• Journal of the Society of Cosmetic Scientists of Korea
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• v.39 no.2
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• pp.133-140
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• 2013

This in vivo study via ASTM E2752-10, cup scrub method, was performed to evaluated the residual effectiveness of PCMX and IPMP commonly used in antibacterial soap. The liquid soap having 5% of PCMX and 0.1% of IPMP showed statistically significant reduction of E. coli and S. aurues as compared with control in a trial of 80 healthy volunteers. And its efficacy was maintained for 27 h at least. We report the result of residual effectiveness of antibacterial agents for the first time in Korea.

• Biomolecules & Therapeutics
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• v.7 no.1
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• pp.44-53
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• 1999

The resistant strains due to the extended-spectrum $\beta$-lactamase (ESBL) were susceptible to cefatrizine combined with clavulanic acid. The purpose of this study was to evaluate the in vitro and in vivo antibacterial activities of cefatrizine/clavulanic acid (CTRZ/CV) combination at a ratio of 2 : 1 in comparison with cefaclor (CCLO), cefuroxime (CRXM), cefuroxime axetil (CRXMA) and amoxicillin/clavulanic acid (AMXCCV). CTRZ/CV showed good activity against laboratory strains of gram-positive and gram-negative bacteria and exhibited excellent antibacterial activity against $\beta$-lactamase-producing strains. The bactericidal activity of CTRZ/CV was superior to that of CCLO and CRXM, and almost equal to that of AMXCCV against the $\beta$-lactamase-producing strains. The in vitro results were substantiated. by in vivo mouse experimental infection studies with $\beta$-lactamase-producing and non-producing strains. In mixed experimental infection due to $\beta$-lactamase-producing and non-producing strains, the therapeutic efficacy of CTRZ/CV was superior to that of CTRZ, CCLO, CRXMA and AMXCCV. In respiratory tract infection in mice due to Klebsiella pneumoniae EB4O, CTRZ/CV was more erective than CCLO, CRXMA and AMXCCV and also more efficacious than CCLO, CRXMA and AMXCCV in urinary tract infection in mice due to Escherichia coli EB13. These results indicate that CTRZ/CV is a useful drug for the treatment of infection caused by $\beta$-1actamase-producing strains including ESBL-producing strains.

• Korean Journal of Pharmacognosy
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• v.50 no.2
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• pp.112-117
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• 2019

In this study, extracts of bark from Ulmus davidiana var. japonica and its fractions were investigated the antioxidative, antibacterial and tyrosinase inhibition activity for physiological activity towards functional applications. In the measurement of DPPH radical scavenging activity, the ethyl acetate fraction showed higher radical scavenging ability than others. Moreover, in the tyrosinase inhibition assay, showed that the ethyl acetate fraction has good inhibition effects. Results of the DPPH radical scavenging and tyrosinase inhibition activity are related with the total polyphenol concentrations of ethyl acetate fraction. In antibacterial activity used to find out by utilizing the disc diffusion assay, chloroform fraction showed strong effect against Staphylococcus aureus and S. epidermidis. These results are related with the flavonoid contents of chloroform fraction. On the other hand, in the L929 cell viability measurement by MTT assay, the hexane, butanol and aqueous fraction treated at high concentration were showed cytotoxicity. But the others samples were exhibited a moderate viabilities. As a result of investigated the antioxidant and tyrosinase inhibition activity, the ethyl acetate fraction could be applicable for cosmetics related fields. And the chloroform fraction showed significant antibacterial activity against S. aureus and S. epidermidis.

