• 대한소아치과학회지
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• 제46권4호
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• pp.382-391
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• 2019

와동 형성이 시작된 우식병소에는 병소 본체 주변으로 탈회가 진행 중인 초기 병소가 혼재한다. 이 연구에서는 법랑질에 국한된 우식 와동을 복합레진으로 수복 시 레진침투법을 병행하는 기법이 치질 보존 측면에서 의미를 갖는지를 평가하고자 하였다. 인접면 우식병소가 있는 탈락된 유구치를 이용, 레진침투(I, Infiltration), 치아삭제(P, preparation), 복합레진 수복(F, filling)의 적용 순서를 달리하여 IPF군과 PFI군으로 나누었다. 수복 범위, 레진침투 양상, 변연부 미세누출의 관점에서 수복물을 평가하였다. 치질 삭제범위는 수복 전후에 micro-CT를 이용하여 평가하였고, 두 실험군 모두에서 치료 전 병소의 크기보다 복합레진 수복물의 크기가 작았다. 공초점 레이저 주사현미경을 이용한 레진침투 양상 평가 결과 두 실험군 모두 복합레진 수복물 주변에서 침투레진이 확인되었으며, 인공 탈회 유발 후에도 침투레진은 대부분 유지되었다. 수복물 변연부 미세누출은 micro-CT로 확인하였고, PFI군에서 더 빈번하게 확인되었다. 복합레진 수복과 레진침투법의 병용은 치질 보존 측면에서 의미를 가지며, 접착 향상을 위하여 레진침투-와동 형성-복합레진 수복의 순으로 진행하는 것이 추천된다.

• 비파괴검사학회지
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• 제14권3호
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• pp.177-184
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• 1994

본 연구는 X선 비파괴시험법을 활용하여 피사체 내부에 존재하는 기공의 3차원적 형상, 위치 및 크기를 측정하고 검사 조건에 따른 오차를 최소화하는 계산기법을 제시하였다. 제시한 계산기법을 실용화하기 위하여 기공측정전산코드(PEVACA)를 개발하고 다양한 형상의 모의 기공을 적용한 검증시험과 실제 피사체를 검사 후 절단하여 측정비교시험을 통하여 본 계산기법의 신뢰성을 검토하였다. 본 연구를 통하여 개발된 PEVACA는 작도법에 의한 기존의 수작업보다 측정 신뢰도(${\pm}0.5mm$ 이내의 오차 범위)를 항상시켰을 뿐만 아니라 작업시간 단축과 자료전산화에도 크게 기여할 것으로 판단된다.

• 대한후두음성언어의학회지
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• 제4권1호
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• pp.24-32
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• 1991

Cleft palate or velopharyngeal incompetence shows many disorders and disabilities affecting speech transmission. including distortion. substitution. and the nasalization of the vowels. The nasalized vowels are produced primarily by lowering of the velum. resulting in opening a side passage for the air flow through the nasal cavity. These abnormal movements give rise to complex modification of the physical property of the sound or in the sound spectrum. The authors employed Sonagraph$^{\circledR}$ as a sound analyzer in order to ascertain the features which characterize the nasalization of vowels. Twenty healthy Korean male adult voluteers were analyzed in artificial conditions of anterior and posterior nasal obstruction. and velo-pharyngeal incompetence. The results were as follows : 1) Fundamental frequency was not changed by nasal obstruction or velopharyngeal incompetence. 2) There was no significant difference of the formant intensity between normal and nasal vowels. 3) In VPI, a decrease of the frequency of $F_2$ was observed in /e/ and /i/ vowels(p<0.001). 4) In VPI, the $F_2$ was frequently missed in /o/ and /u/ vowels. 5) In the consonant spectra of VPI, the 'release burst' was usually not observed.

• 한국임상수의학회지
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• 제20권3호
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• pp.323-327
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• 2003

This study has been conducted to compare the efficacy of sodium carboxymethylcellulose (SCMC) and hyaluronic acid (HA) on prevention of adhesion after artificial wound was induced in intestine. 1 % SCMC and 0.3% HA solution and saline solution were respectively administered to abdominal cavity. Each of the three groups consists of 11 rats. The abdominal cavity of each rat was coated with 2 ml of the allocated solution just after the abdomen was cut open, and it was coated with each solution of 1 ml before abrasion were caused on the cecum, the ascending colon and the transverse colon. Then, an additional 1 ml solution was injected before the abdomen was closed. On day 14 after the operation, each adhesion formation was evaluated at the score of 0-4. The HA group and SCMC group showed significantly lower adhesion scores than control group in all regions(P< 0.05). The adhesion scores of ascending colon, transverse colon and no abrasion region of the viscera showed little difference between HA group and SCMC group(P< 0.05), but the effect of adhesion reduction showed higher tendency in the HA group than the SCMC. The adhesion score of the cecum was significantly lower in HA group than SCMC group(P< 0.05). In conclusion, the SCMC solution and HA solution were effective on prevention of abdominal adhesion resulting from the celiotomy. Among of them, the HA solution could be more effective on prevention of adhesion than SCMC solution.

