• 한국지하수토양환경학회지:지하수토양환경
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• 제13권5호
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• pp.74-80
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• 2008

중금속 오염 토양(Cd, Pb)에 대한 음이온성 계면활성제, AOS(alpha olefin sulfonate), SDS(sodium dodecyl sulfate) 및 LAS(linear alkyl benzene sulfonic acid)의 중금속 추출능력을 평가하였다. 계면활성제의 pH와 탄소성분 개수가 중금속 추출율에 지대한 영향을 미치는 것으로 나타났다. LAS는 산성 pH에 의한 중금속 추출효과가 높게 나타났다. SDS는 탄소개수가 AOS에 비해 적지만 중금속 추출율이 보다 높게 나타난 것은 AOS에 비하여 SDS가 작은 크기 마이셀을 형성하기에 토양과의 접촉이 보다 원활하게 일어난 것으로 판단된다. 계면활성제에 음이온성 리간드(ligand) NaI을 첨가한 결과 중금속 추출율이 Cd의 경우 1.2-2.7배 증가하였다. 반면 Pb의 경우는 0.56-1.76배로 오히려 감소하였다. 이는 $I^-$ 이온과 Pb 사이에서 형성된 비수용성 화합물이 토양에 그대로 침전되기 때문이었다. 연속식 토양칼럼실험에서도 적은 탄소개수 및 마이셀의 크기를 가지는 SDS가 토양과의 접촉 및 용탈에 보다 효율적인 것으로 나타났다.

• The Korean Journal of Physiology and Pharmacology
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• 제15권1호
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• pp.31-36
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• 2011

To understand the roles of purinergic receptors and cellular molecules below the receptors in the vascular inflammatory response, we determined if extracellular nucleotides up-regulated chemokine expression in vascular smooth muscle cells (VSMCs). Human aortic smooth muscle cells (AoSMCs) abundantly express $PSY_1$, $PSY_6$, and $PSY_{11}$ receptors, which all respond to extracellular nucleotides. Exposure of human AoSMCs to $NAD^+$, an agonist of the human $PSY_{11}$ receptor, and $NADP^+$ as well as ATP, an agonist for $PSY_1$ and $PSY_{11}$ receptors, caused increase in chemokine (C-C motif) ligand 2 gene (CCL2) transcript and CCL2 release; however, UPT did not affect CCL2 expression. CCL2 release by $NAD^+$ and $NADP^+$ was inhibited by a concentration dependent manner by suramin, an antagonist of P2-purinergic receptors. $NAD^+$ and $NADP^+$ activated protein kinase C and enhanced phosphorylation of mitogen-activated protein kinases and Akt. $NAD^+$- and $NADP^+$-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. These results indicate that extracellular nucleotides can promote the proinflammatory VSMC phenotype by up-regulating CCL2 expression, and that multiple cellular elements, including phosphatidylinositol 3-kinase, Akt, protein kinase C, and mitogen-activated protein kinases, are involved in that process.

• 대한정형외과학회지
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• 제52권1호
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• pp.25-32
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• 2017

목적: 고령 환자에서 발생한 불안정성 대퇴골 전자간부 골절의 치료 시 골수강내 금속정의 길이에 따른 방사선적, 임상적 치료 결과를 비교 분석하고자 한다. 대상 및 방법: 2009년 8월부터 2014년 12월까지 방사선 영상상 AO/OTA 분류 31-A2 대퇴골 전자간부 골절로 진단되어 골수강 내 금속정을 이용한 내고정을 시행한 뒤 최소 1년 이상 추시가 가능하였던 65세 이상의 환자 139예를 대상으로 후향적 대조군 연구를 시행하였다. 대상군을 짧은 골수정(I군)과 긴 골수정(II군)을 사용한 군으로 분류하였으며 각각 106예, 33예로 조사되었다. 방사선적인 평가로 골절의 정복 정도, 골유합까지의 기간, 합병증 발생을 조사하였으며 수술 전 혈색소, 수술 시간, 수술 중 출혈량, 수혈 유무, 입원 기간 및 최종 추시 시 Charnley 고관절 점수를 통한 임상적 평가를 시행하였다. 결과: 수술 후 단순 방사선 검사상 전 예에서 good 또는 acceptable한 정복 상태를 얻었다. 골유합까지 평균 4.8개월이 걸렸으며 두 군 간의 차이는 없었다. II군(57.87분)이 I군(45.65분)보다 수술 시간이 길었던 것으로 확인되었다(p=0.003). 수술 중 출혈량의 경우 II군(288.78 ml)이 I군(209.90 ml)보다 많은 것으로 확인되었다(p=0.046). 최종 추시 시 임상적 결과는 두 군 모두 만족스러웠다. 결론: 고령의 환자에서 발생한 후내측 골편을 동반한 불안정성 대퇴골 전자간부 골절의 치료 시 골절 부위의 정복을 잘 시행한 경우 긴 골수정과 짧은 골수정 모두 만족스러운 방사선적, 임상적 결과를 보였다.

