• 동의생리병리학회지
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• 제24권5호
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• pp.866-871
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• 2010

The antidiabetic effects of Rosa rugosa Radix were investigated in streptozotocine-induced diabetic rats. Research methods and procedure: In the present study, effects of oral administration of Rosa rugosa Radix extract(100, 250, and 500 mg/kg body wt.) for 28 days on the level of serum glucose, total cholosterol, triglycerides, cereatinine, aspartate amino transferase(AST) and alanine amino transferase(ALT) in normal and streotozotocine-induced diabetic rats were evaluated. Oral administrations of the Rosa rugosa Radix extract significantly decreased serum glucose, total cholesterol, triglyceride, AST, and ALT levels, while increased serum insulin and HDL-C in diabetic rats(p<0.05). The hypoglycemic effect of the Rosa rugosa Radix extract was more effective than normal group. It is concluded that the Rosa rugosa Radix must be considered as excellent candidate for future studies on diabetes mellitus.

• 한국임상수의학회지
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• 제17권1호
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• pp.163-167
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• 2000

Cholelithiasis and choledolithiasis were diagnosed with serum chemistry, abdominal radiography and ultrasonography in a 2.0 kg, 10 year-old Yorkshire Terrier dog showing signs of anorexia, vomiting, iceterus and depression. In serum chemistry, the level of alanine transferase, alkaline phosphatase, aspartate transferase, total bilitrubin and direct bilirubin were elevated. On abdominal radiographs, focal lesions with increased radiopacity were seen in the hepatic region and the size of liver was increased. In ultrasonographic examination, it were seen that distension of gall bladder, hypercehoic change of liver, obstruction of cystic duct by calcult and calculi in the gall bladder. Cholecystectomy was undertaken and there were no complications after the operation.

• 생물정신의학
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• 제24권4호
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• pp.219-224
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• 2017

Objectives This study sought to investigate the relationship between age, sex and alterations in levels of % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transferase (GGT) in patients admitted with alcohol dependence. Methods The study retrospectively enrolled 187 patients who were diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) and were admitted into a closed ward in Hallym University Hangang Sacred Heart Hospital from 2009 to 2012 and Hallym University Kangnam Sacred Heart Hospital from 2012 to 2017. Demographic factors (age, sex) and biochemical markers [%CDT, GGT, mean corpuscular volume (MCV), aspartate transferase (AST), alanine transferase (ALT)] were collected by reviewing medical records. Alterations in the levels of %CDT and GGT in different groups for each demographic factor were compared after correcting for confounding variables (age, initial %CDT, GGT, MCV, AST, ALT). Results Decreased %CDT and GGT were observed during the period of abstinence after admission. The normalization period for %CDT increased with age, while the normalization period for GGT was longer in female patients. Conclusions These results suggest that alcohol-dependent patients that vary in age have different alterations in %CDT, while different sexes have different alterations in GGT. Age and sex can be potential indicators of treatment response after abstinence in patients with alcohol dependence. Further studies are needed to evaluate the relationship between these factors with regards to physiological and hematological changes in alcohol dependence.

• 한국식품영양과학회지
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• 제37권3호
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• pp.302-308
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• 2008

비배당체 이소플라본 고함유 대두분말이 고지방식이를 섭취한 흰쥐의 지질대사와 항산화 효과에 미치는 영향을 조사하고자 식이성 고지혈 흰쥐를 정상군(NO), 고지방식이군(CO), 고지방식이에 비배당체 이소플라본 고함유 대두분말 10%, 20%(w/w) 첨가군(BFF10, BFF20)으로 나누어 7주간 사육한 결과는 다음과 같다. 비배당체 이소플라본 고함유 대두분말 섭취는 체중과 간 무게를 유의적으로 감소시켰으며, CO군에 비해 혈청의 총 콜레스테롤, LDL-콜레스테롤, 중성지질 농도가 유의적으로 감소하였다. 간조직 손상시 활성증가가 우려되는 alanine amino transferase와 aspartate amino transferase 수준도 유의적으로 감소하였다. Thiobarbituric acid reactive substance의 생성량은 비배당체 이소플라본 고함유 대두분말의 첨가량이 높을수록 현저하게 감소되었으며 superoxide dismutase 활성은 농도 의존적으로 증가시키는 것으로 나타났다.

