• Journal of the Semiconductor & Display Technology
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• v.21 no.3
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• pp.130-134
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• 2022

An anti-reflective coating is used to improve the performance of the solar cell. The anti-reflective coating changes the value of the short-circuit current about the thickness. However, the current-voltage characteristics about the anti-reflective coating are difficult to calculate without simulation tool. In this paper, a modeling technique to determine the short-circuit current value and the current-voltage characteristics in accordance with the thickness is proposed. In addition, artificial neural network is used to predict the short-circuit current with the dependence of temperature and thickness. Simulation results incorporating the artificial neural network model are obtained using MATLAB/Simulink and show the current-voltage characteristic according to the thickness of the anti-reflective coating.

• The Korean Journal of Physiology
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• v.26 no.1
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• pp.37-44
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• 1992

The encapsulation of the Purified bovine hemoglobin with Phospholipids obtained from egg folk was performed using a rotary vacuum evaporator. The prepared Hb-containing liposome (hemosome) had good properties as artificial red blood cell. The shape and size of the hemosomes were measured by a phase contrast microscope and image analyzer. The function of the hemosome as oxygen carrier was tested by measuring oxygen saturation curve with blood gas analyzer and infusing it into rats. The prepared hemosome was 1.184 + 0.423 ${\mu}m$ in diameter and round in shape. $P_{50}$ value of the hemosome solution was 28 mmHg. The synthesized red cells seem to function as oxygen carrier, because the severely bled rats were prolonged in their life by transfusion of the hemosome solution containing bovine hemoglobin.

• Smart Structures and Systems
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• v.7 no.3
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• pp.199-211
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• 2011

Using computational modeling, we design a pair of biomimetic microcapsules that exploit chemical mechanisms to communicate and alter their local environment. As a result, these synthetic objects can undergo autonomous, directed motion. In the simulations, signaling microcapsules release "agonist" particles, while target microcapsules release "antagonist" particles and the permeabilities of both capsule types depend on the local particle concentration in the surrounding solution. Additionally, the released nanoscopic particles can bind to the underlying substrate and thereby create adhesion gradients that propel the microcapsules to move. Hydrodynamic interactions and the feedback mechanism provided by the dissolved particles are both necessary to achieve the cooperative behavior exhibited by these microcapsules. Our model provides a platform for integrating both the spatial and temporal behavior of assemblies of "artificial cells", and allows us to design a rich variety of structures capable of exhibiting complex dynamics. Due to the cell-like attributes of polymeric microcapsules and polymersomes, material systems are available for realizing our predictions.

• Journal of Korea Multimedia Society
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• v.25 no.8
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• pp.1203-1211
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• 2022

Melanoma is a skin cancer that starts in pigment-producing cells (melanocytes). The death rates of skin cancer like melanoma can be reduced by early detection and diagnosis of diseases. It is common for doctors to spend a lot of time trying to distinguish between skin lesions and healthy cells because of their striking similarities. The detection of melanoma lesions can be made easier for doctors with the help of an automated classification system that uses deep learning. This study presents a new approach for melanoma classification based on an ensemble of deep convolution neural networks and a Log-Gabor filter. First, we create the Log-Gabor representation of the original image. Then, we input the Log-Gabor representation into a new ensemble of deep convolution neural networks. We evaluated the proposed method on the melanoma dataset collected at Yonsei University and Dongsan Clinic. Based on our numerical results, the proposed framework achieves more accuracy than other approaches.

• YAKHAK HOEJI
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• v.44 no.4
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• pp.347-353
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• 2000

To examine influence of artificial digestive juice on the antitumor activity of Ganoderma lucidum-A(GL-A), protein-bound polysaccharide from Ganoderma lucidum, we compared the digested protein-bound polysaccharide with undigested one both on immunopotentiating activity and influence of digestive juices. Protein-bound polysaccharide GL-B was obtained by digesting the antitumor component GL-A with artificial digestive Juices in vitro. When GL-A was administered orally to sarcoma 180 tumor-bearing ICR mice, the life prolonging effect was exhibited in a dose dependent manner Not only GL-A but GL-B increased the production of colony forming unit (CFU) to 10- and 8-fold of that of the control, respectively. Both of the protein-bound polysaccharides also showed the secretion of nitric oxide in RAW 264.7 cell lines to 3.5-and 3.7-fold of that of the control, respectively: GL-A activated components of the alternative complement pathway, whereas GL-B did not. In humoral immunity GL-A increased the activity of alkaline phosphatase in differentiated B cells to 3 times and GL-B to 4 times of that of the control. These results showed that the artificial digestive juices had no influence on the antitumor activity of the protein-bound polysaccharide from Ganoderma lucidum and that its immunomodulating activity retained after treatment with artificial digestive juice. And this provides a basis of the protein-bound polysaccharide of Ganoderma lucidum as an peroral anticancer drug.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.115.5-115
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• 2001

