• The Journal of Pediatrics of Korean Medicine
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• v.1 no.1
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• pp.1-12
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• 1986

The Woo-Whang-po-Lyong-Whan has been used as one of the traditional medicines in the field of pediatrics so far since Song dynasty, and still it is widely being used nowadays. It might be considered to be a contribution to do further basic experimental studies on antipyretic, anticonvulsive and analgetic action of the Woo-Whang-po-Lyong-Whan. So it's pharmacological studies were carried out comparing to control drugs. ?Following conclusions were obtained. 1. It's antipyretic action was compared to that of aspirin by Writhing response using acetic acid-method. Mice were given one twentith, one tenth and one fifth tablets of the Woo-Whang-po-Lyong-Whan per Kg of body weight, respecitively. Writhing syndrome frequencies were noted as 38.4 in control group. and $18.0{\pm}12$, $13.17{\pm}2.28$, $7.33{\pm}12$ in above esperimental groups, respectively. In aspirin group it was $18.5{\pm}1.0$ when 2mg aspirin per body weight of mice was given. So it was recognized that antipyretic action of the Woo-Whang-Po-Lyong-Whan become remarkable by increasing amounts of the Woo-Whang-Po-Lyong-Whan. ?2. Antipyretic action in normal temperature mice group was not significant by increasing concentration of the Woo-Whang-Po-Lyong-Whan, but body temperature dropping in normal mice group was slightly noted than control. group, but less temperature dropping was noted than aminopyrin group. ?3. In fever provocated rats groups using Salmonella typhimurium, antipyretic action of the Woo-Whang-Po-Lyong-Whan was not observed significantly than control group. And slight antipyretic action was noted in aminopyrin group. So that antipyretic action of the Woo-Whang-Po-Lyong-Whan was not significant than those of general antipyretic used nowadays, but slower action was recognized. ?4. Anticonvulsive action of the Woo-Whang-Po-Lyong-Whan was studies comparing to that of phenobarbital. Action was not remarkable than phenobarbital, but was significant than control group. No significant intesifying action was noted by increasing amounts of the Woo-Whang-Po- Lyong-Whang.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.7 no.1
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• pp.1-13
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• 1994

The Effects of Hoichunyanggyuksan on the Anti-allergic Effect, Analgesic Action, Anti-inflammatory Action and Antipyretic Action. Experimental studies were done to research the clinical effects of Hoichunyanggyuksan on the Anti-allergic effect, Analgesic action, Anti-inflammatory action and Antipyretic action. The results obtained as follows; 1. On vascular permeability responses to intradermal histamine, Hoichnyanggyuksan showed significant effect. 2. In the homologous PCA provoked by the IgE-like antibody against white egg albumin, Hoichunyanggyuksan showed the decreasing tendency, but was none significant effect. 3. In the delayed type hypersensitivity responses to Picryl chloride, Hoichunyanggyuksan was proved significant effect. 4. In the delayed type hypersensitivity resposes to SRBC, Hoichunyanggyuksan revealed significant effect. 5. In Anti-pyretic action by yeast method, Hoichunyanggyuksan showed significant effect. 6. In Anti-inflammatory action by carrageenin method, Hoichunyanggyuksan showed significant effect. 7. In analgesic action by acetic acid method, Hoichunyanggyuksan was recognized significantly.

• The Journal of Pediatrics of Korean Medicine
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• v.9 no.1
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• pp.257-278
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• 1995

Experimental studies were done to research the clinical effect of Bojeosodokeum on the Analgesic, Antipyretic, Anti-inflammatory, Antimicrobial and Anti-convulsive effects in mice and rats. The results obtained as follows : 1. The solid extract powders of Bojeosodokeum was revealed significant action on analgesic effect. 2. the solid extract powders of Bojeosodokeum was revealed significant action on Anti-inflammatory effect. 3. The solid extract powders of Bojeosodokeum was revealed significant action on antipyretic effect. 4. Antimicrobial effects of solid extract powders of Bojeosodokeum against Escherichia coli and staphylococcus aureus was observed. 5. The solid extract powders of Bojeosodokeum was revealed significant action on anticonvulsive effect. According to the above results, it is confirmed that analgestic, anti-inflammatory, antipyretic, antimicrobial and anticonvulsive effect were recognized in solid extract powders of Bojeosodokeum.

