• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8613-8616
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• 2014

Background: The diagnostic approach to thyroid nodules involves ultrasound-guided fine needle aspiration biopsy (US-FNAB). We especially aimed to evaluate the contribution and the place of US-FNAB in preoperative evaluation of the malignant cases and draw attention to discordant cases diagnosed with papillary thyroid microcarcinoma (PTMC). Materials and Methods: A total of 276 cases were retrospectively reviewed who were subsequently diagnosed with a malignancy and who underwent US-FNAB. Results: Some 45 were found to have previously undergone the US-FNAB procedure. Of the patients in whom the surgical specimen was diagnosed with a malignancy, 21 (46.7%) were diagnosed as malignant or suspicious for malignancy, and 24 (53.3%) were concluded as benign or insufficient for diagnosis. Patients with the diagnosis of PTMC outnumbering the others was a striking finding (11 cases, 24%). Conclusions: We suggest performing repeat aspiration biopsy considering sampling errors in cases where inconsistency exists between clinical findings and cytological results in thyroid nodules smaller than 10 mm in diameter and with suspicious findings on ultrasonography.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1041-1045
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• 2015

Background: Paget's disease (PD) is a rare form of intraepithelial adenocarcinoma that involves breast and extramammarian tissues. It is often associated with ductal carcinoma in situ and/or invasive ductal cancer. Molecular pathways that play a role in development of Paget's disease are stil unclear. Expression patterns of Cox-2 and bcl-2 were therefore assessed. Materials and Methods: Patients with a histopathological diagnosis of Paget's disease were included in this study. Patient files were analysed retrospectively. Results: Invasive cancer was diagnosed in 35 (76.1%) of the patients, 7 (15.2%) had ductal carcinoma in situ and 4 (8.7%) patients had no associated neoplasm. Twenty four (52.2%) patients showed COX-2 expression in Paget cells whereas no expression was seen in 22 (47.8%) patients. No relation was found between COX-2 expression and the lesion underlying Paget's disease (p=0.518). Bcl-2 expression in Paget cells was found positive in 12 (26.1%) and negative in 27 (58,7%) cases. There was no relation between Bcl-2 expression and the lesion accompanying Paget's disease (p=0.412). No relation was observed between COX-2 expression and Bcl-2 expression (p=0.389). Conclusions: In breast cancer, COX-2 expression is associated with poor prognostic factors. As COX-2 expression increases the tendency to metastasize also increases. In our study we found a significantly high COX-2 expression in Paget's disease of the breast. We suggest that COX-2 expression and inflammatory processes may play a role in pathogenesis of the Paget's disease of the breast.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5729-5733
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• 2012

Background and Objectives: This study aimed to present the clinicopathological characteristics and treatment of patients with bladder carcinoma with sarcomatoid differentiation at our institution. Methods: Between 1995-2009, 950 patients were followed-up for bladder carcinoma. Among them, 14 patients with sarcomatoid carcinoma were retrospectively reviewed, and their clinical, pathological features and treatment were recorded. Results: Median age of the patients was 65 years (range: 41-86 years), 12 (86%) being male and 2 (14%) female. All the patients presented with hematuria and 11 (88%) had a history of smoking. The tumor growth pattern was solid in 10 patients, papillary in 2, and mixed in 2. In all, 5 of the patients had urothelial carcinoma with sarcomatoid differentiation and 9 were diagnosed with sarcomatoid carcinoma. Five patients underwent radical cystectomy with ileal conduit surgery, 2 patients refused cystectomy, and 8 patients underwent re-TUR. Following diagnosis, 12 of the patients died in mean 10.7 months (range: 1-48 months). Conclusion: Urothelial carcinomas with sarcomatoid features are aggressive and are usually at advanced stage at the time of diagnosis. The outcomes of multimodal treatment are not satisfactory. Significant findings of the present study are that early diagnosis positively affect survival and that gemcitabine and cisplatin in combination can positively affect survival.

• Structural Engineering and Mechanics
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• v.50 no.4
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• pp.419-439
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• 2014

In this study, the structural performance of a seven span masonry arch bridge was evaluated. Investigations were performed on Aspendos (Belkis) Masonry Arch Bridge which was located on road of Aspendos Acropolis City in Antalya, Turkey. The old bridge was constructed in the early of fourth century AD, but it was exposed to the earthquakes in this region and the overloading by the river water. The old bridge was severely damaged and collapsed by probably an earthquake many years ago and a new bridge was then reconstructed on the remains of this old bridge by Seljuk in the 13th century. The bridge has also been affected from overflowing especially in the spring of each year, so some protective measures should be taken for this monumental bridge. Therefore, the structural performance under these loading has to be known. For this purpose, an initial finite element model was developed for the bridge and it was calibrated according to ambient vibration test results. After that, it was analyzed for different load cases such as dead, live, earthquake and overflow. Three load combinations were taken into account by deriving from these load cases. The displacements and the stresses for these combination cases were attained and compared with each other. The structural performance of Aspendos Masonry Arch Bridge was determined by considering the demand-capacity ratio for the tensile stress of the mortar used in Aspendos Masonry Arch Bridge. After these investigations, some concluding remarks and offers were presented at the end of this study.

