• Journal of information and communication convergence engineering
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• v.5 no.1
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• pp.7-11
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• 2007

The aim of this paper is to design and implement a new ECG signal monitoring and analysis method for the home care of elderly persons or patients, using wireless sensor network (WSN) technology. The wireless technology for home-care purpose gives new possibilities for monitoring of vital parameter with wearable biomedical sensors and will give the patient freedom to be mobile and still be under continuously monitoring. Developed platform for portable real-time analysis of ECG signals can be used as an advanced diagnosis and alarming system. The ECG features are used to detect life-threatening arrhythmias, with an emphasis on the software for analyzing the P-wave, QRS complex, and T-wave in ECG signals at server after receiving data from base station. Based on abnormal ECG activity, the server transfer diagnostic results and alarm conditions to a doctor's PDA. Doctor can diagnose the patients who have survived from arrhythmia diseases.

• Journal of the Institute of Convergence Signal Processing
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• v.16 no.1
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• pp.29-34
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• 2015

The ECG(Electrocardiograph) ambulatory test as called Holter is performed usually to diagnose several heart diseases causing different arrhythmias. This paper exposes the insights of the design of a 10-lead ambulatory ECG recorder. Reducing the size and minimizing the power consumption of the ECG recorder are crucial to allow long recording time without causing discomfort to the patient. This paper proposes lower hardware design and differential compression algorithm to extend the maximum 72 hours recording time in consideration of smaller and light-weighted recorder size. The performance results by newly introduced compression algorithm are shown and discussed.

• Journal of Pharmacopuncture
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• v.20 no.4
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• pp.243-256
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• 2017

Doxorubicin as a chemotherapeutic drug is widely used for the treatment of patients with cancer. However, clinical use of this drug is hampered by its cardiotoxicity, which is manifested as electrocardiographic abnormalities, arrhythmias, irreversible degenerative cardiomyopathy and congestive heart failure. The precise mechanisms underlying the cardiotoxicity of doxorubicin are not clear, but impairment of calcium homeostasis, generation of iron complexes, production of oxygen radicals, mitochondrial dysfunction and cell membrane damage have been suggested as potential etiologic factors. Compounds that can neutralize the toxic effect of doxorubicin on cardiac cells without reducing the drug's antitumor activity are needed. In recent years, numerous studies have shown that herbal medicines and bioactive phytochemicals can serve as effective add-on therapies to reduce the cardiotoxic effects of doxorubicin. This review describes different phytochemicals and herbal products that have been shown to counterbalance doxorubicin-induced cardiotoxicity.

• 한국초전도학회:학술대회논문집
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• v.15
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• pp.50-50
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• 2005

• Proceedings of the Korean Information Science Society Conference
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• 2010.06c
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• pp.230-234
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• 2010

심전도는 가장 일반화되어 있는 생체신호의 하나이다. 심전도를 측정하여 심장병의 유무와 여러 질환들을 예측하고 예방할 수 있다. 심전도 신호를 추출 하는 방법에는 여러 방법이 있는데, 본 논문에서 활용한 두 논문은 계층적인 분류로 HOS, HBF, HMH 세 방법으로 실험을 하였고, 적응가변형 윈도우를 이용한 R파 추출을 실행하였다. 두 논문은 공통적으로 MIT-BIH Arrhythmias Database(MIT-BIT 부정맥 데이터베이스)를 데이터로 실험 하였으며, 알고리즘으로는 SVM, Cross-Validation등을 사용하였다. 마지막으로 두 논문의 실험결과를 바탕으로 정확도를 높일 수 있는 효과적인 알고리즘 연구를 제안하였다.

• ETRI Journal
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• v.43 no.5
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• pp.881-890
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• 2021

Photoplethysmography (PPG) is a noninvasive technique that can be used to conveniently measure heart rate (HR) and thus obtain relevant health-related information. However, developing an automated PPG system is difficult, because its waveforms are susceptible to motion artifacts and between-patient variation, making its interpretation difficult. We use deep neural network (DNN) filters to mimic the cognitive ability of a human expert who can distinguish the features of PPG altered by noise from various sources. Systolic (S), onset (O), and first derivative peaks (W) are recognized by three different DNN filters. In addition, the boundaries of uninformative regions caused by artifacts are identified by two different filters. The algorithm reliably derives the HR and presents recognition scores for the S, O, and W peaks and artifacts with only a 0.7-s delay. In the evaluation using data from 11 patients obtained from PhysioNet, the algorithm yields 8643 (86.12%) reliable HR measurements from a total of 10 036 heartbeats, including some with uninformative data resulting from arrhythmias and artifacts.

• Clinical and Experimental Pediatrics
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• v.64 no.5
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• pp.188-195
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• 2021

Acute fulminant myocarditis (AFM) occurs as an inflammatory response to an initial myocardial insult. Its rapid and deadly progression calls for prompt diagnosis with aggressive treatment measures. The demonstration of its excellent recovery potential has led to increasing use of mechanical circulatory support, especially extracorporeal membrane oxygenation (ECMO). Arrhythmias, organ failure, elevated cardiac biomarkers, and decreased ventricular function at presentation predict requirement for ECMO. In these patients, ECMO should be considered earlier as the clinical course of AFM can be unpredictable and can lead to rapid haemodynamic collapse. Key uncertainties that clinicians face when managing children with AFM such as timing of initiation of ECMO and left ventricular decompression need further investigation.

