• Title/Summary/Keyword: Ar Addition

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The Effects of $Hwangryunhaedok$-$tang$ Pharmacopuncture by the Anti-inflammatory Action of Suppression of iNOS Production on Mice with Allergic Rhinitis (황련해독탕 약침액의 iNOS 생성 억제를 통한 항염증효과가 알레르기성 비염 유발 생쥐의 치료에 미치는 영향)

  • Cho, Jae-Yong;Kim, Yu-Jong;Kim, Eun-Jung;Lee, Seung-Deok;Kim, Kap-Sung
    • Journal of Acupuncture Research
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    • v.29 no.1
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    • pp.89-101
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    • 2012
  • Objectives : The purpose of this study was find out the therapeutic effects of its exclusive use on the rat with allergic rhinitis. Materials and Methods : Thirty Sprague-Dawley rats were divided into three group : normal group, control group and sample group. To induce the allergic rhinitis in control group and sample group, rats were sensitized intraperitoneally with 0.1% ovalumin solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalumin solution 3 times at intervals of 2 days. After that time, rats in the sample group were administered by $Yonghyang$($LI_{20}$) subcutaneously to treat the inflammation. Results : 1. The anti-oxidant effects of $Hwangryunhaedok-tang$ extract was dose-dependantly increased. 2. The RAW 264.7 cells were treated with LPS for 1 hours prior to the addition of indicated concentrations ($0.4,-1.0mg/m{\ell}$) of HHT, and the cells were further incubated for 24 hours. The LPS-induced iNOS mRNA expression and NO production were dose-dependantly decreased in HHT treated RAW 264.7 cells. 3. The number of eosinophil in HP noticeably decreased than CON and this decrease had probability. The infiltration of eosinophil in HP noticeably decreased than CON. 4. The damaged mucosa as disruption of cilia in respiratory cell and vacant mucose secreting cell were increased CON, but HP same as normal configuration. Decrease of PAS positive cell were shown in CON, but goblet cell occupied with neutral mucous were shown in HP. Decrease of mucosal stress(HSP70). Decrease of perennial sign(PPAR-${\gamma}$). Decrease of icthing and sneezing intricate neurotransmitter-(substance P). 5. The anti-inflammation of HHT pharmacopuncture for AR caused mucosa comes to result as belows. Decrease of pre-inflammation cytokine(TNF-${\alpha}$). Decrease of transcription factor (NF-${\kappa}B$ p65). Decrease of transcription factor inhibitor(p-$I{\kappa}B$). Decrease of inflammation cytokine(iNOS). Conclusions : The results may suggest that administration treatment using $Hwangryunhaedok-tang$ pharmacopucnture decreases the inflammatory response on an animal model with allergic rhinitis.

A Study on Development of Experimental Contents Using 3-channel Multi-Image Playback Technique: Based on transparent OLED and dual layer display system (3채널 멀티 영상 재생 기법과 증강현실을 이용한 체험 콘텐츠 제작에 관한 연구: 투명 OLED 및 듀얼 레이어 디스플레이 시스템 기반)

  • Lee, Sang-Hyun
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.17 no.6
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    • pp.151-160
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    • 2017
  • Among the methods of developing tourist spots and culture as the experience contents, it is a common method to display high-quality video images on a large display, and it is necessary to make a special difference between the participant's active participation and the visual experience in other regions. In this paper, using the single molecular OLED and active type, the regional tourist spots blend transparent OLED dual-layer display systems with the extended image implementation and augmented interaction techniques to give the participants a real-world experience, such as directing to new experiences and beautiful sights. In this paper, additional images and UI layers are applied to the layers of the images to allow visitors to experience sightseeing information, weather, maps, accommodations, festivals and photo materials with image. In addition to the dual-layer system, it also added a multi-display system that additionally has one vertical 55-inch display on each side, adding to the experience the immersive experience and interface interlocking fun. By using transparent OLED, dual layer panel and 3-channel Multi-image playback technique, the augmented type experience contents which can experience the local attractions in Jeollanamdo province in Korea at all time without any limitation of time and space were developed.

