• 국제초고층학회논문집
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• 제1권4호
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• pp.271-281
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• 2012

Tianjin Goldin Finance 117 tower has an architectural height of 597 m, total of 117 stories, and the coronation of having the highest structural roof of all the buildings under construction in China. Structural height-width ratio is approximately 9.5, exceeding the existing regulation code significantly. In order to satisfy earthquake and wind-resisting requirements, a structure consisting of a perimeter frame composed of mega composite columns, mega braces and transfer trusses and reinforced concrete core containing composite steel plate wall is adopted. Complemented by some of the new requirements from the latest Chinese building seismic design codes, design of the super high-rise building in high-intensity seismic area exhibits a number of new features and solutions to professional requirements in response spectrum selection, overall stiffness control, material and component type selection, seismic performance based design, mega-column design, anti-collapse and stability analysis as well as elastic-plastic time-history analysis. Furthermore, under the prerequisite of economic viability and a series of technical requirements prescribed by the expert review panel for high-rise buildings exceeding code limits, the design manages to overcome various structural challenges and realizes the intentions of the architect and the client.

• 수완나부미
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• 제12권1호
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• pp.7-47
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• 2020

This article is a sub-section of a comparative analysis of depictions of violence in Jakarta's Museum of the Indonesian Communist Party's Treachery, Ho Chi Minh City's War Remnants Museum, and Phnom Penh's Tuol Sleng Genocide Museum. In comparing these public history sites, I analyze how memories of mass violence were central to state formation in both Suharto's anti-Communist New Order (1966-1998), the Socialist Republic of Vietnam (1976-present), and Cambodia since the collapse of Democratic Kampuchea (1979-present). While this comparison points out specific distinctions about the role of the military, the nature of revolution, and conceptions of gender, it argues for a central similarity in the use of a mythology of victimization in building these post-conflict nation-states. This article focuses on my gendered analysis of the use of images of women and children in each museum. Depending on context and political purpose, these museums cast women as tragic victim, revolutionary heroine, or threat to the social order. My analysis of gender places stereotypical images of violence against women (the trope of women and children as the ultimate victims) in conversation with dark fantasies of women as perpetrators of savage violence and heroic images of women liberated by participation in violence.

• Tuberculosis and Respiratory Diseases
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• 제86권4호
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• pp.245-250
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• 2023

The healing process of tracheobronchial tuberculosis (TB) results in tracheobronchial fibrosis causing airway stenosis in 11% to 42% of patients. In Korea, where pulmonary TB is still prevalent, post-TB tracheobronchial stenosis (PTTS) is one of the main causes of benign airway stenosis causing progressive dyspnea, hypoxemia, and often life-threatening respiratory insufficiency. The development of rigid bronchoscopy replaced surgical management 30 years ago, and nowadays PTTS is mainly managed by bronchoscopic intervention in Korea. Similar to pulmonary TB, tracheobronchial TB is treated with combination of anti-TB medications. The indication of rigid bronchoscopy is more than American Thoracic Society (ATS) grade 3 dyspnea in PTTS patients. First, the narrowed airway is dilated by multiple techniques including ballooning, laser resection, and bougienation under general anesthesia. Then, most of the patients need silicone stenting to maintain the patency of dilated airway; 1.5 to 2 years after indwelling, the stent could be removed, this has shown a 70% success rate. Acute complications without mortality develop in less than 10% of patients. Subgroup analysis showed successful removal of the stent was significantly associated with male sex, young age, good baseline lung function and absence of complete one lobe collapse. In conclusion, rigid bronchoscopy could be applied to PTTS patients with acceptable efficacy and tolerable safety.

