• 한국해양공학회지
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• 제37권5호
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• pp.215-224
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• 2023

While melting glaciers due to global warming have facilitated the development of polar routes, Arctic vessels require reliable anti-icing methods to prevent hull icing. Currently, the existing anti-icing method, i.e., the heating coil method, has disadvantages, such as disconnection and power inefficiency. Therefore, a carbon nanotube-based surface heating element method was developed to address these limitations. In this study, the numerical analysis of the surface heating element method was performed using ANSYS. The numerical analysis included conjugate heat transfer and computational fluid dynamics to consider the conduction solids and the effects of wind speed and temperature in cold environments. The numerical analysis method of the surface heating element method was validated by comparing the experimental results of the heating coil method with the numerical analysis results (under the -30 ℃ conditions). The surface heating element method demonstrated significantly higher efficiency, ranging from 56.65-80.17%, depending on the conditions compared to the heating coil method. Moreover, even under extreme environmental conditions (-45 ℃), the surface heating element method satisfied anti-icing requirements. The surface heating element method is more efficient and economical than the heating coil method. However, proper heat flux calculation for environmental conditions is required to prevent excessive design.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5343-5348
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• 2014

Background: A meta-analysis was performed to examine the benefit/risk ratio for the addition of anti- HER MoAbs to chemotherapy in patients with advanced gastric and gastroesophageal cancer from six randomized phase II/III trials. Materials and Methods: We searched relative trials from Pubmed, EMBASE, Cochrane library databases, China National Knowledge Infrastructure databases, Google Scholar and the NIH ClinicalTrials. Primary outcomes were overall response rate (ORR), progression-free survival (PFS), overall survival (OS). Secondary outcomes were toxicities. All analyses were performed using STATA 12.0. Results: This meta-analysis included six randomized controlled trials (RCTs) with 2, 297 patients and we demonstrated that the anti-HER MoAbs arm did have a positive effect on ORR in the anti-HER MoAbs arm (OR 1.28, 95% CI 1.00-1.64, p=0.01). There was an increasing benefit regarding OS (HR 0.74, 95% CI 0.60-0.88, p<0.05) and PFS (HR 0.72, 95% CI 0.60-0.84, p<0.05) in the anti-HER2 subgroup, but a reduction of OS (HR 1.11, 95% CI 0.87-1.36, p<0.05) and PFS (HR 1.13, 95% CI 0.98 -1.28, P<0.05) in anti-EGFR subgroup. Some grade 3-4 toxicity had a significantly higher incidence in the anti-HER MoAbs arm. There was no significant publication bias for all endpoints. Conclusions: The addition of trstuzumab MoAb to chemotherapy for gastric and gastroesophageal cancer significantly improved outcome of OS and PFS endpoints, while other MoAbs led to no improvement in results. Some adverse events were increased in anti-HER MoAbs arm compared with the control.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.127-127
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• 2000

The anti-windup schemes developed so far are summarized and the similarities/differences schemes are discussed. The anti-windup schemes are applied to a DC servomotor control system with PID controller to perform comparative study and sensitivity analysis. Based on those results, some criteria for choosing anti-windup scheme are suggested. The results of this study provide a very useful guideline for selecting and designing the anti-windup scheme for various types of PID control systems.

• 한국도로학회논문집
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• 제18권2호
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• pp.83-90
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• 2016

