• Parasites, Hosts and Diseases
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• 제59권3호
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• pp.257-263
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• 2021

Human gnathostomiasis is a parasitic disease caused by Gnathostoma nematode infection. A rapid, reliable, and practical immunoassay, named dot immuno-gold filtration assay (DIGFA), was developed to supporting clinical diagnosis of gnathostomiasis. The practical tool detected anti-Gnathostoma-specific IgG4 in human serum using crude extract of third-stage larvae as antigen. The result of the test was shown by anti-human IgG4 monoclonal antibody conjugated colloidal gold. The sensitivity and specificity of the test were both 100% for detection in human sera from patients with gnathostomiasis (13/13) and from healthy negative controls (50/50), respectively. Cross-reactivity with heterogonous serum samples from patients with other helminthiases ranged from 0 (trichinosis, paragonimiasis, clonorchiasis, schistosomiasis, and cysticercosis) to 25.0% (sparganosis), with an average of 6.3% (7/112). Moreover, specific IgG4 antibodies diminished at 6 months after treatment. This study showed that DIGFA for the detection of specific IgG4 in human sera could be a promising tool for the diagnosis of gnathostomiasis and useful for evaluating therapeutic effects.

• The Korean Journal of Legal Medicine
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• 제39권4호
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• pp.115-119
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• 2015

We investigated event-related potentials (ERPs) to estimate the accuracy of eyewitness memories. Participants watched videos of vehicles being driven dangerously, from an anti-impaired driving initiative. The four-letter license plates of the vehicles were the target stimuli. Random numbers were presented while participants attempted to identify the license plate letters, and electroencephalograms were recorded. There was a significant difference in activity 300-500 milliseconds after stimulus onset, between target stimuli and random numbers. This finding contributes to establishing an eyewitness recognition model where different ERP components may reflect more explicit memory that is dissociable from recollection.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.111-113
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• 2021

이동식 저장매체로 대표되는 USB 저장장치는 클라우드 서비스가 일상화된 요즘에도 널리 사용되고 있다. 하지만 USB 저장장치에 은닉영역을 생성하여 악용하는 경우가 있기 때문에 안티 포렌식 관점에서도 이를 탐지하고 분석하는 연구가 필요하다. 본 논문에서는 은닉 파티션을 생성하고 이곳에 파일을 저장할 수 있어 안티 포렌식으로 악용 될 수 있는 프로그램과 이것으로 만들어진 파일 시스템을 디지털 포렌식 관점에서 분석한다.

• 한국화재소방학회논문지
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• 제33권3호
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• pp.121-127
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• 2019

본 논문에서는 자동차 ABS 모듈의 결함으로 인한 화재사고에 대하여 기술하였다. 최근 발생한 화재 사례 중 동일 제조사의 ABS 모듈을 적용하는 다수의 차량에서 유사한 결함으로 인해 화재가 발생하는 경향을 나타내었다. 앞서 언급한 ABS 모듈에서는 배터리를 통해 상시전원으로 공급되는 전원배선 사이에서 절연파괴가 발생되는 특징을 나타내는데 이러한 부분은 연소 확대 과정에서 외부 화염에 의해 형성되기 어려운 부분으로 ABS 모듈 자체의 결함으로 판단된다. 본 연구의 결과로 부터 특정 제조사에서 생산 판매되는 차량에 대한 화재원인 조사에 있어서는 반드시 ABS 모듈의 결함 여부에 대한 조사가 필수적으로 진행되어야 할 것이다.

• 산경연구논집
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• 제12권6호
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• pp.47-55
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• 2021

Purpose: Organizational crime is an offense committed by an individual or an official in a corporate entity for organizational gain. This study aims to explore the literature on challenges facing digital forensics and further discuss possible solutions to such challenges as far as the protection of corporate crime is concerned. Research design, data and methodology: Qualitative textual methodology matches the interpretative approach since it is a quality method meant to consider the inductivity of strategies. Also, a qualitative approach is vital because it is distinct from the techniques used in optimistic paradigms linked to science laws. Results: For achieving justice through the investigation of digital forensic, there is a need to eradicate corporate crimes. This study suggests several solutions to reduce corporate crime such as 'Solving a problem to Anti-forensic Techniques', 'Cloud computing technique', and 'Legal Framework' etc. Conclusion: As corporate crime increases in rate, the data collected by digital forensics increases. The challenge of analyzing chunks of data requires digital forensic experts, who need tools to analyze them. Research findings shows that a change of the operating system and digital evidence interpretation is becoming a challenge as the new computer application software is not compatible with older software's structure.

• 약학회지
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• 제55권2호
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• pp.106-115
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• 2011

Systematic toxicological analysis (STA) means the process for general unknown screening of drugs and toxic compounds in biological fluids. In order to establish STA, in previous study we investigated pattern of drugs & poisons in autopsy cases during 2007~2009 in Korea, and finally selected 62 drugs as target drugs for STA. In this study, rapid and simple drug identification and quantitative analytical program by gas chromatography-mass spectrometry(GC-MS) was developed. The in-house program, "DrugMan", consisted of modified chemstation data analysis menu and newly developed macro modules. Total 55 drugs among 62 target drugs were applied to this program, they were 14 antidepressants, 8 anti-histamines, 5 sedatives/hypnotics, 5 narcotic analgesics, 3 antipsychotic drugs, and etc. For calibration curves, fifty five drugs were divided into four groups of range considering their therapeutic or toxic concentrations in blood specimen, i.e. 0.05~1 mg/l, 0.1~1 mg/l, 0.1~5 mg/l or 0.5~10 mg/l. Standards spiked bloods were extracted by solid-phase extraction (SPE) with trimipramine-D3 as internal standard. Parameters such as retention times, 3 mass fragment ions, and calibration curves for each drug were registered to DrugMan. A series of identification, semi quantitation of target drugs and reporting the results were performed automatically. Calibration curves for most drugs were linear with correlation coefficients exceeding 0.98. Sensitivity rate of DrugMan was 0.90 (90%) for 55 drugs at the level of 0.5 mg/l. For standard spiked bloods at the level of 0.5 mg/l for 29 drugs, semi quantitative concentrations were ranged 0.36~0.64 mg/l by DrugMan. If more drugs are registered to database in DrugMan in further study, it will be useful tools for STA in forensic toxicology.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7617-7623
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• 2014

