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Synthesis of Ferrocenyl and Diphenyl Substituted Bispyridino-18-Crown-6 Ether for Chiral Recognition

  • Jo, Sun-Jin;Jin, Young-Eup;Kim, Jae-Hong;Suh, Hong-Suk
    • Bulletin of the Korean Chemical Society
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    • v.28 no.11
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    • pp.2015-2019
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    • 2007
  • The article reports the synthesis of a novel bispyridino-18-crown-6 ether, 7-{[(5S,15S)-5,15-diphenyl- 3,6,14,17-tetraoxa-23,24-diazatricyclo[17.3.1.18,12]tetracosa-1(23),8(24),9,11,19,21-hexaen-10-yl]oxy}heptylferrocenamide 6, bearing the C2-symmetric diphenyl substituents as chiral barriers and the ferrocenyl groups serving as an electrochemical sensor, and its electrochemical study with D- and L-AlaOMe·HCl as the guest by cyclovoltametry.

TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics

  • Faith Fore;Cut Indriputri;Janet Mamutse;Jusak Nugraha
    • IMMUNE NETWORK
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    • v.20 no.3
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    • pp.21.1-21.10
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    • 2020
  • TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an "orphan receptor" but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.

The Review on the Ophthalmology related articles published in the Journal of Korean Medical Ophthalmology, Otolaryngology, Dermatology (한방안이비인후피부과학회지에 게재된 안과 관련 논문에 관한 고찰)

  • Kim, Chul-Yun;Lee, Dong-Jin;Seo, Hyung-Sik;Kwon, Kang
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.27 no.2
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    • pp.14-32
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    • 2014
  • Objective : This study was carried out to analyze the trends of ophthalmology related articles that have been published in the Journal of Korean Medical Ophthalmology, Otolaryngology, Dermatology(JKOOD). Method : We studied 72 research papers relevant to Ophthalmology that published in JKOOD from 1988 to 2013. All the paper were classified into three categories; original article, review article and case report. We also analyzed the articles according to the sort of diseases. We sub-classified the original articles into three categories descriptive study, analytic study and experimental study. We analyzed the case report according to various types of treatment. Result : 1. The number of searched journals is 72 papers; 21 review articles, 18 original articles, 33 case reports 2. Classification of 18 original articles into three categories; 12 descriptive studies, 0 analytic study, 6 experimental studies. 3. Distribution of diseases in ophthalmology; the percentage of 'strabismus' ranked the highest(25%) in case report. 4. Method of Evaluation in retina disease ; the percentage of fundus photography ranked the highest(50%) Conclusions : It is needed to develop the methods of study in part of eye disease. The studies using modern medical equipment should be increased in ophthalmology of Korean Medicine. It will be helpful to obtain objectivity and increase quality of studies.

Develop and Deliver Essential Information Literacy Programs

  • Eisenderg, Michael B.
    • Journal of the Korean Society for Library and Information Science
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    • v.45 no.2
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    • pp.5-21
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    • 2011
  • There is an explosion of talk about crucial, new literacies for the 21st Century, for example critical thinking, problem-solving, media literacy, technology literacy, digital literacy, visual literacy. The other day, there was even an article about "gaming literacy!" How does one make sense of it all? The common factor in all these literacies is "information" - information seeking, information use, information processing, information presentation, and information evaluation. And, these "information" elements come together in information literacy: the ability to engage in effective and efficient information problem-solving. Information literacy is the overarching and unifying literacy, and all libraries have a unique and essential role to play in delivering meaningful information literacy programs to people of all ages. In this keynote paper and address, Professor and Dean Emeritus Mike Eisenberg will define the concept and structure of library-based information literacy programs and offer strategies for developing and implementing information literacy programs that are comprehensive(reaching all users), predictable (consistent over time), and accountable(measured and reported).

Infocommunication Technologies In Education: Problems Of Implementation

  • Rebenok, Vadym;Al-Namri, Roza;Butko, Oleksandr;Fedorenko, Viktoriia;Tereshchenko, Olha;Tsimokh, Nataliia
    • International Journal of Computer Science & Network Security
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    • v.21 no.12
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    • pp.41-44
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    • 2021
  • This article proposes to consider the experience of using information and communication technologies in educational processes and social practices of Ukrainian universities. The history of the introduction of information and communication technologies in the development of the higher education system is considered, the system of organizing the information space of universities is investigated. The distinctive features of the structure of a single information space, as well as distance e-learning technologies are highlighted. Empirical material obtained in the course of sociological research is used to discuss specific examples of the use of ICT in universities.

