• Asian-Australasian Journal of Animal Sciences
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• v.25 no.9
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• pp.1322-1328
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• 2012

Antibiotic resistance patterns of bacterial isolates from both quarter teat-tip swabs and their quarter milk samples were evaluated in smallholder dairy farms in northern Thailand with excessive use of antibiotics (HIGH) compared with normal use (NORM). Results from teat-tip swab samples showed that the percentage of Bacillus spp. resistance to overall antibiotics was significantly lower in the NORM group than that of the HIGH group, whereas, the resistance percentage of coagulase-negative staphylococci in the NORM group was higher than that of the HIGH one. The overall mastitis-causing bacteria isolated from milk samples were environmental streptococci (13.8%), coagulase-negative staphylococci (9.9%), Staphylococcus aureus (5.4%), and Corynebacterium bovis (4.5%). Both staphylococci and streptococci had significantly higher percentages of resistance to cloxacillin and oxacillin in the HIGH group when compared to the NORM one. An occurrence of vancomycin-resistant bacteria was also observed in the HIGH group. In conclusion, the smallholder dairy farms with excessive use of antibiotics had a higher probability of antibiotic-resistant pattern than the farms with normal use.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.26 no.3
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• pp.135-145
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• 2023

Antibiotics are frequently administered during pregnancy. Although necessary to address acute infections, their use facilitates antibiotic resistance. Other associations have also been found with the use of antibiotics, such as perturbations of gut bacteria, delays in microbial maturation, and increased risks of allergic and inflammatory diseases. Little is known about how the prenatal and perinatal administration of antibiotics to mothers affects the clinical outcomes of their offspring. A literature search was conducted of the Cochrane, Embase, and PubMed engines. The retrieved articles were reviewed by two authors and verified for relevance. The primary outcome was the effect of pre- and perinatal maternal antibiotic use on clinical outcomes. Thirty-one relevant studies were included in the meta-analysis. Various aspects are discussed, including infections, allergies, obesity, and psychosocial factors. In animal studies, antibiotic intake during pregnancy has been suggested to cause long-term alterations in immune regulation. In humans, associations have been found between antibiotic intake during pregnancy and different types of infections and an increased risk of pediatric infection-related hospitalization. A dose-dependent positive association between pre- and perinatal antibiotic use and asthma severity has been reported in animal and human studies, while positive associations with atopic dermatitis and eczema were reported by human studies. Multiple associations were identified between antibiotic intake and psychological problems in animal studies; however, relevant data from human studies are limited. However, one study reported a positive association with autism spectrum disorders. Multiple animal and human studies reported a positive association between pre- and perinatal antibiotic use by mothers and diseases in their offspring. Our findings have potentially significant clinical relevance, particularly considering the implications for health during infancy and later in life as well as the related economic burden.

• Animal Bioscience
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• v.35 no.8
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• pp.1109-1120
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• 2022

Antibiotics used to be supplemented to animal feeds as growth promoter and as an effective strategy to reduce the burden of pathogenic bacteria present in the gastro-intestinal tract. However, in-feed antibiotics also kill bacteria that may be beneficial to the animal. Secondly, unrestricted use of antibiotics enhanced the antibiotic resistance in pathogenic bacteria. To overcome above problems, scientists are taking a great deal of measures to develop alternatives of antibiotics. There is convincing evidence that probiotics could replace in-feed antibiotics in poultry production. Because they have beneficial effects on growth performance, meat quality, bone health and eggshell quality in poultry. Better immune responses, healthier intestinal microflora and morphology which help the birds to resist against disease attack were also identified with the supplementation of probiotics. Probiotics establish cross-feeding between different bacterial strains of gut ecosystem and reduce the blood cholesterol level via bile salt hydrolase activity. The action mode of probiotics was also updated according to recently published literatures, i.e antimicrobial substances generation or toxin reduction. This comprehensive review of probiotics is aimed to highlight the beneficial effects of probiotics as a potential alternative strategy to replace the antibiotics in poultry.

• Korean Journal of Agricultural Science
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• v.43 no.1
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• pp.14-20
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• 2016

One of the most powerful health management practices is the use of antibiotics, but their use is being restricted because of health safety issues. The swine industry has been looking for various alternatives to antibiotics and increasingly considers the use of dietary factors like feed ingredients, feed additives, feed formulation practices, or feeding methods, instead of using antibiotics to improve pig health and performance. Among other alternatives to antibiotics, spray-dried plasma may be a candidate. Spray-dried plasma is a blood product that provides bioavailable nutrients and physiologically active components such as immunoglobulins, glycoproteins, growth factors, peptides, etc. It is an excellent protein source with balanced and highly digestible amino acids. Several beneficial physiological activities depend on components of spray-dried plasma, such as immune competence (antibacterial activity), modulation of microbiota and/or immune system, integrity of intestinal barrier function, etc. These beneficial effects can contribute to improvement of pig performance and health by modulation of microbiota in the digestive tract and/or immune system. Therefore, it is suggested that spray-dried plasma has great potential as an antibiotics alternative.