• Journal of Applied Biological Chemistry
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• 제57권2호
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• pp.103-111
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• 2014

A1E is an extract from traditional Asian medicinal plants that has therapeutic activities against cancers, metabolic disease, and other intractable conditions. However, its mechanism of action on cervical cancer has not been studied. In order to ascertain if A1E would have pronounced anti-cervical cancer effect, cervical cancer cells were incubated with A1E and apoptosis was detected by nuclear morphological changes, annexin V-FITC/PI staining, cell cycle analysis, western blotting, Reverse-transcription polymerase chain reaction, and measurement of mitochondrial membrane potential. Expression of human papiloma virus E6 and E7 oncogenes was down-regulated in A1E-treated cervical cancer cells, while p53 and retinoblastoma protein levels were enhanced. A1E also perturbed cell cycle progression at sub-G1 and altered cell cycle regulatory factors in SiHa cervical cancer cells. A1E activated apoptotic intrinsic pathway markers such as caspase-9, caspase-3 and poly ADP-ribose polymerase, and down-regulated expression of Bcl-2 and Bcl-xl. A1E induced mitochondrial membrane potential collapse and cytochrome c release, and inhibited phosphatidylinositol 3-kinase (PI3K)/Akt, key factors involved in cell survival signaling. Taken all these results, A1E induced apoptosis via activation of the intrinsic pathway and inhibition of the PI3K/Akt survival-signaling pathway in SiHa cervical cancer cells. In conclusion, A1E exerts anti-proliferative action growth inhibition on cervical cancer cells through apoptosis which demonstrates its anti-cervical cancer properties.

• 만화애니메이션 연구
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• 통권41호
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• pp.75-106
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• 2015

애니메이션 작품에서는, 캐릭터의 내적갈등을 효과적으로 전개하고 주제를 강화하기 위한 주요한 전략의 하나로서 공간을 성격화한다. 내적갈등의 과정은, 캐릭터가 결핍에 의해 형성된 두려움으로부터 자아를 보호하기 위하여 무의식적 차원에서 방어기제를 사용하며, 그 자기기만적 속성 때문에 현실이 왜곡되며 갈등이 강화되는 것으로 구체화된다. 본 논문은 애니메이션에 나타나는 공간의 구분에 있어서 갈등이 심화되는 공간인 '안티돔'의 개념에 주목하고, 작품 분석을 통해 내적갈등의 양상과 공간의 특성을 '은유 구조의 틀'로 해석하여, 캐릭터의 내적갈등을 증폭시키는 방어기제의 작용이 '안티돔'으로 성격화되는 그 근원적 관계성을 밝히고자 했다. 분석은 <신세기 에반게리온>의 TV 시리즈와 극장판 를 중심으로 이루어졌다. 이는 극중의 캐릭터들이 모두 심각한 가정사적 결핍과 A.T.필드로 상징되는 배타적 경계의 심리적 속성을 공유하고 있다는 점과, 무엇보다도 핵심 캐릭터인 '이카리 신지'를 통해 내적갈등에 대한 강박적 방어기제의 사용, 그 결과로 나타난 자아의 붕괴와 성찰의 과정을 전체 플롯의 핵심 맥락으로 묘사하고 있기 때문이다. 분석을 통해서, 캐릭터의 방어기제와 '안티돔(안티고로드로 확장된)' 공간과의 유사적 관계를 추론하였으며, (1) X축의 '수평공간'과 (2) Y축의 '수직공간', (3) 모든 공간이 '탈출구가 존재하지 않는' 구조로 이루어졌다는 의미에서 Z축의 '모순의 심도 공간'으로 구축되어 있다는 결론을 도출할 수 있었다. 본 논문은, 방어기제와 안티돔의 은유 관계 분석에 있어서 첫 출발의 의미로, <에반게리온>이 가장 적합한 분석 작품이라는 판단에 의해 시작되었다. 그러나 일본 애니메이션 특유의 현학적 구성과 확장적 해석의 가능성 때문에 오히려 명료한 검증이 어려웠다는 점이 연구의 한계로 작용했다. 후속 연구를 통해 보완되기를 바라며, 본 논문이 애니메이션 텍스트의 해석에 있어서 공간의 중요성을 제고하고, 창작을 위한 데이터베이스로 기능할 수 있기를 기대한다.