• Korean Journal of Pharmacognosy
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• v.32 no.3 s.126
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• pp.242-247
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• 2001

The anti-inflammatory activity of water extract of Mahaengeuigam-Tang(MHEGTWE) was examined using the carrageenin and acetic acid induced edema, croton oil induced granuloma pouch, and adjuvant arthritis in rats. In addition, the acute toxicity, analgesic and antipyretic effects of MHEGTWE were investigated by the general experimental methods. In acute toxicity test in mice, MHEGTWE showed 10% mortality at 2400 mg/kg(p.o), but it did not showed at 1200 mg/kg(i.p). It was also showed significant analgesic action on the writhing syndrome induced by 0.7% acetic acid at 600 mg/kg(p.o) and its antipyretic activity was observed in the typhoid vaccine induced fevered rats at 300 mg/kg(p.o). By the oral administration of the MHEGTWE, the significant anti-inflammatory activity was observed on 1% carrageenin induced edema, and it significantly inhibited the granuloma and exudate formation in rats. In the adjuvant arthritis experiment, the MHEGTWE decreased the hind paw edema in rats for 19 days. The results suggest that MHEGTWE has analgesic, anti-inflammatory and antipyretic action.

• Korean Journal of Pharmacognosy
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• v.31 no.2
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• pp.216-223
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• 2000

The anti-inflammatory activity of SEO-KYONG-TANG extract(SKTWE) was examined by using carrageenin- and acetic acid-induced edema, croton oil-induced granuloma pouch, and adjuvant arthritis in rats. In addition, the acute toxicity, analgesic and antipyretic effects of SKTWE were investigated by using general experimental methods in mice. SKTWE did not show acute toxicity at 2400 mg/kg(p.o.) nor 1200 mg/kg(i.p.). After oral administration of the SKTWE to rats, significant anti-inflammatory activity was observed on 1% carrageenin- and 5% acetic acid-induced edema. Also, it significantly inhibited granuloma and exudation in these. In the adjuvant arthritis experiment, the SKTWE decreased the hind paw edema after 3 days of oral administration. In addition, it inhibited the writhing syndromes induced by 0.7% acetic acid in mice. The antipyretic activity of SKTWE was also observed through the typhoid vaccine experiment. These results suggest that SKTWE has analgesic, anti-inflammatory and antipyretic action.

• YAKHAK HOEJI
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• v.7 no.2_3
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• pp.55-57
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• 1963

Antipyretic substance is isolated from roots of Scrophularia Oldhami which is used as antipyretic and anti-inflammatory drug. This substance is identified as p-methoxycinnamic acid which rarely occurs in plants.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.2 no.1
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• pp.1-16
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• 1989

The studies were attempted experimental effects of Jingyochangchooltang (Sample A), Jingyochangchooltang plus Sophorae Semen (Sample B) and Deungyangjingyochangchooltang (Sample C) on analgesia, antipyretic, antiinflammatory action and Tramsport of Intestinal contents in mice. The result of studies were as follows: 1. Analgesia action by Acetic acid method was showed significant effect at all sample groups. 2. Analgesia action by Acetylcholine-HCil method was showed significant effect in sample A group. 3. Analgesia action by Reandall-selitto method was showed significant effect at all sample groups especially sample B group was showed more significant effect from 2 hours to 3 shours. 4. Antipyretic action by yeast method was showed significant effect at all sample groups, especially sample A group and sample C group were showed more significant effect after 6 hours than sample B group. 5. Antiinflammatory action by carrageenine method was showed significant effect at all simple groups. 6. In the intestinal transport, in contrast to control group, sample A group revealed the increasing rate $38.7\%$ and sample B group revealed the increasing rate $47.7\%$. According to the above result, it can be concluded that Jingyochangchooltang, Jingyochangchooltang plus sophorae Semen and Deungyangjingyochangchooltang had a remarkable effect on the treatment of hemorrhoids caused by Pung Yul and inflammation of anus.