PURPOSES : Nowadays, cavity phenomena occur increasingly in pavement layers of downtown areas. This leads to an increment in the number of potholes, sinkholes, and other failure on the road. A loss of earth and sand from the pavement plays a key role in the occurrence of cavities, and, hence, a structural-performance evaluation of the pavement is essential. METHODS: The structural performance was evaluated via finite-element analysis using KPRP and KICTPAVE. KPRP was developed in order to formulate a Korean pavement design guide, which is based on a mechanical-empirical pavement design guide (M-EPDG). RESULTS: Installation of the anti-freezing layer yielded a fatigue crack, permanent deformation, and international roughness index (IRI) of 13%, 0.7 cm, and 3.0 m/km, respectively, as determined from the performance analysis conducted via KPRP. These values satisfy the design standards (fatigue crack: 20%, permanent deformation: 1.3 cm, IRI: 3.5 m/km). The results of FEM, using KICTPAVE, are shown in Figures 8~12 and Tables 3~5. CONCLUSIONS: The results of the performance analysis (conducted via KPRP) satisfy the design standards, even if the thickness of the anti-freezing layer is not considered. The corresponding values (i.e., 13%, 0.7 cm, and 3.0 m/km) are obtained for all conditions under which this layer is applied. Furthermore, the stress and strain on the interlayer between the sub-grade and the anti-freezing layer decrease gradually with increasing thickness of the anti-freezing layer. In contrast, the strain on the interlayer between the sub-base and the anti-freezing layer increases gradually with this increase in thickness.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8177-8182
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• 2014

Background: Blocking angiogenesis by targeting vascular endothelial growth factor (VEGF) signaling pathway to inhibit tumor growth has proven to be successful in treating a variety of different metastatic tumor types, including kidney, colon, ovarian, and lung cancers, but its role in castration-resistant prostate cancer (CRPC) is still unknown. We here aimed to determine the efficacy and toxicities of anti-VEGF agents in patients with CRPC. Materials and Methods: The databases of PubMed, Web of Science and abstracts presented at the American Society of Clinical Oncology up to March 31, 2014 were searched for relevant articles. Pooled estimates of the objective response rate (ORR) and prostate-specific antigen (PSA) response rate (decline ${\geq}50%$) were calculated using the Comprehensive Meta-Analysis (version 2.2.064) software. Median weighted progression-free survival (PFS) and overall survival (OS) time for anti-VEGF monotherapy and anti-VEGF-based doublets were compared by two-sided Student's t test. Results: A total of 3,841 patients from 19 prospective studies (4 randomized controlled trials and 15 prospective nonrandomized cohort studies) were included for analysis. The pooled ORR was 12.4% with a higher response rate of 26.4% (95%CI, 13.6-44.9%) for anti-VEGF-based combinations vs. 6.7% (95%CI, 3.5-12.7%) for anti-VEGF alone (p=0.004). Similarly, the pooled PSA response rate was 32.4% with a higher PSA response rate of 52.8% (95%CI: 40.2-65.1%) for anti-VEGF-based combinations vs. 7.3% (95%CI, 3.6-14.2%) for anti-VEGF alone (p<0.001). Median PFS and OS were 6.9 and 22.1 months with weighted median PFS of 5.6 vs. 6.9 months (p<0.001) and weighted median OS of 13.1 vs. 22.1 months (p<0.001) for anti-VEGF monotherapy vs. anti-VEGF-based doublets. Conclusions: With available evidence, this pooled analysis indicates that anti-VEGF monotherapy has a modest effect in patients with CRPC, and clinical benefits gained from anti-VEGF-based doublets appear greater than anti-VEGF monotherapy.

• The Korean Journal of Pain
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• 제35권1호
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• pp.33-42
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• 2022

