• 대한기계학회논문집A
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• 제23권6호
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• pp.912-921
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• 1999

Shear stress acting on the arterial wall by blood flow is an important hemodynamic factor influencing blocking of blood vessel by thickening of an arterial wall. In order to study the effects of wall elasticity on the wall shear rate distribution in an artery-divergent graft anastomosis, a rigid and a elastic model are manufactured. These models are placed in a pulsatile flow loop, which can generate the desired flow waveform. Flow visualization method using a photochromic dye is used to measure the wall shear rate distribution. The accuracy of measuring technique is verified by comparing the measured wall shear rate in the straight portion of a model with the theoretical solution. Measured wall shear rates depend on the wall elasticity and flow waveform. The mean and maximum shear rate in the elastic model are lower than those in rigid model, and the decreases are more significant near the end of a divergent tube. The reduction of mean and maximum of wall shear rate in an elastic model are up to 17 percent.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1674-1678
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• 2008

본 연구에서는 심장의 세포 변화에서부터 혈류 순환의 시스템 변화까지 일련의 과정을 시뮬레이션 할 수 있는 통합모델을 개발하였다. 본 통합 모델을 이용하여 대동맥의 탄성도 변화 따른 Pulse Wave Velocity를 추정하였으며 심근의 수축 Mechanics의 변화를 시뮬레이션 하였다. 심장은 단순한 구 형상으로 모델링 되었다. 특히 동맥순환의 특성인 Wave propagation 과 Wave deflection의 현상을 모델링하기 위해 기존 모델에서 사용된 동맥계 순환 모델을 수정하였다. 즉 기존의 동맥 모델을 1차원의 운동방정식과 연속방정식을 기반으로 하는 Distributed arterial model로 대체하였다. Distributed arterial model은 혈액의 점성에 의한 에너지 손실, 혈관의 점탄성 효과 그리고 분지 되는 혈관에서의 에너지 손실을 포함하는 정교한 동맥 순환 모델이다. 정교한 동맥계 순환 모델의 동맥 탄성도 값을 조절함으로써 탄성도 변화에 대한 PWV를 계산 할 수 있었다. 이러한 수치적 방법을 사용하여 노화에 따른 동맥벽 탄성도의 저하가 심근세포의 Cross-bridge 동역학에 미치는 영향을 시뮬레이션 하였다.

• Biomolecules & Therapeutics
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• 제27권3호
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• pp.254-264
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• 2019

Atherosclerosis is a widespread and chronic progressive arterial disease that has been regarded as one of the major causes of death worldwide. It is caused by the deposition of cholesterol, fats, and other substances in the tunica intima which leads to narrowing of the blood vessels, loss of elasticity, and arterial wall thickening, thus causing difficulty in blood flow. Natural products have been used as one of the most important strategies for the treatment and prevention of cardiovascular diseases for a long time. In recent decades, as interests in natural products including medicinal herbs have increased, many studies regarding natural compounds that are effective against atherosclerosis have been conducted. The purpose of this review is to provide a brief overview of the natural compounds that have been used for the treatment and prevention of atherosclerosis, and their mechanisms of action based on recent research.

• 전기학회논문지
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• 제57권5호
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• pp.902-907
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• 2008

Shape of the pulse waveform is affected by the visco-elasticity characteristics of the arterial wall and the reflection waves generated at the bifurcations of arterial branches. This study was designed to improve the accuracy for the extraction of pulse wave features, then proved the superiority of the developed algorithm by clinical evaluation. Upstroke point of the pulse wave was used as an extraction feature since it is minimally affected by the waveform variation. R-peak of the ECG was used as a reference to decide the minimum level, then intersection of the least squares of regression line was used as an upstroke point. Developed algorithm was compared with the existing minimum value detection algorithm and tangent-intersection algorithm using data obtained from 102 subjects. Developed algorithm showed the least standard deviation of $0.29{\sim}0.44\;m/s$ compared with that of the existing algorithms, $0.91{\sim}3.66\;m/s$. Moreover, the rate of standard deviation of more than 1.00m/s for the PWV values reduced with the range of $29.0{\sim}42.4%$, which proved the superiority of the newly developed algorithm.

• 대한중풍순환신경학회지
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• 제10권1호
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• pp.54-61
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• 2009

Arteriosclerosis is a pathologic term that contains hardening of arterial wall, loss of arterial elasticity and stenosis of artery. To diagnose this disease, conventional angiography, MRA, transcranial doppler ultrasonography are commonly used. And it causes various clinical phases by a region of the disease. In oriental medicine, arteriosclerosis is classified into congested fluids(痰飮), blood stasis(瘀血), stagnation of Gi(氣滯) and treated by Herb-Med, acupuncture, cupping, moxibustion, and the like. The purpose of this study was to investigate the effect of oriental medical therapy on cerebral arteriosclerosis. A patient with cerebrovascular disease admitted due to dizziness, mild dysarthria, tinnitus, anxiety disorder and his Brain MRA showed severe arteriosclerosis in right anterior cerebral artery(ACA) and middle cerebral artery(MCA). Every day, we administered to patient Herb Med and Herb pills. Also, acupuncture, moxibustion were done, too. As a result of the treatment, the patient's follow up Brain MRA showed improved state of ACA stenosis.