• 생명과학회지
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• 제23권3호
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• pp.389-398
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• 2013

Platycodin D는 도라지(Platycodon grandiflorum)의 뿌리인 길경(Platycodi Radix)에 함유된 은 triterpene saponin의 일종으로 다양한 약리효능이 있는 것으로 알려져 있다. 본 연구에서는 다양한 암세포 중 platycodin D의 항암활성 감수성이 가장 높았던 인체 혈구암 U937 세포를 대상으로 platycodin D 처리에 따른 apoptosis 유발기전에 대하여 조사하였다. 본 연구의 결과에 의하면 U937 세포에서 platycodin D 처리에 의한 증식억제는 apoptosis 유발과 밀접한 연관이 있음을 알 수 있었다. 이러한 platycodin D에 의한 apoptosis 유발은 pro-apoptotic Bax의 발현 증가와 연관된 미토콘드리아 막 전위의 소실 및 caspase-3의 활성화와 기질단백질들의 분해에 의한 것임을 알 수 있었으며, IAP family 인자들의 발현 감소가 caspase의 활성 증가에도 영향을 미친 것으로 추정된다. 또한 z-DEVD-fmk 선처리에 의하여 platycodin D에 의하여 유발된 apoptosis가 유의적으로 억제되었기에, platycodin D 처리에 의하여 유발되는 apoptosis는 미토콘드리아 경로에 의하여 조절되며, caspase-3의 활성화가 핵심적인 역할을 한 것으로 생각된다.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.922-929
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• 1997

저자들은 호흡곤란으로 내원한 환자에서, 외이, 코, 기관과 기관지를 침범한 재발성 다발성 연골염 1예를 경험하였기에 보고하는 바이다.

• The Korean Journal of Physiology and Pharmacology
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• 제17권4호
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• pp.267-274
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• 2013

A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed to investigate whether curcumin, which is known to have anti-inflammatory and antioxidant properties, could ameliorate radiation-induced pulmonary inflammation and fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior to a single irradiation and for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage accumulation, interstitial edema, alveolar septal thickness, perivascular fibrosis, and collapse in radiation-treated lungs were inhibited by curcumin administration. Radiation-induced transforming growth factor-${\beta}1$ (TGF-${\beta}1$), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin. Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2). Curcumin also inhibited the nuclear translocation of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) p65 in radiation-treated lungs. These results indicate that long-term curcumin administration may reduce lung inflammation and fibrosis caused by radiation treatment.

• PNF and Movement
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• 제17권2호
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• pp.215-222
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• 2019

Purpose: The objective of this study was to investigate whether augmented low-dye taping treatment, which consists of low-dye, reverse-six, and calcaneal-sling taping, is effective in alleviating the collapse of the medial longitudinal arch, which is used for physical balancing during one leg standing. Methods: The subjects comprised 27 students in their 20s whose navicular bone height was lowered by 10 mm or more when evaluated using the navicular drop test. Those with interference factors like deformities, fractures, or traumas were excluded. Frequency-division multiplexing was used to measure one leg standing, and the method to avoir the average each time after 3 times of measurement was applied. Results: Significant differences in the center of pressure (COP) path length, COP average velocity, and forefoot force were observed during left leg standing (p<0.05), but for right leg standing, only changes in forefoot force were noted. Conclusion: Based on the changes to the non-dominant leg in terms of COP path length, COP average velocity, and forefoot force, the immediate effect of augmented low-dye taping, which combines three types of anti-pronation taping, on one leg standing balance in people with flat feet was confirmed.

• 생명과학회지
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• 제17권12호
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• pp.1709-1716
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• 2007

본 연구에서는 몇 가지 암세포를 대상으로 마늘 열수추출물(WEAS)의 항암활성을 조사하였으며, 비교적 높은 감수성을 보인 백혈병세포를 대상으로 세포증식억제가 apoptosis 유도와 연관성이 있음을 제시하였다. WEAS에 의한 U937 세포의 apoptosis 유도는 세포주기 G2/M arrest와 연관성이 있었으며, 다양한 apoptosis조절 유전자들의 발현 변화를 동반하였음을 확인하였다. 이러한 apoptosis조절 인자들의 발현변화는 미토콘드리아 막 전위의 소실과 연관성이 있었으며, WEAS에 의한 암세포의 G2/M arrest에 의한 apoptosis 유발에 ROS가 중요한 조절자로 작용함을 알 수 있었다.