• Journal of Digital Convergence
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• v.14 no.6
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• pp.325-333
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• 2016

This study was conducted to provide the base line for the use of prophylactic antibiotics and the standard of antibiotic use and the evaluation based on analysis of current use, quality assessment and periodic changes of prophylactic antibiotics in a university hospital. We chose the year 2008, 2009, 2010, 2012, and 2014 as the study periods since the primary evaluation on the first year of implementation in 2007. For this study, healthcare benefit quality assessment data from the Health Insurance Review and Assessment Service was used. We analyzed the differences each year of treatment period; one category for initial treatment timing, three categories for selecting antibiotics, and two categories for the length of treatment from multiple evaluation indices of gastric surgeries, colorectal surgeries, and cholecystectomy. The analysis revealed the followings: Regarding length of antibiotics treatment, total days of treatment decreased down to 1.5, 1.5, and 0.6 days in the year 2014, from 13.5, 12.8, and 6.9 days in the year 2007, for gastric surgeries, colorectal surgeries, and cholecystectomy. Based on these outcomes, the efforts to devise efficient delivery and distribution of the recommendations or indices which medical staff could adhere for quality improvement of the prophylactic antibiotics would be necessary. Also implementing monitoring system to help the hospitals to acknowledge their own faults may be helpful.

• Journal of the korean veterinary medical association
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• v.20 no.1
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• pp.26-28
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• 1984

This study was undertaken to investigate drug susceptibility against the major antibiotics used in this country by the use of the disc diffusion susceptibility test. The results are summarized as follows: 1. Comparatively highly sensitive to antibiotics e

• The Journal of the Korean dental association
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• v.51 no.3
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• pp.148-155
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• 2013

Antibiotic is one of the mainly prescribed drugs in dental office. The substantial part of all antibiotics used in dental office is given to patients without signs or symptoms of infection to prevent infections, and antibiotics became the most widely abused prescribed drugs on the basis of inappropriate indications, dosages and durations. Considering that antibiotics are one of the drugs that affect not only a single patient but also entire populations of individuals through their collective effects on microbial ecology, the importance of proper use of antimicrobial therapy can hardly be overemphasized. Therefore, the main considerations for antibiotic therapy in denial office were summarized here.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.3
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• pp.410-416
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• 2010

Methane emitted from ruminant livestock is regarded as a loss of feed energy and also a contributor to global warming. Methane is synthesized in the rumen as one of the hydrogen sink products that are unavoidable for efficient succession of anaerobic microbial fermentation. Various attempts have been made to reduce methane emission, mainly through rumen microbial manipulation, by the use of agents including chemicals, antibiotics and natural products such as oils, fatty acids and plant extracts. A newer approach is the development of vaccines against methanogenic bacteria. While ionophore antibiotics have been widely used due to their efficacy and affordable prices, the use of alternative natural materials is becoming more attractive due to health concerns regarding antibiotics. An important feature of a natural material that constitutes a possible alternative methane inhibitor is that the material does not reduce feed intake or digestibility but does enhance propionate that is the major hydrogen sink alternative to methane. Some implications of these approaches, as well as an introduction to antibiotic-alternative natural materials and novel approaches, are provided.

• Journal of Wetlands Research
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• v.14 no.3
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• pp.365-374
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• 2012

Due to the wide use of feed additives on pig farms, large content of heavy metals and antibiotics have been found in piggery wastes. More than 90 % of piggery wastes were applied to crop field in Korea. The metals and antibiotics originated from piggery waste in the soil may affect plant growth and human health. To examine the adsorption capacity and residual ratio of heavy metals and antibiotics to the soil, a couple of jar test and leaching tests were conducted. While 86.4 % of zinc and 68% of copper applied were adsorbed to soil particles, while over than 60% of antibiotics in pig manure liquid fertilizer were leaked out to effluent.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.29 no.4
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• pp.329-332
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• 2007

This study compared and evaluated the variation of patients' symptoms depending on whether or not antibiotics had been used in the recovery period after the orthognathic surgery. 28 patients, with no particular medical history, were divided into two groups on the basis of whether antibiotics had been applied after the orthognathic surgery. All patients had been operated on maxilla and mandible simultaneously and were investigated with any symptom changes within the postoperative 4 days. Among the symptoms that could follow after the orthognathic surgery, 6 symptoms were checked every 24 hours on 5 points basis. Phases of each symptom improvements were checked and analyzed by ANOVA statistical method. Aspects of symptom changes according to application of antibiotics showed no statistical significance. Symptoms, except for swelling, showed continuous improvements after the surgery. Swelling increased until postoperative $2^{nd}\;day$, and then started to decrease. This study shows that post-surgical use of antibiotics has no significance provided that post-surgical infection had not occurred.