Effects of Mixed Medicinal Herbs on Adipogenesis and Apoptosis in 3T3-L1 Adipocytes (배합된 한약재의 추출물이 3T3-L1 지방세포의 지방생성과 세포사멸에 미치는 영향)

  • Hwang, Su-Jung;Shin, In-Soon;Kim, Mi-Ryeo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.24 no.4
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    • pp.661-667
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    • 2010
  • Astragali Radix (AR) has been used in traditional medicinal herb, which is known to tonify the qi and blood. It has been asserted to be a tonic that can improve the function of the lungs, adrenal glands and the gastrointestinal tract, increase metabolism, promote healing and reduce fatigue. Also, Plantago asiatica (PA) has the anti-inflammatory, antiseptic, antitussive, cardiac, diuretic, expectorant, haemostatic effects, though it is considered to be less powerful than the seed. Recent research is showing that it is promising in lowering cholesterol and controlling diabetes. Obesity is characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic preadipocytes in adipose tissue. In the present study, we investigated the effects of 3 to 7 extracts of mixed medicinal herbs (water and ethanol extract of Astragali Radix; ARW and ARE, water and ethanol extract of Plantago asitica; PAW and PAE, and those mixed extracts; ARW+PAE, ARW+PAW and ARE+PAE) on adipogenesis and apoptosis in 3T3-L1 adipocytes by MTT assay, Oil-Red-O staining and TUNEL assay. And then, we determined total contents of phenolic compounds and flavonoid compounds in mixed herbal extracts. These result showed that herbal extracts (ARW, PAE and ARW+PAE) affected on adipogenesis and apoptosis in 3T3-L1 adipocytes among 3 to 7 extracts tested. Especially herbal mixed extracts (ARW+PAE) had the highest inhibition on differentiation of preadipocytes and lipoid accumulation of maturing adipocytes. And it did not affect cell viability of mature adipocytes, but herbal mixed extracts (ARW+PAE) increased apoptosis in mature adipocytes, as proved by highest concentration $200\;{\mu}g/m{\ell}$ using TUNEL assay. In addition, contents of total phenoilc compounds and flavonoids showed the highest level in ARE+PAE and PAE than ARW. These results suggest that this main target for adipocyte functions could be effective in improving the metabolic syndrome including obesity.

The Inhibition of Green Discoloration in Garlic by Conditioning (Conditioning에 의한 마늘의 녹변억제)

  • Hwang, Jin-Bong;Shin, Dong-Bin;Park, Wan-Su;Lee, Young-Chun
    • Korean Journal of Food Science and Technology
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    • v.35 no.6
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    • pp.1007-1016
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    • 2003
  • Garlic was stored at 4, 8, and $12^{\circ}C$ to investigate the development of green discoloration. Green discoloration developed after 7 day of storage ar $4^{\circ}C$, while it developed after 15 day of storage at 8 and $12^{\circ}C$. The effect of maleic hydrazide fertilization on green discoloration of garlic was not observed. Green discoloration of garlic was accelerated by gamma-radiation treatment. The addition of cysteine did not prevent green discoloration, which decreased the commercial value of the garlic due to the presence of white specks on the surface. When 3% ascorbic acid was added to the garlic, green discoloration developed in 6 and 24 hr at room temperature and $4^{\circ}C$, respectively. The tendency of garlic to discolor was also investigated at various storage temperatures. Discolored garlic stored for 30 day at low temperatures was conditioned at $20{\sim}45^{\circ}C$ for 20 day. The green discoloration of garlic conditioned at 20 and $25^{\circ}C$ did not disappear in 20 day, but disappeared in 20 day when conditioned at $30^{\circ}C$. The L, a, and b values of garlic conditioned at 35, 40, and $45^{\circ}C$ for 4 day were similar to those of normal garlic. Conclusively, our results indicated that the best method for suppressing green discoloration was conditioning discolored garlic at $35^{\circ}C$ for 4 day.

