• Biomolecules & Therapeutics
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• 제25권2호
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• pp.165-170
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• 2017

Cordyceps bassiana is one of Cordyceps species with anti-oxidative, anti-cancer, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic, and anti-nociceptive activities. This mushroom has recently demonstrated to have an ability to reduce 2,4-dinitrofluorobenzene-induced atopic dermatitis symptoms in NC/Nga mice. In this study, we further examined phytochemical properties of this mushroom by column chromatography and HPLC analysis. By chromatographic separation and spectroscopic analysis, 8 compounds, such as 1,9-dimethylguanine (1), adenosine (2), uridine (3), nicotinamide (4), 3-methyluracil (5), 1,7-dimethylxanthine (6), nudifloric acid (7), and mannitol (8) were identified from 6 different fractions and 4 more subfractions. Through evaluation of their anti-inflammatory activities using reporter gene assay and mRNA analysis, compound 1 was found to block luciferase activity induced by $NF-{\kappa}B$ and AP-1, suppress the mRNA levels of cyclooxygenase (COX)-2 and tumor necrosis factor $(TNF)-{\alpha}$. Therefore, our data strongly suggests that compound 1 acts as one of major principles in Cordyceps bassiana with anti-inflammatory and anti-atopic dermatitis activities.

• 정보보호학회논문지
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• 제34권3호
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• pp.403-416
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• 2024

악성코드는 금전적인 목적에 의하여 서비스의 한 형태로 블랙마켓에 판매되고 있다. 판매에 따른 수요가 증가함에 따라 악성코드를 통한 공격이 확장되었다. 이에 대응하기 위해 인공지능을 활용한 탐지 및 분류 연구들이 등장하였지만, 공격자들은 분석을 방지하고자 다양한 안티 분석기술을 악성코드에 적용하고 있다. 본 논문에서는 안티 분석 기술이 적용된 악성코드들로부터 데이터셋을 확보하기 위해 하이브리드형 바이너리 분석 프레임워크 Malware Analysis with Dynamic Extraction(MADE)을 제안한다. MADE 프레임워크는 Anti-VM, Anti-Debugging이 적재된 바이너리를 포함하여 자동화된 동적 분석을 수행할 수 있다. MADE 프레임워크는 Anti-Analysis 기술이 적용된 다양한 악성코드들에 대해 90% 이상 우회가 가능하며, API 호출 정보를 포함한 데이터셋 추출이 가능함을 실험을 통해 검증하였다.

• BMB Reports
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• 제31권3호
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• pp.296-302
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• 1998

A potentiometric flow injection biosensor for the analysis of anti-cholinesterases (anti-ChEs), based on inhibition of enzyme activity, was developed. The sensor system consists of a reactor with acetylcholinesterase (AChE) immobilized on controlled pore glass and a detector with an $H^{+}-selective$ PVC-based membrane electrode. The principle of the analysis is based on the fact that the degree of inhibition of AChE by an anti-ChE is dependent on the concentration of the anti-ChE in contact with AChE. The sensor system was optimized by changing systematically the operating parameters of the sensor to evaluate the effect of the changes on sensor response to ACh. The optimized biosensor was applied to the analysis of paraoxon, an organophosphorus pesticide. Treatment of the inhibited enzyme with pyridine-2-aldoxime fully restored the enzyme activity allowing repeated use of the sensor.

• 대한한의학방제학회지
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• 제22권2호
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• pp.87-103
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• 2014

Objectives : Herbal formulas are complicated to analyze and difficult to compose because of its mixed, complex features. So we discussed about how to compose herbal formulas effective and efficient by analyzing various effectiveness of each herbal extracts. Methods : To evaluate the effectiveness of herbal formula, anti-oxidative and anti-inflammatory effectiveness were mathematically analyzed. DPPH, superoxide anions, Nitric Oxide scavenging activity was measured to evaluate the effectiveness of 7 herbal extracts. And next, cytotoxic activity of extracts on RAW 264.7 cells were measured using MTS assay. To asses anti-inflammatory effect, nitric oxide and $PGE_2$ production were measured. Based on these anti-oxidative and anti-inflammatory experiment result, mathematical analyzation were carried out with constOptm function, and determined efficacy-maximizing ratio. Results : This mathematical analysis based formula showed significantly outstanding effectiveness than other formulae. And estimated tendency of anti-inflammatory effectiveness was matched with real effectiveness. Conclusions : So, mathematical analysis can be available to evaluate and estimate the effectiveness of herbal formulae.

• 분석과 대안
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• 제3권2호
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• pp.87-108
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• 2019

The purpose of this study is to examine the relationship between anti-Korean media and behavior. This study analyzed anti-Korean books published in Japan from 2000 to 2016. This study also analyses a survey conducted by those who have read that publication. According to the result, over half of the anti-Korea books published after 2010 and related to politics, history, and society of Korea. According to a result of the survey, people mainly get anti-Korean information from the Internet. Anti-Korean books affect to the anti-Korean information behavior not directly. In conclusion, while anti-Korean books affect anti-Korean behavior, it depends on the type of media.

