• 대한본초학회지
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• 제37권4호
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• pp.17-29
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• 2022

Objective : The present study comparatively analyzed the anti-obesity effect of Arctium lappa L. roots with and without microwave processing. Methods : Four HFD groups except for the Normal group (n=8) were allocated: Control, microwave-processed dried Arctium lappa L. roots (MAL) extract 400 mg/kg/d (MAL400), MAL extract 800 mg/kg/d (MAL800), and the dried Arctium lappa L. roots (DAL) extract 800 mg/kg/d (DAL800). The efficacy of MAL and DAL was confirmed in terms of the serum biochemical index, protein expressions related to the synthesis of triglyceride (TG) and total cholesterol (TC) and 𝛽-oxidation, and histopathological staining. Results : Both MAL and DAL treatments significantly reduced final body weight and body weight gain. MAL800 treatment significantly reduced serum TG, TC, low-density lipoprotein cholesterol, and leptin levels, but the serum high-density lipoprotein cholesterol and adiponectin concentrations were dramatically increased. In particular, leptin in the MAL800 group was reduced by 14.1% compared with the DAL800 group. Moreover, the MAL800 treatment showed an effect superior to the DAL800 treatment in the reduction of serum TC, the sirtuin 1 (Sirt1) activation, and the inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGCR) gene expression. In particular, unlike the DAL800 treatment, MAL treatment significantly led to the activation of peroxisome proliferator-activated receptor alpha (PPAR𝛼). Subsequently, PPAR𝛼 meaningfully regulated downstream proteins associated with 𝛽-oxidation. Conclusion : These findings suggest that Arctium lappa L. roots with microwave processing effectively ameliorate obesity through the regulation of leptin and TC and the promotion of 𝛽-oxidation compared with Arctium lappa L. roots without microwave processing.

• Natural Product Sciences
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• 제13권4호
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• pp.304-310
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• 2007

Saussurea costus (Falc.) Lipchitz syn S. lappa C. B. Clarke (commonly known as 'Kuth') belonging to the family Asteraceae is a well known medicinal plant which finds wide usage in different indigenous systems of medicine of India, China, Korea & Tibet. In different folk medicines the roots of S. costus are used to treat various disorders like ulcer, stomachache, malaria, leprosy, dysentery and toothache. However due to over exploitation, it has become endangered and has become the concern of different governmental bodies in India. The increasing demand of this endangered Himalayan species has resulted in a situation where it is often substituted, knowingly or unknowingly, by other morphologically similar species. Arctium lappa, belonging to the same family, is one such plant that has often been found to be present in the market samples of 'Kuth'. The present study was thus carried out and morphoanatomical characters, physicochemical as well as chemical parameters were developed for proper identification of roots of S. costus and its differenciation from A. lappa as well as authentication of the commercial market samples. The detailed morphoanatomical studies revealed that roots of S. costus can be distinguished from A. lappa on the basis of some important microscopial characters eg. the schizogenous resin ducts observed in roots of S. costus, were absent in A. lappa.. Besides, the HPTLC fingerprint profile showed a distinct band at Rf. 0.72 in S. costus, which was totally absent in A. lappa and a band at $R_f$ 0.64 in A. lappa which was absent in S. costus Chlorogenic acid, used as a chemical marker for HPTLC analysis, was estimated to be 0.077% in S. costus as compared to 0.107% in A. lappa. Thus these detailed pharmacognostical parameters can be successfully used to distinguish between roots of S. costus and A. lappa.

• 한국약용작물학회지
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• 제24권5호
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• pp.351-359
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• 2016

Background: We investigated the optimal aqueous extraction conditions for recovery of high yields of total phenolic compounds from roots of Arctium lappa L. (burdock, Asteraceae), and we compared their antioxidant capacity. Methods and Results: The antioxidant activity of the extracts was tested using 2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)-diammonium salt, and oxygen radical absorbance capacity assays. In addition, the major phenolic compounds present in the extracts were determined by high performance liquid chromatography analysis. Our results suggest that the roasted burdock $100^{\circ}C$, 15 min extract exhibited the strongest radical scavenging activity and possessed the highest concentration of phenolic compounds. The polyphenol content of both dried burdock and roasted burdock significantly increased with increase in the extraction temperature and time. Conclusions: These results indicated a relationship between phenolic compound levels in burdock and their free radical scavenging activities. This suggests that phenolic compounds significantly increase the antioxidant potential of burdock extracts.

• 동아시아식생활학회지
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• 제25권5호
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• pp.902-910
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• 2015

우엉을 식재료로 이용함에 있어서 당연시 수반되었던 박피 과정으로 인한 급격한 갈변현상과 조직의 연화, 미생물의 오염 등으로 양질의 우엉을 얻는데 어려움이 있었다. 본 연구에서는 좋은 품질의 우엉을 좀 더 쉽고, 간편하게 식품소재로 활용하기 위해 박피 여부에 따른 이화학적 특성을 분석하였다. 수분 함량은 박피에 의한 차이가 없었고, 회분, 조단백질, 조지방 및 총식이섬유의 함량은 박피하지 않은 우엉이 박피한 우엉에 비해 높았다. 고형분($^{\circ}Bx$), pH, 그리고 총 산도는 박피 유무에 영향을 받지 않았고, 색도에 있어 L값은 박피한 우엉이 박피하지 않은 우엉에 비해 더 높아 명도가 밝은 반면에 a값과 b값은 낮았다(p<0.05). 무기질 함량의 경우, 박피하지 않은 우엉의 K, Ca, Fe, P 함량은 박피한 우엉보다 높았지만(p<0.05), Mg과 Na 함량은 박피한 우엉이 더 높았다(p<0.05). 총 지방산의 경우 우엉의 박피에 의한 함량 차이는 없었다. Palmitic acid 함량은 박피하지 않은 우엉이 박피한 우엉보다 높았다(p<0.05). 하지만 oleic acid는 이와는 다른 양상이었다(p<0.05). 총 유리당 함량은 박피 유무에 따라 그 값이 달랐는데(p<0.05), 박피하지 않은 우엉의 fructose, glucose 함량이 박피한 우엉보다 높았고, sucrose 함량은 박피한 우엉이 높았으며, maltose 함량은 박피에 의한 차이가 없었다. D-Malic acid와 acetic acid를 제외한 oxalic, citric, succinic acid의 유기산은 박피하지 않은 우엉이 더 높았고, 유리 아미노산은 박피한 우엉이 필수, 비필수아미노산 모두 높게 나타났다. 향후 본 연구결과에 이어 박피 여부에 따른 기능성 및 생리활성, 조리적성, 관능평가 등과 같은 식품소재로 사용하기 위한 연구가 지속되어야 할 것이다.

• Applied Biological Chemistry
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• 제37권6호
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• pp.503-508
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• 1994

17종과 45종 한방 식물체 메탄올 추출물의 배추좀나방과 담배거세미나방 유충에 대한 살충활성 및 섭식저해활성을 잎침지법으로 조사하였다. 살충활성은 8,000 ppm에서 조사하였는바, 현호색 추출물만이 담배거세미나방 유충에 대해 강한 살충활성을 보였다. 섭식저해활성은 5,000 ppm에서 조사한 결과, 누리장나무, 거문누리장나무, 목향, 우방자, 인진, 전호, 백지 및 현호색 추출물이 강한 섭식저해활성을 나타내었다.