electroless plating treatment as a base layer. A gold coating was formed on it by reducing $Au^{3+}$ to gold with hydroxylamine. Finally micro-SPE bed was formed by self-assembly adsorption of 1-dodecanethiol on it. Micro-SPE beds were about 100-150 ${\mu}m$ long. Approximately $10^3$ fold sensitivity enhancements for Sulforhodamine B, and Fluorescein in nM concentration levels were possible with 80 s preconcentration. Basic extraction characteristics were studied.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.985-990
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• 2003

With the rotational speed of the hard disk drive (HDD) increased, the low frequency structural vibration induced by the unbalance force gives rise to the structure home noise of the personal computer, and finally degrades the noise quality. As the unbalance of the hard disk drive is decided by the mechanical assembly allowance between clamping and platter disk, there is limit to control this unbalance by the improved assembly method. To improve the noise and vibration performance of PC, basically the unbalance of HDD needs to be measured absolutely and reduced during the stage of the disk assembly. This study introduces the HDD unbalance measurement methods of the absolute magnitude based on the mobility concept, and the unbalance location information with the acceleration orbit.

• Korean Journal of Computational Design and Engineering
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• v.7 no.3
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• pp.170-176
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• 2002

To exchange CAD data between heterogeneous CAD systems, we generally use a neutral format especially STEP, which is the international standard (ISO-10303) for product model data exchange. AP214 (Application Protocol) for the automotive industry not only takes into account geometry and organizational data, but also provides a classification mechanism for product modeling. When reading a STEP file during a design process that is exported from other CAD systems, it is a burden to a designer to go through the tedious process of removing duplicate or non-manifold entities, adjusting parts, and rearranging text. We analyze the structure of AP214 and develop a healing tool to solve the following problem. Without the assembly information in the Master workspace of CATIA, or to read a STEP file from Pro/Engineer, a designer should do a repetitive process of disintegrating an assembly into parts one by one. We have developed a post-processing tool for STEP AP214 that separates out a part from an assembly model and adjusts superfluous or useless entities using the ACIS kernel.

• Proceedings of the Korean Nuclear Society Conference
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• 2002.05a
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• pp.123.2-123
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• 2002

• Journal of Welding and Joining
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• v.24 no.5
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• pp.22-28
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• 2006

A spacer grid assembly, which is an interconnected array of slotted grid straps and is welded at the intersections to form an egg crate structure, is one of the main structural components of the nuclear fuel assembly for Pressurized Water Reactors (PWRs). The weld quality of spacer grids in PWRs fuel is extremely important for the fuel assembly performance in the nuclear renter. The spacer grid welds are currently evaluated mainly by the metallographic examination although it reveals only cross-points which are welded by the laser beam. This experiment is also to compare the weldability of Zircaloy-4 spacer grids using by the GTA and LB. The effect of node geometries of spacer grids for the GTAW and LBW has been studied and optimum conditions of spacer grid welding have been found. Microstructures and micro-hardness of the GTA and LB welded zones have been also compared.

• Journal of the Korean Operations Research and Management Science Society
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• v.35 no.3
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• pp.25-43
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• 2010

We consider a multi-objective balancing and sequencing problem in mixed model assembly lines, which is important for an efficient use of the assembly lines. In this paper, we present a neighborhood symbiotic evolutionary algorithm to simultaneously solve the two problems of balancing and model sequencing under multiple objectives. We aim to find a set of well-distributed solutions close to the true Pareto optimal solutions for decision makers. The proposed algorithm has a two-leveled structure. At Level 1, two populations are operated : One consists of individuals each of which represents a partial solution to the balancing problem and the other consists of individuals for the sequencing problem. Level 2, which is an upper level, works one population whose individuals represent the combined entire solutions to the two problems. The process of Level 1 imitates a neighborhood symbiotic evolution and that of Level 2 simulates an endosymbiotic evolution together with an elitist strategy to promote the capability of solution search. The performance of the proposed algorithm is compared with those of the existing algorithms in convergence, diversity and computation time of nondominated solutions. The experimental results show that the proposed algorithm is superior to the compared algorithms in all the three performance measures.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.16 no.1
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• pp.30-36
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• 2020

In SMART, the flow mixing header assembly (FMHA) is used to mix the coolant flowing into the reactor core to maintain a uniform temperature. The FMHA is designed to have enough stiffness so the resonance with reactor internal structures does not occurs during the pipe break and the seismic accidents. Since the gap between the FMHA and the core support barrel assembly is very narrow compared with the diameter of FMHA, the hydrodynamic mass effect acting on the FMHA is not negligible. Therefore the hydrodynamic mass characteristics on the FMHA are investigated to consider the fluid and structure interaction effects. The result of modal analysis for the dry and underwater conditions, the natural frequency of primary vibration mode for the horizontal direction is reduced from 136.67 Hz to 43.76 Hz. Also the result of frequency response spectrum seismic analysis for the dry and underwater conditions, the maximum equivalent stress are increased from 13.89 MPa to 40.23 MPa. Therefore, reactor internal structures located in underwater condition shall consider carefully the hydrodynamic mass effects even though they have sufficient stiffness required for performing its functions under the dry condition.