• 대한족부족관절학회지
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• 제1권1호
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• pp.30-37
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• 1997

Pilon fracture is an intraarticular fracture of distal tibia. It is high energy injury with significantly associated soft tissue damage, bone comminution, and articular surface disruption. Until recently, this treatment has followed the AO principles, Because the risk of complications outweighs potential benefits, the principle of a Pilon fracture treatment are changing. Newer techniques using articulated external fixation minimize disturbance of the soft tissue envelope and have decreased these complications. Series of 5 patients with Pilon fracture were treated by articulated external fixator and followed up more than 12 monthes at the Department of orthopaedic surgery, Kang Dong Sacred Heart Hospital, College of medicine, Hallym University. The results were as follows: 1. The type of fracture were type C2(3 cases),type C3(2 cases) according to AO-$M{\ddot{u}}ller$ classification. 2. The clinical results according to functional criteria by Mast and Teipner were good in 4 cases and poor in 1 case, which is an old fracture. 3. Techniques utilizing articulated external fixator were associated with satisfactory results and appeared to significantly decrease the incidence of soft tissue complication, post-traumatic arthritis, osteoporosis, and fibrosis of ankle joint.

• 대한족부족관절학회지
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• 제19권4호
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• pp.151-155
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• 2015

Purpose: The purpose of this study was to analyze the frequency and patterns of intra-articular lesions detected during ankle fracture surgery using ankle arthroscopy. Materials and Methods: Thirty patients (31 ankles) who underwent open reduction and internal fixation combined with ankle arthroscopy for acute ankle fracture at Inje University Busan Paik Hospital from June 2011 to September 2013 were evaluated. The ankle fractures were classified according to the AO/OTA (AO Foundation and Orthopaedic Trauma Association) classification and the intraarticular injuries were identified by ankle arthroscopy. Osteochondral lesions of the talus were divided into nine subtypes based on their locations, and the ligament injuries were classified according to avulsion fracture and rupture. Results: Using arthroscopy, abnormality in the distal tibiofibular ligament was found in 21 cases and osteochondral lesions and defects of the talus larger than 5 mm were detected in 26 cases. Among ligament injuries, anterior inferior tibio-fibular ligament injury was found in 14 cases, posterior inferior tibio-fibular ligament injury was found in two cases, deep deltoid ligament injury was found in three cases, and deep transverse tibio-fibular ligament injury was found in five cases. The locations of the osteochondral lesions were on the antero-lateral, antero-medial, centro-medial, centro-central, centro-lateral, and postero-lateral talus in 11, one, two, one, two, and nine cases, respectively. Conclusion: With early diagnosis and treatment arthroscopy performed at the time of intra-articular fracture surgery is expected to result in a good outcome.