• 한국방사선학회논문지
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• 제17권3호
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• pp.423-431
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• 2023

본 연구의 목적은 환자의 신체정보와 인공지능 기법을 활용하여 부작용에 영향을 미치는 인자들을 분석하고 조영제 부작용의 정도를 예측하여 이를 완화하는 기초자료로 활용되고자 한다. 연구에 사용한 데이터는 서울 소재 종합병원의 검진을 시행한 CT 검사 58,000건 중 조영제 부작용이 발생한 1,235건 중 과거력 조사에서 조영제 부작용이 없었던 606명의 검사자를 대상자로 하였다. 606개 샘플 중 70%는 훈련 셋으로 사용하고 나머지 30%는 검증을 위한 테스트 셋으로 사용하였다. 나이, BMI(Body Mass Index), GFR(Glomerular Filtration Rate), BUN(Blood Urea Nitrogen), GGT(Gamma Glutamyl Transgerase), AST(Aspartate Amino Transferase,), and ALT(Alanine Amiono Transferase)의 feature를 독립변수로 조영제 중증도를 목표변수로 사용하였다. AdaBoost, Tree, Neural network, SVM, Random foest 알고리즘을 통해 AUC(Area under curve), CA(Classification Accuracy), F1, Precision, Recall을 파악하였다. 분류 예측에 사용된 알고리즘 중 가장 높은 평가지표를 나타내 것은 AdaBoost와 Random Forest이다. 모든 모델의 예측에서 가장 큰 요인은 GFR, BMI, GGT 이였다. 이는 신장 여과 기능, 비만에 따라 주입되는 조영제 양의 차이와 대사증후군의 여부에 따라 조영제 부작용 중증도에 영향을 미치는 것을 알 수 있었다.

• Advances in Traditional Medicine
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• 제10권4호
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• pp.263-270
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• 2010

Scoparia dulcis L. is widely used in the traditional system of medicine for treating liver ailments. In the present study the terpenoids and terpenoid fractions isolated from 1:1:1 petroleum ether, diethyl ether and methanol (PDM) extract of Scoparia dulcis L. were tested for their in vitro 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Selected samples from the assay were further tested for their in vitro hepatoprotective activity against $CCl_4$ induced hepatotoxicity in freshly isolated rat hepatocytes. In the in vitro antioxidant study, fractions 7, 11, 13, 14, and 15 and PDM extract show the DPPH radical scavenging activity. The phytochemical screening of all these fractions show the presence of terpenoids. In the in vitro hepatoprotective study all these fractions and the PDM extract significantly prevent the $CCl_4$ induced changes in the aspartate aspartate amino transferase, alanine amino transferase and alkaline phosphatase levels (p < 0.05). The above results are comparable with the standard, silymarin. The results of the study indicate that, the PDM extract of Scoparia dulcis L. possesses potential hepatoprotective activity and this may be attributed to its free radical scavenging potential, which in turn may be attributed to the presence of terpenoids.

• 한국식품영양학회지
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• 제29권3호
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• pp.411-419
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• 2016

In this study, we determined the effect of the mulberry leaf powder on blood lipid metabolism and liver function improvement of mice fed a high fat diet. The mulberry leaf showed a moisture content of $10.74{\pm}0.56%$, ash $9.67{\pm}0.56%$, crude protein $25.24{\pm}1.02%$, and crude fat $2.66{\pm}0.08%$. In the group with high fat diet supplemented with mulberry leaf powder, serum low-density lipoprotein (LDL-cholesterol) and total cholesterol levels were significantly lower (p<0.05); also, serum phospholipid and aspartate amino transferase (AST) levels were significantly lower (p<0.05). Serum insulin and leptin levels were high in mice fed a high fat diet; however, addition of mulberry leaf powder 10% in the diet had no significant effect on blood insulin and leptin control. The results of the study suggested that various plant sterols in mulberry leaf improve lipid metabolism and liver function in ICR-mice.