• The Korean Journal of Food & Health Convergence
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• v.8 no.5
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• pp.11-20
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• 2022

Honey was diluted with different percentages of water and was analysed rheologically at room temperature of 27℃. The rheological profiles of pure and impure honey samples were measured at low shear rates (0.01-4.16s^-1). This work developed a structural kinetic model, which correlated well with the rheological data. The new model was used to categorise honey samples using their average molecular weights as one of the distinctive properties. Also, the kinetics order in the new model predicts the number of active components in the "honey" undergoing deformation. Honey produced third order kinetics to depict the monomers, oligomers and water content in honey. Pure honey exhibits peculiar non-Newtonian rheological behaviour. The behaviour of water is Newtonian. Dilution of honey with different percentages of water turns the resulting fluid Newtonian from 10% dilution with water. This study analysed the antibacterial activities of honey and serially adulterated samples against Staphylococcus aureus and Pseudomonas aeruginosa. The antibacterial analyses of honey were conducted using Kirby Bauer's well diffusion method. The results indicated that pure honey exhibited a zone of inhibition against both organisms. Also, the diameter of the zone of inhibition decreased with increasing dilution of honey, suggesting a correlation with the rheological method.

• Korean Journal of Metals and Materials
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• v.48 no.5
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• pp.401-409
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• 2010

This study was performed to develop an antibacterial film that can be dried at room temperature. A nanosized TiO$_2$ particle-dispersed solution was prepared by the hydrothermal treatment of peroxo-titanic acid at 160${^{\circ}C}$ for 4h. The binder was synthesized through the hydrolysis and condensation reactions of TEOS (10cc) and GPTS (3.5cc) in the mixture of H$_2$O (30cc) and EtOH (30cc). The synthesized binder was mixed with 0.1 M of TiO$_2$ solution in a volume ratio of binder/TiO$_2$ solution=0.25~0.5. The glass substrate was coated after using the dip coating method, which was then followed by drying for over 2h at room temperature. Although the TiO$_2$ particles did not chemically-bond to the binder, the coating layer strongly adhered to the substrate and displayed good antibacterial properties.

• Journal of Apiculture
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• v.34 no.2
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• pp.131-136
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• 2019

Recently, number of honeybees (Apis mellifera) has visibly decreased because they are vulnerable to some diseases like American foulbrood disease. American foulbrood disease, which is caused by Paenibacillus larvae, is emerged as great cause of decrease in number of honeybees. After antibiotic-resistant strain emerged, it is now more difficult to treat those pathogens successfully. Researches on finding alternative antibacterial compound are ongoing. In this study, we examined the antibacterial effect of honokiol on P. larvae. Honokiol showed great antibacterial effect with minimum inhibitory concentration of 12.5 ㎍/mL and minimum bactericidal concentration of 50 ㎍/mL. An agar diffusion test also confirmed the anti-Paenibacillus larvae activity of honokiol with an inhibitory zone of 9±0.5 mm. Since honokiol is known to interact membrane of some bacteria, we measured 260 nm absorbing particles, which could be induced by leakage of cells, and confirmed that the leakage of P. larvae occurred in dose-dependent manners. However, result of crystal violet assay suggested that honokiol has only mild anti-biofilm formation effect on P. larvae, which means honokiol controls the bacteria by inducing the bursting of membrane. Finally, an additive effect of honokiol with tetracycline and terramycin was found using a checkerboard assay with a fractional inhibitory concentration index value of 0.5.

• Journal of the Korea Fashion and Costume Design Association
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• v.23 no.4
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• pp.95-103
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• 2021

This study aims to examine the antibacterial effects of cotton and silk fabrics naturally dyed with Artemisia princeps extract on antibiotic-resistant strains of bacteria. The concentrated natural dye of the Artemisia princeps extract was made at the liquor ratio of 1:10 at 40-60℃ for 60 minutes. The concentration of FeSO4·7H2O, Al2(SO4)3, and CuSO4 5H2O mordant was 3% (owf), and the liquor ratio was 1:20. In order to experiment on the antimicrobial activity of the naturally dyed fabrics, Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33591, was used by breeding it in Brain Heart Infusion Agar (BHA) containing Oxacillin (2㎍/ml), Fungizone (2.5㎍/ml), and Brain Heart Infusion broth (BHI; Detroit, MI, USA). As a result of examining the bacterial growth reduction rate on dyed cotton and silk fabrics against antibiotic-resistant strains, it was found that the copper mordant in cotton fabric shows the highest antibacterial activity with a bacterial growth reduction rate of 99.9%, and the non-mordant cotton fabric shows the lowest antibacterial activity with a reduction rate of 18.6%. In the case of the naturally dyed silk fabric, it indicates the highest reduction rate of strains in the Al mordanting (94.9%), and Cu mordanting (99.9%).