• Tuberculosis and Respiratory Diseases
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• 제40권4호
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• pp.449-453
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• 1993

A 64-year-old male was admitted due to abruptly developed, severe dyspnea via local clinic. He had been a heavy smoker and alcoholic for a long time. Chest PA showed huge haziness in right upper lung field. Sputum culture for bacteriology was positive for Klebsiella pneumoniae. Immediately, appropriate antibiotics were administered and artificial ventilation was started. On 40th hospital day, simple chest roentgenogram taken due to sudden aggravated dyspnea showed marked hyperlucency in right upper lung field, suggestive of rupture of abscess cavity and resultant pneumothorax. At that time, chest tube was inserted but air leakage from the chest tube persisted. Chest CT scan taken after chest tube insertion showed the tube inserted into a thin-walled cavity in the above lesion. on 84th hospital day, right upper lobectomy with decortication was performed. Pathologically, cavittary lung abscess was diagnosed on the findings of partial re-epithelialization of ciliated columnar epithelium with severe pulmonary vascular occlusion and extensive fibrous pleural adhesions.

• 대한소아치과학회지
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• 제43권1호
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• pp.44-50
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• 2016

본 연구는 탈회 유전치에 3가지 불소바니쉬를 이용하여 인공우식의 재광화 효과를 비교 평가하였다. 인공우식용액에 40개의 건전한 유전치 시편을 침적시킨 후, $37^{\circ}C$ 항온기에 7일 동안 보관하여 유전치에 탈회를 형성하였다. Cavity shield$^{TM}$, V varnish$^{TM}$, MI varnish$^{TM}$를 1주일에 한 번씩 3주 동안 탈회된 유전치에 도포 후 불소바니쉬 종류에 따른 미세경도 변화를 평가하였다. 1주차에서는 MI varnish$^{TM}$군이 가장 높은 재광화 효과를 보였고 다음으로 V varnish$^{TM}$군이 높았으며, Cavity shield$^{TM}$군이 낮은 재광화 효과를 보였으며, 세 군 모두 유의한 차이는 없었다(p > 0.05). 2주차에서는 V varnish$^{TM}$군이 가장 높은 재광화 효과를 보였으며 그 다음으로 MI varnish$^{TM}$군 높았지만 V varnish$^{TM}$군과 유의한 차이는 없었다(p > 0.05). Cavity shield$^{TM}$군은 V varnish$^{TM}$군과 MI varnish$^{TM}$군에 비해 유의하게 낮은 재광화 효과를 보였다(p < 0.05). 3주차에서는 V varnish$^{TM}$군이 나머지 두 군과 유의한 차이를 보이며 가장 높은 재광화 효과를 보였고(p < 0.05), 다음으로 MI varnish$^{TM}$군이 높았으며 Cavity shield$^{TM}$군이 가장 낮은 재광화 효과를 보였지만, MI varnish$^{TM}$군과의 유의한 차이는 없었다(p > 0.05). 총 미세경도 증가량은 Cavity shield$^{TM}$군에 비해 V varnish$^{TM}$군과 MI varnish$^{TM}$군이 높았으며(p < 0.05), V varnish$^{TM}$군과 MI varnish$^{TM}$군 사이 통계학적 유의한 차이는 없었다(p > 0.05).

• Clinical and Experimental Reproductive Medicine
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• 제35권4호
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• pp.275-283
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• 2008