Modernization of Education in the Context of Informatization and Automation

  • Moroz, Liudmyla;Shabelnyk, Tetiana;Zelinska-Liubchenko, Kateryna;Varakuta, Volodymyr;Push, Olena;Vysochan, Lesia;Blahun, Nataliia
    • International Journal of Computer Science & Network Security
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    • v.21 no.4
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    • pp.41-46
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    • 2021
  • The article studies the implementation of automation in the education process as a convenient interface of a document management system, on the one hand, which makes it easy to navigate the program, requiring from the user only a small amount of any special skills in working with electronic computers, on the other hand, it provides to the user operational information about all the data of interest to him, taking into account the access rights given to this or that information, stored in the enterprise database.

Theoretical And Technological Aspects Of Intelligent Systems: Problems Of Artificial Intelligence

  • Frolov, Denys;Radziewicz, Wojciech;Saienko, Volodymyr;Kuchuk, Nina;Mozhaiev, Mykhailo;Gnusov, Yurii;Onishchenko, Yurii
    • International Journal of Computer Science & Network Security
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    • v.21 no.5
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    • pp.35-38
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    • 2021
  • The article discusses approaches to the definition and understanding of artificial intelligence, research directions in the field of artificial intelligence; artificial intelligence in the anthropological dimension; the importance of the systems approach as a methodological basis for the design of intelligent systems; structural and functional components of intelligent systems; intelligent systems in the technological aspect; problems and prospects of relations in the system "man - intellectual system".

Modeling of Regional Management of Innovation Activity: Personnel Policy, Financial and Credit and Foreign Economic Activity

  • Prylipko, Sergii;Vasylieva, Nataliia;Kovalova, Olena;Kulayets, Mariia;Bilous, Yana;Hnatenko, Iryna
    • International Journal of Computer Science & Network Security
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    • v.21 no.11
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    • pp.43-48
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    • 2021
  • The article proposes a method of modeling a comprehensive indicator for evaluating the effectiveness of regional management of innovation activity. This will make it possible to assess the effectiveness of personnel, financial and credit and foreign economic activity of the regions from the standpoint of an integrated approach. The modeling technique is proposed to be carried out using the tools of taxonomic analysis and the calculation of a complex indicator of the effectiveness of the innovation activity management.

Analysis of Research Papers Published in the Korean Journal of Clinical Laboratory Science from 1985 to 2012

  • Koo, Bon Kyung
    • Korean Journal of Clinical Laboratory Science
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    • v.45 no.4
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    • pp.180-187
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    • 2013
  • The author surveyed and analyzed the research papers of korean journal of clinical laboratory science (KJCLS) that have been posted for 28 years from 17 volumes in 1985 to 44 volumes in 2012 in the time of 50th anniversary of foundation of the korean association of medical technologists (KAMT) of in 2012. This study is aimed to provide members with basic materials helpful to research development and suggest development measures of journal. The author analyzed the number of papers, research field, type of papers, and number of authors based on the title of paper. The total number of papers is 916 and average number of paper is 33. The research field was biochemistry 167 (18.2%), microbiology 160 (17.4%), histology & cytology 99 (10.8%), molecular genetics 77 (8.5%), hematology 69 (7.5%), physiologic function 64 (7.0%), immunology 60 (6.5%), blood bank 33 (3.6%), radioimmunoassay 33 (3.6%), parasitology 27 (2.9%), quality control 18 (2.0%), urinalysis & body fluid 13 (1.4%), cytogenetics 12 (1.3%), flow cytometry analysis 6 (0.7%), and other articles were 78 (8.5%). Regarding the type of papers, original article was 777 (84.8%), case report 52 (5.7%), review 23 (2.5%), others 64 (7.0%). Regarding the number of paper authors, single author was 208 (22.7%), 2-man joint authors 178 (19.4%), 3-man joint authors 181 (19.8%), 4-man joint authors 151 (16.5%), over-5-man joint authors 198 (21.6%). The average number of papers was 33 for 28 years from 1985 to 2012, it is fewer than number of technologists and professors working currently regardless of the level of quantity and quality. The KAMT needs paper promoting measures and strategic investment on the scholarly journals that can aggressively promote to members and inspire research desire for korea citation index (KCI) registered article selection of KJCLS in the future.

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Solvent-free Microwave-Assisted Ortho-Alkylation of Aromatic Ketimine with Acrylic Acid Derivatives by Rh(I) Catalyst

  • Jo, Eun-Ae;Ahn, Jeong-Ae;Jun, Chul-Ho
    • Bulletin of the Korean Chemical Society
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    • v.28 no.11
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    • pp.2020-2024
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    • 2007
  • The article reports the synthesis of a novel bispyridino-18-crown-6 ether, 7-{[(5S,15S)-5,15-diphenyl- 3,6,14,17-tetraoxa-23,24-diazatricyclo[17.3.1.18,12]tetracosa-1(23),8(24),9,11,19,21-hexaen-10-yl]oxy}heptylferrocenamide 6, bearing the C2-symmetric diphenyl substituents as chiral barriers and the ferrocenyl groups serving as an electrochemical sensor, and its electrochemical study with D- and L-AlaOMe·HCl as the guest by cyclovoltametry.