Objective: The mechanism of action of fatty acid synthase (FASN) in drug tolerance of breast cancer cells with epithelial-mesenchymal transition (EMT) features was investigated. Methods: The breast cancer cell line MCF-7-MEK5 with stably occurring EMT and tumour necrosis factor-${\alpha}$ (TNF-${\alpha}$) tolerance was used as the experimental model, whereas MCF-7 acted as the control. Tumour cells were implanted into nude mice for in vivo analysis, and cerulenin was used as a FASN inhibitor. RT-PCR, real-time quantitative PCR and Western blot were employed to detect the expression of FASN, TNFR-1, TNFR-2, Wnt-1, ${\beta}$-catenin and cytC at the RNA and protein levels. Results: Compared with MCF-7, TNFR-1 expression in MCF-7-MEK5 was slightly changed, TNFR-2 was decreased, and FASN, Wnt-1, ${\beta}$-catenin and cytC were increased. The expression of Wnt-1 and ${\beta}$-catenin in MCF-7-MEK5 decreased after cerulenin treatment, whereas cytC expression increased. Conclusions: The important function of FASN in the drug tolerance of breast cancer may be due to the following mechanisms: FASN downregulated TNFR-2 expression through lipid rafts to make the cells less sensitive to TNF-${\alpha}$, and simultaneously activated the Wnt-$1/{\beta}$-catenin signalling pathway. Thus, cytC expression increased, which provided cells with anti-apoptotic capacity and induced drug tolerance.

• 약학회지
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• 제57권6호
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• pp.420-425
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• 2013

Phentermine (PT) and phenmetrazine (PM) have been widely used as anti-obesity drugs. These drugs should be used with caution due to its close relation to amphetamine in its structure and toxicity. PT and PM, amphetamine-type anorectics, have recently been considered as alternatives for methamphetamine abuse in Korea. In addition, the misuse and abuse of PT and PM obtained by illegal sources such as the internet become a serious social problem. In the present study, a simultaneous detection and quantification method for determining PT and PM in human urine was developed and validated according to the international guidelines. The urine samples were screened using a fluorescence polarization immunooassay and analyzed by gas chromatography mass spectrometry (GC-MS) after extraction using automatic solid phase extraction (SPE) with a mixed-mode cation exchange cartridge and derivatization with pentafluoropropionic anhydride (PFPA). The validation results for selectivity, linearity, limits of detection (LOD) and quantification (LOQ), intra- and inter-assay precision and accuracy and recovery were satisfactory. The validated method was successfully applied to authentic urine samples collected from 38 drug abuse suspects. PT and/or PM were identified with or without methamphetamine in urine samples. Abuse of PT and PM have increased continuously in Korea, therefore, closer supervision of the inappropriate use of anoretics is necessary.

• 정보보호학회논문지
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• 제24권1호
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• pp.107-122
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• 2014

DDoS 공격과 APT 공격은 좀비 컴퓨터들로 정해진 시간에 동시에 공격을 가하여 사회적 혼란을 유발하였다. 이러한 공격에는 공격자의 명령을 수행하는 많은 좀비 컴퓨터들이 필요하며 좀비 컴퓨터에는 안티바이러스 제품의 탐지를 우회하는 알려지지 않은 악성코드가 실행되어야한다. 그동안 시그니처로 탐지하던 안티바이러스 제품을 벗어나 알려지지 않은 악성코드 탐지에 많은 방법들이 제안되어 왔다. 본 논문은 디지털 포렌식 기법을 활용하여 알려지지 않은 악성코드 탐지 방법을 제시하고 정상 파일과 악성코드의 다양한 샘플들을 대상으로 수행한 실험 결과에 대하여 기술한다.

• 정보보호학회논문지
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• 제25권5호
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• pp.1059-1065
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• 2015

하드디스크에 설정되는 패스워드는 일반적으로 잘 알려지지 않았을 뿐만 아니라, 설정되면 데이터에 접근이 불가능하기 때문에 포렌식 조사를 방해하는 목적으로 사용될 수 있다. 하드디스크의 패스워드를 해제하기 위해서는 PC-3000과 같은 고가의 도구가 필요한데 이는 조직에 비용 부담을 주며, 해당 도구에 익숙지 않은 조사관에게는 조사 시 어려움을 준다. 본 논문에서는 하드디스크 패스워드를 해제하기 위해 필요한 내용을 정리하고 고가의 도구없이 하드디스크에 설정된 패스워드를 해제하는 방법들을 제안한다. 그리고 이 중 특정 제조사에 특화된 방법을 이용하여 패스워드를 획득하고 하드디스크의 잠금을 해제하는 절차를 제시한다.