• The Journal of the Korea Contents Association
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• v.19 no.3
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• pp.365-374
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• 2019

Unlike benign tumors, malignant tumors are capable of metastasis, easy to relapse, poor survival, and low quality of life. In Korea, here is a tendency to treat the tumors collectively according to the General Principles of Cancer Chemotherapy(GPCC) of the Health Insurance Review & Assessment Service (HIRA). But recently, companion diagnostics(CDx) is recommended rather than unilateral medication because biomarker-based molecular diagnostics is possible to predict the drug response of patients before drug treatment. Not only domestic but also overseas Food and Drug Administratio (FDA) recommends the development of the CDx system at the stage of drug development to ensure the responsiveness and safety of medicines. In this study, I focused on the necessity of CDx development direction as well as CDx development status through literature review. Furthermore I also discussed CDx types according to the molecular diagnostic technology such as immunohistochemistry (IHC), polymerase chain reaction (PCR), in situ hybridization (ISH), and next-generation sequencing (NGS) not only in the approved CDx but also in the developing one by US FDA. And I suggested the technology issue of CDx development process such as a selection of molecular diagnostics at the time of release, a clear understanding of the CDx mechanism, and a convergence of drug with CDx development. The necessity of social insurance system also was proposed for CDx development.

• Journal of Wetlands Research
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• v.21 no.1
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• pp.57-65
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• 2019

LID(Low Impact Development) facility classified as a social infrastructure can maintain landscape sustainability and functional sustainability through continuous maintenance and management. Since LID is a natural-based solution, the sustainability can be secured through the management of weeds, wastes and vegetation. The LID facility is distributed in the city and is an infrastructure that can be managed through citizen participation because of simple maintenance. Therefore, this study was conducted to investigate the maintenance factors affecting the sustainability of the LID facilities and to suggest measures for maintenance by investigating the participation of the peoples. The factors for landscape sustainability were derived to waste and weed management. Also the factors for functional sustainability were assessed to identification and management of dead bodies and selection of applicable soil and plant species. The citizens showed high agreement of more than 80% in the questionnaires on expanding and managing LID facilities, enacting LID ordinances, and participating in the national movement. The intention to participate in LID management linked to jobs was about 64%, indicating that LID could become a job for the vulnerable. Maintenance of the LID can easily be carried out by non-specialists, which can lead to citizen participation with low cost for each facility. The maintenance cost for citizen participation can be allocated from the social infrastructure management cost reduced by LID application of the local government and the social welfare budget of the central government.

• Korean Journal of Ichthyology
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• v.30 no.4
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• pp.238-241
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• 2018

The purpose of this study was to investigate color pattern and growth in cross progenies between kois and red common carp (Cyprinus carpio). Coverage of red color patches in skin was investigated in $koi{\times}koi$ (KK), $koi{\times}red$ common carp (KR) and red common $carp{\times}koi$ (RK) progenies in 170 days post-hatching (DPH) by analysis of digital photographs. KR cross group had higher length (P<0.05) and the mean weight than in the KK but there were no significant difference between KR and RK. All groups consisted of three color pattern white, white-red and red. The percentage of red-area coverage in skin was 64% in KK progenies, 56% in KR and 36% in RK. The red coverage (30~50%) was highly in KR (15%) than in KK (10%) and RK (12%). The application of red-area body coverage analysis may suggest potentially useful tool for ornamental fish selection.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.2
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• pp.139-150
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• 2019

Though, fishing vessel accidents account for 70 % of all maritime accidents in Korean waters, most research has focused on identifying causes and developing mitigation policies in an attempt to reduce this rate. However, predicting and evaluating accident risk needs to be done before the implementation of such reduction measures. For this reasons, we havve performed a risk analysis to calculate the risk of accidents and propose a risk criteria matrix with 4 quadrants, within one of which forecasted risk is plotted for the relative comparison of risks. For this research, we considered 9 types of fishing vessel accidents as reported by Korea Maritime Safety Tribunal (KMST). Given that no risk evaluation criteria have been established in Korea, we established a two-dimensional frequency-consequence grid consisting of four quadrants into which paired frequency and consequence for each type of accident are presented. With the simple structure of the evaluation model, one can easily verify the effect of frequency and consequence on the resulting risk within each quadrant. Consequently, these risk evaluation results will help a decision maker employ more realistic risk mitigation measures for accident types situated in different quadrants. As an application of the risk evaluation matrix, accident types were further analyzed using accident causes including human error (factor) and appropriate risk reduction options may be established by comparing the relative frequency and consequence of each accident cause.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.2
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• pp.273-279
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• 2019

Development of mountain area is increasing due to the demand for improvement of traffic convenience and development of underdeveloped area. Therefore, there frequently are sections where tunnels and interchanges are located close to each other. These sections do not only affect tunnel planning, types and length of interchanges, but also affect more on route selection. In Korea, several design criteria present each reference value but these values are very similar. In the situation, the minimum value among them is usually applied when planning roads and it could cause traffic safety problems in different site conditions. In this study, the problems of design speed, illuminance adaptation distance, and lane change intervals are analyzed by simulating the cases that the problem could occur when calculating the separation distance between tunnel and interchange. The results obtained from this study can be summarized as following: the driving speed should be applied in case that the site has a big gap between design speed and driving speed because the uniform application of the design speed is not safe; the illuminance adaptation distance should include the influence distance in the section affected by the direct light; in addition, the lane change distance should include the time to perceive the situation of the next lane after the lane change in the section required for successive lane change.