Impact of Climate Change on Fungicide Spraying for Anthracnose on Hot Pepper in Korea During 2011-2100 (한국의 2011-2100년 기후변화가 고추 탄저병 살균제 살포에 미치는 영향)

  • Shin, Jeong-Wook;Yun, Sung-Chul
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.13 no.1
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    • pp.10-19
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    • 2011
  • In order to predict the risk of anthracnose on hot pepper in the future, the projected climate data from SRES A1B scenario in South Korea were used with the modified anthracnose model to calculate Infection Risk (IR), which was to estimate the number of fungicide sprays. Based on daily temperature and precipitation, the anthracnose model resulted in an empirical relationship that IR = (Daily temperature - $16^{\circ}C$) ${\times}$ 0.07 + (Daily precipitation ${\times}$ 0.11). For 135 locations in South Korea, the total number of fungicide sprays needed from 2011 to 2100 was 12,150, indicating a complicated change with an overall increase in anthracnose development in all locations until 2100. In particular, radical changes in anthracnose development were predicted at Yeongdeok, Yeongyang, and Uiseong, whereas gradual changes were predicted at Heongsung, Hamyang and Taean. The eastern counties of Gyeongbuk Province, which ar the major plantation area in these days, would be the place with the highest disease pressure in the future. In addition, the years of 2058, 61, 78 and 2096 will be most severe, requiring 8-11 times of fungicide spraying. The GIS maps show that the mountain areas of Jeonbuk and Chungbuk Province would have the least disease pressure of anthracnose in the future.

Geochronology and Petrogenetic processes of the so-called Hongjesa granite in the Seogpo-Deogku Area (석포(石浦)-덕구간(德邱間)에 분포(分布)하는 소위(所謂) 홍제사화강암(洪濟寺花崗岩)의 지질연대(地質年代)와 생성과정(生成過程)에 대(對)한 硏究(연구))

  • Kim, Yong Jun;Lee, Dai Sung
    • Economic and Environmental Geology
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    • v.16 no.3
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    • pp.163-221
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    • 1983
  • Main aspects of this study are to clarify geochronology and petrogenetic processes of the so-called Hongjesa granite, which is a member of various intrusive rocks exposed in the northeastern part of the Ryongnam Massif, one of the Precambrian basements of South Korea. In this study, the Hongjesa grainte is divided into four rock units based on the geologic age, mineralogical and chemical constituents, and texture: the Precambrian Hongjesa granite gneiss (Hongjesa granite Proper) and leucogranite gneiss, the Paleozoic gnessic two mica granite, and the Jurassic muscovite granite. The Hongjesa granite gneiss is identified by its grayish color, slight foliation, and porphyroblastic texture. The leucogranite gneiss is distinct by its light gray color, sand medium to coarse grained texture. The gneissic two mica granite is distinguished from others by its strong foliation, containing gray-colored feldspar phenocrysts with biotite and muscovite in varying amounts. The muscovite granite occurs as a small stock containing feldspar phenocrysts along margin of the stock. These granitic rocks vary widely in composition, reflecting the facts that they partly include highly metamorphosed xenolith and schlierens as relics of magmatic and anatectic processes. In particular, grayish porphyroblasts of microcline perthite is characteristic of the Hongjesa granite gneiss, whereas epidote and garnet occur in both the Hongjesa granite gneiss and leucogranite gneiss. These minerals are considered to be formed by potassic metasomatism and contamination of highly metamorphosed rocks deeply buried under the level of the Hongjesa granite emplacement. The individual synchronous granitic rocks plotted on Harker diagram show mostly similar trends to the Daly's values. The plots of the Hongjesa granite gneiss and gneissic two mica granite concentrate near the end part of the calc-alkalic rock series on the AMF diagrams, whereas those of the leucogranite gneiss and muscovite granite indicate the trend of the Skaergaard pluton. These granitic rocks plotted on a Q-Ab-Or diagram (petrogeny's residua system) fall well outside the trough of the system. This can be attributed to the potassic matasomatism of these rocks. On the ACF diagram, these rocks appear to be dominantly I-type prevailing over S-type. The K-Ar ages, obtained from a total of 7 samples of the leucogranite gneiss, gneissic two mica granite, muscovite granite, porphyritic alkali granite, and rhyolitic rock, in addition to the Rb/Sr ages of the Hongjesa granite gneiss by previous workers, permit the rock units to be arranged in the following chronological order: The middle Proterozoic Hongjesa granite gneiss (1714-1825 m.y.), the upper proterozoic leucogranite gneiss (875-880 m. y.), the middle Paleozoic gneissic two mica granite (384 m. y.) the upper Jurassic muscovite granite (147 m. y.), the Eocene alkali granite (52 m. y.), and the Eocene rhyolitic rock (45 m. y.). From the facts and data mentioned above, it is concluded that the so-called Hongjesa granite is not a single granitic mass but is further subdivided into the four rock units. The Hongjesa granite gneis, leucogranite gneiss, and gneissic two mica granite are postulated to be either magmatic or parautochtonous, intrusive, and the later muscovite granite is to be magmatic in origion.

