• Journal of Sensor Science and Technology
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• v.16 no.1
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• pp.44-51
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• 2007

A hybridized simulator for generating blood pressure waveform is proposed to study the remedy and/or evaluation of the conventional sphygmomanometer utilizing the oscillometric method which is widely applied. The blood pressure of a flowing fluid was controlled for the blood vessel's condition caused by a rhythmical and periodical contraction/relaxation because of the special excitatory and conductive system of the heart. In this study, a hybridized controller composed of the PI feedback controller and the feedforward controller. The inverse dynamics function is proposed to operating the control valve while the pressure is applied in an oil pressure tank. The proposed hybrid simulator reproducing the blood pressure waveform in an artificial blood vessel has kept the control performance consistent over all range. Based on these results, the proposed simulators could be applied to the development and compensation of the non invasive sphygmomanometer type as well as to study the characteristics of the blood pressure and blood vessel.

• Biomaterials and Biomechanics in Bioengineering
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• v.3 no.3
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• pp.141-155
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• 2016

Two-dimensional (2D) cell culture and in vivo cancer model systems have been used to understand cancer biology and develop drug delivery systems for cancer therapy. Although cell culture and in vivo model studies have provided critical contribution about disease mechanism, these models present important problems. 2D tissue culture models lack of three dimensional (3D) structure, while animal models are expensive, time consuming, and inadequate to reflect human tumor biology. Up to the present, scaffolds and 3D matrices have been used for many different clinical applications in regenerative medicine such as heart valves, corneal implants and artificial cartilage. While tissue engineering has focused on clinical applications in regenerative medicine, scaffolds can be used in in vitro tumor models to better understand tumor relapse and metastasis. Because 3D in vitro models can partially mimic the tumor microenvironment as follows. This review focuses on different scaffold production techniques and polymer types for tumor model applications in cancer tissue engineering and reports recent studies about in vitro 3D polymeric tumor models including breast, ewing sarcoma, pancreas, oral, prostate and brain cancers.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.222-226
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• 1995

인공심장에서의 박출량제어는 전부하에 따른 심박출균형, 심실내 완전충만과 완전구출을 구현하는데 그 목적이 있다. 본 논문에서는 인공심장 내부의 심실간 공간 압력파형을 심박출량의 제어에 활용하였다. 이를 위해서는 심실간 공간의 압력파형을 심실 유입부와 유출부의 혈류량에 대한 정보, 이동작동기의 위치신호와 동기시켜 해석하는 것이 필요하다. 이러한 압력파형의 해석을 바탕으로, 심실간 공간의 음압 크기로 좌,우 심방압을 추정하고 작동기의 좌,우 수축기때 심실간 공간의 음압크기를 비슷하게 유지하도록 작동거리를 제어하면 좌우 심박출 균형을 이룰 수 있음을 확인하였다. 또한, 심실의 완전충만과 완전구출의 실현을 위한 심실 충만 정도를 추정할 수 있게 하는 인자를 제시하였다.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.243-244
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• 1998

The second telemetry is designed for supplying additional function which the first telemetry system doesn't have and as a part system of the External Management System (EMS). It makes a patient and an animal move more freely with wireless communication at a distance of free activity from the PC and can get most data from the first telemetry to send to the PC. Recently, our laboratory is developing a RF system for the second telemetry.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.11
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• pp.117-122
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• 1992

In systems in which inductive coupling between a pancake-shaped coil on the surface of the body and a similar coil within the body is utilized for the transfort of electromagnetic energy, the minimization of temperature rise in the tissue is intimately related to the achievement of minimum losses in the region of the implanted coil. The new class of amplifiers, named "class E", for inverter is defined and is illustrated by a detailed description and a set of desist equations for one simple member of the class. For TET circuit the authors measured 65 to 76 percent efficiency at 1985kHz at 30 to 50 W output from IRF250 MOSFET transistor.

• Journal of Sensor Science and Technology
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• v.15 no.6
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• pp.417-424
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• 2006

An ubiquitous healthcare monitoring system for elderly person at home was designed for continuous healthy monitoring of elderly person or patients. Human vital signals, such as ECG and body temperature, were monitored by terminal PC or PDA via ECG and temperature sensor nodes on the patient's body. From the ECG data, the heart rate, tachycardia, bradycardia and arrhythmia were diagnosed on the terminal PC or PDA to assist doctor's or nurse's aid or patient itself to monitor the patient's condition and give medical examination. Artificial judgement support system was designed in server computer and the system support a doctor or nurser for management or treatment of the patient. This system can be applied to vital signal monitoring system for solitude elderly person at self house or home health care service part. And this ubiquitous healthcare system can reduce the medical expenses in coming aging or aged society.

• Journal of Biomedical Engineering Research
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• v.16 no.4
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• pp.447-456
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• 1995

As a part of electro-mechanical totally implantable artificial heart (TIAH) program, a transcut- aneous energy transmission system has been developed. By mutual magnetic induction between the first coil on the skin and the subcutaneously implanted second coil, the system transfers elctrical power through the skin. This research aimed at minimizing the size of the implanted part as well as maximizing the transfer efficiency. Using class I amplifier, we achieved above 75% power transfer efficiency at average 40W power transfer level which is required for normal TIAH operation. In vivo performance of the developed system and bio-compatibility of the material used in Implanted parts were evaluated through animal experiments.

• Journal of Biomedical Engineering Research
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• v.17 no.3
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• pp.387-394
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• 1996

This paper presents a Neural Network Identification(NNI) method for modeling of highly complicated nonlinear and time varing human system with a pneumatically driven mock circulatory system of Left Ventricular Assist Device(LVAD). This system consists of electronic circuits and pneumatic driving circuits. The initiation of systole and the pumping duration can be determined by the computer program. The line pressure from a pressure transducer inserted in the pneumatic line was recorded System modeling is completed using the adaptively trained backpropagation learning algorithms with input variables, heart rate(HR), systole-diastole rate(SDR), which can vary state of system. Output parameters are preload, afterload which indicate the systemic dynamic characteristics. Consequently, the neural network shows good approximation of nonlinearity, and characteristics of left Ventricular Assist Device. Our results show that the neural network leads to a significant improvement in the modeling of highly nonlinear Left Ventricular Assist Device.

• Journal of IKEEE
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• v.21 no.3
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• pp.309-319
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• 2017

The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor ($IC_{50}$) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology - Jadavpur University - India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.18 no.3
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• pp.310-316
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• 2011

Purpose: In the present study, the difference in patients' nursing demands and nursing performance as perceived by the patients was examined. Methods: The participants were 272 patients on maintenance hemodialysis at five university hospitals. Nursing need and nursing performance were measured using the tool developed by Lee for this study. Results: The mean score for nursing demand was 3.35 points out of 4. The scores were higher for participants with middle school graduation or less, those not professing religion, and those whose medical insurance was of the medicaid type. The mean score for perceived nursing performance was 3.22 points out of 4. Nursing performance as perceived by hemodialysis patients was lower than nursing demand for 22 of 28 items. The item with the largest difference between nursing performance and nursing demand was 'Give a pain-free injection', followed by 'Explain about insurance benefits and supports' and 'Maintain quiet environment in the hemodialysis unit enabling rest during hemodialysis'. Conclusion: The results show that nursing performance as perceived by hemodialysis patients was lower than nursing demand. This result indicates a need to develop appropriate strategies to enhance nursing performance, especially for items that showed low nursing performance.