목 적: 본 연구는 유리화동결 전 인공수축과 보조부화술 (부분투명대절개)이 유리화동결 후 생쥐 포배아의 생존율과 부화율에 미치는 영향을 알아보기 위해 시행되었다. 연구방법: 생쥐 2-세포기 배아를 획득하여 G1.1과 G2.2 배양액에서 포배아까지 배양하였다. 실험은 대조구군과 3개의 처리군으로 나누었다. 인공수축과 보조부화술 없이 동결한 군 (-AS/-AH)을 대조군으로 하였고, 보조부화술만 시행한 군 (-AS/+AH), 인공수축만 시행한 군 (+AS/-AH), 인공수축과 보조부화술을 동시에 처리한 군 (+AS/+AH)을 처리군으로 하였다. 모든 포배아는 G10과 G10E20 용액에서 각각 3분씩 평형을 실시하였고, G25E25 유리화용액에 노출직후 capped pulled-straw에 mouth 피펫으로 부하하여 유리화동결하였다. 융해 후 24시간 동안 배양하면서 생존율과 부화율을 조사하였다. 결 과: 인공수축을 시행한 후 보조부화술을 시행한 군 (+AS/+AH)과 보조부화술을 시행하지 않은 군 (+AS/-AH)에서의 생존율과 부화율은 각각 98%와 100%, 92%와 41%였으며, 인공수축을 시행하지 않고 보조부화술을 시행한 군(-AS/+AH)과 보조부화술을 시행하지 않은 군 (-AS/-AH, 대조군)에서의 생존율과 부화율은 각각 54%와 96%, 58%와 34%를 나타내어 인공수축과 보조부화술 생쥐 포배아의 생존율과 부화율 향상에 매우 효과적인 방법임을 알 수 있었다 (p<0.01). 또한 capped pulled-straw라고 명명한 스트로우를 이용한 유리화동결은 융해 후 회수율이 100%였으며, 동결과 융해과정에 매우 편리하여 배아의 유리화동결에 매우 유용할 것으로 생각된다. 결 론: 인공수축과 보조부화술은 포배아의 유리화동결 후 생존율과 부화율을 유의하게 향상시켜 포배아의 동결보존에 매우 효과적인 방법으로 생각된다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1990년도 춘계학술대회
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• pp.1-6
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• 1990

A new version of moving actuator electromechanical total artificial heart was designed to improve total efficiency, durability, and fitting inside thoracic cavity. As compared with our present type of the rolling cylinder actuator, this new model has a pendulum-type actuator with reciprocating motion around the fixed circular path, connected through the gear mechanisms to the motor. By using this mechanism, the efficiency and durability could be improved by replacing sliding mechanism with rolling contact elements. Also, the height of the pump could be decreased from 9cm to 7cm with static stroke volume 65cc. With these improvements, we have implanted this new pump in human size animal (less than 70Kg weight).

• 대한소아치과학회지
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• 제25권3호
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• pp.619-626
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• 1998

The critical etiologic factor in the development of dental caries is dental plaque. The main component of dental plaque is the mutan produced by Streptococcus mutans. The following results were obtained by using blue mutan to assess the factors affecting the mutan-digesting activity of Micromonospora aurantiaca isolated from oral cavity. Micromonospora aurantiaca digested more blue mutan in the minimal essential broth at pH 7.0 than at pH 5.5 or 8.5, and at $37^{\circ}C$ than at $32^{\circ}C\;or\;42^{\circ}C$. Blue mutan was similarly digested at the range of 1mM to 16mM of $CaCl_2$ and 0.1mM to 6.4 mM of $MgCl_2$, while being significantly digested at the concentration of 2.5mM of KCl. When the concentration of glucose was decreased in the minimal essential broth, the digestion of blue mutan was increased. When the culture supernatant of Micromonospora aurantiaca in the RL broth with 1% glucose or 0.5% mutan was mixed with 2 ${\times}$ BHIYS broth containing 0.5% yeast extract and 10% sucrose, the formation of artificial plaque on the orthodontic wires by Streptococcus mutans was inhibited(p<0.05). These results indicated that the production of mutanase was identified in the culture supernatant of Micromonospora aurantiaca, suppressing the formation of artificial plaque by Streptococcus mutans.

• Clinical and Experimental Reproductive Medicine
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• 제38권2호
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• pp.87-92
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• 2011

Objective: This study aimed to determine the safety and clinical effect of artificial shrinkage (AS) in terms of assisted hatching of fresh blastocysts. Also, we evaluated the correlation between patient age and the effect of AS on clinical outcome. Methods: Two AS methods, using a 29-gauge needle and laser pulse, were compared. Seventy-three blastocysts were shrunk using a 29-gauge needle and the same number of other blastocysts were shrunk by a laser pulse. We evaluated the shrunken blastocysts hourly and considered them viable if they re-expanded >70%. Blastocyst transfer cycles (n=134) were divided into two groups: a control group consisted of the cycles whose intact embryos were transferred (n=100), while the AS group consisted of the cycles whose embryos were replaced following AS (n=34). The implantation and pregnancy rates of the control group and AS group were compared ($p$ <0.05). Results: The re-expansion rates of the 29-gauge needle and laser pulse AS groups were similar (56 [76.7%] vs. 62 [84.9%], respectively). All of the remaining shrunken blastocysts were re-expanded within 2 hours. There was no degeneration of shrunken blastocysts. The total and clinical pregnancy rate of the AS group (23 [67.6%]; 20 [58.8%], respectively) was significantly higher than that of the control group (47 [47.0%]; 39 [39.0%], respectively). In the older patient group, there was no difference in the clinical outcomes between the AS and control groups. Conclusion: These results suggest that AS of blastocoele cavity, followed by the transfer, would be a useful approach to improve the clinical outcome in cycles in which fresh blastocyst stage embryos are transferred.