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A Study on Examples Applicable to Numerical Land Cover Map Data for Atmospheric Environment Fields in the Metropolitan Area of Seoul - Real Time Calculation of Biogenic CO2 Flux and VOC Emission Due to a Geographical Distribution of Vegetable and Analysis on Sensitivity of Air Temperature and Wind Field within MM5 - (수도권지역에서 수치 토지피복지도 작성을 통한 대기환경부문 활용사례 연구 - MM5내 기온 및 바람장의 민감도 분석과 식생분포에 기인한 VOC 배출량 및 CO2 플럭스의 실시간 산정을 중심으로 -)

  • Moon, Yun-Seob;Koo, Youn-Seo
    • Journal of Korean Society for Atmospheric Environment
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    • v.22 no.5
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    • pp.661-678
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    • 2006
  • Products developed in this research is a software which can transfer the type of shape(.shp) into the type of ascii using the land cover data and the topography data in the metropolitan area of Seoul. In addition, it can calculate the $CO_2$ flux according to distribution of plants within the land cover data. The $CO_2$ flux is calculated by the experimental equation which is compose of the meteorological parameters such as the solar radiation and the air temperature. The net flux was shown in about $-19ton/km^2$ by removing $CO_2$ through the photosynthesis during daytime, and in 2 ton/km2 by producing it through the respiration during nighttime on 10 August 2004, the maximum day of air temperature during the period of 3yr(2001 to 2004), in the metropolitan area of Seoul. Spatial distribution of the air temperature and the wind field is simulated by substituting the middle classification of the land cover map data, upgraded by the Korean Ministry of Environment(KME), for the land-use data of the United States Geological Survey(USGS) within the Meteorological Mesoscale Model Version 5(MM5) on 10 August 2006 in the metropolitan area of Seoul. Difference of the air temperature between both data was shown in the maximum range of $-2^{\circ}C\;to\;2.9^{\circ}C$, and the air temperature due to the land use data of KME was higher than that of USGS in average $0.4^{\circ}C$. Also, those of wind vectors were meanly lower than that of USGS in daytime and nighttime. Furthermore, the hourly time series of Volatile Organic Components(VOCs) is calculated by using the Biosphere Emission and Interaction System Version 2(BEIS2) including the new land cover data and the meteorological parameters such as the air temperature and so]ar insolation. It is possible to calculate the concentration of ozone due to the biogenic emission of VOCs.

Evidence for the Association of Ce11u1ar Iron Loss in Nitric Oxide-induced Apoptosis of HL-60 Cells: Involvement of p38 Kinase, c-Jun N-terminal Kinase, Cytochrome C Release, and Caspases Pathways