Background: Cupressus arizonica Greene is a coniferous tree with great importance in fragrance and pharmaceutical industries. Essential oils from C. arizonica (EC) have shown potential antioxidant, and anti-microbial activities. This study aimed at investigating the anti-nociceptive and anti-inflammatory effects/mechanisms of EC. Methods: The EC was evaluated for anti-nociceptive and anti-inflammatory activities on male Wistar rats using a formalin test and carrageenan-induced paw edema, respectively. Also, we pre-treated some of the animals with naloxone and flumazenil in the formalin test to find out the possible contributions of opioid and benzodiazepine receptors to EC anti-nociceptive effects. Finally, gas chromatography/mass spectrometry (GC/MS) analysis was used to identify the EC's constituents. Results: EC in intraperitoneal doses of 0.5 and 1 g/kg significantly decrease the nociceptive responses in both early and late phases of the formalin test. From a mechanistic point of view, flumazenil administration 20 minutes before the most effective dose of EC (1 g/kg) showed a meaningful reduction in the associated anti-nociceptive responses during the early and late phases of the formalin test. Naloxone also reduced the anti-nociceptive role of EC in the late phase. Furthermore, EC at the doses of 1, 0.5, and 0.25 g/kg significantly reduced paw edema from 0.5 hours after carrageenan injection to 4 hours. GC/MS analysis showed that isolated EC is a monoterpene-rich oil with the major presence of α-pinene (71.92%), myrcene (6.37%), δ-3-carene (4.68%), β-pinene (3.71%), and limonene (3.34%). Conclusions: EC showed potent anti-nociceptive and anti-inflammatory activities with the relative involvement of opioid and benzodiazepine receptors.

• 한국작물학회지
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• 제51권spc1호
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• pp.103-106
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• 2006

Anthocyanins are water-soluble glycosides and acylglycosides of anthocyanidins, having different color variations due to its substitution patterns. Anthocyanins, present in various fruits, vegetables and crops as natural colorant, have been well characterized for its bioactive properties, anti-oxidant, anti-cancer, anti-proliferative and anti-inflammatory properties. During extraction and purification, the factors, such as pH, temperature, oxygen, light, enzymes, nucleophilic agents, sugar derivatives and co-pigments, have affected on anthocyanin stability. For this reason, the extraction method should be thoroughly checked for the qualitative/quantitative analysis of anthocyanin in particular plant material. To identify the optimum extraction method of cyanidin-3-glucoside, major anthocyanin of dark purple-colored grains, Oryza sativa cv. Heugjinjubyeo, Phaselous vulgaris, Phynchosia gngularis, Sesamum indium, Rhynchosia nulubilis and Lablab purpureus, reversed-phase HPLC analysis using solvent system of acetonitrile, methanol and water were accomplished.

• Journal of Positioning, Navigation, and Timing
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• 제12권3호
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• pp.229-236
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• 2023

As the importance and dependency of the positioning, navigation, and timing (PNT) information provided by the radio navigation satellite service (RNSS) increases, the vulnerability of RNSS to jamming can lead to significant risks. The signal design under the consideration of anti-jamming performance helps to provide service which is robust to jamming environment. Therefore, it is necessary to evaluate the jamming robustness performance during the design of new signals. In this paper, we introduce figures-of-merit (FoMs) that can be used for an anti-jamming performance analysis of designed signals of interest. We then calculate the FoMs, such as the quality factor (Q factor), tolerable jamming-to-signal ratio (tolerable J/S), and range to jammer (d) for legacy RNSS signals and analyze the results. Finally, based on the results of the analysis, we derive waveform design conditions to obtain good anti-jamming performance. As a result, this paper shows that the waveforms with wide bandwidth leading to good spectral efficiency provide strong anti-jamming performance.

• Journal of Mechanical Science and Technology
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• 제17권11호
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• pp.1732-1738
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• 2003

The test specimen in environmental vibration test is connected to the fixture through several attachment points. The forces generated by the shaker must be transmitted equally to all attachment points. The forces transmitted to attachment points, however, are different because of the flexural vibration of the fixture. The variations of the transmitted force cause the under-test, especially at anti-resonance frequencies, in vibration test control. Anti-resonance frequencies at the attachment points of the fixture must be same in order to avoid the under-test in vibration test control. The structural modification of the fixture is needed so that anti-resonance frequencies at attachment points have the same value. In this paper, the method to calculate the anti-resonance frequencies and those sensitivities is presented. This sensitivity analysis is applied to the structural modification of the fixture excited at multi-points by the shaker. The antiresonance frequencies at the attachment points of the fixture can have the same value after structural modification, and the under-test in the vibration test control can be removed. Several computer simulations show that the proposed method can remove the under-tests, which are not removed in conventional vibration test control.