• 한국환경과학회지
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• 제21권12호
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• pp.1425-1433
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• 2012

Water temperature in the eastern part of the Yellow Sea (EYS) during winter (JFM) and summer (JJA) from 1964 to 2009 and Siberian High Pressure Index (SHI) and Arctic Oscillation index (AOI) during winter (JFM) from 1950 to 2011 were used to analyze long-term variation in oceanic and atmospheric conditions and relationship between winter and summer bottom water temperature. Winter water temperature at 0, 30 and 50 m had fluctuated highly till the late of 1980s, but after this it was relatively stable. The long-term trends in winter water temperature at both depths were separated with cold regime and warm regime on the basis of the late 1980s. Winter water temperature at 0m and 50m during warm regime increased about $0.9^{\circ}C$ and $1.1^{\circ}C$ respectively compared to that during cold regime. Fluctuation pattern in winter water temperature matched well with SHI and AOI The SHI had negative correlation with water temperature at 0 m (r=-0.51) and 50 m (r=-0.58). On the other hand, the AO had positive correlation with Winter water temperature at 0 m (r=0.34) and 50 m (r=0.45). Cyclic fluctuation pattern of winter water temperature had a relation with SHI and AO, in particular two to six-year periodicity were dominant from the early of the 1970s to the early of the 1980s. Before the late of 1980s, change pattern in winter water temperature at 0 and 50 m was similar with that in the bottom water temperature during summer, but after this, relationship between two variables was low.

• Clinical and Experimental Pediatrics
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• 제55권7호
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• pp.238-248
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• 2012

Purpose: Hypoxic-ischemic encephalopathy is an important cause of neonatal mortality, as this brain injury disrupts normal mitochondrial respiratory activity. Carnitine plays an essential role in mitochondrial fatty acid transport and modulates excess acyl coenzyme A levels. In this study, we investigated whether treatment of primary cultures of rat cortical neurons with L-carnitine was able to prevent neurotoxicity resulting from oxygen-glucose deprivation (OGD). Methods: Cortical neurons were prepared from Sprague-Dawley rat embryos. L-Carnitine was applied to cultures just prior to OGD and subsequent reoxygenation. The numbers of cells that stained with acridine orange (AO) and propidium iodide (PI) were counted, and lactate dehydrogenase (LDH) activity and reactive oxygen species (ROS) levels were measured. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and the terminal uridine deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay were performed to evaluate the effect of L-carnitine (1 ${\mu}M$, 10 ${\mu}M$, and 100 ${\mu}M$) on OGD-induced neurotoxicity. Results: Treatment of primary cultures of rat cortical neurons with L-carnitine significantly reduced cell necrosis and prevented apoptosis after OGD. L-Carnitine application significantly reduced the number of cells that died, as assessed by the PI/AO ratio, and also reduced ROS release in the OGD groups treated with 10 ${\mu}M$ and 100 ${\mu}M$ of L-carnitine compared with the untreated OGD group (P<0.05). The application of L-carnitine at 100 ${\mu}M$ significantly decreased cytotoxicity, LDH release, and inhibited apoptosis compared to the untreated OGD group (P<0.05). Conclusion: L-Carnitine has neuroprotective benefits against OGD in rat primary cortical neurons in vitro.

• Journal of Korean Neurosurgical Society
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• 제46권4호
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• pp.385-388
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• 2009

Objective : We analyzed the methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter in World Health Organization (WHO) grade III gliomas in association with other molecular markers to evaluate their prevalence. Methods : The samples of a total of 36 newly WHO grade III glioma patients including 19 anaplastic oligodendrogliomas (AO), 7 anaplastic oligoastrocytomas (AOA), and 10 anaplastic astrocytomas (AA) were analyzed. The methylation status of the MGMT gene promoter was confirmed by methylation-specific polymerase chain reaction. The 1p/19q chromosomal deletion status and EGFR amplification were assessed by Fluorescence In-Situ Hybridization. MGMT, EGFR, EGFRvlll, and p53 expression were analyzed by immunohistochemical staining. Results : The MGMT gene promoter was methylated in 32 (88.9%) and unmethylated in 4 (11.2%) Among them, all of the AO and AOA had methylated MGMT gene promoter without exception. Significant associations between MGMT gene promoter hypermethylation and 1p/19q deletion was observed (p=0.003). Other molecular markers failed to show significant associations between MGMT gene promoter statuses. Conclusion : There was extensive epigenetic silencing of MGMT gene in high grade gliomas with oligodendroglial component. Together with frequent 1p/19q co-deletion in oligodendroglial tumors, this may add plausible explanations supporting the relative favorable prognosis in oligodendroglial tumors compared with pure astrocytic tumors.