• Journal of Environmental Health Sciences
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• v.45 no.1
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• pp.82-96
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• 2019

Objective: The aims of this study were to provide the basic data for establishing a precautionary management policy and to develop a methodology for selecting a radon management priority target area suitable for the Korean domestic environment. Methods: A suitable mapping method for the domestic environment was derived by conducting a quantitative comparison of predicted values and measured values that were calculated through implementation of two models such as IDW and RBF methods. And a qualitative comparison including the clarity of information transmission of the written radon map was carried out. Results: The predicted and measured values were obtained through the implementation of the spatial analysis models. The IDW method showed the lowest in the calculated mean square error and had a higher correlation coefficient than the other methods. As results of comparing the uncertainty using the jackknife concept and the concept of error distance for comparison of the differences according to the model interpolation method, the sum of the error distances showed a modest increase compared with the RBF method. As a result of qualitatively comparing the information transfer clarity between the radon maps prepared with the predicted values through the model implementation, it was found that the maps plotted using the predicted values by the implementation of the IDW method had greater clarity in terms of highness and lowness of radon concentration per area compared with the maps plotted by other methods. Conclusions: The radon management priority area suggests selecting a metropolitan city including an area with a high radon concentration.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.291-298
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• 2019

We describe the improvement of insulation performance and the prevention of electrolyte leakage in a single cell in order to prevent the fuming phenomenon caused by leakage of electrolyte in a lithium secondary battery in a submerged weapon (torpedo) operated in Korea. A torpedo using lithium secondary battery as a main power source (propulsion battery) can induce the heat and fuming phenomenon, which makes it inconvenient for naval equipment operation in Korea. In the simulation test, the electrolyte of some battery cells leaked in the battery pack unit, leading to a short circuit between the main power circuit and the terminal tab of the high voltage part. We analyzed the characteristics and mechanism of the lithium secondary battery during this heat generation and fuming phenomenon. In order to prevent leakage of the electrolyte in the lithium secondary battery, the design was improved via fundamental (terminal tap enhancement) and complementary (insulation block selection and installation) measures. Comparison of the performance test before and after the improvement showed that the tensile strength of the tap terminal was improved about 2 times and the withstand voltage characteristic was improved. The application of quality improvement measures resulted in no fuming even after more than 3 years of field operation. This result is expected to improve the operation and storage stability of the torpedo propulsion cell.

• The Journal of Engineering Geology
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• v.31 no.1
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• pp.1-17
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• 2021

It is important to evaluate the fracture network in a rock volume because fractures control the ground conditions and fluid flow characteristics. Therefore, various attempts have been made to quantify fracture networks to better understand ground and flow conditions. The use of fracture density alone (a quantitative parameter based on geometric analysis) does not fully explain the evolution of fracture networks, or quantify the spatial relationship (e.g. connectivity) of fractures in a rock mass. Therefore, the need for fracture network characterization based on topological analysis has recently emerged. In Korea however, the topological analysis of fracture networks within a rock mass has rarely been studied. As such, the definition of the topological analysis of fracture networks and the graph theory related to the topological analysis are briefly summarized in this study. We also introduce an application method for these analyses to fracture characterization. If the topological method is used for the analysis of fracture networks, it can also be adopted to analyze fluid flow characteristics of groundwater, characterize petroleum reservoirs, and analyze the evolution of a fracture network. In addition, topological analysis can be useful for site selection of major facilities such as nuclear waste disposal sites because it can be used to evaluate the stability of the potential sites.

• Korean Journal of Food Science and Technology
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• v.53 no.1
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• pp.72-77
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• 2021

Silkworms have traditionally been used to produce silk and textiles. However, steamed and freeze-dried mature silkworm larval powder (SMSP) contain large amounts of amino acids, vitamins, and essential minerals. In this study, we investigated the potential of SMSP as a hangover-relieving agent. Thirty individuals who met the selection criteria and exclusion criteria were included in the study and subsequently underwent a double-blind, randomized, placebo-controlled, cross-design human application test. Importantly, the test product containing SMSP (CKDHC) was proven to alleviate hangovers through a significant reduction in the plasma concentration of acetaldehyde in the context of an alcohol-induced hangover model. In particular, from 0.5 h after SMSP intake, the blood acetaldehyde concentration (mg/L), area under the time curve (AUC; indicating the degree of bioabsorption of blood acetaldehyde), and the highest blood acetaldehyde concentration (Cmax) were reduced. Altogether, these results suggest that the test product (CKDHC) exhibits an accelerated hangover-relieving effect.

• Journal of the Korean GEO-environmental Society
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• v.12 no.4
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• pp.53-63
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• 2011

Selection or generation of appropriate input ground motion is very important in performing a dynamic analysis. In Korea, it is a common practice to use recorded strong ground motions or artificial motions. The recorded motions show non-stationary characteristics, which is a distinct property of all earthquake motions, but have the problem of not matching the design response spectrum. The artificial motions match the design spectrum, but show stationary characteristics. This study generated ground motions that preserve the non-stationary characteristics of a real earthquake motion, but also matches the design spectrum. In the process, an impulse function-based algorithm that adjusts a given time series in time domain such that it matches the target response spectrum is used. Application of the algorithm showed that it can successfully adjust any recorded motions to match the target spectrum and also preserve the non-stationary characteristics. The modified motions are used to perform a series of nonlinear site response analyses. It is shown that the results using the adjusted motions result in more reliable estimates of ground vibration. It is thus recommended that the newly adjusted motions be used in practice instead of original recorded motions.