This paper suggests that the immune algorithm can effectively be used in tuning of a multivariable system. Then artificial immune network always has a new paraller decentralized processing mechanism for various situations, since antibodies communication to each other among different species of antibodies/B-cells through the simulation and suppression chains among antibodies that form a large-scaled network. In addition to that, the structure of the network is not fixed, but varies continuously. That is, the artificial immune network flexibly self-organizes according to dynamic changes of external environment (meta-dynamics function). However, up to the present time, models based on the conventional crisp approach ...

• Journal of Korean Society of Industrial and Systems Engineering
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• v.18 no.34
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• pp.91-97
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• 1995

This paper presents a possible application of artificial neural network in CM system design. CM systems can be designed based on product lines, part characteristics or part routines. GT(Group Technology) which uses part characteristics to design cells is widely applied, however, the identification of the part-machine families is the fundamental problem in the design process. A heuristic procedure using SOFM which requires only part-machine incidence matrix is proposed in this research. Comparison studies on ZODIAC and ROC with SOFM model are done and the results are discussed and summarized in this paper.

• Proceedings of the Korean Vacuum Society Conference
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• 2006.08a
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• pp.50-50
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• 2006

• BMB Reports
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• v.35 no.5
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• pp.459-464
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• 2002

Fusogenic liposomes that incorporate Sendai virus envelope proteins, so-called Sendai virosomes, have been developed for in vitro and in vivo genetic modification of animal cells. In this study, several different virosomes of varying lipid compositions were formulated and their in vitro gene-transfer efficiencies compared. The virosomes were prepared by quantitative reconstitution of the Sendai envelope, fusion (F) and hemagglutinin-neuraminidase (HN) proteins into liposomal vesicles. Virosomes that contained luciferase reporter genes were tested in 293 transformed human kidney cells. F/HN-virosomes that were prepared with an artificial Sendai viral envelope (ASVE-virosomes) or phosphatidylserine (PS-virosomes) exhibited an 8- or 6-fold higher gene-transfer efficiency than cationic liposomes that were made with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). F/HN-virosomes that were prepared with phosphatidic acid (PA-virosomes) instead of PS were less efficient in gene transfer than either ASVE- or PS-virosomes. In addition, the genetransfer capability of ASVE- and PS-virosomes was maximal at a $Ca^{2+}$ concentration of 510 mM. These results suggest that the incorporated lipid components significantly affect the in vitro gene transfer that is mediated by Sendai F/HN-virosomes.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.129-130
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• 1994

The science of toxicology is the understanding of the mechanisms by which exogenous agents produce deleterious effects in biological systems. The actions of chemicals such as drugs are ultimately exerted at the cellular and gene levels. Over the past decade. several in vitro alternative methods such as cultured cells for assessing the toxicity of various xenobiotics have been proposed to reduce the use of animals. In this workshop three advanced methods will be presented. These methods are novel important models for toxicologic studies. Dr. Tabuchis group has establishcd two immortalized gastric surface mucosa cell lines from the pminary cultore of gastric fundic mucosal cells of adult transgenic mice harboring a temperature sensitive simian virus 40 large T-anugen gene. As the immortalized cell lines of various tissues possess unique characteristics to maintain their normal functions for several months, these cell lines are extremely useful for not only toxicity testing but also pharmacological screening in new drug development. Professor Funatsu have studied the formation of spherical multicelluar aggregates of adult rat hepatocytes(spheroid) having tissue like structure. The sphcroid shown thre is a prototype module of an artificial liver support system. Thus, the urea synthesis activity of the artificial liver was maintained at least to days in 100％ rat blood plasma. Dr. Takezawa and his coworkers have developed a novel culture system of multicellular spheroids considered 〃organoids〃 by utilizing a thermo-responsive polymer as a substratum of anchorage dependent cells. His final goal is to reconstitute the organoids of various normal organs, e.g., liver, skin etc. and also abnormal deseased organs such as tumor.