  • Choi, Suck-Chei;Kim, Beom-Su;Yoon, Kwon-Ha;Song, Moon-Young;Oh, Hyun-Mee;Han, Weon-Cheol;Kim, Tae-Hyeon;Kim, Eun-Cheol;Jun, Chang Duk
    • Animal cells and systems
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    • v.6 no.2
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    • pp.171-180
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    • 2002
  • Nitric oxide has high affinity for iron, and thus it can cause intracellular iron loss. We tested the idea that intracellular iron can be the primary target of NO toxicity by comparing the signaling mechanisms involved in cell death caused by iron depletion and that caused by NO. Treatment of HL-60 cells with a NO donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP), decreased the intracellular iron level rapidly as that observed with the iron chelator deferoxamine (DFO). Iron chelators such as DFO and mimosine could induce death of human leukemic HL-60 cells by a mechanism requiring activation of p38 kinase, c-Jun N-terminal kinase, caspase-3 and caspase-8. DFO and SNAP also caused release of cytochrome c from mitochondria. Inhibition of p38 kinase by a selective inhibitor, SB203580, abolished the NO and DFO-induced cell death, release of cytochrome c, and activation of caspase-3 and caspase-8, thus indicating that p38 kinase lies upstream in the cell death processes. In a parallel situation, the cells that are sensitive to NO showed similar sensitivity to DFO. Moreover, simultaneous addition of ferric citrate, an iron-containing compound, inhibited the SNAP and DFO-induced activation of caspases and also blocked the NO-mediated cell cycle arrest at $G_1$ phase. Collectively, our data implicate that the NO-induced cell death of tumor cells including HL-60 cells is mediated by depletion of iron and further suggest that activation of p38 kinase lies upstream of cytochrome c release and caspase activation involved in this apoptotic process.

Changes of Soil Properties and Evaluation of Plant Utilization According to the Application of Compost Used with Phyllite (Phyllite를 이용한 퇴비 시용에 따른 토양 특성 변화 및 작물에 대한 효용성 평가)

  • Park, Young-Hee;Chang, Ki-Woon;Hong, Jei-Gu
    • Journal of the Korea Organic Resources Recycling Association
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    • v.10 no.2
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    • pp.92-99
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    • 2002
  • The study was conducted to investigate the changes of soil properties and evaluation of plant utilization according to the application of compost used with phyllite. At this experiment, the plant cultivation test(lettuce and radish plant) was carried out to know about physico-chemical properties of compost, humus degradarion and stabilization degree, and some effects among rhe treatments were best at 20Mg/ha in PSPC 10(Phyllite, Saw dust, Pig manure Compost) plots and ar 10Mg/ha in PSPC 20 treatments, respectively. The EC value was high in the compost. Therefore the EC was appeared more than 2ds/m at the applied 40Mg/ha with compost. And in case of lettuce, Avail.-$P_2O_5$ and EC were more increased than in the radish plots, highly. In contrast, in case of radish, Toral-N, Total-C, and EC contents were decreased after plant cultivation. That is, it could know that radish was fond of absorprion of nitrogen. Also, BD values of soil physical properties were decreased according to increasing of phyllite addition ratio, however water holding capacity(WHC) was increased. The plant test had not been darnaged through the application of compost used with phyllite in soil and there had not been worse on changing of soil physico-chemical properties. Consequently, phyllite composts have been thought on agricultural utilized possibility.

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A Study on the Evaluating Method the most Favorable Mixture Proportion of Blended Fine Aggregate for Effective Application of Recycled Aggregate (재생골재의 효율적인 활용을 위한 혼합잔골재의 최적배합평가방법에 관한 연구)

  • Han, Cheon-Goo;Yoon, Gi-Won;Lee, Gun-Cheol;Park, Yong-Kyu
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.2 no.1
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    • pp.113-119
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    • 2006
  • It is now established that more than two types of blended aggregate have beneficial effects on quality and supply of concrete in the long run. However, studies on blended aggregate have not widely been progressive and the evaluation method of its most favorable mixture proportion is still needed. Therefore this study investigated the most favorable mixture proportion through the physical experiment of fresh and hardened state's cement mortar, in response to three types of composite ratio, natural fine aggregate(Ns), crushed fine aggregate(Cs) and recycled fine aggregate(Rs). Test showed that increase of blending ratio of Ns and Cs improved fluidity of mot1ar. For the properties of compressive and flexural strength, mortar blending Ns and Cs properly, exhibited similar value to one using only Cs, while mortar mixing Rs showed lower strength value as less as 6% of control one. Mortar using only Rs exhibited the largest drying shrinkage value. In addition, even thought it is not a clear quantitative analysis, technical-imaging-skill presenting the most favorable mixture proportion 3-dimensionally is proposed in this research, in order to notify the proportion easily.

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