• Journal of Chest Surgery
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• v.40 no.12
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• pp.811-816
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• 2007

Background: We analyzed our experience of arrhythmia surgery in patients with congenital heart disease. Material and Method: A retrospective review was performed on 43 consecutive patients with congenital heart disease, who underwent arrhythmia surgery between June 1998 and June 2006. Result: The median age at surgery was 52 years ($4{\sim}75$ years). The most frequent cardiac anomaly was an atrial septal defect (23/43, 53.5%). The types of arrhythmias were atrial flutter-fibrillation, intermittent non-sustainable ventricular tachycardia and others in 37, 2 and 4, respectively. Arrhythmia surgery consisted of a bi-atrial maze operation in 18 patients (modified cox maze III procedure in 5 patients, and a right side maze plus pulmonary vein cryo-isolation in 13), right side maze operation in 18 patients, cavo-tricuspid isthmus cryoablation for benign atrial flutter in 4 patients, right ventricular endocardial cryoablation in 2 patients and extranodal cryoablation for atrioventricular node re-entry tachycardia in 1 patient. The median follow-up was 23.8 months ($1{\sim}95.2$ months). There was no early mortality, and one late non-cardiac related death. The overall rates of restored sinus rhythm before discharge and $3{\sim}6$ months after surgery were 79% and 81%, respectively (bi-atrial maze group: 72% and 83%, right-side maze group: 77%, 77%). Conclusion: Arrhythmias associated with congenital heart disease can be safely treated surgically with an excellent intermediate-term outcome.

• Journal of Chest Surgery
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• v.37 no.8
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• pp.644-651
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• 2004

Background: Refractory atrial arrhythmias in patients late after the Fontan operation result in significant morbidity and mortality. We reviewed our experience with arrhythmia surgery in patients who had Fontan operation. Material and Method: Between July 1986 and December 2003, 275 early survivors after Fontan operation were reviewed. Fourteen patients underwent. arrhythmia surgery at reoperation after Fontan operation, and mean age at reoperation was 16.8$\pm$7.1 (range: 4.5 ∼ 30.6) years. Mechanisms of arrhythmia included atrial flutter in 8 patients, and atrial fibrillation in 2. Arrhythmia surgery has evolved from isthmus cryoablation in 12 patients to right-sided maze in 2 patients. Thirty-two patients. underwent prophylactic isthmus cryoablation concomitantly at initial Fontan operation. Result: Postoperative arrhythmias occurred in 68 patients (24.7%) among 275. There was no early and late mortality after the arrhythmia surgery. After redo Fontan operation, all patients maintained normal sinus rhythm. Atrial flutter recurred in 3 patients who had sinus conversion with medication and 7 required permanent pacemakers with a mean follow-up of 26.5$\pm$29.1 (range: 2 ∼ 73) months. All patients have improved to NYHA class I or II. After prophylactic cryoablation at initial Fontan operation, 29 patients (90.6%) had sinus rhythm, 1 patient had junctional tachycardia, 1 patient had sinus nodal dysfunction, and 1 patient had AV block with a mean follow-up of 51.3$\pm$19.8 (range: 4∼80) months. Conclusion: Redo Fontan operation, and concomitant arrhythmia surgery reduced atrial arrhythmias and improved NYHA functional classification.

• Journal of Chest Surgery
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• v.29 no.1
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• pp.1-6
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• 1996

We developed an experimental model of brain death using dogs. Brain death was induced by increasing the intracranial pressure (ICP) gradually by continuous Infusion of saline through an epidural Foley catheter in 5 mongrel dogs (weight, 18~22kg). Hemodynamic and electrocardiographic changes were evaluated continuously during the process of brain death and obtained the following results. 1. The average volume and time required to induce brain death was 4.8$\pm$1.0ml and 143.0$\pm$30.9minutes respectively. 2. There was a steady rise of the ICP after starting the constant infusion of saline, and ICP rised continuously until the brain death (122.0$\pm$62.5mmHg). After reaching to the maximal value (125.0$\pm$47.7mmHg) at 30 minutes after brain death, the ICP dropped and remained approximately constant at the slightly higher level than the mean arterial pressure (MAP). 3. MAP showed no change until the establishment of brain death and it declined gradually. The peak heart rate reached to 172.6$\pm$35.3/min at 30 minutes after the brain death. 4. Even though the body temperature and all hemodynamic variables, such as cardiac output, mean pulmonary arterial pressure, left ventricular (LV) end-diastolic pressure and LV maximum + dp/dt, were slightly greater than those of basal state, at the point of brain death, there was no statistically significant change during t e process of brain death. 5. There was no remarkable arrhythmias during the experiment except ventricular premature beats which was observed transiently in one dog at the time of brain death. Hemodynamic changes in the brain death model induced by gradual ICP increment were inconspicuous, and arrhythmias were rarely seen. Hyperdynamic state, which was observed at the point of brain death in another brain death model caused by abrupt ICP increase, was not observed.