• Korean Journal of Pharmacognosy
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• v.19 no.2
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• pp.141-151
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• 1988

The sedative, antipyretic, analgesic and anticonvulsive action, action on the isolated ileum in mice, retricting action on edema, action on blood pressure and respiration of Sipmidojuksan were evaluated. The results were as follows; sedative effects were recognized by the unbalanced effects of spontaneous momentum by wheel cage method, muscle relaxing action by rotor rod method and prolongation of sleeping hours. In mice, a significant antipyretic effect to endotoxin was recognized. Significant anagesic effects by acetic acid and Randall-Sellito method were recognized. Significant anticonvulsive effects to strychnine and picrotoxin were recognized. Spontaneous momentum of isolated ileum in mice was restricted, and relaxing effects on smooth muscle of digestive organ were noted by anti-acetylcholine, anti-barium chloride and anti-histamine effects. Significant antiedemic effects to carrageenin and histamine were recognized. Dilatation of blood vessels and decrease of blood pressure were noted.

• Korean Journal of Pharmacognosy
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• v.30 no.1
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• pp.18-24
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• 1999

This study was investigated on anti-inflammatory and analgesic activity on Gu-Mi-Gang-Hwal-Tang which has been used for the treatment of common cold and headache, arthralgia, fever in oriental medicine. The anti-inflammatory activities of Gu-Mi-Gang-Hwal-Tang water extract (GMGHT) on the carrageenin induced edema, acetic acid induced edema, and corton oil induced granuloma pouch in rats were examined. The analgesic effect of the GMGHT was investigated utilizing acetic acid induced writhing syndrome in mice. The antipyretic activity of the GMGHT was also investigated. The oral administration of GMGHT has been shown the anti-inflammatory activities in 1% carrageenin and acetic acid induced edema in rats. The GMGHT has been shown significant inhibitory effects on glanuloma and exudate formation in rats, especially the GMGHT (450 mg/kg) has the efficacy more than the GMGHT (150 mg/kg). The writhing syndromes induced by acetic acid in mice were inhibited, especially analgesic activity of the GMGHT (450 mg/kg) is similar to that of piroxicam and antipyretic activities were recognized in rats. In the present study, the GMGHT is indicated to have the anti-inflammatory, analgesic and antipyretic activities.

• Journal of Oriental Neuropsychiatry
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• v.8 no.1
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• pp.95-109
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• 1997

In order to prove the experimental effectiveness of ChongsimOndamTang by categotizing COTⅠ, COTIⅡ, COTⅢ and COTⅣ according to the volume of COT extract,the anticonvulsion action, the antipyretic action, the analgesic action,the sedative action, and the activity of GABA transaminase, the actuvity concentration of GABA,the activity of GAD in GABAergic system comparing data with control group and observation data show the results as follows.1. The anticonvulsion effect on the convulsion induced by strychine it was significantly effective in COTⅣ and the time to death after the occurrence of the convulsion it was significantly effective in COTⅢ and COTⅣ, and the time to death after the occurrence the convulsion induced by the electrical shock of ECT unit it was significantly effective in all sample groups.2. The hypothemic effect was significantly effective in COT Ⅲ after 1 hour and 2 hour and was significantly effective COTⅣafter 1 hour and 4 hour, and the antipyretic effect on the febrile induced by endotoxin it was significantly effective in COTⅢ every 3 hour and was significantly effective in COTⅣ after 3 hour and 4 hour.3. The analgesic effect was significantly effective in COTⅢ and COTⅣ by decreasing the number of writhing syndrome.4. The sedative effect was decreased significantly all in COTⅢ and COTⅣ after 60 min, 90 min and 120 min.5. The activity of GABA transaminase was decreased significantly in COTⅡ and COTⅢ. 6. The activity concrntration of GABA was increased signifivantly in COTⅡ and COTⅢ. 7. The activity of GAD was increased significantly in COTⅡ and COTⅢ. The results show that ChongsimOndamTang can be an effective cure in mice on the anticonvulsion,the antipyretic , the analgesic,the sedative and the control of the GABAergic system in brain, and it can be used of the epilepsy and convulsive diseases clinically.