• International Journal of Computer Science & Network Security
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• 제21권3호
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• pp.134-140
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• 2021

The development of technology speeds up the process of obtaining information and its analysis to track the level of corruption in different countries and develop countermeasures. This study examines the role of information and analytical support of anti-corruption policy as a tool for government accountability and analysis, evaluation, combating corruption in Eastern Europe. The purpose of the article is to identify the components of the information-analytical system that help reduce the level of corruption. The research methodology is based on a qualitative content analysis of the functioning of information and analytical systems of Ukraine used by anti-corruption bodies. A quantitative analysis of the CPI score was conducted, according to Transparency International, to identify the effectiveness of anti-corruption policies in developing countries. The results show similar trends in countries developing on the effect of the use of information and analytical systems in the implementation of anti-corruption policies, strategies and measures. The strategy to combat corruption mainly involves increasing the independence and powers of anti-corruption bodies. Therefore, the development of information and analytical support is aimed at automating the processes of pre-trial investigations and criminal proceedings, information protection. As a tool for accountability, information and analytical systems may be ineffective due to the abuse of power by higher anti-corruption bodies due to political pressure from elite structures. Restrictions on political will are a major problem for the effectiveness of anti-corruption policies.

• 무역상무연구
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• 제30권
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• pp.145-174
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• 2006

An anti-dumping has become the trade policy of choice for developing countries as well as advanced countries, hence it is the impending issue to the export-oriented countries including Korea. After colligating the analysis on the trade and industrial policy between Korea and China as well as the analysis on the preceding research, the main reasons of anti-dumping were selected as followings; an unemployment rate, real GDP growth rate and consumer price increase as internal factors, and trade balance, regional coefficient and trade specification index as external factors. Then, the research on how the above seven variable factors can affect the number of anti-dumping measures was accomplished. For the empirical analysis, the above information was used after reorganizing them by on the quarterly basis. Through the use of the correlation analysis, backward elimination of multiple regression analysis model and time-series analysis, it has appeared that the unemployment rate appeared to be the most important factors of anti-dumping measures in addition to the increase rate of trade balance. The variable such as the unemployment rate is uncontrollable for us, so it is appropriate to establish and operate an preemptive monitoring system based on the increasing rate of the amount of export and increasing rate of trade surplus.

• Structural Engineering and Mechanics
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• 제43권4호
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• pp.459-473
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• 2012

Post-tensioned concrete voided slab girders are widely used in highway bridge constructions. To obtain greater section hollow rate and reduce the self-weight, the plate thickness of slab girders are designed to be small with the adoption of flat anchorage system. Since large prestress is applied to the anchor end section, it was found that longitudinal shear cracks are easy to occur along the voided slab girder. The reason is the existence of great shearing effect at the junction area between web and bottom (top) plate in the anchor end section. This paper focuses on the longitudinal anti-cracking problem at the anchor end of post-tensioned concrete voided slab girders. Two possible models for longitudinal anticracking analysis are proposed. Differential element analysis method is adopted to derive the solving formula of the critical cracking state, and then the practical analysis method for longitudinal anti-cracking is established. The influence of some factors on the longitudinal anti-cracking ability is studied. Results show that the section dimensions (thickness of bottom, web and top plate) and prestress eccentricity on web plate are the main factors that influence the anti-cracking ability. Moreover, the proposed method is applied into three engineering examples to make longitudinal anti-cracking verification for the girders. According to the verification results, the design improvements for these girders are determined.

• 보건교육건강증진학회지
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• 제31권1호
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• pp.1-11
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• 2014

Objectives: In this study, the most executed social norm and advertisement about health consequences status were examined. The direction of effective anti-smoking advertisement is suggested in this study by figuring out the primary factors which affect smoking attitudes. Methods: The survey period of this study was from Nov $5^{th}$ to Nov $16^{th}$, 2012. 423 complete questionnaires were used for final analysis. The collected data were analyzed by SPSS Ver. 14.0, and reliability analysis, factor analysis, frequency analysis, F/t qualification, t-test, and multiple regression analysis, were performed. Results: This study is worth as a diagnosis of current status by using advertisement about social norm(51.4%) and health result(34.3%), which covers total of 85% in appeal types of anti-smoking advertisement that has been practically used in Korea. As a result, the health result type showed better result on belief and attitude. Conclusions: When establishing message strategy for anti-smoking advertisement, this study can help future direction for effective anti-smoking advertisement by figuring out effect of factors on smoking attitude.

• 대한본초학회지
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• 제22권4호
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• pp.187-199
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• 2007

Objectives : The present study purposed to compare the antioxidant effect, anti inflammatory effect and cancer cell multiplication inhibition effect of Fructificatio Inonoti Obliqui aqueous extract according to extraction temperature. Methods : We medicated animal models, which had experimental oxidation, with Fructificatio Inonoti Obliqui total extract and $50^{\circ}C$ low temperature leachate, and performed hematological analysis and blood chemical analysis with measuring SOD, GSH, catalase, NO and MDA content in the liver. In addition, we made comparative observation of anti inflammatory effect and anti-cancer effect. Results : Compared to the control group, both the group medicated with Fructificatio Inonoti Obliqui total extract and with $50^{\circ}C$ low-temperature leachate were found to decrease the number of thrombocytes in blood plasma and NO content while to increase SOD activity and catalase activity significantly. Both groups also showed anti-inflammatory effect against THP-1 cells and a multiplication inhibition effect against liver cancer cells and stomach cancer cells significantly. Conclusions : Both Fructificatio Inonoti Obliqui total extract and Fructificatio Inonoti Obliqui $50^{\circ}C$ low-temperature leachate have significant antioxidant effect, anti inflammatory effect and anti cancer effect.