• Ocean and Polar Research
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• 제40권3호
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• pp.127-143
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• 2018

This study analyzed the influence of climate change on the spawning ground area of the common squid, Todarodes pacificus. To estimate long term changes in the area of the spawning ground of the common squid, water temperature at 50 m deep that can be inferred from sea surface temperature (SST) based on both NOAA/AVHRR (1981.07-2002.12) and MODIS/AQUA (2003.01-2009.12) ocean color data was analyzed. In addition, five climate indices, Arctic Oscillation Index (AO), Siberian High Index (SH), Aleutian Low Pressure Index (ALP), East Asia Winter Monsoon Index (EAWM) and Pacific Decadal Oscillation (PDO) which are the main indicators of climate changes in the northwestern Pacific were used to study the relationship between the magnitude of the estimated spawning ground and climate indices. The area of the estimated spawning ground was highly correlated with the total catch of common squid throughout four decades. The area of the estimated spawning ground was negatively correlated with SH and EAWM. Especially, PDO was negatively correlated with the area of the spawning ground in the northwestern Pacific (r = -0.39) and in the southern part of the East Sea (r = -0.38). There was a positive relationship between the AO and the area of the spawning ground in the northwestern Pacific (r = 0.46) as well as in the southern part of the East Sea (r = 0.32). Temporally, the area of the winter spawning ground in the southern part of the East Sea in the 1980s was smaller than those areas in the 1990s and 2000s, because the area was disconnected with the western coastal spawning ground of Japan in the 1980s, while the area had been made wider and more continuous from the Korea strait to the western coastal water of Honshu in the 1990s and 2000s.

• 한국통신학회논문지
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• 제26권7A호
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• pp.1152-1161
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• 2001

본 논문에서는 이동국 수신 신호의 SINR을 최대화하는 빔 성형 알고리듬을 이용하여, 폐쇄 루프 송신 빔 성형기술을 적용한 순방향 링크 CDMA 시스템에서의 안테나 수, 귀환 채널의 구조, 귀환 지연 등과 시스템 성능과의 상관관계를 연구하였다. 폐쇄 루프 전송 빔 성형에서는 이동국이 각 안테나가 겪는 채널을 추정하여 수신 SINR을 최대화시키는 가중치 벡터를 계산하고, 귀환채널을 통해 가중치 벡터의 양자화된 진폭과 위상정보를 전송한다. 컴퓨터 모의 실험 결과는 송신 안테나가 2개, 3개, 4개로 늘어남에 따라 빔 성형 이득은 단일 송신 안테나와 비교해 $10^{-5}$ BER 근방에서 4.2dB, 5.8dB, 7dB로 증가하지만 양자화 오류에 의한 성능 저하 또한 0.1dB, 0.6dB, 1.3dB로 커지는 것을 보여준다. 또한 순방향 채널의 최대 도플러 주파수가 100Hz일 때에는 귀환 채널을 통한 소신 가중치 벡터를 보다 빠르게 갱신하는 것이 가중치 벡터의 양자화 레벨의 수를 늘여주는 것보다 $10^{-5}$ BER 근방에서 0.6dB 더 좋은 성능을 보이며, 최대 도플러 주파수가 10Hz일 때에는 가중치 벡터의 갱신 속도를 늘이기 보다 양자화 레벨의 수를 늘여주어 정확한 가중치 벡터를 전송하는 편이 0.9dB의 성능 향상을 보인다. 두 전력제어 그룹 길이의 귀환지연으로 인한 성능저하는 채널의 최대 도플러 주파수가 50Hz인 경우가 채널의 최대 도플러 주파수가 100Hz인 경우보다 $10^{-5}$ BER 근방에서 0.3dB 정도 더 작다. 또한 AOS가 3$^{\circ}$인 경우가 AOS가 $10^{\circ}$인 경우보다 $10^{-5}$ BER 근방에서 1.9dB 정도, 주파수 선택적 페이딩 채널이 주파수 비선택적 페이딩 채널보다 $10^{-5}$ BER 근방에서 1dB 정도 귀환 지연으로 인한 성능의 저하가 작다.