• Steel and Composite Structures
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• v.12 no.5
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• pp.413-426
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• 2012

In this paper, nonlinear static analysis of three-dimensional cable stayed bridges is performed for the time dependent materials properties such as creep, shrinkage and aging of concrete and relaxation of cable. Manavgat Cable-Stayed Bridge is selected as an application. The bridge located in Antalya, Turkey, was constructed with balanced cantilever construction method. Total length of the bridge is 202 m. The bridge consists of one $\ddot{e}$ shape steel tower. The tower is at the middle of the bridge span. The construction stages and 3D finite element model of bridge are modeled with SAP2000. Large displacement occurs in these types of bridges so geometric nonlinearity is taken into consideration in the analysis by using P-Delta plus large displacement criterion. The time dependent material strength and geometric variations are included in the analysis. Two different finite element analyses carried out which are evaluated with and without construction stages and results are compared with each other. As a result of these analyses, variation of internal forces such as bending moment, axial forces and shear forces for bridge tower and displacement and bending moment for bridge deck are given with detailed. It is seen that construction stage analysis has a remarkable effect on the structural behavior of the bridge.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.6131-6134
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• 2013

Background: The two basic methods that are currently accepted to identify the HER2 status are immunohistochemistry and flyorescence in situ hybridization (FISH). The aim of this study was to perform the dual-color silver in situ hybridization (dc-SISH) technique as an alternative to FISH. Materials and Methods: A total of 40 invasive breast carcinoma cases were assessed for HER2 gene amplification by FISH and dual-color SISH. Results: Significant correlation was found in the HER2 expression results obtained with the two approaches (p=0.001, p<0.05). The concordance rate was 92.3%. Conclusions: Foutine practical use of the dc-SISH method, which is much easier to apply, score, and evaluate, has many advantages. HER2 and CEN17 status can be evaluated simultaneously with the newly developed "Dual-Color Probe". All these specifications and the reliable results obtained support the widespread use of SISH technique in clinical practice.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5911-5913
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• 2013

Cyclamen coum is a traditional medicinal plant in the Turkey. Its anticancer properties and whether cyclamen extract induces any cytotoxicity in solid cancer cell lines have not been thoroughly investigated previously. Therefore we examined cytotoxic effects on cervical cells; HeLa and non small cell lung cancer cell, H1299, lines; Cyclamen extract induced cellular death of both HeLa and H1299 cells in a dose dependent manner. We also analyzed the capacity of cyclamen extract to induce apoptosis by the TUNEL method. Here, for the first time we report that the extract of Cyclamen coum, an endemic plant for Turkey, Bulgaria, Georgia and the Middle East can induce cytotoxicity via apoptosis in HeLa and H1299 cells. These results imply that cyclamen extract can be further analyzed to potentially find novel anticancer compounds.

• Asian Journal of Business Environment
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• v.6 no.4
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• pp.5-12
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• 2016

Purpose - Not all firms are able to completely eliminate the risk arising out of the crisis. Success hides in the ability to perceive the market expectations accurately and take correct decisions. This study aims to analyze the firms' decisions at gross-root level. Research Design, Data, and Methodology - Primary data is obtained with the help of specially designed questionnaires from the agriproducts export firms that are members of export union of Turkey. The study is based on four theoretical structures: general planned behavior theory model, perception-leading behavior control and subjective norm model, perceived-behavioral-control leading perception and subjective norm models, and perceptions and subjective norms leading behavior control model. Structural Equation Models (SEM) is used to conduct the empirical analysis. Results - The findings show perceptions and subjective norms leading behavior control model as the best one, concluding that the environmental pressures and positive perceptions have significant effect on the strategic decisions of the agriproducts export firms. Conclusion - Policy tools like creating positive perception in the markets, providing sufficient information and financial support to the firms and increasing market competition can be used effectively to achieve the said objective.

• Steel and Composite Structures
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• v.18 no.5
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• pp.1259-1277
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• 2015

The present study is focused on the behavior and design of perforated steel storage rack columns under axial compression. These columns may exhibit different types of behavior and levels of strength owing to their peculiar features including their complex cross-section forms and perforations along the member. In the present codes of practice, the design of these columns is carried out using analytical formulas which are supported by experimental tests described in the relevant code document. Recently proposed analytical approaches are used to estimate the load carrying capacity of axially compressed steel storage rack columns. Experimental and numerical studies were carried out to verify the proposed approaches. The experimental study includes compression tests done on members of different lengths, but of the same cross-section. A comparison between the analytical and the experimental results is presented to identify the accuracy of the recently proposed analytical approaches. The proposed approach includes modifications in the Direct Strength Method to include the effects of perforations (the so-called reduced thickness approach). CUFSM and CUTWP software programs are used to calculate the elastic buckling parameters of the studied members. Results from experimental and analytical studies compared very well. This indicates the validity of the recently proposed approaches for predicting the ultimate strength of steel storage rack columns.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.11
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• pp.169-178
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• 2021

Motivating employee work engagement, which has emerged as one of the most significant drivers of high performance and achievement in today's dynamic environment, has become essential in gaining a sustainable competitive advantage. As widely known, leadership is a primary factor affecting work engagement. This is also directly related to a specific style of leadership exercised. Leadership styles affect the work engagement levels of the employees. The distracting nature of leadership type can have adverse impacts on individuals' behaviors. To provide a comprehensive understanding of the phenomenon, this article draws on social interaction theory and social exchange theory to investigate the potential effects of inclusive leadership on work engagement within the workplace, and the mediating role of psychological safety on the relationship between inclusive leadership and the work engagement. Here, psychological safety is needed by employees to avoid and manage negative feelings. SPSS and AMOS software was applied to survey data obtained from (n = 373) employees. Results revealed that inclusive leadership is a strong predictor for work engagement, and psychological safety partially mediates the link between inclusive leadership and work engagement. Implications for theory and practice alongside limitations are discussed.