• Journal of Pharmacopuncture
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• v.26 no.1
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• pp.53-59
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• 2023

Objectives: The most prominent microorganisms that cause hospital infections and acquire antibiotic resistance are Staphylococcus aureus and Pseudomonas aeruginosa. The present study aimed to compare the phenolic and flavonoid compounds of various Allium ampeloprasum and Allium porrum extracts and evaluate the antibacterial effects of these extracts against these two microorganisms. Methods: The total phenolic and flavonoid contents of the acetone, methanol, aqueous, and hexane leeks extracts from A. ampeloprasum and A. porrum were measured. The antibacterial activity of these extracts against S. aureus and P. aeruginosa was tested using the disk diffusion method for 24, 48, and 72 hours. Further, the minimum inhibitory concentrations and the minimum bactericidal concentrations of these extracts for these two bacteria were evaluated and compared with those of common antibiotics. Results: The aqueous extracts showed the highest phenolic and flavonoid contents and at concentrations of 35 and 40 mg per disk, showed the most antibacterial activity against S. aureus and P. aeruginosa; P. aeruginosa showed more sensitivity to the aqueous extracts than S. aureus. Conclusion: Aqueous A. ampeloprasum and A. porrum extracts may prevent the growth of hospital pathogens, especially P. aeruginosa; our findings will aid the discovery of new antimicrobial substances against antibiotic-resistant bacteria.

• Korean Journal of Materials Research
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• v.33 no.1
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• pp.1-7
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• 2023

The physical and antibacterial properties of ophthalmic lenses fabricated by copolymerization with hydrogel monomers using two types of graphene were measured, and their usability as contact lens materials was analyzed. For polymerization, silicone monomers, including SID-OH, 3-(methacryloxy)propyl tris(trimethylsiloxy)silane, and decamethylcyclopentasiloxane, were used, and N,N-dimethylacetamide, ethylene glycol dimethacrylate as a crosslinking agent, and azobisisobutyronitrile as an initiator were added. Also, graphene oxide nanoparticle (GON) and graphene nanoplate (GNP) were used as an additive, and the physical properties of the lenses fabricated after copolymerization were evaluated. The fabricated lenses satisfied the basic physical properties of general hydrogel contact lenses and showed the characteristics of lenses with high water content, and the disadvantage of very weak durability, due to low tensile strength. However, it was confirmed that the tensile strength and antibacterial properties were greatly improved by adding GON and GNP. With GON, the oxygen permeability and refractive index of the fabricated lenses were slightly improved. Therefore, it was determined that the graphene materials used in this study can be used in various ways as a contact lens material.

• Fashion & Textile Research Journal
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• v.25 no.1
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• pp.62-71
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• 2023

Recently, interest in natural fabric materials that are not harmful has increased, and hemp is being studied as a new eco-friendly product. This study produced hemp fabric with improved flexibility and increased antibacterial properties by blending it with Hanji yarn. Various weaving methods were proposed to overcome the rough physical properties of hemp, and the functions of the developed products were evaluated through antibacterial tests. The mixing ratios of hemp and Hanji yarns was 50% hemp: 50% Hanji weft, 70% hemp: 30% Hanji weft, 30% hemp: 70% Hanji weft, and 100% hemp. Overall, the higher the ratio of Hanji yarn, the higher the fastness property, and the higher the ratio of hemp yarn, the higher the flexibility of the fabric, which was evaluated to be comfortable to wear. The 99.9% antibacterial properties of hemp products were considered to contribute to maintaining the health of modern people. Owing to its high intensity and high air permeability, it is considered highly usable in the production of children's clothing with a lot of activity. It was evaluated as an advantage that the disadvantage of hemp, which was limited as a material for summer clothing, was broadened to use for all seasons due to the fusion of Hanji. Otherwise, low consumer satisfaction as an outdoor wear is a disadvantage because hemp products had low elasticity and wrinkles.