• Asian-Australasian Journal of Animal Sciences
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• 제9권4호
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• pp.471-476
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• 1996

Blood biochemical and histopathological changes in vital organs of rabbits were studied after 19 wk of feeding composite diets (75 concentrate : 25 roughage) incorporating either urea (2%, wt/wt) ammoniated or alkali (1.5%, wt/wt) treated neem kernel meal (NKM) replacing peanut meal protein of control diet by either 50 or 100%. The blood biochemical constituents (Haemoglobin, Alanine amino transferase, Aspartate amino transferase, Total protein, Blood urea nitrogen &Cholesterol) in rabbits fed on processed NKM diet at either levels, were comparable to the values of thos on control diet except a lowered (p < 0.05) blood glucose concentration in processed NKM fed rabbits as compared to that in control diet fed ones. Histological examination revealed increased goblet cell activity, stunting of jejunal villi, mild tubular degeneration in kidney and hepatic fibro-cellular reaction in rabbits fed on urea ammoniated and alkali treated NKM diets with less marked changes in the latter. Testicular changes with variable degree of disorganization and vacuolation of spermatogonial cells were noticed in rabbits fed higher levels of urea-ammoniated and alkali treated NKM. Thus, alkali treatment and urea-ammoniation were effective in detoxification of meal, but the processing technology is to be further perfected to prevent cumulative effect of residual neem bitters in long term feeding.

• 동의생리병리학회지
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• 제25권5호
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• pp.919-926
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• 2011

The purpose of this study is to inspect trends of the paper of Korean medical treatment on Carbon Tetrachloride-induced Hepatotoxicity and try to establish the future direction for development of Korean herbal medicine. We reviewed 79 papers which had been published from 1981 to 2010 in journals published in Korea. According to these studies, Carbon Tetrachloride-induced hepato-celluar degeneration and necrosis induced to increase in serum aspartate amintransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), ${\gamma}$-Glutamyl transferase (${\gamma}$-GTP), lactate dehydrogenase (LDH), bilirubin, blood urea nitrogen (BUN) and albumin levels. In biochemical analyses, antioxidant enzymes such as superoxide dismutase (SOD), Glutathione S-transferase (GST) and catalase in hepatic tissue were remarkably incresed by Carbon Tetrachloride treatment. We found that some of the herbal extracts have a protective effect against Carbon Tetrachloride-induced Hepatotoxicity. More studies of oriental medicinal herbs are required for developing a treatment of hepatotoxicity.

• Natural Product Sciences
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• 제12권1호
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• pp.8-13
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• 2006

The present study was carried out to investigate the hepatoprotective effect of the extract of Pterocarpus santalinus Linn on acute hepatotoxicity induced in Wistar albino rats by a single dose of Galactosamine (400 mg/kg). Suspensions of methanolic extract of heartwood of P. santalinus (200 and 400 mg/kg) in 0.3% Carboxy Methyl Cellulose (CMC) were administered p.o. to experimental animals and hepatoprotective activity was monitored by estimating aspartate amino transferase (ASAT, GOT), alanine amino transferase (ALAT, GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), total cholesterol (TC), triglycerides (TGL), albumin, total protein (TP) levels. The methanolic extract significantly reduced the elevation of serum transaminases and alterations of biochemical parameters induced by hepatotoxin, and alleviated the degree of liver damage. The results were supported by histopathological studies of liver samples showing regeneration of hepatocytes in treated animals. Silymarin (25 mg/kg), a known hepatoprotective drug was used for comparison. Based on the results obtained, it can be concluded that P. santalinus exerts hepatoprotective activity and may serve as a useful adjuvant in several clinical conditions associated with liver damage.