• Bulletin of the Korean Chemical Society
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• 제32권12호
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• pp.4450-4453
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• 2011

• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.641-644
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• 2013

• 한국어병학회지
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• 제13권1호
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• pp.45-51
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• 2000

최근 육상의 넙치 양식장에서는 두 가지의 서로 다른 특성을 가지는 세균성질병이 같이 감염되는 혼합감염증이 빈번하게 발생하고 있는데, 혼합감염증은 서로 다른 원인균의 특성 때문에 단일 종류의 약제만으로는 치료효과를 거두기가 어려운 실정이다. 그러므로 본 연구는 약제의 병용 투여에 의해 이들의 상승작용을 이용함으로써 합병증에 대한 치료효과를 높이기 위한 기초자료를 얻고자 실시하였다. 어류 세균성질병의 원인세균인 Vibrio anguillarum, Edwardsiella tarda, Streptococcus sp., Staphylococcus epidermidis을 선정하여 병용 항균제의 시험관내 활성을 평가하는 대표적 방법인 Checkerboard법을 적용하여 fractional inhibitory concentration (FIC)지수를 구하여 상승효과를 나타내는 병용 항균제를 찾아내었다. (OTC+LM), (TC+FF), (OTC+FF)의 병용 항균제는 V. anguillarum에 대하여, (SNF+FF), (TC+FF), (SNF+OXA), (OTC+FF)의 병용 항균제는 E. tarda에 대하여, (CFX+OL), (OTC+OL), (TC+OL), (OTC+LM), (OTC+SPM), (OTC+EM), (DOXY+OL), (TC+SPM)의 병용 항균제는 Streptococcus sp.에 대하여, (CFX+EM), (FF+EM), (DOXY+OL), (CFX+OL)의 병용 항균제는 S. epidermidis에 대하여 시험관내 상승적 상호작용을 나타내었다.

• Bulletin of the Korean Chemical Society
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• 제17권1호
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• pp.90-93
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• 1996

• Bulletin of the Korean Chemical Society
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• 제19권8호
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• pp.819-821
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• 1998

• Bulletin of the Korean Chemical Society
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• 제15권7호
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• pp.592-595
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• 1994

• 대한화학회지
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• 제61권5호
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• pp.291-295
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• 2017

• 한국임상수의학회지
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• 제14권2호
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• pp.215-222
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• 1997

Enrofloxacin-colistin combination, widely used in Gram negative infections in veterinary sector, was investigated in terms of MIC and initial killing rate using E coli k 88ab, Salmonella typhimurium, Pasteurella multocida type A, Bordetella bronchiseptica and Staphylococcus aureus as test organisms. On the basis of MICs of enrofloxacin-colistin combination against the above bacteria, killing rates of the combination of enrofloxacin and colistin at the ratio of 5:0, 4:1, 3:2, 1:1, 2:3, 1:4 and 0:5, indicated high and rapid antibacterial acitivities against all but Staphylococcus aureus R-209, with the number of bacteria reducing to less than one percent within two hours. At the MIC of enrofloxacin or colistin, both antibacterials showed the highest killing rates during 2-4 hours against Gram negatives such as E coli K88ab,Pasteurella multocida type A and Bodetella bronchiseptica but allowed the regrowth of the same pathogens thereafter. On the while, the combination of two antibacterials at a fourth MIC resulted in high killing rate without bacterial regrowth during 24 hours, suggesting the synergistic antivacterial effects. The combination, however, did not show favourable activity against Gram negatime S typhimurium and Gram positive S aureus ergistic antibacterial activity against Gram negatime pathogens but also colistin showed LPS-neutraization, we could suggest the combination should provide clinically positive therapeutic armarium in Gram negative infections.

• Toxicological Research
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• 제8권1호
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• pp.144-156
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• 1992

The residue of drug in foods of animal origin has increasingly become of interest to the entire livestock industry as growing consumer health concerns. The current overvie of feed additives and veterinary drugs used in Japan and their residual analysis has been reviewed. High performance liquid chromatographic technique(HPLC) with various detectors can be expected to be successfully applied for the routine analysis of residual feed additives and veterinary drugs including anabolic agents in livestock products.

• Archives of Pharmacal Research
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• 제13권2호
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• pp.187-191
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• 1990

A convenient method for the preparation of imidazobenzimidazole 3, imidazoimidazole 5, imidazotriazole 6 and pyrano [2, 3-c] oxazole 7 derivatives is described. This depends on interaction of 2-methyl-4-arylidene-2-oxazolin-5-ones 1 with o-diamines, thiosemicarbazide and/or ethylcyanoacetate. The effect of alcoholic potassium cyanide on axazolinone 1 was studied. Antibacterial activity of the obtained products was studied.